JP2009107941A - 頭皮用育毛剤 - Google Patents
頭皮用育毛剤 Download PDFInfo
- Publication number
- JP2009107941A JP2009107941A JP2007279347A JP2007279347A JP2009107941A JP 2009107941 A JP2009107941 A JP 2009107941A JP 2007279347 A JP2007279347 A JP 2007279347A JP 2007279347 A JP2007279347 A JP 2007279347A JP 2009107941 A JP2009107941 A JP 2009107941A
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- JP
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- Prior art keywords
- hair
- scalp
- ceramide
- growth
- nanoparticles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
【解決手段】ステビア抽出物と、セラミド前駆体と、セラミドと、血流促進成分とをそれぞれ生体適合性ナノ粒子内に封入して頭皮用育毛剤とする。このナノ粒子が毛穴や頭皮表面から頭皮の深部にまで浸透することにより、育毛成分を頭皮深部にまで到達させるとともに、頭皮深部において作用機序の異なる4種類の育毛成分をナノ粒子から徐々に放出させることができる。
【選択図】なし
Description
0.25重量%のポリビニルアルコール(PVA EG05:日本合成化学工業製)水溶液80mLを調製し貧溶媒とした。乳酸・グリコール酸共重合体(PLGA7520:和光純薬工業製)2gをアセトン40mLに溶解し、精製水4mLで溶解したステビア抽出物(丸善製薬製)60mgを添加、混合し良溶媒とした。この良溶媒を、先の貧溶媒中に40℃、400rpmで攪拌下、一定速度(4mL/分)で滴下し、良溶媒の貧溶媒中への拡散によってステビア抽出物封入PLGAナノ粒子の懸濁液を得た。
0.375重量%のポリビニルアルコール(PVA EG05:日本合成化学工業製)水溶液80mLを調製し貧溶媒とした。乳酸・グリコール酸共重合体(PLGA7520:和光純薬工業製)2gをアセトン40mLに溶解し、エタノール20mLで溶解したコメヌカスフィンゴ糖脂質(日本製粉製)100mgを添加混合し良溶媒とした。この良溶媒を先の貧溶媒中に40℃、400rpmで攪拌下、一定速度(4mL/分)で滴下し、良溶媒の貧溶媒中への拡散によって、コメヌカスフィンゴ糖脂質封入PLGAナノ粒子の懸濁液を得た。
0.375重量%のポリビニルアルコール(PVA EG05:日本合成化学工業製)水溶液80mLを調製し貧溶媒とした。乳酸・グリコール酸共重合体(PLGA7520:和光純薬工業製)2gをアセトン40mLに溶解し、エタノール20mLで溶解したセラミド2(高砂香料工業製)20mgを添加混合し良溶媒とした。この良溶媒を先の貧溶媒中に40℃、400rpmで攪拌下、一定速度(4mL/分)で滴下し、良溶媒の貧溶媒中への拡散によって、セラミド2封入PLGAナノ粒子の懸濁液を得た。
0.25重量%のポリビニルアルコール(PVA EG05:日本合成化学工業製)水溶液80mLを調製し貧溶媒とした。乳酸・グリコール酸共重合体(PLGA7520:和光純薬工業製)2gをアセトン40mLに溶解し、エタノール20mLで溶解した酢酸トコフェロール(エーザイ製)200mgを添加混合し良溶媒とした。この良溶媒を先の貧溶媒中に40℃、400rpmで攪拌下、一定速度(4mL/分)で滴下し、良溶媒の貧溶媒中への拡散によって、酢酸トコフェロール封入PLGAナノ粒子の懸濁液を得た。
上記の方法で作製したステビア抽出物封入PLGAナノ粒子、コメヌカスフィンゴ糖脂質封入PLGAナノ粒子、セラミド2封入PLGAナノ粒子、酢酸トコフェロール封入PLGAナノ粒子の懸濁液を、各懸濁液の粒子濃度に基づいて各粒子の凍乾後の重量がそれぞれ17.0mg、6.0mg、6.0mg、5.8mgとなるように調整混合してバイアル瓶分注した。さらに、水で溶解した賦形剤のトレハロース32.0mgとビタミンC誘導体5.7mgを添加し混合した(固形分濃度1.45重量%)。その後、真空凍結乾燥機(宝製作所製)にて、3日間凍結乾燥してPLGA複合粒子を得た。該PLGA複合粒子の水分散時におけるナノ粒子の平均粒子径は280nmであり、再分散が良好であった。また、HPLCにより、複合粒子内のステビア抽出物、コメヌカスフィンゴ糖脂質、セラミド3、及び酢酸トコフェロールの封入率を定量したところ、それぞれ0.62%、0.35%、0.07%、及び0.69%であった。
次に、上記PLGA複合粒子を分散させるローションの処方1、処方2、処方3を表1〜表3に示す。なお、表1、表2において、6番目以降の各成分は微量(1%以下)であり、これらを加えた処方液全体で100%となるように調製した。
上記実施例において作製した各育毛成分(ステビア抽出物、コメヌカスフィンゴ糖脂質、セラミド2、酢酸トコフェロール)含有PLGAナノ粒子の発毛効果を、C3H/HeN Slcマウスを用いて以下の手順により評価した。このC3H/HeN Slcマウスは、毛刈りをすると毛周期が休止期に入る特徴があり、毛刈り後15日間は発毛しないことがわかっている。
1)1週間馴化したC3H/HeN Slcマウス(雄、生後8週齢、試験区毎にn=8、同一ケージ内で飼育)の背部下部(2×4cm)の毛を、皮膚を傷つけたり、刺激したりしないように注意深くバリカンで刈り取り、一日後シェーバーで剃毛し皮膚を露出させた。
2)マウスの剃毛部に本発明、比較例1〜9の検体溶液100μLをピペットで塗布した後、ピペットチップの側面で刺激を与えないようにして薄く全体に広げた。各検体溶液は1日1回100μLを14日間連日塗布した。また、対照例として検体溶液を塗布しない無処理区を設けた。なお、各検体溶液の調製は7日おきに行い、冷蔵保管した。検体溶液の処方を表4に示す。
(評価基準)
スコア : 状態
0 : 黒化が全く見られない
1 : 黒化が見られる
2 : 育毛(毛の伸張が認められる、披毛再生率30%未満)
3 : 育毛(毛の伸張が認められる、披毛再生率30〜60%未満)
4 : 育毛(毛の伸張が認められる、披毛再生率60%以上)
観察結果を表5に示す。
上記実施例5で作製した各育毛成分(ステビア抽出物、コメヌカスフィンゴ糖脂質、セラミド2、酢酸トコフェロール)含有PLGA複合粒子(実施例1〜4で作製した各ナノ粒子を3:1:1:1の割合で複合)を、処方1のローションに混合分散させたナノ粒子分散液を用いて細毛・白髪の抑制効果を評価した。このときの複合粒子とローションの混合割合は、複合粒子約0.07gに対してローション28mLとした。そして、白髪が気になると感じる被験者(年齢32〜60歳、平均年齢49.6歳の女性15名)に1日1回の洗髪後、ナノ粒子分散液を4mLずつ6ヶ月にわたって頭皮に擦り込んでもらった。白髪の多い箇所の使用前、使用開始3ヶ月後、6ヶ月後の毛穴拡大写真をマイクロスコープを用いて撮影し、各被験者について黒髪と白髪の本数、並びに太毛(60μm以上)、細毛(40〜60μm)、産毛(40μm以下)の本数をカウントして平均値を算出し、白髪・毛髪成長効果について評価した。白髪の評価結果を図1に、毛髪成長の評価結果を図2に示す。
Claims (10)
- ステビア抽出物と、セラミド前駆体と、セラミドと、血流促進成分とをそれぞれ封入した生体適合性ナノ粒子を含む頭皮用育毛剤。
- 前記セラミド前駆体がグルコシルセラミドであることを特徴とする請求項1又は請求項2に記載の頭皮用育毛剤。
- 前記血流促進成分がビタミンE誘導体であることを特徴とする請求項1乃至請求項3のいずれか1項に記載の頭皮用育毛剤。
- 前記生体適合性ナノ粒子に対する前記各成分の封入率が0.5重量%以上20重量%以下であることを特徴とする請求項1乃至請求4のいずれか1項に記載の頭皮用育毛剤。
- 前記生体適合性ナノ粒子を形成する生体適合性高分子が、ポリ乳酸、ポリグリコール酸、乳酸・グリコール酸共重合体、若しくはアスパラギン酸・乳酸共重合体のいずれかであることを特徴とする請求項1乃至請求項5のいずれか1項に記載の頭皮用育毛剤。
- 前記生体適合性ナノ粒子と共に糖アルコールが複合化されることを特徴とする請求項1乃至請求項6のいずれか1項に記載の頭皮用育毛剤。
- 前記生体適合性ナノ粒子と共にビタミンまたはビタミン誘導体が複合化されることを特徴とする請求項1乃至請求項7のいずれか1項に記載の頭皮用育毛剤。
- 複合化された前記生体適合性ナノ粒子を液中に分散させて成る請求項7又は請求項8に記載の頭皮用育毛剤。
- 前記液中に他の育毛成分を配合したことを特徴とする請求項9に記載の頭皮用育毛剤。
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