EA013542B1 - Производные индола, обладающие противоопухолевой активностью - Google Patents
Производные индола, обладающие противоопухолевой активностью Download PDFInfo
- Publication number
- EA013542B1 EA013542B1 EA200702672A EA200702672A EA013542B1 EA 013542 B1 EA013542 B1 EA 013542B1 EA 200702672 A EA200702672 A EA 200702672A EA 200702672 A EA200702672 A EA 200702672A EA 013542 B1 EA013542 B1 EA 013542B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- indol
- bis
- arom
- compound
- hydroxyamide
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05012562 | 2005-06-10 | ||
| PCT/EP2006/062798 WO2006131484A1 (en) | 2005-06-10 | 2006-05-31 | Indole derivatives having antitumor activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200702672A1 EA200702672A1 (ru) | 2008-04-28 |
| EA013542B1 true EA013542B1 (ru) | 2010-06-30 |
Family
ID=35062959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200702672A EA013542B1 (ru) | 2005-06-10 | 2006-05-31 | Производные индола, обладающие противоопухолевой активностью |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8053460B2 (enExample) |
| EP (1) | EP1891007A1 (enExample) |
| JP (1) | JP2008542428A (enExample) |
| KR (1) | KR20080029967A (enExample) |
| CN (1) | CN101193861A (enExample) |
| AR (1) | AR053891A1 (enExample) |
| AU (1) | AU2006256771A1 (enExample) |
| BR (1) | BRPI0612542A2 (enExample) |
| CA (1) | CA2607337A1 (enExample) |
| EA (1) | EA013542B1 (enExample) |
| MX (1) | MX2007015274A (enExample) |
| TW (1) | TW200716545A (enExample) |
| WO (1) | WO2006131484A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2633266C2 (ru) * | 2015-07-02 | 2017-10-11 | Рауф Ашрафович Ашрафов | Способ моделирования карциноидного синдрома |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2650810T3 (es) * | 2009-01-28 | 2018-01-22 | Karus Therapeutics Limited | Isósteros de Scriptaid y su uso en terapia |
| TWI429628B (zh) * | 2010-03-29 | 2014-03-11 | Univ Taipei Medical | 吲哚基或吲哚啉基羥肟酸化合物 |
| MX364295B (es) * | 2012-11-07 | 2019-04-22 | Karus Therapeutics Ltd | Inhibidores de histona desacetilasa novedosos y su uso en terapia. |
| LT2994465T (lt) | 2013-05-10 | 2018-10-10 | Karus Therapeutics Limited | Nauji histono deacetilazės inhibitoriai |
| GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| CN105367479A (zh) * | 2015-11-16 | 2016-03-02 | 青岛大学 | 一种组蛋白去乙酰酶抑制剂2-(1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1氢-吲哚-3-基-n-(2-(羟氨基)-2-酮乙基)乙酰胺及其制备方法和应用 |
| CN109928909A (zh) * | 2019-04-02 | 2019-06-25 | 南华大学 | 具有抗抑郁活性化合物及其制备方法 |
| CN120136763B (zh) * | 2025-03-13 | 2025-10-10 | 遵义医科大学 | 一种c-3苄基化吲哚类化合物、制备方法及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999000381A1 (en) * | 1997-06-25 | 1999-01-07 | Roche Diagnostics Gmbh | Bis-indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them |
| WO2002036561A1 (en) * | 2000-11-03 | 2002-05-10 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Bis-heterocyclic compounds with antitumour and chemosensitising activity |
| WO2003032982A1 (en) * | 2001-10-19 | 2003-04-24 | Transtech Pharma, Inc. | Bis-heteroaryl alkanes as therapeutic agents |
| WO2004076386A2 (en) * | 2003-02-25 | 2004-09-10 | Topotarget Uk Limited | Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors |
-
2006
- 2006-05-24 TW TW095118475A patent/TW200716545A/zh unknown
- 2006-05-31 JP JP2008515199A patent/JP2008542428A/ja not_active Withdrawn
- 2006-05-31 KR KR1020077029390A patent/KR20080029967A/ko not_active Ceased
- 2006-05-31 MX MX2007015274A patent/MX2007015274A/es not_active Application Discontinuation
- 2006-05-31 WO PCT/EP2006/062798 patent/WO2006131484A1/en not_active Ceased
- 2006-05-31 EA EA200702672A patent/EA013542B1/ru not_active IP Right Cessation
- 2006-05-31 AU AU2006256771A patent/AU2006256771A1/en not_active Abandoned
- 2006-05-31 EP EP06777259A patent/EP1891007A1/en not_active Withdrawn
- 2006-05-31 CA CA002607337A patent/CA2607337A1/en not_active Abandoned
- 2006-05-31 BR BRPI0612542-5A patent/BRPI0612542A2/pt not_active IP Right Cessation
- 2006-05-31 CN CNA2006800205522A patent/CN101193861A/zh active Pending
- 2006-05-31 US US11/917,065 patent/US8053460B2/en not_active Expired - Fee Related
- 2006-06-08 AR ARP060102385A patent/AR053891A1/es not_active Application Discontinuation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999000381A1 (en) * | 1997-06-25 | 1999-01-07 | Roche Diagnostics Gmbh | Bis-indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them |
| WO2002036561A1 (en) * | 2000-11-03 | 2002-05-10 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Bis-heterocyclic compounds with antitumour and chemosensitising activity |
| WO2003032982A1 (en) * | 2001-10-19 | 2003-04-24 | Transtech Pharma, Inc. | Bis-heteroaryl alkanes as therapeutic agents |
| WO2004076386A2 (en) * | 2003-02-25 | 2004-09-10 | Topotarget Uk Limited | Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors |
Non-Patent Citations (4)
| Title |
|---|
| BENGHIAT E ET AL: "MULTISUBSTRATE ADDUCTS AS POTENTIAL INHIBITORS OF S-ADENOSYLMETHIONINE DEPENDENT METHYLASES: INHIBITION OF INDOLE N-METHYLTRANSFERASE BY (5'DEOXYADENOSYL)[3-(3-INDOLYL)PROP-1-YL]M ETHYLSULFONIUM AND (5'-DEOXYADENOSYL)[4-(3-INDOLYL)BUT-1-YL]M ETHYLSULFONIUM" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 26, no. 10, 1983, pages 1470-1477, XP008048705 ISSN: 0022-2623, …compounds 3A, 9C, 9D * |
| BÖTTCHER, H. ET AL.: "Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro-l-pyridylalkyl)indol es. A novel conformational model to explain structure-activity relationship." J. MED. CHEM., vol. 35, no. 22, 1992, pages 4020-4026, XP002350276, Compounds of formula 9 wherein n=3 R1=H; n=5 R1=H; n=6 R1=H; n=4 R1=1-Me; n=4 R1=5-F; n=4 R1=5-Cl; n=4 R1=5-OMe; n=4 R1=6-OMe (disclosed in final paragraph, registry number listing). * |
| DATABASE CA [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KAYUMOV, V. ET AL.: "Indole derivatives. LXXXIV. Hydroxamic acids of the indole series", XP002350280, retrieved from STN, Database accession no. 1973:491888, 1H-indole-3-butanamide, N-hydroxy, RN 42885-60-9, abstract & KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, (6), 756-8 CODEN: KGSSAQ; ISSN: 0132-6244, 1973. * |
| DATABASE CA [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TOKMAKOV, G. P. ET AL.: "Interaction of 3,4-dihydro-2H-thiopyan with phenylhydrazines. Synthesis of homothiotryptophols" XP002350279, retrieved from STN, Database accession no. 1990:440383 1H-indole-3-propanethiol (RN 128083-19-2), 1H-indole-3-propanethiol, l-methyl (RN 128083-18-1), 1H-indole-3-propanethiol, 1-(phenylmethyl)-(RN128083-17-0), abstract & KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, (10), 1356-62 CODEN: KGSSAQ; ISSN: 0453-8234, 1989. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2633266C2 (ru) * | 2015-07-02 | 2017-10-11 | Рауф Ашрафович Ашрафов | Способ моделирования карциноидного синдрома |
Also Published As
| Publication number | Publication date |
|---|---|
| TW200716545A (en) | 2007-05-01 |
| CN101193861A (zh) | 2008-06-04 |
| EA200702672A1 (ru) | 2008-04-28 |
| AR053891A1 (es) | 2007-05-23 |
| EP1891007A1 (en) | 2008-02-27 |
| US8053460B2 (en) | 2011-11-08 |
| BRPI0612542A2 (pt) | 2010-11-23 |
| WO2006131484A1 (en) | 2006-12-14 |
| CA2607337A1 (en) | 2006-12-14 |
| JP2008542428A (ja) | 2008-11-27 |
| KR20080029967A (ko) | 2008-04-03 |
| MX2007015274A (es) | 2008-02-22 |
| US20080207729A1 (en) | 2008-08-28 |
| AU2006256771A1 (en) | 2006-12-14 |
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