JP2008543956A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008543956A5 JP2008543956A5 JP2008518659A JP2008518659A JP2008543956A5 JP 2008543956 A5 JP2008543956 A5 JP 2008543956A5 JP 2008518659 A JP2008518659 A JP 2008518659A JP 2008518659 A JP2008518659 A JP 2008518659A JP 2008543956 A5 JP2008543956 A5 JP 2008543956A5
- Authority
- JP
- Japan
- Prior art keywords
- tfa
- acn
- oxadiazolyl
- ymc
- thiadiazolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05013868.4 | 2005-06-28 | ||
| EP05013868 | 2005-06-28 | ||
| PCT/EP2006/005648 WO2007000240A1 (en) | 2005-06-28 | 2006-06-13 | Isoquinoline derivatives as inhibitors of rho-kinase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008543956A JP2008543956A (ja) | 2008-12-04 |
| JP2008543956A5 true JP2008543956A5 (https=) | 2009-07-30 |
| JP5097701B2 JP5097701B2 (ja) | 2012-12-12 |
Family
ID=35395794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008518659A Expired - Fee Related JP5097701B2 (ja) | 2005-06-28 | 2006-06-13 | Ｒｈｏ−キナーゼの阻害剤としてのイソキノリン誘導体 |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US8501736B2 (https=) |
| EP (1) | EP1899322B1 (https=) |
| JP (1) | JP5097701B2 (https=) |
| KR (1) | KR101327780B1 (https=) |
| CN (1) | CN101213187B (https=) |
| AR (1) | AR054518A1 (https=) |
| AT (1) | ATE441641T1 (https=) |
| AU (1) | AU2006264043B2 (https=) |
| BR (1) | BRPI0613597A2 (https=) |
| CA (1) | CA2611295C (https=) |
| CY (1) | CY1110108T1 (https=) |
| DE (1) | DE602006008945D1 (https=) |
| DK (1) | DK1899322T3 (https=) |
| DO (1) | DOP2006000149A (https=) |
| ES (1) | ES2331853T3 (https=) |
| GT (1) | GT200600273A (https=) |
| HR (1) | HRP20090589T1 (https=) |
| IL (1) | IL188380A (https=) |
| MA (1) | MA29535B1 (https=) |
| MX (1) | MX2008000017A (https=) |
| MY (1) | MY146037A (https=) |
| NZ (1) | NZ565040A (https=) |
| PA (1) | PA8683501A1 (https=) |
| PE (1) | PE20070141A1 (https=) |
| PL (1) | PL1899322T3 (https=) |
| PT (1) | PT1899322E (https=) |
| RS (1) | RS51139B (https=) |
| RU (1) | RU2443688C2 (https=) |
| SI (1) | SI1899322T1 (https=) |
| TW (1) | TWI372756B (https=) |
| UY (1) | UY29641A1 (https=) |
| WO (1) | WO2007000240A1 (https=) |
| ZA (1) | ZA200710001B (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2651072A1 (en) * | 2006-05-01 | 2007-11-08 | Pfizer Products Inc. | Substituted 2-amino-fused heterocyclic compounds |
| PT2125744E (pt) * | 2006-12-27 | 2011-07-01 | Sanofi Aventis | Derivados de isoquinolona e isoquinolinona substituídos com cicloalquilamina |
| MX2009005964A (es) | 2006-12-27 | 2009-06-15 | Sanofi Aventis | Derivados de isoquinolina sustituidos con cicloalquilamina. |
| MY148902A (en) | 2006-12-27 | 2013-06-14 | Sanofi Aventis | Substituted isoquinolines and their use as rho-kinase inhibitors |
| JP5421783B2 (ja) | 2006-12-27 | 2014-02-19 | サノフイ | Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体 |
| GB0719644D0 (en) | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| GB0803018D0 (en) * | 2008-02-19 | 2008-03-26 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| CA2728137C (en) * | 2008-06-24 | 2016-10-18 | Sanofi-Aventis | Substituted isoquinolines and isoquinolinones as rho kinase inhibitors |
| MY153756A (en) * | 2008-06-24 | 2015-03-13 | Sanofi Aventis | Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as rho kinase inhibitors |
| MY153615A (en) * | 2008-06-24 | 2015-02-27 | Sanofi Aventis | 6-substituted isoquinolines and isoquinolinones |
| GB0812969D0 (en) * | 2008-07-15 | 2008-08-20 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| EP2366699B1 (en) | 2008-10-02 | 2013-08-07 | Asahi Kasei Pharma Corporation | 8-substituted isoquinoline derivative and use thereof |
| EP2177218A1 (en) | 2008-10-15 | 2010-04-21 | Medizinische Universität Wien | Regenerative therapy |
| JP5391372B2 (ja) * | 2009-07-08 | 2014-01-15 | 公益財団法人名古屋産業科学研究所 | 芳香族アミン化合物の製造方法 |
| RU2012146246A (ru) * | 2010-03-31 | 2014-05-10 | Актелион Фармасьютиклз Лтд | Антибактериальные производные изохинолин-3-илмочевины |
| EA026115B1 (ru) | 2010-12-17 | 2017-03-31 | Ф. Хоффманн-Ля Рош Аг | Замещенные 6,6-конденсированные азотсодержащие гетероциклические соединения и их применение |
| GB201104267D0 (en) | 2011-03-14 | 2011-04-27 | Cancer Rec Tech Ltd | Pyrrolopyridineamino derivatives |
| JP6073910B2 (ja) | 2011-11-09 | 2017-02-01 | キャンサー・リサーチ・テクノロジー・リミテッド | ５−（ピリジン−２−イル−アミノ）−ピラジン−２−カルボニトリル化合物及びその治療使用 |
| ES2624307T3 (es) | 2012-05-15 | 2017-07-13 | Cancer Research Technology Ltd | 5-[[4-[[Morfolin-2-il]metilamino]-5-(trifluorometil)-2-piridil]amino]pirazin-2-carbonitrilo y usos terapéuticos del mismo |
| GB201216017D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Inhibitor compounds |
| GB201216018D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Pharmacologically active compounds |
| KR20210130843A (ko) | 2013-07-31 | 2021-11-01 | 노파르티스 아게 | 1,4-이치환된 피리다진 유사체 및 smn-결핍-관련 상태를 치료하기 위한 그의 용도 |
| FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB201403536D0 (en) | 2014-02-28 | 2014-04-16 | Cancer Rec Tech Ltd | Inhibitor compounds |
| TWI699355B (zh) | 2014-12-24 | 2020-07-21 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
| SG11201705192PA (en) | 2014-12-24 | 2017-07-28 | Gilead Sciences Inc | Fused pyrimidine compounds for the treatment of hiv |
| BR112017013440A2 (pt) | 2014-12-24 | 2018-01-09 | Gilead Sciences, Inc. | compostos de isoquinolina para o tratamento de hiv |
| EP3601259B1 (en) | 2017-03-30 | 2022-02-23 | F. Hoffmann-La Roche AG | Isoquinolines as inhibitors of hpk1 |
| GB201709840D0 (en) | 2017-06-20 | 2017-08-02 | Inst Of Cancer Research: Royal Cancer Hospital | Methods and medical uses |
| US10696638B2 (en) | 2017-12-26 | 2020-06-30 | Industrial Technology Research Institute | Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same |
| CN110117278B (zh) * | 2018-02-07 | 2022-07-19 | 石家庄以岭药业股份有限公司 | 烷氧基苯并五元(六元)杂环胺类化合物及其药物用途 |
| CN112839647B (zh) * | 2018-06-07 | 2025-09-23 | 达萨玛治疗公司 | Sarm1抑制剂 |
| TW202019905A (zh) | 2018-07-24 | 2020-06-01 | 瑞士商赫孚孟拉羅股份公司 | 異喹啉化合物及其用途 |
| TW202024053A (zh) | 2018-10-02 | 2020-07-01 | 美商建南德克公司 | 異喹啉化合物及其用途 |
| US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
| CN110407777B (zh) * | 2019-08-15 | 2022-09-09 | 湖北远大富驰医药化工股份有限公司 | 一种呋虫胺的合成方法 |
| TW202204348A (zh) | 2020-04-07 | 2022-02-01 | 美商西爾拉癌症醫學公司 | Ｃｈｋ１抑制劑之合成方法 |
| CN111574413B (zh) * | 2020-06-08 | 2022-04-05 | 杭州尚合生物医药科技有限公司 | 一种2-氨甲基吡啶与dmf-dma作为胺源的磺酰脒的制备方法 |
| CN113372341A (zh) * | 2021-07-02 | 2021-09-10 | 黄淮学院 | 三氟醋酸二氢异喹啉衍生物的合成方法及装置 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2485537B2 (fr) | 1977-04-13 | 1986-05-16 | Anvar | Dipyrido(4,3-b)(3,4-f)indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant |
| EP0541559A1 (en) | 1990-07-31 | 1993-05-19 | E.I. Du Pont De Nemours And Company | Catalytic equilibration of selected halocarbons |
| US5480883A (en) * | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
| ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| BR9711154A (pt) * | 1996-08-12 | 1999-08-17 | Yoshitomi Pharmaceutical | Agente farmac-utico contendo inibidor cinase rho |
| JPH1087629A (ja) | 1996-09-18 | 1998-04-07 | Fujisawa Pharmaceut Co Ltd | 新規イソキノリン誘導体、およびその医薬用途 |
| EP1007525A1 (en) | 1997-08-29 | 2000-06-14 | Zeneca Limited | Aminometyl oxooxazolidinyl benzene derivatives |
| TW575567B (en) | 1998-10-23 | 2004-02-11 | Akzo Nobel Nv | Serine protease inhibitor |
| GB9912701D0 (en) | 1999-06-01 | 1999-08-04 | Smithkline Beecham Plc | Novel compounds |
| US6541456B1 (en) | 1999-12-01 | 2003-04-01 | Isis Pharmaceuticals, Inc. | Antimicrobial 2-deoxystreptamine compounds |
| BR0107732A (pt) | 2000-01-20 | 2003-03-11 | Eisai Ltd | Método para prevenir ou tratar uma doença |
| US7217722B2 (en) | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
| AU2001239947A1 (en) | 2000-02-29 | 2001-09-12 | Curis, Inc. | Methods and compositions for regulating adipocytes |
| GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| AR033517A1 (es) | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
| GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
| AU2001296008A1 (en) | 2000-10-27 | 2002-05-06 | Takeda Chemical Industries Ltd. | Process for preparing substituted aromatic compounds and intermediates therefor |
| JP2004520347A (ja) | 2001-01-15 | 2004-07-08 | グラクソ グループ リミテッド | Ｌｄｌ−受容体発現のインデューサーとしてのアリールピペリジンおよびピペラジン誘導体 |
| SE0101038D0 (sv) | 2001-03-23 | 2001-03-23 | Astrazeneca Ab | Novel compounds |
| UY27224A1 (es) | 2001-03-23 | 2002-10-31 | Bayer Corp | Inhibidores de la rho-quinasa |
| EP1389194A2 (en) | 2001-04-27 | 2004-02-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
| WO2002100833A1 (en) * | 2001-06-12 | 2002-12-19 | Sumitomo Pharmaceuticals Company, Limited | Rho KINASE INHIBITORS |
| GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
| WO2003024450A1 (en) | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methods for treating prion diseases |
| SE0104340D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
| EP1541559A4 (en) * | 2002-07-22 | 2007-08-22 | Asahi Kasei Pharma Corp | 5-SUBSTITUTED ISOQUINOLINE DERIVATIVE |
| AU2003264427A1 (en) | 2002-09-12 | 2004-04-30 | Kirin Beer Kabushiki Kaisha | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same |
| WO2004105757A2 (en) | 2003-05-29 | 2004-12-09 | Schering Aktiengesellschaft | Use of rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy |
| WO2004113297A2 (en) | 2003-06-24 | 2004-12-29 | Neurosearch A/S | Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2005030130A2 (en) | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Isoquinoline potassium channel inhibitors |
| US7723352B2 (en) | 2003-09-23 | 2010-05-25 | Merck Sharp & Dohme | Isoquinolinone potassium channel inhibitors |
| US20050067037A1 (en) | 2003-09-30 | 2005-03-31 | Conocophillips Company | Collapse resistant composite riser |
| US20070060595A1 (en) * | 2003-10-10 | 2007-03-15 | Toshio Yoshizawa | Novel fused heterocyclic compound and use thereof |
| US7449477B2 (en) | 2003-11-25 | 2008-11-11 | Eli Lilly And Company | 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (protein kinase B) |
| JP2005232175A (ja) * | 2004-01-21 | 2005-09-02 | Asahi Kasei Pharma Kk | ５−置換イソキノリン医薬 |
| WO2005074535A2 (en) | 2004-01-30 | 2005-08-18 | Eisai Co., Ltd. | Cholinesterase inhibitors for spinal cord disorders |
| EP1729761A4 (en) | 2004-03-05 | 2008-09-03 | Eisai Co Ltd | TREATMENT OF CADASIL WITH CHOLINESTERASE INHIBITORS |
| SE0400850D0 (sv) | 2004-03-30 | 2004-03-31 | Astrazeneca Ab | Novel Compounds |
| US7517991B2 (en) * | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
| RS52241B (sr) | 2005-07-26 | 2012-10-31 | Sanofi | Derivati cikloheksilamin izohinolona kao inhibitori rho-kinaze |
| CA2615577C (en) | 2005-07-26 | 2014-09-09 | Sanofi-Aventis | Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors |
| TW200745101A (en) | 2005-09-30 | 2007-12-16 | Organon Nv | 9-Azabicyclo[3.3.1]nonane derivatives |
| JP4033221B2 (ja) | 2005-12-02 | 2008-01-16 | ダイキン工業株式会社 | 冷媒加熱装置 |
| TW200738682A (en) | 2005-12-08 | 2007-10-16 | Organon Nv | Isoquinoline derivatives |
| US7618985B2 (en) * | 2005-12-08 | 2009-11-17 | N.V. Organon | Isoquinoline derivatives |
| US7893088B2 (en) * | 2006-08-18 | 2011-02-22 | N.V. Organon | 6-substituted isoquinoline derivatives |
| MY148902A (en) | 2006-12-27 | 2013-06-14 | Sanofi Aventis | Substituted isoquinolines and their use as rho-kinase inhibitors |
| RU2468011C2 (ru) | 2006-12-27 | 2012-11-27 | Санофи-Авентис | Замещенные циклоалкиламином производные изохинолина и изохинолинона |
-
2006
- 2006-06-13 CN CN2006800238102A patent/CN101213187B/zh not_active Expired - Fee Related
- 2006-06-13 AU AU2006264043A patent/AU2006264043B2/en not_active Ceased
- 2006-06-13 SI SI200630484T patent/SI1899322T1/sl unknown
- 2006-06-13 WO PCT/EP2006/005648 patent/WO2007000240A1/en not_active Ceased
- 2006-06-13 JP JP2008518659A patent/JP5097701B2/ja not_active Expired - Fee Related
- 2006-06-13 KR KR1020077030517A patent/KR101327780B1/ko not_active Expired - Fee Related
- 2006-06-13 BR BRPI0613597-8A patent/BRPI0613597A2/pt not_active IP Right Cessation
- 2006-06-13 DK DK06754323T patent/DK1899322T3/da active
- 2006-06-13 PL PL06754323T patent/PL1899322T3/pl unknown
- 2006-06-13 RS RSP-2009/0516A patent/RS51139B/sr unknown
- 2006-06-13 EP EP06754323A patent/EP1899322B1/en active Active
- 2006-06-13 HR HR20090589T patent/HRP20090589T1/hr unknown
- 2006-06-13 RU RU2008102968/04A patent/RU2443688C2/ru not_active IP Right Cessation
- 2006-06-13 AT AT06754323T patent/ATE441641T1/de active
- 2006-06-13 MX MX2008000017A patent/MX2008000017A/es active IP Right Grant
- 2006-06-13 PT PT06754323T patent/PT1899322E/pt unknown
- 2006-06-13 NZ NZ565040A patent/NZ565040A/en not_active IP Right Cessation
- 2006-06-13 CA CA2611295A patent/CA2611295C/en not_active Expired - Fee Related
- 2006-06-13 DE DE602006008945T patent/DE602006008945D1/de active Active
- 2006-06-13 ES ES06754323T patent/ES2331853T3/es active Active
- 2006-06-26 PE PE2006000735A patent/PE20070141A1/es not_active Application Discontinuation
- 2006-06-26 AR ARP060102738A patent/AR054518A1/es unknown
- 2006-06-26 TW TW095122877A patent/TWI372756B/zh not_active IP Right Cessation
- 2006-06-26 GT GT200600273A patent/GT200600273A/es unknown
- 2006-06-26 DO DO2006000149A patent/DOP2006000149A/es unknown
- 2006-06-27 PA PA20068683501A patent/PA8683501A1/es unknown
- 2006-06-27 MY MYPI20063032A patent/MY146037A/en unknown
- 2006-06-29 UY UY29641A patent/UY29641A1/es unknown
-
2007
- 2007-11-20 ZA ZA200710001A patent/ZA200710001B/xx unknown
- 2007-12-07 MA MA30457A patent/MA29535B1/fr unknown
- 2007-12-20 US US11/961,193 patent/US8501736B2/en not_active Expired - Fee Related
- 2007-12-24 IL IL188380A patent/IL188380A/en not_active IP Right Cessation
-
2009
- 2009-11-25 CY CY20091101226T patent/CY1110108T1/el unknown
-
2011
- 2011-06-15 US US13/160,983 patent/US8722671B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008543956A5 (https=) | ||
| JP2006528601A5 (https=) | ||
| JP2010514715A5 (https=) | ||
| JP2010514717A5 (https=) | ||
| ES2632009T3 (es) | Ligandos de receptores de opioides y métodos para utilizar y obtener los mismos | |
| ES2600161T3 (es) | Compuestos para uso en el tratamiento de enfermedades mediadas por linfocitos T | |
| ES2937236T3 (es) | Derivados de dihidro-pirrolo-piridina | |
| RU2125047C1 (ru) | N-производные хинолина или их аддитивные соли с неорганическими и органическими кислотами или с неорганическими и органическими основаниями, способы их получения и фармацевтическая композиция на их основе | |
| JP2010514720A5 (https=) | ||
| JP2010514716A5 (https=) | ||
| TW201010992A (en) | Pharmaceutical composition | |
| ES2397934T3 (es) | Compuestos de aminopiridina y carboxipiridina como inhibidores de fosfodiesterasa 10 | |
| ES2852351T3 (es) | Pirrolamidas como inhibidores de la integrina alfa V | |
| SA01220441B1 (ar) | المركبات عديدة الكربوكسي أميدات polyarylcarboxamides كعوامل خافضة للدهون lipid lowering agents | |
| TW201139406A (en) | Voltage-gated sodium channel blockers | |
| CN106458956B (zh) | 杂芳基取代的杂环基砜 | |
| AU2015291477B2 (en) | Novel 2,5-substituted pyrimidines as PDE inhibitors | |
| BRPI0713576A2 (pt) | composto, formulação farmacêutica, uso de um composto, e, métodos para prevenir e/ou tratar condição, distúrbio e doença, para aumentar a formação óssea, para aumentar a formação óssea de estrutura esponjosa e/ou nova formação óssea, para aumentar a densidade mineral óssea, para reduzir a incidência de fratura e para melhorar a cicatrização de fratura, e, processo para preparar um composto | |
| CA2798622A1 (en) | Indoles | |
| CN102030750A (zh) | 用作CB1受体配体的新四氢-1H-吡啶并[4,3-b]吲哚衍生物 | |
| AU2005205090A1 (en) | Indole derivatives and use thereof as kinase inhibitors in particular IKK2 inhibitors | |
| BR112020007466A2 (pt) | compostos inibidores de tbk/ikképsilon de pirimidina e usos dos mesmos | |
| CN106029655A (zh) | 新型吲哚衍生物化合物和包含其的药物组合物 | |
| TW201529574A (zh) | 磺醯胺衍生物及其醫藥用途 | |
| JP2008543957A5 (https=) |