JP2008538115A5 - - Google Patents
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- JP2008538115A5 JP2008538115A5 JP2008503573A JP2008503573A JP2008538115A5 JP 2008538115 A5 JP2008538115 A5 JP 2008538115A5 JP 2008503573 A JP2008503573 A JP 2008503573A JP 2008503573 A JP2008503573 A JP 2008503573A JP 2008538115 A5 JP2008538115 A5 JP 2008538115A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- composition according
- composition
- solvates
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 38
- 238000000034 method Methods 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 9
- 238000004519 manufacturing process Methods 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 239000012453 solvate Substances 0.000 claims 9
- 206010011224 Cough Diseases 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 6
- 239000003981 vehicle Substances 0.000 claims 5
- 208000006673 asthma Diseases 0.000 claims 4
- 230000002458 infectious effect Effects 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 244000005700 microbiome Species 0.000 claims 4
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 206010028813 Nausea Diseases 0.000 claims 2
- 208000003251 Pruritus Diseases 0.000 claims 2
- 206010037660 Pyrexia Diseases 0.000 claims 2
- 208000032023 Signs and Symptoms Diseases 0.000 claims 2
- 206010040880 Skin irritation Diseases 0.000 claims 2
- 230000036528 appetite Effects 0.000 claims 2
- 235000019789 appetite Nutrition 0.000 claims 2
- 230000005540 biological transmission Effects 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 206010016256 fatigue Diseases 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 230000007794 irritation Effects 0.000 claims 2
- 230000007803 itching Effects 0.000 claims 2
- 230000008693 nausea Effects 0.000 claims 2
- 230000000241 respiratory effect Effects 0.000 claims 2
- 230000035807 sensation Effects 0.000 claims 2
- 230000036556 skin irritation Effects 0.000 claims 2
- 231100000475 skin irritation Toxicity 0.000 claims 2
- 230000005586 smoking cessation Effects 0.000 claims 2
- KFBJJLDMFHOVAM-LVQVYYBASA-N 2-methylpropyl (2r)-2-[[(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]propanoate Chemical compound CC(C)COC(=O)[C@@H](C)NC(=O)[C@@H]1C[C@H](C)CC[C@H]1C(C)C KFBJJLDMFHOVAM-LVQVYYBASA-N 0.000 claims 1
- 206010016334 Feeling hot Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 229920002807 Thiomer Polymers 0.000 claims 1
- 230000036626 alertness Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000037007 arousal Effects 0.000 claims 1
- KGMRZHHSSLQVMK-MOTUXRJWSA-N butan-2-yl (2r)-2-[[(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]propanoate Chemical compound CCC(C)OC(=O)[C@@H](C)NC(=O)[C@@H]1C[C@H](C)CC[C@H]1C(C)C KGMRZHHSSLQVMK-MOTUXRJWSA-N 0.000 claims 1
- QEDYKIJFHMQOLN-LVQVYYBASA-N butyl (2r)-2-[[(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]propanoate Chemical compound CCCCOC(=O)[C@@H](C)NC(=O)[C@@H]1C[C@H](C)CC[C@H]1C(C)C QEDYKIJFHMQOLN-LVQVYYBASA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- KLOKSRAWLQVZFV-YIYPIFLZSA-N ethyl (2r)-2-[[(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]propanoate Chemical compound CCOC(=O)[C@@H](C)NC(=O)[C@@H]1C[C@H](C)CC[C@H]1C(C)C KLOKSRAWLQVZFV-YIYPIFLZSA-N 0.000 claims 1
- XKZFMXOKCQATDH-FVCCEPFGSA-N methyl (2r)-2-[[(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]propanoate Chemical compound COC(=O)[C@@H](C)NC(=O)[C@@H]1C[C@H](C)CC[C@H]1C(C)C XKZFMXOKCQATDH-FVCCEPFGSA-N 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- VJKCLYOUWLDAPV-APIJFGDWSA-N propan-2-yl (2r)-2-[[(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]propanoate Chemical compound CC(C)OC(=O)[C@@H](C)NC(=O)[C@@H]1C[C@H](C)CC[C@H]1C(C)C VJKCLYOUWLDAPV-APIJFGDWSA-N 0.000 claims 1
- USUIAHWJKQIGNA-APIJFGDWSA-N propyl (2r)-2-[[(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]propanoate Chemical compound CCCOC(=O)[C@@H](C)NC(=O)[C@@H]1C[C@H](C)CC[C@H]1C(C)C USUIAHWJKQIGNA-APIJFGDWSA-N 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 150000005846 sugar alcohols Polymers 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66716605P | 2005-03-29 | 2005-03-29 | |
| US68338405P | 2005-05-20 | 2005-05-20 | |
| US70250505P | 2005-07-25 | 2005-07-25 | |
| US20372805A | 2005-08-13 | 2005-08-13 | |
| US77237406P | 2006-02-09 | 2006-02-09 | |
| PCT/GB2006/001093 WO2006103401A2 (en) | 2005-03-29 | 2006-03-23 | N-alkylcarbonyl-amino acid ester and n-alkylcarbonyl-amino lactone compounds and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010243617A Division JP2011068656A (ja) | 2005-03-29 | 2010-10-29 | Ｎ−アルキルカルボニル−アミノ酸エステルおよびｎ−アルキルカルボニル−アミノラクトン化合物およびそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008538115A JP2008538115A (ja) | 2008-10-09 |
| JP2008538115A5 true JP2008538115A5 (https=) | 2009-05-07 |
Family
ID=36498694
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503573A Pending JP2008538115A (ja) | 2005-03-29 | 2006-03-23 | Ｎ−アルキルカルボニル−アミノ酸エステルおよびｎ−アルキルカルボニル−アミノラクトン化合物およびそれらの使用 |
| JP2010243617A Pending JP2011068656A (ja) | 2005-03-29 | 2010-10-29 | Ｎ−アルキルカルボニル−アミノ酸エステルおよびｎ−アルキルカルボニル−アミノラクトン化合物およびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010243617A Pending JP2011068656A (ja) | 2005-03-29 | 2010-10-29 | Ｎ−アルキルカルボニル−アミノ酸エステルおよびｎ−アルキルカルボニル−アミノラクトン化合物およびそれらの使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20110082204A1 (https=) |
| EP (2) | EP2161252A1 (https=) |
| JP (2) | JP2008538115A (https=) |
| KR (1) | KR20070116133A (https=) |
| CN (1) | CN101184725B (https=) |
| AU (1) | AU2006228280B2 (https=) |
| BR (1) | BRPI0609784C1 (https=) |
| CA (1) | CA2602075C (https=) |
| CY (1) | CY1109420T1 (https=) |
| DE (1) | DE602006007831D1 (https=) |
| DK (1) | DK1871738T3 (https=) |
| ES (1) | ES2328847T3 (https=) |
| IL (1) | IL186297A0 (https=) |
| MX (1) | MX2007011831A (https=) |
| PL (1) | PL1871738T3 (https=) |
| PT (1) | PT1871738E (https=) |
| SI (1) | SI1871738T1 (https=) |
| WO (1) | WO2006103401A2 (https=) |
| ZA (1) | ZA200709252B (https=) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102027176B1 (ko) * | 2005-03-29 | 2019-10-01 | 악살비온 에스아 | 〔（（1ｒ,2ｓ,5ｒ）―2―이소프로필―5―메틸―시클로헥산카르보닐）―아미노〕―아세트산 이소프로필 에스테르와 관련 화합물 및 요법에서 그의 용도 |
| DE102006047164A1 (de) * | 2006-09-29 | 2008-04-03 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an 2-Isopropyl-5-Methyl-Cyclohexancarbonyl-D-Alaninmethylester und einem oder mehreren Hautbefeuchtungsmitteln |
| DE102006047162A1 (de) * | 2006-09-29 | 2008-04-03 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit Kombinationen aus (R)-2-[((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-propionsäure methyl ester und einer oder mehreren Lichtschutzfiltersubstanzen |
| EP1913976A1 (de) * | 2006-10-18 | 2008-04-23 | Symrise GmbH & Co. KG | N-alpha-(Menthancarbonyl)aminosäureamide und deren Verwendung als physiologische Kühlwirkstoffe |
| JP2010509299A (ja) * | 2006-11-08 | 2010-03-25 | ウェイ，エドワード，タク | Ｎ−アルキルカルボニル−ｄ−アミノ酸ヒドロキシアルキルエステル化合物およびそれらの使用 |
| EP2014333A1 (en) * | 2007-07-12 | 2009-01-14 | Hakiman Shargh Research Company | Use of cooling agents for treatment or prevention of lacrimation or eye burning |
| GB2451503B (en) * | 2007-08-01 | 2011-10-12 | Lrc Products | Stimulating gel comprising a cyclic carboxamide coolant |
| CN101903023A (zh) * | 2007-12-21 | 2010-12-01 | 爱德华·塔克·韦 | 治疗呼吸道疾病的对薄荷烷3-羧酸酯 |
| DE102008015426A1 (de) * | 2008-03-20 | 2009-09-24 | Beiersdorf Ag | Kühlende kosmetische oder dermatologische Zubereitungen mit einem Gehalt an (1R,2S,5R)-2-Isopropyl-5-methyl-N-(2-(pyridyn-2-yl)ethyl-cyclohexancarboxamid und/oder (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)-2-isopropyl-5-methylcyclohexancarboxamid zu Reduktion von Hautrötungen |
| DE102008015424A1 (de) * | 2008-03-20 | 2009-09-24 | Beiersdorf Ag | Kühlende kosmetische oder dermatologische Zubereitungen mit einem Gehalt an (1R,2S,5R)-2-Isopropyl-5-methyl-N-(2-(pyridyn-2-yl)ethyl-cyclohexancarboxamid und/oder (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)-2-isopropyl-5- methylcyclohexancarboxamid mit Menthoxypropandiol |
| RU2517179C2 (ru) | 2008-08-15 | 2014-05-27 | Дзе Проктер Энд Гэмбл Компани | Синтез производных циклогексана, используемых в потребительских товарах в качестве оказывающих сенсорное воздействие веществ |
| CN102123695A (zh) | 2008-08-15 | 2011-07-13 | 宝洁公司 | 用于消费品中的薄荷酰胺溶液 |
| AU2009318056B2 (en) | 2008-11-20 | 2014-07-24 | The Procter & Gamble Company | Personal care compositions providing enhanced cooling sensation |
| WO2010139954A1 (en) * | 2009-06-05 | 2010-12-09 | Wei Edward Tak | Treatment of eye discomfort by topical administration of a cooling agent to the external surface of the eyelid |
| US9446267B2 (en) | 2009-10-06 | 2016-09-20 | Symrise Ag | Products comprising a flavoring agent composition |
| EP2186506B1 (de) | 2009-10-06 | 2015-09-30 | Symrise AG | Mentholhaltige Zahnputz-Zusammensetzung mit reduzierter Bitterwahrnehmung |
| JP2013535450A (ja) | 2010-07-19 | 2013-09-12 | ザ プロクター アンド ギャンブル カンパニー | 精油化合物の誘導体を含む組成物、及びパーソナルケア製品における使用 |
| CN103140209B (zh) | 2010-10-01 | 2017-10-13 | 宝洁公司 | 具有改善的风味的口腔护理组合物 |
| CA2819466C (en) * | 2010-12-06 | 2019-11-26 | Axalbion Sa | [((1r,2s,5r)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-acetic acid isopropyl ester and related compounds and their use in therapy |
| CA2824827A1 (en) | 2011-01-18 | 2012-07-26 | Edward Tak Wei | (r)-1,2-propanediol for use as a solvent in therapeutic cooling agent compositions |
| US8426463B2 (en) * | 2011-04-04 | 2013-04-23 | Edward T. Wei | [((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-acetic acid isopropyl ester and related compounds and their use in therapy |
| US20130042482A1 (en) | 2011-08-16 | 2013-02-21 | Valerie Jean Bradford | Skin Engaging Member Comprising An Anti-Irritation Agent |
| CN103930091B (zh) | 2011-09-01 | 2016-03-02 | 宝洁公司 | 具有改善的流变特性的口腔护理组合物 |
| US20150272161A1 (en) * | 2011-12-21 | 2015-10-01 | Wm. Wrigley Jr. Company | Chewing gum products containing (r)-2-[((1r,2s,5r)-2-isopropyl-5-methylclohexanecarbonyl)-amino]-acetic acid isopropyl ester |
| US20130315843A1 (en) | 2012-05-25 | 2013-11-28 | The Procter & Gamble Company | Composition for reduction of trpa1 and trpv1 sensations |
| MX354139B (es) | 2012-09-28 | 2018-01-08 | Gillette Co Llc | Un miembro auxiliar de afeitado de acoplamiento con la piel que comprende al menos un agente percibido por los sentidos termicamente resilente. |
| AU2013323690B2 (en) | 2012-09-28 | 2016-09-22 | The Gillette Company Llc | A skin engaging member comprising at least one thermally resilient sensate |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
| US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
| AU2013403622B2 (en) | 2013-10-22 | 2019-05-16 | Edward Tak Wei | Di-isopropyl-phosphinoyl-alkane (DAPA) compounds as topical agents for the treatment of sensory discomfort |
| AU2013403623A1 (en) | 2013-10-22 | 2016-06-09 | Edward Tak Wei | 1-di(sec-butyl)-phosphinoyl-pentane (DAPA-2-5) as a topical agent for the treatment of discomfort from non-keratinized stratified epithelial (NKSE) tissue |
| US9884130B2 (en) | 2013-11-13 | 2018-02-06 | The Procter & Gamble Company | Compositions for delivery of oral comfort sensations |
| CN106029175A (zh) | 2014-02-27 | 2016-10-12 | 宝洁公司 | 具有减少的苦味感受的口腔护理组合物 |
| US20150272847A1 (en) | 2014-03-26 | 2015-10-01 | The Gillette Company | Skin Engaging Shaving Aid Comprising A Thermally Resilient Sensate And A TRPA1 Receptor Inhibitor |
| US20150273711A1 (en) | 2014-03-26 | 2015-10-01 | The Gillette Company | Razor Comprising A Molded Shaving Aid Composition Comprising A Thermally Resilient Sensate |
| JP2017518963A (ja) | 2014-04-23 | 2017-07-13 | ザ プロクター アンド ギャンブル カンパニー | 生体表面付着組成物 |
| MX2017002100A (es) | 2014-08-15 | 2017-05-04 | Procter & Gamble | Dentifrico con sustancias quimicas incrementales. |
| CA2956964C (en) | 2014-08-15 | 2019-07-16 | The Procter & Gamble Company | Oral care compositions with an enhanced sensory experience |
| EP3180090A1 (en) | 2014-08-15 | 2017-06-21 | The Procter and Gamble Company | Oral care compositions and regimens |
| BR112017011022B1 (pt) | 2014-11-26 | 2021-02-17 | The Gillette Company Llc | dispositivo de remoção de pelo e processo de formação de um membro de engate à pele |
| US9951295B2 (en) | 2015-02-19 | 2018-04-24 | The Procter & Gamble Company | Compositions for deposition on biological surfaces |
| AR104220A1 (es) | 2015-04-09 | 2017-07-05 | Procter & Gamble | Reducción de la aversión al sabor del cpc mediante la reducción de la activación del cpc de los receptores de trpa1, receptores de trpv1, o ambos |
| MX2017017169A (es) * | 2015-06-30 | 2018-03-09 | Wrigley W M Jun Co | Formulaciones refrigerantes de larga duracion. |
| EP3365324A1 (en) | 2015-10-22 | 2018-08-29 | The Procter and Gamble Company | Synthesis of cyclohexane carboxamide derivatives useful as sensates in consumer products |
| JP2018533567A (ja) | 2015-10-22 | 2018-11-15 | ザ プロクター アンド ギャンブル カンパニー | クロマトグラフィー分離方法 |
| CN108368035A (zh) | 2015-12-18 | 2018-08-03 | 宝洁公司 | 在消费品中可用作感觉剂的环己烷酯衍生物的合成 |
| CA3018559A1 (en) | 2016-04-01 | 2017-10-05 | The Procter & Gamble Company | Oral care compositions with an effective flavor display |
| EP3435957A1 (en) | 2016-04-01 | 2019-02-06 | The Procter and Gamble Company | Oral care compositions containing gel networks and potassium nitrate |
| BR112018069874A2 (pt) | 2016-04-01 | 2019-02-05 | Procter & Gamble | composições para tratamento bucal contendo uma fase de rede de gel e nitrato de potássio |
| AU2017240034B2 (en) | 2016-04-01 | 2020-02-06 | The Procter & Gamble Company | Oral care compositions containing a gel network phase |
| AU2017240683B2 (en) | 2016-04-01 | 2020-01-16 | The Procter & Gamble Company | Oral care compositions containing potassium nitrate and peroxide |
| US20170334082A1 (en) | 2016-05-18 | 2017-11-23 | The Gillette Company Llc | Skin Engaging Member Comprising Ethylene Vinyl Acetate |
| WO2018081190A1 (en) | 2016-10-25 | 2018-05-03 | The Procter & Gamble Company | Fibrous structures |
| WO2018081189A1 (en) | 2016-10-25 | 2018-05-03 | The Procter & Gamble Company | Fibrous structures |
| WO2018085479A1 (en) | 2016-11-03 | 2018-05-11 | The Gillette Company Llc | Skin engaging member comprising ethylene vinyl acetate |
| EP3541476A1 (en) | 2016-11-17 | 2019-09-25 | The Gillette Company LLC | Skin engaging member comprising ethylene vinyl acetate and a fragrance |
| WO2018144678A1 (en) * | 2017-02-03 | 2018-08-09 | The Johns Hopkins University | Mini-cancers utilization for personalized cancer drug regimens |
| EP3801449A1 (en) | 2018-05-28 | 2021-04-14 | The Procter & Gamble Company | Oral care composition with improved deposition efficacy of a cooling sensate agent in the oral cavity |
| KR102132713B1 (ko) | 2018-12-04 | 2020-07-13 | 주식회사 오스테온 | 모발 또는 두피 상태 개선용 조성물 |
| GB201908219D0 (en) * | 2019-06-10 | 2019-07-24 | Axalbion Sa | Therapeutic use of a compound |
| MX2023003549A (es) | 2020-09-28 | 2023-04-21 | Procter & Gamble | Composiciones para el cuidado bucal que comprenden lupulo y saborizante. |
| JP7592526B2 (ja) * | 2021-03-19 | 2024-12-02 | 株式会社マンダム | Ｔｒｐｖ１活性抑制剤、およびその利用 |
| US12397518B2 (en) * | 2021-04-29 | 2025-08-26 | Coopervision International Limited | WS12-releasing contact lens |
| EP4337157A1 (en) | 2021-05-11 | 2024-03-20 | The Procter & Gamble Company | Oral care compositions comprising block copolymer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4136163A (en) * | 1971-02-04 | 1979-01-23 | Wilkinson Sword Limited | P-menthane carboxamides having a physiological cooling effect |
| PH10359A (en) * | 1971-02-04 | 1977-01-05 | Wilkinson Sword Ltd | N-substituted-p-methane-3-carboxamides having physiological cooling activity and compositions containing them |
| US4178459A (en) * | 1971-02-04 | 1979-12-11 | Wilkinson Sword Limited | N-Substituted paramenthane carboxamides |
| US4150052A (en) * | 1971-02-04 | 1979-04-17 | Wilkinson Sword Limited | N-substituted paramenthane carboxamides |
| GB1351761A (en) * | 1971-02-04 | 1974-05-01 | Wilkinson Sword Ltd | Substituted p-menthane carboxamides and compositions containing them |
| US3889804A (en) * | 1973-03-14 | 1975-06-17 | Gorham Int Inc | Disposable towel |
| JP2978043B2 (ja) * | 1993-09-16 | 1999-11-15 | 高砂香料工業株式会社 | （２ｓ）−３−｛（１ｒ，２ｓ，５ｒ）−［ ５−メチル−２−（１−メチルエチル）シクロヘキシル ］オキシ｝−１，２−プロパンジオール，その製造方法および用途 |
| US7189760B2 (en) * | 2004-04-02 | 2007-03-13 | Millennium Specialty Chemicals | Physiological cooling compositions containing highly purified ethyl ester of N-[[5-methyl-2-(1-methylethyl) cyclohexyl] carbonyl]glycine |
| US20080227857A1 (en) * | 2005-03-29 | 2008-09-18 | Edward Tak Wei | N-Alkylcarbonyl-Amino Acid Ester and N-Alkylcarbonyl-Amino Lactone Compounds and Their Use |
-
2006
- 2006-03-23 MX MX2007011831A patent/MX2007011831A/es active IP Right Grant
- 2006-03-23 CN CN2006800189445A patent/CN101184725B/zh not_active Expired - Lifetime
- 2006-03-23 ZA ZA200709252A patent/ZA200709252B/xx unknown
- 2006-03-23 PL PL06710144T patent/PL1871738T3/pl unknown
- 2006-03-23 CA CA2602075A patent/CA2602075C/en not_active Expired - Lifetime
- 2006-03-23 PT PT06710144T patent/PT1871738E/pt unknown
- 2006-03-23 WO PCT/GB2006/001093 patent/WO2006103401A2/en not_active Ceased
- 2006-03-23 EP EP09165292A patent/EP2161252A1/en not_active Withdrawn
- 2006-03-23 KR KR1020077024165A patent/KR20070116133A/ko not_active Ceased
- 2006-03-23 SI SI200630404T patent/SI1871738T1/sl unknown
- 2006-03-23 DE DE602006007831T patent/DE602006007831D1/de not_active Expired - Lifetime
- 2006-03-23 DK DK06710144T patent/DK1871738T3/da active
- 2006-03-23 AU AU2006228280A patent/AU2006228280B2/en not_active Expired
- 2006-03-23 JP JP2008503573A patent/JP2008538115A/ja active Pending
- 2006-03-23 ES ES06710144T patent/ES2328847T3/es not_active Expired - Lifetime
- 2006-03-23 EP EP06710144A patent/EP1871738B1/en not_active Expired - Lifetime
- 2006-03-23 BR BRPI0609784A patent/BRPI0609784C1/pt active IP Right Grant
-
2007
- 2007-09-25 IL IL186297A patent/IL186297A0/en unknown
-
2009
- 2009-09-23 CY CY20091100988T patent/CY1109420T1/el unknown
-
2010
- 2010-10-29 JP JP2010243617A patent/JP2011068656A/ja active Pending
- 2010-12-06 US US12/928,184 patent/US20110082204A1/en not_active Abandoned
-
2011
- 2011-01-18 US US12/930,794 patent/US8853267B2/en active Active
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