JP2019178099A - Wnt10b産生促進剤、及びそれを含有する頭皮頭髪用化粧料 - Google Patents
Wnt10b産生促進剤、及びそれを含有する頭皮頭髪用化粧料 Download PDFInfo
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- JP2019178099A JP2019178099A JP2018068176A JP2018068176A JP2019178099A JP 2019178099 A JP2019178099 A JP 2019178099A JP 2018068176 A JP2018068176 A JP 2018068176A JP 2018068176 A JP2018068176 A JP 2018068176A JP 2019178099 A JP2019178099 A JP 2019178099A
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- wnt10b
- production promoter
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Abstract
Description
すなわち、本発明は、チンピ抽出物、セイヨウイラクサ抽出物、ボタン抽出物、センキ
ュウ抽出物、ウメ抽出物、ステビア抽出物からなる群より選ばれる少なくとも1種の植物抽出物を含有することを特徴とするWnt10b産生促進剤を提供するものである。
でいてもよい。
本発明の頭皮頭髪用化粧料における上記植物抽出物の総含有量は、特に限定されないが、製剤化する場合、剤形や使用回数、配合する賦形剤や添加剤の種類などに応じて適宜選択され得る。
(原料製造例1)チンピ抽出物
ウンシュウミカンの果皮を50g採取し、375mlの50質量%エタノール水溶液に室温(約25℃)下で浸漬した。24時間後これをろ過し、得られた抽出液から水、エタノールを減圧留去後、凍結乾燥しチンピ抽出物14.3g得た。
セイヨウイラクサの葉を50g採取し、375mlの50質量%エタノール水溶液に室温(約25℃)下で浸漬した。24時間後これをろ過し、得られた抽出液から水、エタノールを減圧留去後、凍結乾燥しセイヨウイラクサ抽出物4.8g得た。
ボタンの根を50g採取し、375mlの50質量%エタノール水溶液に室温(約25℃)下で浸漬した。24時間後これをろ過し、得られた抽出液から水、エタノールを減圧留去後、凍結乾燥しボタン抽出物6.5g得た。
センキュウの根茎を50g採取し375mlの50質量%エタノール水溶液に室温(約25℃)下で浸漬した。24時間後これをろ過し、得られた抽出液から水、エタノールを減圧留去後、凍結乾燥センキュウ抽出物7.4g得た。
ウメの果実を50g採取し375mlの50質量%エタノール水溶液に室温(約25℃)下で浸漬した。24時間後これをろ過し、得られた抽出液から水、エタノールを減圧留去後、凍結乾燥ウメ抽出物10.3g得た。
ステビアの葉、茎を50g採取し、375mlの50質量%エタノール水溶液に室温(約25℃)下で浸漬した。24時間後これをろ過し、得られた抽出液から水、エタノールを減圧留去後、凍結乾燥しステビア抽出物17.2g得た。
(2−1)細胞培養
細胞はヒト頭髪毛乳頭細胞(東洋紡(株))を使用した。サブコンフルエント状態の毛乳頭細胞をトリプシン処理で剥離し、24ウェルプレートの各ウェルに播種し、10%胎仔ウシ血清含有ダルベッコ改変イーグル培地で、37℃、5%CO2条件下でサブコンフルエントになるまで培養した。乾燥物換算で表2に記載の濃度となるように原料製造例1〜6の各植物抽出物、比較成分であるカルシトリオール(Cayman CHEMICAL製)を同培地にそれぞれ添加し48時間培養した。培養後、培地を除去し毛乳頭細胞にISOGEN−II((株)
ニッポンジーン製)を添加し付属のプロトコルに従って、トータルRNAを得た。
精製したトータルRNAを元に、PrimeScript RT Master Mix(タカラバイオ(株)製)を用い、付属のプロトコルに従ってcDNAを合成した。
PCR用の96ウェルプレートの各ウェルへ、SYBR Premix Ex TaqII(タカラバイオ(株)製)12.5μL、フォワードプライマー(0
.4μM)1μL、リバースプライマー(0.4μM)1μL、cDNA(20ng/μL)2μL、RNaseフリー水8.5μLを加え、Thermal Cycler Dice Real Time System Software(タカラバイオ(株)製)用いてリアルタイムRT−PCRを行った。リアルタイムRT−PCRの反応は、95℃で30秒の初期変性、95℃で5秒の変性、60℃で30秒のアニーリング・伸長反応からなるサイクルを40回行った。表1にWnt10b増幅用プライマー及びハウスキーピング遺伝子として使用したグリセルアルデヒド3リン酸脱水素酵素(GAPDH)の増幅用プライマー(インビトロジェン社製)の配列を示す。
施例1〜12)、さらにこれらを組み合わせると相乗効果がみられた(実施例13〜36)。
本発明のWnt10b産生促進剤としてチンピ抽出物、セイヨウイラクサ抽出物、ボタン抽出物、センキュウ抽出物、ウメ抽出物、ステビア抽出物を頭皮頭髪用化粧料(シャンプー、コンディショナー、ヘアトニック)に配合して育毛効果を評価した。
試験用頭皮頭髪用化粧料として、シャンプー、コンディショナー及びヘアトニックを以下の組成で調製した。なお、配合量の単位は質量部で、精製水の「残量」とは全量を100質量部とするのに要する量である。また、シャンプーにおけるクエン酸25質量%水溶液の適量とはpHを4〜6に調整するのに要する量、塩化ナトリウム10質量%水溶液の適量とは粘度を1000〜3000mPa・sに調製するのに要する量である。コンディショナーにおけるクエン酸25質量%水溶液の適量とは、pHを3〜6に調製するのに要する量である。
ポリクオタニウム−10 0.3
コカミドプロピルベタイン 10
ココイルメチルタウリンナトリウム 5
コカミドモノエタノールアミド 1
メチルパラベン 0.2
クエン酸25質量%水溶液 適量
塩化ナトリウム10質量%水溶液 適量
香料 0.4
精製水 残量
Wnt10b産生促進剤 表3に記載の量
比較成分 表3に記載の量
────────────────────────────────────
合計 100
(ii) コンディショナー
ジメチコン 3
セタノール 4
パルミチン酸イソプロピル 1
ステアルトリモニウムクロリド 2.5
メチルパラベン 0.2
クエン酸25質量%水溶液 適量
香料 0.4
精製水 残量
Wnt10b産生促進剤 表3に記載の量
比較成分 表3に記載の量
────────────────────────────────────
合計 100
(iii)ヘアトニック
エタノール 40
ポリオキシエチレン(40モル)硬化ヒマシ油 1
メチルパラベン 0.2
香料 0.1
精製水 残量
Wnt10b産生促進剤 表3に記載の量
比較成分 表3に記載の量
────────────────────────────────────
合計 100
実施例37〜42、比較例3〜4の頭皮頭髪用化粧料組成物(シャンプー、コンディショナー、ヘアトニック)について、それぞれ30〜60歳代の男女5名8グループを被験者とした。
5点:40%以上の減少
4点:30%以上から40%未満の減少
3点:20%以上から30%未満の減少
2点:10%以上から20%未満の減少
1点:1%以上から10%未満の減少
0点:1%未満の減少、変化なし、抜け毛が増加した
Claims (4)
- チンピ抽出物、セイヨウイラクサ抽出物、ボタン抽出物、センキュウ抽出物、ウメ抽出物、ステビア抽出物からなる群より選ばれる少なくとも1種の植物抽出物を含有することを特徴とするWnt10b産生促進剤。
- チンピ抽出物、セイヨウイラクサ抽出物、ボタン抽出物からなる群より選ばれる少なくとも2種の植物抽出物を含有することを特徴とするWnt10b産生促進剤。
- センキュウ抽出物、ウメ抽出物、ステビア抽出物からなる群より選ばれる少なくとも1種の植物抽出物をさらに含有することを特徴とする請求項2に記載のWnt10b産生促進剤。
- 請求項1〜3のいずれか一項に記載のWnt10b産生促進剤を含有する頭皮頭髪用化粧料。
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Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01233207A (ja) * | 1988-03-15 | 1989-09-19 | Chiyuuwa Internatl:Kk | 養毛剤 |
JPH02121911A (ja) * | 1988-10-28 | 1990-05-09 | Seiho:Kk | 育毛用化粧料及びその製造方法 |
JPH03188014A (ja) * | 1989-12-15 | 1991-08-16 | Shiseido Co Ltd | 化粧料 |
JPH03188013A (ja) * | 1989-12-15 | 1991-08-16 | Shiseido Co Ltd | テストステロン―5α―レダクターゼ阻害剤 |
US5407675A (en) * | 1990-08-10 | 1995-04-18 | Etemad-Moghadam; Parviz | Method and composition for use on the scalp and eyebrow region of a subject |
JPH1036229A (ja) * | 1996-07-18 | 1998-02-10 | Mandamu:Kk | ステビア抽出物および育毛組成物 |
JPH10226628A (ja) * | 1997-02-18 | 1998-08-25 | Shiseido Co Ltd | 毛乳頭活性化剤 |
JP2000086459A (ja) * | 1998-09-09 | 2000-03-28 | Fujii Kk | 女性用養毛剤 |
JP2002284648A (ja) * | 2001-03-27 | 2002-10-03 | National Institute Of Advanced Industrial & Technology | 育毛剤組成物 |
JP2006282597A (ja) * | 2005-03-31 | 2006-10-19 | Naris Cosmetics Co Ltd | 毛乳頭細胞増殖促進剤、血管内皮増殖因子(vegf)産生促進剤、養毛・育毛剤 |
JP2007022957A (ja) * | 2005-07-15 | 2007-02-01 | Tsumura & Co | TGF−β受容体拮抗剤 |
JP2009107941A (ja) * | 2007-10-26 | 2009-05-21 | Hosokawa Funtai Gijutsu Kenkyusho:Kk | 頭皮用育毛剤 |
JP2011084523A (ja) * | 2009-10-16 | 2011-04-28 | Nicca Chemical Co Ltd | 線維芽細胞増殖因子−7産生促進剤、及びそれを含有する頭皮・頭髪用化粧料、並びに飲食物 |
JP2012236774A (ja) * | 2011-05-09 | 2012-12-06 | Kyoei Kagaku Kogyo Kk | 線維芽細胞増殖因子産生促進剤、血管内皮細胞増殖因子産生促進剤、及び毛髪化粧料 |
JP2013203730A (ja) * | 2012-03-29 | 2013-10-07 | Kobayashi Pharmaceutical Co Ltd | 発毛促進剤 |
JP2014122183A (ja) * | 2012-12-21 | 2014-07-03 | Kose Corp | Dna損傷抑制剤 |
JP2014185131A (ja) * | 2013-03-25 | 2014-10-02 | Maruzen Pharmaceut Co Ltd | 育毛剤及び育毛用頭髪化粧料 |
-
2018
- 2018-03-30 JP JP2018068176A patent/JP7161302B2/ja active Active
Patent Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01233207A (ja) * | 1988-03-15 | 1989-09-19 | Chiyuuwa Internatl:Kk | 養毛剤 |
JPH02121911A (ja) * | 1988-10-28 | 1990-05-09 | Seiho:Kk | 育毛用化粧料及びその製造方法 |
JPH03188014A (ja) * | 1989-12-15 | 1991-08-16 | Shiseido Co Ltd | 化粧料 |
JPH03188013A (ja) * | 1989-12-15 | 1991-08-16 | Shiseido Co Ltd | テストステロン―5α―レダクターゼ阻害剤 |
US5407675A (en) * | 1990-08-10 | 1995-04-18 | Etemad-Moghadam; Parviz | Method and composition for use on the scalp and eyebrow region of a subject |
JPH1036229A (ja) * | 1996-07-18 | 1998-02-10 | Mandamu:Kk | ステビア抽出物および育毛組成物 |
JPH10226628A (ja) * | 1997-02-18 | 1998-08-25 | Shiseido Co Ltd | 毛乳頭活性化剤 |
JP2000086459A (ja) * | 1998-09-09 | 2000-03-28 | Fujii Kk | 女性用養毛剤 |
JP2002284648A (ja) * | 2001-03-27 | 2002-10-03 | National Institute Of Advanced Industrial & Technology | 育毛剤組成物 |
JP2006282597A (ja) * | 2005-03-31 | 2006-10-19 | Naris Cosmetics Co Ltd | 毛乳頭細胞増殖促進剤、血管内皮増殖因子(vegf)産生促進剤、養毛・育毛剤 |
JP2007022957A (ja) * | 2005-07-15 | 2007-02-01 | Tsumura & Co | TGF−β受容体拮抗剤 |
JP2009107941A (ja) * | 2007-10-26 | 2009-05-21 | Hosokawa Funtai Gijutsu Kenkyusho:Kk | 頭皮用育毛剤 |
JP2011084523A (ja) * | 2009-10-16 | 2011-04-28 | Nicca Chemical Co Ltd | 線維芽細胞増殖因子−7産生促進剤、及びそれを含有する頭皮・頭髪用化粧料、並びに飲食物 |
JP2012236774A (ja) * | 2011-05-09 | 2012-12-06 | Kyoei Kagaku Kogyo Kk | 線維芽細胞増殖因子産生促進剤、血管内皮細胞増殖因子産生促進剤、及び毛髪化粧料 |
JP2013203730A (ja) * | 2012-03-29 | 2013-10-07 | Kobayashi Pharmaceutical Co Ltd | 発毛促進剤 |
JP2014122183A (ja) * | 2012-12-21 | 2014-07-03 | Kose Corp | Dna損傷抑制剤 |
JP2014185131A (ja) * | 2013-03-25 | 2014-10-02 | Maruzen Pharmaceut Co Ltd | 育毛剤及び育毛用頭髪化粧料 |
Non-Patent Citations (1)
Title |
---|
WELLA, JAPAN: "Gentle Care Treatment (Fresh)", MINTEL GNPD [ONLINE], JPN6021048469, March 2005 (2005-03-01), ISSN: 0004797867 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230098000A (ko) | 2021-12-24 | 2023-07-03 | 닛카 가가쿠 가부시키가이샤 | 두피 두발용 화장료 |
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