JP2008543887A5 - - Google Patents
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- Publication number
- JP2008543887A5 JP2008543887A5 JP2008517280A JP2008517280A JP2008543887A5 JP 2008543887 A5 JP2008543887 A5 JP 2008543887A5 JP 2008517280 A JP2008517280 A JP 2008517280A JP 2008517280 A JP2008517280 A JP 2008517280A JP 2008543887 A5 JP2008543887 A5 JP 2008543887A5
- Authority
- JP
- Japan
- Prior art keywords
- complex
- calcium
- phosphate
- calcium phosphate
- amorphous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 102000007982 Phosphoproteins Human genes 0.000 claims 13
- 108010089430 Phosphoproteins Proteins 0.000 claims 13
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 6
- 229910001424 calcium ion Inorganic materials 0.000 claims 6
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 6
- 239000001506 calcium phosphate Substances 0.000 claims 6
- 235000011010 calcium phosphates Nutrition 0.000 claims 6
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 5
- 108010001441 Phosphopeptides Proteins 0.000 claims 5
- 229910052791 calcium Inorganic materials 0.000 claims 5
- 239000011575 calcium Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 238000009472 formulation Methods 0.000 claims 4
- MFLAROGHONQVRM-UHFFFAOYSA-L calcium;dihydrogen phosphate;fluoride Chemical compound [F-].[Ca+2].OP(O)([O-])=O MFLAROGHONQVRM-UHFFFAOYSA-L 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 208000006558 Dental Calculus Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010044029 Tooth deposit Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 239000005018 casein Substances 0.000 claims 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 1
- 235000021240 caseins Nutrition 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 238000005260 corrosion Methods 0.000 claims 1
- 230000007797 corrosion Effects 0.000 claims 1
- 208000002925 dental caries Diseases 0.000 claims 1
- GUYBGCBOZOALMT-UHFFFAOYSA-J dicalcium;fluoride;phosphate Chemical compound [F-].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O GUYBGCBOZOALMT-UHFFFAOYSA-J 0.000 claims 1
- 230000003628 erosive effect Effects 0.000 claims 1
- 230000009610 hypersensitivity Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000000395 remineralizing effect Effects 0.000 claims 1
Claims (10)
- リンペプチドまたはリンタンパク質（ＰＰ）によって安定化された無定形リン酸カルシウムまたは無定形リン酸フッ化カルシウムの複合体であって、ＰＰ１モル当たりのカルシウムが約３０モルよりも高いカルシウムイオン含量を有する、複合体。
- 前記ＰＰがカゼインホスホペプチド（ＣＰＰ）である、請求項１に記載の複合体。
- 前記カルシウムイオン含量が、ＰＰ１モル当たりカルシウム３０〜５０モルの範囲内にある、請求項１に記載の複合体。
- 請求項１に記載の複合体を含む、口腔ケア配合物。
- リンペプチドまたはリンタンパク質（ＰＰ）によって安定化された無定形リン酸カルシウム（ＡＣＰ）および／または無定形リン酸フッ化カルシウム（ＡＣＦＰ）の複合体であってＰＰ１モル当たりのカルシウムが約３０モルよりも高いカルシウムイオン含量を有する複合体を生成するための方法であって、
（ｉ）ＰＰ−ＡＣＰおよび／またはＰＰ−ＡＣＦＰの複合体を含む溶液を得る工程；ならびに
（ｉｉ）該溶液のｐＨを７未満に保持しながらカルシウムイオンおよびリン酸イオンと混合する工程
を包含する、方法。 - ＰＰによって安定化されたＡＣＰおよび／またはＡＣＦＰの複合体を少なくとも等重量のリン酸カルシウムと一緒にした配合物。
- 前記リン酸カルシウムがＣａＨＰＯ４の形態にある、請求項６に記載の配合物。
- 請求項７に記載の配合物を含む、口腔ケア配合物。
- 歯の表面または表層下を再石灰化するための医薬の製造における、リンペプチドまたはリンタンパク質（ＰＰ）によって安定化された無定形リン酸カルシウムまたは無定形リン酸フッ化カルシウムの複合体の使用であって、該複合体がＰＰ１モル当たりカルシウム約３０モルより高いカルシウムイオン含量を有する、使用。
- 齲蝕、歯の侵食／腐食、象牙質知覚過敏および歯石の１つ以上を処置および／または予防するための医薬の製造における、リンペプチドまたはリンタンパク質（ＰＰ）によって安定化された無定形リン酸カルシウムまたは無定形リン酸フッ化カルシウムの複合体の使用であって、該複合体がＰＰ１モル当たりカルシウム約３０モルより高いカルシウムイオン含量を有する、使用。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69401905P | 2005-06-24 | 2005-06-24 | |
| PCT/AU2006/000885 WO2006135982A1 (en) | 2005-06-24 | 2006-06-23 | Ionic complexes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012237656A Division JP5709818B2 (ja) | 2005-06-24 | 2012-10-29 | イオン性複合体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008543887A JP2008543887A (ja) | 2008-12-04 |
| JP2008543887A5 true JP2008543887A5 (ja) | 2009-07-23 |
Family
ID=37570039
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008517280A Withdrawn JP2008543887A (ja) | 2005-06-24 | 2006-06-23 | イオン性複合体 |
| JP2012237656A Active JP5709818B2 (ja) | 2005-06-24 | 2012-10-29 | イオン性複合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012237656A Active JP5709818B2 (ja) | 2005-06-24 | 2012-10-29 | イオン性複合体 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8603988B2 (ja) |
| EP (1) | EP1901702B1 (ja) |
| JP (2) | JP2008543887A (ja) |
| CN (1) | CN101208070B (ja) |
| AR (1) | AR057402A1 (ja) |
| AU (1) | AU2006261597B2 (ja) |
| BR (1) | BRPI0611976B1 (ja) |
| CA (1) | CA2612172C (ja) |
| ES (1) | ES2530396T3 (ja) |
| MX (1) | MX2007016312A (ja) |
| NZ (1) | NZ564129A (ja) |
| PL (1) | PL1901702T3 (ja) |
| RU (1) | RU2413497C2 (ja) |
| WO (1) | WO2006135982A1 (ja) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101098675B (zh) | 2004-11-25 | 2013-04-10 | 墨尔本大学 | 稳定的磷酸钙复合物 |
| AU2006261597B2 (en) * | 2005-06-24 | 2011-06-23 | The University Of Melbourne | Ionic complexes |
| WO2007090242A1 (en) | 2006-02-09 | 2007-08-16 | The University Of Melbourne | Fluoride composition and methods for dental mineralization |
| RU2421207C2 (ru) * | 2006-04-05 | 2011-06-20 | КЭДБЕРИ АДАМС ЮЭсЭй ЛЛС | Оральная композиция для улучшения подповерхностной реминерализации эмали в зубах млекопитающего |
| WO2007117629A2 (en) | 2006-04-05 | 2007-10-18 | Cadbury Adams Usa, Llc | Impact of calcium phosphate complex on dental caries |
| JP2009532065A (ja) * | 2006-04-05 | 2009-09-10 | キャドバリー アダムス ユーエスエー エルエルシー | 酸含有チューインガム中のリン酸カルシウム錯体 |
| WO2008153725A2 (en) | 2007-05-25 | 2008-12-18 | North Carolina State University | Viral nanoparticle cell-targeted delivery platform |
| DE102008014225A1 (de) * | 2008-03-16 | 2009-09-17 | MEDERER Süßwarenvertriebs GmbH | Remineralisierende Zahnpflegemittel und Verfahren zu deren Herstellung |
| DE102008014227A1 (de) * | 2008-03-16 | 2009-10-01 | Nova Dentalia Zahnpflege Gmbh | Remineralisierende Speichelersatzmittel und Verfahren zu deren Herstellung |
| JP2010047494A (ja) * | 2008-08-20 | 2010-03-04 | Gc Corp | 歯牙塗布用組成物 |
| US8951505B2 (en) | 2008-10-08 | 2015-02-10 | Georgia Health Sciences University Rsearch Institute, Inc. | Methods and systems for mineralization of demineralized tissue |
| GB0908433D0 (en) * | 2009-05-15 | 2009-06-24 | Glaxo Group Ltd | Movel composition |
| CN102946889B (zh) * | 2010-03-31 | 2015-05-06 | 东洋水产株式会社 | 钙剂及其制造方法 |
| MX2013002113A (es) * | 2010-08-24 | 2013-06-05 | Safewhite Llc | Metodos y materiales para proporcionar a los dientes con una apariencia blanca. |
| US9107838B2 (en) | 2012-04-25 | 2015-08-18 | Therametrics Technologies, Inc. | Fluoride varnish |
| CN117717569A (zh) * | 2013-07-05 | 2024-03-19 | 恒星生物群落有限公司 | 口服组合物 |
| KR102221531B1 (ko) | 2013-07-23 | 2021-03-02 | 더 유니버시티 오브 멜버른 | 치아 광화를 위한 조성물 및 방법 |
| WO2015095932A1 (en) | 2013-12-24 | 2015-07-02 | The University Of Melbourne | Stabilized stannous compositions |
| JP2016102069A (ja) * | 2014-11-27 | 2016-06-02 | 株式会社ジーシー | 歯面清掃方法、歯面清掃用組成物、及びその使用方法 |
| KR20170100580A (ko) * | 2014-12-24 | 2017-09-04 | 더 유니버시티 오브 멜버른 | 광화 플루오라이드 조성물 |
| BR112018074268B1 (pt) | 2016-05-26 | 2022-04-19 | 3M Innovative Properties Company | Pasta dental, kit para tratamento de uma superfície na cavidade oral de um indivíduo, e uso |
| CN107811872B (zh) * | 2016-09-13 | 2020-09-15 | 北京大学 | 一种快速牙釉质矿化的方法 |
| US20190274933A1 (en) | 2016-11-08 | 2019-09-12 | Dentherapy Ltd | Compositions comprising fluoride and calcium and method for preparing them |
| KR101772449B1 (ko) | 2016-12-27 | 2017-08-30 | 주식회사 하이센스바이오 | 신규한 펩타이드 |
| EA201991933A1 (ru) | 2017-03-14 | 2020-03-05 | Де Юниверсити Оф Мельбурн | Лечение гингивита |
| CN108524290A (zh) * | 2018-06-28 | 2018-09-14 | 吉林省登泰克牙科材料有限公司 | 牙科预防龋齿组合物及其制备方法 |
| WO2020240980A1 (ja) * | 2019-05-27 | 2020-12-03 | 株式会社ジーシー | 歯科用キット及びう蝕の予防方法 |
| WO2021059215A2 (en) * | 2019-09-25 | 2021-04-01 | Church & Dwight Co., Inc. | Oral care composition |
| CN111715408B (zh) * | 2020-06-30 | 2021-07-02 | 中南大学 | 一种用于浮选白钨矿中萤石的浮选药剂及其浮选方法 |
| GB202010987D0 (en) | 2020-07-16 | 2020-09-02 | Dentherapy Ltd | Oral care compositions and methods |
| GB202110114D0 (en) | 2021-07-14 | 2021-08-25 | Dentherapy Ltd | Oral care compositions for use in treaatment |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522805A (en) | 1983-06-08 | 1985-06-11 | Norman Gordon | Tooth and gum dentifrice |
| CA1315480C (en) * | 1986-06-12 | 1993-03-30 | Eric Charles Reynolds | Phosphopeptides |
| US5015628A (en) * | 1986-06-12 | 1991-05-14 | The University Of Melbourne | Anticariogenic phosphopeptides |
| US6056930A (en) | 1989-05-24 | 2000-05-02 | American Dental Association Health Foundation | Methods and compositions for mineralizing and fluoridating calcified tissues |
| US5227154A (en) | 1991-08-22 | 1993-07-13 | The University Of Melbourne | Phosphopeptides for the treatment of dental calculus |
| KR100238551B1 (ko) | 1992-06-29 | 2000-02-01 | 도우글라스 웨이르 | 민감성 치아 치료 |
| JP2975337B2 (ja) | 1997-02-20 | 1999-11-10 | 雪印乳業株式会社 | カルシウム複合体 |
| AUPO566297A0 (en) * | 1997-03-13 | 1997-04-10 | University Of Melbourne, The | Calcium phosphopeptide complexes |
| JP3742523B2 (ja) * | 1998-02-27 | 2006-02-08 | 雪印乳業株式会社 | 高分子型カルシウム・ホスホペプチド複合体 |
| FR2791573B1 (fr) | 1999-03-30 | 2003-04-11 | Pf Medicament | Utilisation d'un extrait de serenoa repens pour la fabrication d'un medicament destine au traitement du cancer de la prostate |
| US6521215B2 (en) | 1999-05-28 | 2003-02-18 | Devin Okay | Compositions and methods for tooth treatment |
| US6685920B2 (en) | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| GB9929919D0 (en) | 1999-12-17 | 2000-02-09 | Hannah Research Inst The | Calcium phosphate nanoclusters and their applications |
| AUPR517701A0 (en) * | 2001-05-21 | 2001-06-14 | University Of Melbourne, The | Dental restorative materials |
| MXPA04006542A (es) * | 2002-01-03 | 2004-10-04 | Procter & Gamble | Composiciones bucales estables que contienen complejos de fosfopeptido de caseina y fluooruro. |
| MXPA04006541A (es) | 2002-01-03 | 2004-10-04 | Procter & Gamble | Composiciones bucales estables que contienen complejos de fosfopeptido de caseina y fluoruro. |
| NZ522071A (en) | 2002-10-18 | 2005-07-29 | Patrick Joseph Silcock | Hydrolysed casein phosphoprotein preparations for bioactive metal ion delivery and teeth remineralisation |
| JP4340069B2 (ja) * | 2003-01-10 | 2009-10-07 | 雪印乳業株式会社 | カルシウム複合体の製造法 |
| US20050089481A1 (en) * | 2003-10-23 | 2005-04-28 | Gc Corporation | Composition for caries prevention |
| DK1888014T3 (da) | 2005-06-07 | 2013-02-18 | Univ Melbourne | Tandmineralisering |
| AU2006261597B2 (en) * | 2005-06-24 | 2011-06-23 | The University Of Melbourne | Ionic complexes |
-
2006
- 2006-06-23 AU AU2006261597A patent/AU2006261597B2/en active Active
- 2006-06-23 NZ NZ564129A patent/NZ564129A/en unknown
- 2006-06-23 BR BRPI0611976-0A patent/BRPI0611976B1/pt active IP Right Grant
- 2006-06-23 PL PL06752630T patent/PL1901702T3/pl unknown
- 2006-06-23 US US11/917,395 patent/US8603988B2/en active Active
- 2006-06-23 CN CN2006800227822A patent/CN101208070B/zh active Active
- 2006-06-23 RU RU2008102637/15A patent/RU2413497C2/ru active
- 2006-06-23 AR ARP060102716A patent/AR057402A1/es active IP Right Grant
- 2006-06-23 JP JP2008517280A patent/JP2008543887A/ja not_active Withdrawn
- 2006-06-23 EP EP06752630.1A patent/EP1901702B1/en active Active
- 2006-06-23 WO PCT/AU2006/000885 patent/WO2006135982A1/en active Application Filing
- 2006-06-23 ES ES06752630T patent/ES2530396T3/es active Active
- 2006-06-23 CA CA2612172A patent/CA2612172C/en active Active
- 2006-06-23 MX MX2007016312A patent/MX2007016312A/es active IP Right Grant
-
2012
- 2012-10-29 JP JP2012237656A patent/JP5709818B2/ja active Active
-
2013
- 2013-11-07 US US14/074,022 patent/US9241883B2/en active Active
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