CN105367479A - 一种组蛋白去乙酰酶抑制剂2-(1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1氢-吲哚-3-基-n-(2-(羟氨基)-2-酮乙基)乙酰胺及其制备方法和应用 - Google Patents
一种组蛋白去乙酰酶抑制剂2-(1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1氢-吲哚-3-基-n-(2-(羟氨基)-2-酮乙基)乙酰胺及其制备方法和应用 Download PDFInfo
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- CN105367479A CN105367479A CN201510784033.4A CN201510784033A CN105367479A CN 105367479 A CN105367479 A CN 105367479A CN 201510784033 A CN201510784033 A CN 201510784033A CN 105367479 A CN105367479 A CN 105367479A
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- histone deacetylase
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- 0 CC(C)*C(C)(C)[C@@](C)C1ICC[C@]1C Chemical compound CC(C)*C(C)(C)[C@@](C)C1ICC[C@]1C 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
Abstract
Description
Claims (5)
Priority Applications (1)
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CN201510784033.4A CN105367479A (zh) | 2015-11-16 | 2015-11-16 | 一种组蛋白去乙酰酶抑制剂2-(1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1氢-吲哚-3-基-n-(2-(羟氨基)-2-酮乙基)乙酰胺及其制备方法和应用 |
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CN201510784033.4A CN105367479A (zh) | 2015-11-16 | 2015-11-16 | 一种组蛋白去乙酰酶抑制剂2-(1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1氢-吲哚-3-基-n-(2-(羟氨基)-2-酮乙基)乙酰胺及其制备方法和应用 |
Publications (1)
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CN105367479A true CN105367479A (zh) | 2016-03-02 |
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CN201510784033.4A Pending CN105367479A (zh) | 2015-11-16 | 2015-11-16 | 一种组蛋白去乙酰酶抑制剂2-(1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1氢-吲哚-3-基-n-(2-(羟氨基)-2-酮乙基)乙酰胺及其制备方法和应用 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109879790A (zh) * | 2017-12-06 | 2019-06-14 | 华东师范大学 | 以吲哚或吲哚类似物为母核结构的酰胺类小分子有机化合物、用途及其制备方法 |
CN113149867A (zh) * | 2021-05-06 | 2021-07-23 | 石磊 | 一种姜黄素组蛋白去乙酰化酶抑制剂及其制备方法和医药用途 |
Citations (7)
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WO2006099416A1 (en) * | 2005-03-11 | 2006-09-21 | Nitromed, Inc. | 2-methyl indole cyclooxygenase-2 selective inhibitors, compositions and methods of use |
WO2006101456A1 (en) * | 2005-03-21 | 2006-09-28 | S*Bio Pte Ltd | Bicyclic heterocycles hydroxamate compounds useful as histone deacetylase (hdac) inhibitors |
CN101193861A (zh) * | 2005-06-10 | 2008-06-04 | 希格马托制药工业公司 | 具有抗肿瘤活性的吲哚衍生物 |
CN102746213A (zh) * | 2012-05-18 | 2012-10-24 | 潍坊博创国际生物医药研究院 | 肉桂酰胺类组蛋白去乙酰化酶抑制剂及其制备方法和应用 |
CN103467359A (zh) * | 2013-09-27 | 2013-12-25 | 山东大学 | 一种含有吲哚的肉桂酰胺类组蛋白去乙酰化酶抑制剂及其制备方法和应用 |
US20140128408A1 (en) * | 2011-02-01 | 2014-05-08 | The Board Of Trustees Of The University Of Illinois | Hdac inhibitors and therapeutic methods using the same |
CN103864793A (zh) * | 2014-03-12 | 2014-06-18 | 山东大学 | 取代嘌呤-9-乙酰氨基异羟肟酸类组蛋白去乙酰化酶抑制剂及制备方法和应用 |
-
2015
- 2015-11-16 CN CN201510784033.4A patent/CN105367479A/zh active Pending
Patent Citations (7)
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WO2006099416A1 (en) * | 2005-03-11 | 2006-09-21 | Nitromed, Inc. | 2-methyl indole cyclooxygenase-2 selective inhibitors, compositions and methods of use |
WO2006101456A1 (en) * | 2005-03-21 | 2006-09-28 | S*Bio Pte Ltd | Bicyclic heterocycles hydroxamate compounds useful as histone deacetylase (hdac) inhibitors |
CN101193861A (zh) * | 2005-06-10 | 2008-06-04 | 希格马托制药工业公司 | 具有抗肿瘤活性的吲哚衍生物 |
US20140128408A1 (en) * | 2011-02-01 | 2014-05-08 | The Board Of Trustees Of The University Of Illinois | Hdac inhibitors and therapeutic methods using the same |
CN102746213A (zh) * | 2012-05-18 | 2012-10-24 | 潍坊博创国际生物医药研究院 | 肉桂酰胺类组蛋白去乙酰化酶抑制剂及其制备方法和应用 |
CN103467359A (zh) * | 2013-09-27 | 2013-12-25 | 山东大学 | 一种含有吲哚的肉桂酰胺类组蛋白去乙酰化酶抑制剂及其制备方法和应用 |
CN103864793A (zh) * | 2014-03-12 | 2014-06-18 | 山东大学 | 取代嘌呤-9-乙酰氨基异羟肟酸类组蛋白去乙酰化酶抑制剂及制备方法和应用 |
Non-Patent Citations (1)
Title |
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PATRICIA HAUS ET AL.: "Identification of Selective Class II Histone Deacetylase Inhibitors Using a Novel Dual-Parameter Binding Assay Based on Fluorescence Anisotropy and Lifetime", 《JOURNAL OF BIOMOLECULAR SCREENING》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109879790A (zh) * | 2017-12-06 | 2019-06-14 | 华东师范大学 | 以吲哚或吲哚类似物为母核结构的酰胺类小分子有机化合物、用途及其制备方法 |
CN109879790B (zh) * | 2017-12-06 | 2022-09-20 | 华东师范大学 | 以吲哚或吲哚类似物为母核结构的酰胺类小分子有机化合物、用途及其制备方法 |
CN113149867A (zh) * | 2021-05-06 | 2021-07-23 | 石磊 | 一种姜黄素组蛋白去乙酰化酶抑制剂及其制备方法和医药用途 |
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