JP2017527538A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017527538A5 JP2017527538A5 JP2017502269A JP2017502269A JP2017527538A5 JP 2017527538 A5 JP2017527538 A5 JP 2017527538A5 JP 2017502269 A JP2017502269 A JP 2017502269A JP 2017502269 A JP2017502269 A JP 2017502269A JP 2017527538 A5 JP2017527538 A5 JP 2017527538A5
- Authority
- JP
- Japan
- Prior art keywords
- succ
- asp
- peptidomimetic
- glu
- phe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000816 peptidomimetic Substances 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 11
- 241000251468 Actinopterygii Species 0.000 claims 9
- 235000019688 fish Nutrition 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 125000000539 amino acid group Chemical group 0.000 claims 5
- 235000013305 food Nutrition 0.000 claims 4
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical group C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 3
- 230000002378 acidificating effect Effects 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 230000035800 maturation Effects 0.000 claims 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 3
- 125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 claims 3
- AKCRVYNORCOYQT-YFKPBYRVSA-N N-methyl-L-valine Chemical compound CN[C@@H](C(C)C)C(O)=O AKCRVYNORCOYQT-YFKPBYRVSA-N 0.000 claims 2
- 230000001934 delay Effects 0.000 claims 2
- 230000012173 estrus Effects 0.000 claims 2
- 238000007654 immersion Methods 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- AKCRVYNORCOYQT-RXMQYKEDSA-N (2r)-3-methyl-2-(methylazaniumyl)butanoate Chemical group C[NH2+][C@H](C(C)C)C([O-])=O AKCRVYNORCOYQT-RXMQYKEDSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000972773 Aulopiformes Species 0.000 claims 1
- 241000252233 Cyprinus carpio Species 0.000 claims 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical group OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 claims 1
- 125000000570 L-alpha-aspartyl group Chemical group [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(*)=O 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 125000002068 L-phenylalanino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000510 L-tryptophano group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C(C([H])([H])[C@@]([H])(C(O[H])=O)N([H])[*])C2=C1[H] 0.000 claims 1
- 241001502129 Mullus Species 0.000 claims 1
- 241000276707 Tilapia Species 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 241001233037 catfish Species 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000002778 food additive Substances 0.000 claims 1
- 235000013373 food additive Nutrition 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 230000017448 oviposition Effects 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002028 premature Effects 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000020509 sex determination Effects 0.000 claims 1
- 230000032678 sex differentiation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462025618P | 2014-07-17 | 2014-07-17 | |
| US62/025,618 | 2014-07-17 | ||
| PCT/IL2015/050739 WO2016009439A1 (en) | 2014-07-17 | 2015-07-16 | Antagonists of neurokinin b in fish reproduction |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527538A JP2017527538A (ja) | 2017-09-21 |
| JP2017527538A5 true JP2017527538A5 (enExample) | 2018-07-26 |
| JP6587677B2 JP6587677B2 (ja) | 2019-10-16 |
Family
ID=54062779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017502269A Active JP6587677B2 (ja) | 2014-07-17 | 2015-07-16 | 魚の生殖におけるニューロキニンｂのアンタゴニスト |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10155790B2 (enExample) |
| EP (1) | EP3169700A1 (enExample) |
| JP (1) | JP6587677B2 (enExample) |
| CN (1) | CN106661088B (enExample) |
| AU (1) | AU2015291155B2 (enExample) |
| BR (1) | BR112017000591B1 (enExample) |
| CA (1) | CA2954607C (enExample) |
| CL (1) | CL2017000074A1 (enExample) |
| IL (1) | IL249940B (enExample) |
| PH (1) | PH12017500088A1 (enExample) |
| WO (1) | WO2016009439A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10793614B2 (en) * | 2014-07-17 | 2020-10-06 | Yissum Research Development Company of the Hebrew University ofJerusaIem Ltd. | Antagonists of fish reproduction |
| BR112021018015A2 (pt) * | 2019-03-11 | 2021-11-23 | Aquinovo Ltd | Métodos de melhoria da taxa de conversão de ração e sobrevivência de peixes |
| US20250270330A1 (en) * | 2022-04-25 | 2025-08-28 | Kallyope, Inc. | Treatment of headache disorders with nk3 modulators |
| CN116622715B (zh) * | 2023-04-04 | 2024-01-12 | 河南农业大学 | 一种编码鸡nkb的基因及其应用 |
| TW202446377A (zh) | 2023-04-18 | 2024-12-01 | 美商克力歐普股份有限公司 | Nk3調節劑及其用途 |
| CN118318919B (zh) * | 2024-05-13 | 2025-02-18 | 中国水产科学研究院珠江水产研究所 | 一种提高鱼类繁殖性能的组合物及其应用 |
| CN118649241B (zh) * | 2024-05-24 | 2025-04-25 | 四川大学华西第二医院 | 多肽链的用途、纳米材料及其制备方法和用途、预防和/或治疗中心性性早熟药物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1233696B (it) * | 1989-05-29 | 1992-04-14 | Menarini Farma Ind | Peptidi di sintesi antagonisti della neurochinina a. loro sali e relativi procedimenti di fabbricazione |
| GB9022788D0 (en) | 1990-10-19 | 1990-12-05 | Cortecs Ltd | Pharmaceutical formulations |
| EP2739302A2 (en) * | 2011-08-01 | 2014-06-11 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Novel sequences for the control of reproduction in fish |
| US20150272927A1 (en) * | 2012-12-03 | 2015-10-01 | University Of Washington Through Its Center For Commercialization | Methods and compositions for treating vasomotor symptoms |
-
2015
- 2015-07-16 WO PCT/IL2015/050739 patent/WO2016009439A1/en not_active Ceased
- 2015-07-16 US US15/326,602 patent/US10155790B2/en active Active
- 2015-07-16 JP JP2017502269A patent/JP6587677B2/ja active Active
- 2015-07-16 EP EP15759546.3A patent/EP3169700A1/en active Pending
- 2015-07-16 CN CN201580038809.6A patent/CN106661088B/zh active Active
- 2015-07-16 BR BR112017000591-3A patent/BR112017000591B1/pt active IP Right Grant
- 2015-07-16 CA CA2954607A patent/CA2954607C/en active Active
- 2015-07-16 AU AU2015291155A patent/AU2015291155B2/en not_active Ceased
-
2017
- 2017-01-05 IL IL249940A patent/IL249940B/en active IP Right Grant
- 2017-01-11 CL CL2017000074A patent/CL2017000074A1/es unknown
- 2017-01-12 PH PH12017500088A patent/PH12017500088A1/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017527538A5 (enExample) | ||
| CN100506844C (zh) | 新的肽 | |
| UA103154C2 (uk) | Hla-a*1101-обмежений пептид wt1 і фармацевтична композиція, яка містить його | |
| JP2009108078A5 (enExample) | ||
| RU2020120797A (ru) | Пептидные композиции | |
| RU2016120641A (ru) | Новые полипептиды | |
| KR20010023449A (ko) | 신규한 환상 테트라펩티드 유도체 및 그 의약 용도 | |
| RU2019121566A (ru) | Синтез лираглутида | |
| RU2008100238A (ru) | Соединения оксинтомодулина, фармацевтическая композиция на их основе, способы лечения и профилактики ожирения и сопутствующих заболеваний (варианты) и лекарственное средство (варианты) | |
| JPS6351159B2 (enExample) | ||
| TW200521144A (en) | Macrocyclic peptides active against the hepatitis c virus | |
| JP2014507402A5 (enExample) | ||
| MX2009010965A (es) | Péptidos de tem8 y vacunas que los contienen. | |
| JP2013511554A5 (enExample) | ||
| AU2022209272B2 (en) | Stable modulators of gamma-c-cytokine activity | |
| JP2008530975A5 (enExample) | ||
| HUE031113T2 (en) | Procedure for the preparation of Degarelix and its intermediates | |
| WO2011038900A3 (en) | Peptide analogues of glucagon for diabetes therapy | |
| CN106661088A (zh) | 鱼类繁殖中的神经激肽b拮抗剂 | |
| JP2016516734A5 (enExample) | ||
| CA2200935C (en) | Cyclic motilin-like polypeptides with gastrointestinal motor stimulating activity | |
| CN116888146A (zh) | 胰高血糖素样肽-1受体拮抗剂 | |
| TWI243177B (en) | Neuromedin b and somatostatin receptor agonists | |
| RU2242481C2 (ru) | Аналоги циклического соматостатина | |
| JP6677687B2 (ja) | 高温でのペプチド合成のための過剰カルボジイミドの使用 |