IT1317925B1 - Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante. - Google Patents

Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.

Info

Publication number
IT1317925B1
IT1317925B1 IT2000RM000569A ITRM20000569A IT1317925B1 IT 1317925 B1 IT1317925 B1 IT 1317925B1 IT 2000RM000569 A IT2000RM000569 A IT 2000RM000569A IT RM20000569 A ITRM20000569 A IT RM20000569A IT 1317925 B1 IT1317925 B1 IT 1317925B1
Authority
IT
Italy
Prior art keywords
heterocycles
tumor
bis
chemosensitizing activity
chemosensitizing
Prior art date
Application number
IT2000RM000569A
Other languages
English (en)
Inventor
Mauro Marzi
Patrizia Minetti
Gian Piero Moretti
Giuseppe Giannini
Sergio Penco
Maria Ornella Tinti
Claudio Pisano
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ITRM20000569A0 publication Critical patent/ITRM20000569A0/it
Priority to IT2000RM000569A priority Critical patent/IT1317925B1/it
Priority to KR10-2003-7006154A priority patent/KR20030045165A/ko
Priority to CNB2005100790913A priority patent/CN100351234C/zh
Priority to EP01963372A priority patent/EP1337511A1/en
Priority to PL01364907A priority patent/PL364907A1/xx
Priority to CNB018182933A priority patent/CN1232518C/zh
Priority to AU2001284392A priority patent/AU2001284392B8/en
Priority to US10/415,898 priority patent/US7084166B2/en
Priority to CA002427565A priority patent/CA2427565A1/en
Priority to PCT/IT2001/000407 priority patent/WO2002036561A1/en
Priority to SK535-2003A priority patent/SK5352003A3/sk
Priority to CZ20031178A priority patent/CZ20031178A3/cs
Priority to HU0400584A priority patent/HUP0400584A2/hu
Priority to BR0115139-8A priority patent/BR0115139A/pt
Priority to JP2002539321A priority patent/JP2004513110A/ja
Priority to MXPA03003942A priority patent/MXPA03003942A/es
Publication of ITRM20000569A1 publication Critical patent/ITRM20000569A1/it
Application granted granted Critical
Publication of IT1317925B1 publication Critical patent/IT1317925B1/it
Priority to HK04104340A priority patent/HK1061243A1/xx
Priority to AU2007202805A priority patent/AU2007202805A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT2000RM000569A 2000-11-03 2000-11-03 Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante. IT1317925B1 (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT2000RM000569A IT1317925B1 (it) 2000-11-03 2000-11-03 Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.
CA002427565A CA2427565A1 (en) 2000-11-03 2001-07-26 Bis-heterocyclic compounds with antitumour and chemosensitising activity
SK535-2003A SK5352003A3 (en) 2000-11-03 2001-07-26 Bis-heterocyclic compounds with antitumour and chemosensitising activity
EP01963372A EP1337511A1 (en) 2000-11-03 2001-07-26 Bis-heterocyclic compounds with antitumour and chemosensitising activity
PL01364907A PL364907A1 (en) 2000-11-03 2001-07-26 Bis-heterocyclic compounds with antitumour and chemosensitising activity
CNB018182933A CN1232518C (zh) 2000-11-03 2001-07-26 具有抗肿瘤和化学敏感活性的双杂环化合物
AU2001284392A AU2001284392B8 (en) 2000-11-03 2001-07-26 Bis-heterocyclic compounds with antitumour and chemosensitising activity
US10/415,898 US7084166B2 (en) 2000-11-03 2001-07-26 Bis-heterocyclic compounds with antitumour and chemosensitising activity
KR10-2003-7006154A KR20030045165A (ko) 2000-11-03 2001-07-26 항 종양 및 화학적 감작 활성을 갖는 비스 헤테로사이클릭화합물
PCT/IT2001/000407 WO2002036561A1 (en) 2000-11-03 2001-07-26 Bis-heterocyclic compounds with antitumour and chemosensitising activity
CNB2005100790913A CN100351234C (zh) 2000-11-03 2001-07-26 具有抗肿瘤和化学敏感活性的双杂环化合物
CZ20031178A CZ20031178A3 (cs) 2000-11-03 2001-07-26 Bis-heterocyklické sloučeniny s protinádorovými chemosensitivizujícími účinky
HU0400584A HUP0400584A2 (hu) 2000-11-03 2001-07-26 Tumorellenes és kemoszenzitizáló hatású bisz-heterociklusos vegyületek és ezeket tartalmazó gyógyszerkészítmények
BR0115139-8A BR0115139A (pt) 2000-11-03 2001-07-26 Compostos bis-heterocìclicos com atividade antitumor e quimiossensibilizante
JP2002539321A JP2004513110A (ja) 2000-11-03 2001-07-26 抗腫瘍および化学感作活性を有するビス−複素環式化合物
MXPA03003942A MXPA03003942A (es) 2000-11-03 2001-07-26 Compuestos bis-heterociclicos con actividad antitumoral y quimiosensibilizante.
HK04104340A HK1061243A1 (en) 2000-11-03 2004-06-16 Bis-heterocyclic compounds with antitumour and chemosensitising a activity
AU2007202805A AU2007202805A1 (en) 2000-11-03 2007-06-15 Bis-heterocyclic compounds with antitumour and chemosensitising activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000RM000569A IT1317925B1 (it) 2000-11-03 2000-11-03 Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.

Publications (3)

Publication Number Publication Date
ITRM20000569A0 ITRM20000569A0 (it) 2000-11-03
ITRM20000569A1 ITRM20000569A1 (it) 2002-05-03
IT1317925B1 true IT1317925B1 (it) 2003-07-15

Family

ID=11454975

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000RM000569A IT1317925B1 (it) 2000-11-03 2000-11-03 Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.

Country Status (16)

Country Link
US (1) US7084166B2 (it)
EP (1) EP1337511A1 (it)
JP (1) JP2004513110A (it)
KR (1) KR20030045165A (it)
CN (2) CN1232518C (it)
AU (2) AU2001284392B8 (it)
BR (1) BR0115139A (it)
CA (1) CA2427565A1 (it)
CZ (1) CZ20031178A3 (it)
HK (1) HK1061243A1 (it)
HU (1) HUP0400584A2 (it)
IT (1) IT1317925B1 (it)
MX (1) MXPA03003942A (it)
PL (1) PL364907A1 (it)
SK (1) SK5352003A3 (it)
WO (1) WO2002036561A1 (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060211759A1 (en) * 2001-07-26 2006-09-21 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Bis-heterocyclic compounds with antitumour and chemosensitising activity
US6933316B2 (en) 2001-12-13 2005-08-23 National Health Research Institutes Indole compounds
US7632955B2 (en) 2001-12-13 2009-12-15 National Health Research Institutes Indole compounds
US7528165B2 (en) 2001-12-13 2009-05-05 National Health Research Institutes Indole compounds
US6800655B2 (en) 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
EP1506960B1 (en) * 2003-08-07 2011-04-06 National Health Research Institutes Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis-related disorders
DE10359462A1 (de) * 2003-12-17 2005-07-28 Westfälische Wilhelms-Universität Münster Neuartige Platinkomplexverbindungen, Verfahren zu deren Herstellung sowie deren Verwendung für die Herstellung einer pharmazeutischen Zusammensetzung zur Behandlung von Krebserkrankungen
US7456289B2 (en) 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
JP2008545663A (ja) * 2005-05-27 2008-12-18 クイーンズ ユニバーシティ アット キングストン タンパク質フォールディング障害の治療
TW200716545A (en) * 2005-06-10 2007-05-01 Sigma Tau Ind Farmaceuti Indole derivatives having anti-tumor activity
US9969686B2 (en) * 2014-08-05 2018-05-15 Wisconsin Alumni Research Foundation Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
BR112020020881A2 (pt) * 2018-04-12 2021-04-20 Michael EINZIGER composições fotoprotetoras contendo compostos derivados de malassezia e/ou análogos químicos dos mesmos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3738237A1 (de) * 1987-11-11 1989-05-24 Bayer Ag Bis-indolyl-ethylen
WO1995008540A1 (en) 1993-09-22 1995-03-30 The Wellcome Foundation Limited Bis(amidinobenzimidazolyl)alkanes as antiviral agents
EP0887348A1 (en) * 1997-06-25 1998-12-30 Boehringer Mannheim Italia S.p.A. Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CN100351234C (zh) 2007-11-28
WO2002036561A1 (en) 2002-05-10
MXPA03003942A (es) 2004-05-24
AU8439201A (en) 2002-05-15
EP1337511A1 (en) 2003-08-27
ITRM20000569A1 (it) 2002-05-03
JP2004513110A (ja) 2004-04-30
CA2427565A1 (en) 2002-05-10
KR20030045165A (ko) 2003-06-09
ITRM20000569A0 (it) 2000-11-03
BR0115139A (pt) 2003-09-30
AU2007202805A1 (en) 2007-07-12
AU2001284392B2 (en) 2007-03-08
HUP0400584A2 (hu) 2004-06-28
CN1473150A (zh) 2004-02-04
PL364907A1 (en) 2004-12-27
CN1232518C (zh) 2005-12-21
HK1061243A1 (en) 2004-09-10
CZ20031178A3 (cs) 2003-11-12
SK5352003A3 (en) 2003-11-04
CN1733722A (zh) 2006-02-15
US20040053987A1 (en) 2004-03-18
AU2001284392B8 (en) 2007-04-05
US7084166B2 (en) 2006-08-01

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