JP2008541731A5 - - Google Patents
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- Publication number
- JP2008541731A5 JP2008541731A5 JP2008513753A JP2008513753A JP2008541731A5 JP 2008541731 A5 JP2008541731 A5 JP 2008541731A5 JP 2008513753 A JP2008513753 A JP 2008513753A JP 2008513753 A JP2008513753 A JP 2008513753A JP 2008541731 A5 JP2008541731 A5 JP 2008541731A5
- Authority
- JP
- Japan
- Prior art keywords
- thrombin
- bovine
- purified
- preparation
- substantially free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000190 Thrombin Proteins 0.000 claims 41
- 229960004072 thrombin Drugs 0.000 claims 40
- 241000283690 Bos taurus Species 0.000 claims 34
- 238000000034 method Methods 0.000 claims 23
- 238000002360 preparation method Methods 0.000 claims 12
- 230000007717 exclusion Effects 0.000 claims 10
- 239000012535 impurity Substances 0.000 claims 10
- 230000000694 effects Effects 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 238000000746 purification Methods 0.000 claims 5
- 108010074105 Factor Va Proteins 0.000 claims 4
- 102000029797 Prion Human genes 0.000 claims 3
- 108091000054 Prion Proteins 0.000 claims 3
- 238000011097 chromatography purification Methods 0.000 claims 3
- 244000052613 viral pathogen Species 0.000 claims 3
- 239000003957 anion exchange resin Substances 0.000 claims 2
- 238000005277 cation exchange chromatography Methods 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940077255 thrombin-jmi Drugs 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/140,374 US20060270014A1 (en) | 2005-05-26 | 2005-05-26 | Thrombin purification |
| US11/440,678 US20060270015A1 (en) | 2005-05-26 | 2006-05-24 | Thrombin purification |
| PCT/US2006/020412 WO2006127990A2 (en) | 2005-05-26 | 2006-05-25 | Thrombin purification |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008541731A JP2008541731A (ja) | 2008-11-27 |
| JP2008541731A5 true JP2008541731A5 (https=) | 2009-07-09 |
Family
ID=37452881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008513753A Pending JP2008541731A (ja) | 2005-05-26 | 2006-05-25 | トロンビンの精製 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20060270015A1 (https=) |
| EP (1) | EP1885387A4 (https=) |
| JP (1) | JP2008541731A (https=) |
| KR (1) | KR20080019583A (https=) |
| AR (1) | AR060686A1 (https=) |
| BR (1) | BRPI0610339A2 (https=) |
| CA (1) | CA2609520A1 (https=) |
| IL (1) | IL186790A0 (https=) |
| MX (1) | MX2007014571A (https=) |
| NZ (1) | NZ564058A (https=) |
| WO (1) | WO2006127990A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5253501B2 (ja) * | 2007-06-15 | 2013-07-31 | ザイモジェネティクス， インコーポレイテッド | 安定化トロンビン組成物 |
| US8451208B2 (en) | 2008-03-03 | 2013-05-28 | Samsung Display Co., Ltd. | Organic light emitting display device and method of driving the same |
| TW201702385A (zh) * | 2015-03-13 | 2017-01-16 | 崇謹 孫 | 穩定凝血酶之方法及其組合物 |
| IL261190A (en) | 2018-08-16 | 2019-01-31 | Omrix Biopharmaceuticals Ltd | Stable liquid preparations of thrombin |
| GB2579630A (en) * | 2018-12-07 | 2020-07-01 | Biotherapy Services Ltd | Methods and compositions |
| EP3952991A4 (en) * | 2019-04-12 | 2023-08-09 | Affirmed Pharma, LLC | RUSALATIDE ACETATE COMPOSITIONS |
| KR102624098B1 (ko) | 2021-05-13 | 2024-01-11 | 주식회사 덴하우스 | 순수도가 향상된 트롬빈 대량 정제 방법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4363319A (en) * | 1980-06-30 | 1982-12-14 | Applied Medical Devices, Inc. | Ready-to-use bandage incorporating a coagulant composition and method of preparing same |
| US4965203A (en) * | 1987-01-28 | 1990-10-23 | Warner-Lambert Company | Purified thrombin preparations |
| US5200340A (en) * | 1987-05-22 | 1993-04-06 | Zymogenetics, Inc. | Thrombin-activated tissue plasminogen activators |
| US5281528A (en) * | 1989-12-18 | 1994-01-25 | Warner-Lambert Company | Process for purified thromboplastin for ultra-pure thrombin preparation |
| IE73210B1 (en) * | 1990-01-24 | 1997-05-07 | Warner Lambert Co | Process for the production of thrombin and high purity thrombin preparation thereby obtained |
| US5527692A (en) * | 1991-12-31 | 1996-06-18 | Zymogenetics, Inc. | Methods for producing thrombin |
| AU683834B2 (en) * | 1991-12-31 | 1997-11-27 | Zymogenetics Inc. | Methods for producing thrombin |
| WO1998057678A2 (en) * | 1997-06-18 | 1998-12-23 | Cohesion Technologies, Inc. | Compositions containing thrombin and microfibrillar collagen |
| US6096872A (en) * | 1997-10-14 | 2000-08-01 | Ortho Diagnostic Systems, Inc. | Viral clearance process |
| US5981254A (en) * | 1997-10-30 | 1999-11-09 | Haemacure Corporation | Process for producing thrombin from plasma |
| US6780411B2 (en) * | 1998-05-01 | 2004-08-24 | Zymogenetics, Inc. | Tissue sealant compositions |
| DE10012732A1 (de) * | 2000-03-18 | 2001-09-20 | Aventis Behring Gmbh | Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung |
| DE20221826U1 (de) * | 2002-05-10 | 2008-02-28 | Gkn Driveline International Gmbh | Gegenbahngelenk mit gleicher Orientierung von gegenüberliegenden Bahnpaaren |
| GB0216002D0 (en) * | 2002-07-10 | 2002-08-21 | Nat Blood Authority | Process and composition |
-
2006
- 2006-05-24 US US11/440,678 patent/US20060270015A1/en not_active Abandoned
- 2006-05-25 KR KR1020077026154A patent/KR20080019583A/ko not_active Withdrawn
- 2006-05-25 EP EP06771275A patent/EP1885387A4/en not_active Withdrawn
- 2006-05-25 BR BRPI0610339-1A patent/BRPI0610339A2/pt not_active Application Discontinuation
- 2006-05-25 CA CA002609520A patent/CA2609520A1/en not_active Abandoned
- 2006-05-25 NZ NZ564058A patent/NZ564058A/en not_active IP Right Cessation
- 2006-05-25 WO PCT/US2006/020412 patent/WO2006127990A2/en not_active Ceased
- 2006-05-25 MX MX2007014571A patent/MX2007014571A/es unknown
- 2006-05-25 JP JP2008513753A patent/JP2008541731A/ja active Pending
- 2006-05-26 AR ARP060102209A patent/AR060686A1/es unknown
-
2007
- 2007-10-18 IL IL186790A patent/IL186790A0/en unknown
- 2007-10-30 US US11/927,918 patent/US20080280343A1/en not_active Abandoned
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