JP2007308381A - 油中水乳化剤形の皮膚外用剤 - Google Patents
油中水乳化剤形の皮膚外用剤 Download PDFInfo
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- JP2007308381A JP2007308381A JP2006136245A JP2006136245A JP2007308381A JP 2007308381 A JP2007308381 A JP 2007308381A JP 2006136245 A JP2006136245 A JP 2006136245A JP 2006136245 A JP2006136245 A JP 2006136245A JP 2007308381 A JP2007308381 A JP 2007308381A
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Landscapes
- Cosmetics (AREA)
Abstract
【解決手段】 1)有機変性粘土鉱物と2)次のA群に示される糖類及びその塩から選択される1種乃至は2種以上とを、油中水乳化剤形の皮膚外用剤に含有させる。
(A)硫酸化されていても良いトレハロース、硫酸化アルギン酸、マルチトール、ソルビトール、オリゴガラクツロン酸
更に、塩化L−カルニチン及び/又はその塩を含有することが好ましく、更に、グリセリン、ジグリセリン及びジプロピレングリコールから選択される1種乃至は2種以上を5〜20質量%含有することが好ましい。
【選択図】 なし
Description
(1)1)有機変性粘土鉱物と2)次のA群に示される糖類及びその塩から選択される1種乃至は2種以上とを含有することを特徴とする、油中水乳化剤形の皮膚外用剤。
(A)硫酸化されていても良いトレハロース、硫酸化アルギン酸、マルチトール、ソルビトール、オリゴガラクツロン酸
(2)更に、塩化L−カルニチン及び/又はその塩を含有することを特徴とする、(1)に記載の油中水乳化剤形の皮膚外用剤。
(3)更に、グリセリン、ジグリセリン及びジプロピレングリコールから選択される1種乃至は2種以上を5〜20質量%含有することを特徴とする、(1)又は(2)に記載の皮膚外用剤。
(4)油相において、シクロメチコン及び粘度1mPa・s以下のジメチコンの含有量の和が油相全量に対して、50質量%以上であることを特徴とする、(1)〜(3)何れか1項に記載の皮膚外用剤。
本発明の皮膚外用剤は有機変性粘土鉱物を必須成分として含有することを特徴とする。ここで有機変性とは、粘土鉱物の一部に有機化合物の一部を共有結合乃至はイオン結合を介して強固乃至は緩やかな結合を生ぜしめ、有機化合物の性質の一部乃至は全部を粘土鉱物に付与させることを意味し、この様な変性としては4級アミン基と粘土鉱物のアニオン部分を結合させる方法、カルボキシル基と粘土鉱物のカチオン部分を結合させる方法等が例示でき、4級アミン基と粘土鉱物のアニオン部分を結合させる方法が特に好ましく例示できる。
前記未変性粘土鉱物を分散媒に分散させる。該分散剤は水系の溶媒であることが好ましく、水であってもよい。分散未変性粘土鉱物を含む分散液に、さらに4級アミノ基を有する化合物を加え、よく撹拌する。4級アミノ基を有する化合物は、水に溶解されて加えられてもよい。加えられる4級アミノ基を有する化合物の量は、分散未変性粘土鉱物の量に対して0.1〜20質量%であることが好ましく、0.5〜15質量%であることがより好ましい。この様な構成を取ることにより、乳化系において、好ましい使用感を呈するためである。撹拌後、分散質を濾取し、脱水、乾固することにより本発明における変性粘土鉱物を得ることができる。あるいは、分散質を濾取することなく、減圧濃縮することにより分散剤を除去して乾固させることにより、本発明における変性粘土鉱物を得ることもできる。得られた変性粘土鉱物は、好ましくは所望のサイズ(粒径が1〜1000μmであることが好ましい)に粉砕され、本発明の皮膚外用剤に含有される。
本発明の皮膚外用剤は次のA群に示す糖類及びその塩から選択される1種乃至は2種以上を必須成分として含有することを特徴とする。かかる糖類は、前記有機変性粘土鉱物の形成するエマルションの長期保存条件での安定性を、下記に示す好ましい含有量の範囲に於いて、向上せしめる作用を有する。尚、後記の含有量のものを複数組み合わせて含有させることもできる。
市販のペクチンの5%水溶液、1000gに市販ペクチナーゼ製剤5gを添加し、37℃で4時間撹拌し酵素処理した。この処理液を1000gで10分間遠心し不溶物を除いた。この上澄液を分子量3000カットの限外ろ過膜でろ過し、得られたろ液を更にフリーズドライし30gのパウダーを得た。このパウダ−の主成分は重合度5及び6のオリゴガラクツロン酸の約1:2の混合物であった。
製造例1のオリゴガラクツロン酸10gを水に溶かし、これに10gの塩化第二鉄を加え、溶解させ、これを凍結乾燥し、オリゴガラクツロン酸・鉄複合体を得た。
本発明の皮膚外用剤は、前記必須成分を含有することを特徴とする。本発明の皮膚外用剤としては、皮膚に外用で適用されるものであれば、特段の限定無く使用することができ、例えば、化粧料、皮膚外用医薬、皮膚外用雑貨などが好適に例示でき、化粧料に適用することが特に好ましい。これは本発明の皮膚外用剤が、比類無き使用感の様さを有しているため、使用感が重要な化粧料に特に好適であるためである。化粧料としては、油中水乳化剤形を応用できるものであれば、特段の限定はなく、例えば、エッセンス、乳液、クリーム等の基礎化粧料、アンダーメークアップ、ファンデーション、チークカラー、マスカラ、アイライナーなどのメークアップ化粧料、ヘアクリームなどの毛髪化粧料などが好適に例示できる。
化粧料1、比較例1及び比較例2を20℃に5年間保存し、3年間保存時、4年間保存時及び5年間保存時に、サンプルを顕微鏡で150倍に拡大して、20視野観察し、1視野あたりの結晶物の計数値の平均を求めた。結果を表2に示す。これより、本発明の皮膚外用剤は、有効成分の溶存安定性に極めて優れることがわかる。
Claims (4)
- 1)有機変性粘土鉱物と2)次のA群に示される糖類及びその塩から選択される1種乃至は2種以上とを含有することを特徴とする、油中水乳化剤形の皮膚外用剤。
(A)硫酸化されていても良いトレハロース、硫酸化アルギン酸、マルチトール、ソルビトール、オリゴガラクツロン酸 - 更に、塩化L−カルニチン及び/又はその塩を含有することを特徴とする、請求項1に記載の油中水乳化剤形の皮膚外用剤。
- 更に、グリセリン、ジグリセリン及びジプロピレングリコールから選択される1種乃至は2種以上を5〜20質量%含有することを特徴とする、請求項1又は2に記載の皮膚外用剤。
- 油相において、シクロメチコン及び粘度1mPa・s以下のジメチコンの含有量の和が油相全量に対して、50質量%以上であることを特徴とする、請求項1〜3何れか1項に記載の皮膚外用剤。
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