JP2008542428A - 抗腫瘍活性を有するインドール誘導体 - Google Patents

抗腫瘍活性を有するインドール誘導体 Download PDF

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Publication number
JP2008542428A
JP2008542428A JP2008515199A JP2008515199A JP2008542428A JP 2008542428 A JP2008542428 A JP 2008542428A JP 2008515199 A JP2008515199 A JP 2008515199A JP 2008515199 A JP2008515199 A JP 2008515199A JP 2008542428 A JP2008542428 A JP 2008542428A
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JP
Japan
Prior art keywords
indol
bis
compound
tumor
arom
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JP2008515199A
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English (en)
Japanese (ja)
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JP2008542428A5 (enExample
Inventor
クラウディオ・ピサーノ
ジャンフランコ・バッティストゥッツィ
マリア・ディ・マルツォ
ジュゼッペ・ジャンニーニ
マウロ・マルツィ
ロレダーナ・ヴェスキ
フランコ・ツニーノ
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of JP2008542428A publication Critical patent/JP2008542428A/ja
Publication of JP2008542428A5 publication Critical patent/JP2008542428A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
JP2008515199A 2005-06-10 2006-05-31 抗腫瘍活性を有するインドール誘導体 Withdrawn JP2008542428A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05012562 2005-06-10
PCT/EP2006/062798 WO2006131484A1 (en) 2005-06-10 2006-05-31 Indole derivatives having antitumor activity

Publications (2)

Publication Number Publication Date
JP2008542428A true JP2008542428A (ja) 2008-11-27
JP2008542428A5 JP2008542428A5 (enExample) 2009-07-16

Family

ID=35062959

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008515199A Withdrawn JP2008542428A (ja) 2005-06-10 2006-05-31 抗腫瘍活性を有するインドール誘導体

Country Status (13)

Country Link
US (1) US8053460B2 (enExample)
EP (1) EP1891007A1 (enExample)
JP (1) JP2008542428A (enExample)
KR (1) KR20080029967A (enExample)
CN (1) CN101193861A (enExample)
AR (1) AR053891A1 (enExample)
AU (1) AU2006256771A1 (enExample)
BR (1) BRPI0612542A2 (enExample)
CA (1) CA2607337A1 (enExample)
EA (1) EA013542B1 (enExample)
MX (1) MX2007015274A (enExample)
TW (1) TW200716545A (enExample)
WO (1) WO2006131484A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012516317A (ja) * 2009-01-28 2012-07-19 カルス セラピューティクス リミテッド スクリプタイドアイソスター（ｓｃｒｉｐｔａｉｄｉｓｏｓｔｅｒｅｓ）およびその治療における使用
JP2013523747A (ja) * 2010-03-29 2013-06-17 タイペイ・メディカル・ユニバーシティ インドリルヒドロキサメート化合物又はインドリニルヒドロキサメート化合物
JP2015535273A (ja) * 2012-11-07 2015-12-10 カルス セラピューティクス リミテッド 新規ヒストンデアセチラーゼインヒビターおよび治療におけるその使用
US9862685B2 (en) 2013-05-10 2018-01-09 Karus Therapeutics Limited Histone deacetylase inhibitors
US10407435B2 (en) 2014-10-29 2019-09-10 Karus Therapeutics Limited Diheteroaryl histone deacetylase inhibitors and their use in therapy
US10533003B2 (en) 2014-10-29 2020-01-14 Karus Therapeutics Limited Polyheteroarl histone deacetylase inhibitors and their use in therapy

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2633266C2 (ru) * 2015-07-02 2017-10-11 Рауф Ашрафович Ашрафов Способ моделирования карциноидного синдрома
CN105367479A (zh) * 2015-11-16 2016-03-02 青岛大学 一种组蛋白去乙酰酶抑制剂2-(1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1氢-吲哚-3-基-n-(2-(羟氨基)-2-酮乙基)乙酰胺及其制备方法和应用
CN109928909A (zh) * 2019-04-02 2019-06-25 南华大学 具有抗抑郁活性化合物及其制备方法
CN120136763B (zh) * 2025-03-13 2025-10-10 遵义医科大学 一种c-3苄基化吲哚类化合物、制备方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0887348A1 (en) * 1997-06-25 1998-12-30 Boehringer Mannheim Italia S.p.A. Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them
IT1317925B1 (it) * 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.
WO2003032982A1 (en) 2001-10-19 2003-04-24 Transtech Pharma, Inc. Bis-heteroaryl alkanes as therapeutic agents
JP4790594B2 (ja) * 2003-02-25 2011-10-12 トポターゲット ユーケー リミテッド Ｈｄａｃインヒビターとしての、二環式ヘテロアリール基を含むヒドロキサム酸化合物

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012516317A (ja) * 2009-01-28 2012-07-19 カルス セラピューティクス リミテッド スクリプタイドアイソスター（ｓｃｒｉｐｔａｉｄｉｓｏｓｔｅｒｅｓ）およびその治療における使用
US8748458B2 (en) 2009-01-28 2014-06-10 Karus Therapeutics Limited Scriptaid isosteres and their use in therapy
JP2014159475A (ja) * 2009-01-28 2014-09-04 Karus Therapeutics Ltd スクリプタイドアイソスター（ｓｃｒｉｐｔａｉｄｉｓｏｓｔｅｒｅｓ）およびその治療における使用
US9340503B2 (en) 2009-01-28 2016-05-17 Karus Therapeutics, Limited Scriptaid isosteres and their use in therapy
JP2013523747A (ja) * 2010-03-29 2013-06-17 タイペイ・メディカル・ユニバーシティ インドリルヒドロキサメート化合物又はインドリニルヒドロキサメート化合物
JP2015535273A (ja) * 2012-11-07 2015-12-10 カルス セラピューティクス リミテッド 新規ヒストンデアセチラーゼインヒビターおよび治療におけるその使用
US9676765B2 (en) 2012-11-07 2017-06-13 Karus Therapeutics Limited Histone deacetylase inhibitors and their use in therapy
US10150763B2 (en) 2012-11-07 2018-12-11 Karus Therapeutics Limited Histone deacetylase inhibitors and their use in therapy
US9862685B2 (en) 2013-05-10 2018-01-09 Karus Therapeutics Limited Histone deacetylase inhibitors
US10870624B2 (en) 2013-05-10 2020-12-22 Karus Therapeutics Limited Histone deacetylase inhibitors
US10407435B2 (en) 2014-10-29 2019-09-10 Karus Therapeutics Limited Diheteroaryl histone deacetylase inhibitors and their use in therapy
US10533003B2 (en) 2014-10-29 2020-01-14 Karus Therapeutics Limited Polyheteroarl histone deacetylase inhibitors and their use in therapy

Also Published As

Publication number Publication date
TW200716545A (en) 2007-05-01
CN101193861A (zh) 2008-06-04
EA200702672A1 (ru) 2008-04-28
EA013542B1 (ru) 2010-06-30
AR053891A1 (es) 2007-05-23
EP1891007A1 (en) 2008-02-27
US8053460B2 (en) 2011-11-08
BRPI0612542A2 (pt) 2010-11-23
WO2006131484A1 (en) 2006-12-14
CA2607337A1 (en) 2006-12-14
KR20080029967A (ko) 2008-04-03
MX2007015274A (es) 2008-02-22
US20080207729A1 (en) 2008-08-28
AU2006256771A1 (en) 2006-12-14

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