JP2008537595A - 治療タンパク質に対する免疫反応を評価するための方法および生成物 - Google Patents
治療タンパク質に対する免疫反応を評価するための方法および生成物 Download PDFInfo
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2011506943A (ja) * | 2007-12-15 | 2011-03-03 | エフ．ホフマン−ラ ロシュ アーゲー | 識別アッセイ |
| JP2011510291A (ja) * | 2008-01-15 | 2011-03-31 | スティヒティンク サンクイン ブロイドフォーツィーニンク | 治療用抗体に対する抗体を検出する方法およびキット |
| JP2013536419A (ja) * | 2010-08-19 | 2013-09-19 | エフ．ホフマン−ラ ロシュ アーゲー | 療法用モノクローナル抗体に結合する抗体の測定のためのアッセイ |
| JP2014500950A (ja) * | 2010-10-25 | 2014-01-16 | エラン ファーマシューティカルズ，インコーポレイテッド | ｓＶＣＡＭおよび／またはｓＭＡｄＣＡＭレベルの差を関連付けることにより、アルファ−４インテグリン活性の差を決定するための方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| PL215263B1 (pl) | 2002-02-25 | 2013-11-29 | Elan Pharm Inc | Kompozycja do przewleklego leczenia patologicznego zapalenia i zastosowanie natalizumabu lub jego immunologicznie aktywnego fragmentu do wytwarzania leku |
| DK2645106T4 (da) * | 2005-04-04 | 2024-12-02 | Biogen Ma Inc | Fremgangsmåder til evaluering af et immunrespons på et terapeutisk middel |
| WO2007100770A2 (en) | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
| RS20080391A (sr) | 2006-03-03 | 2009-07-15 | Elan Pharmaceuticals Inc., | Postupci lečenja zapaljenskih i autoimunih bolesti natalizumabom |
| JP2013507618A (ja) | 2009-10-11 | 2013-03-04 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 抗ｖｌａ‐４関連アッセイ |
| RS63744B1 (sr) | 2010-01-11 | 2022-12-30 | Biogen Ma Inc | Test za antitela protiv jc virusa |
| US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| ES2729945T3 (es) | 2011-05-31 | 2019-11-07 | Biogen Ma Inc | Procedimiento para valorar el riesgo de LMP |
| WO2012175201A1 (en) * | 2011-06-20 | 2012-12-27 | Cellzome Ag | Methods for the characterization of antibodies |
| HK1216546A1 (zh) | 2013-05-28 | 2016-11-18 | Biogen Ma Inc. | 评估pml风险的方法 |
| CN103439515B (zh) * | 2013-08-14 | 2015-07-15 | 南方医科大学 | 一种抗体效价的检测方法 |
| US20170059561A1 (en) * | 2015-08-28 | 2017-03-02 | The Florida International University Board Of Trustees | Thermally Stable Electrochemical Sensor With Long Shelf-Life |
| CN111225686A (zh) * | 2017-08-15 | 2020-06-02 | 普罗根尼蒂公司 | 使用可摄入装置释放免疫调节剂治疗炎性疾病 |
| CN112730846B (zh) * | 2020-12-18 | 2023-12-15 | 安渡生物医药(杭州)有限公司 | 一种用于小鼠血样检测免疫复合物的方法 |
| CN114360650A (zh) * | 2022-01-05 | 2022-04-15 | 科临达康医药生物科技(北京)有限公司 | 治疗性蛋白和肽临床免疫原性评估报告的生成方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11190734A (ja) * | 1997-12-26 | 1999-07-13 | Wakamoto Pharmaceut Co Ltd | クローン病の検査方法および検査用キット |
| JP2002071694A (ja) * | 2000-08-25 | 2002-03-12 | Wakamoto Pharmaceut Co Ltd | 炎症性腸疾患の検査方法及び検査用キット |
| WO2003016909A1 (en) * | 2001-08-16 | 2003-02-27 | Ludwig Institute For Cancer Research | Method for determining protein component in a biological sample |
| WO2003072040A2 (en) * | 2002-02-25 | 2003-09-04 | Elan Pharmaceuticals, Inc. | Administration of agents for the treatment of inflammation |
| WO2004043237A2 (en) * | 2002-11-08 | 2004-05-27 | Barnes-Jewish Hospital | Uncoupled collagen synthesis and degradation assays |
| JP2007500844A (ja) * | 2003-07-29 | 2007-01-18 | ジェネンテック・インコーポレーテッド | ヒト抗ｃｄ２０抗体のアッセイとその用途 |
Family Cites Families (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3639350A (en) | 1970-04-15 | 1972-02-01 | Allied Chem | Esterification of terephthalic acid with an alkylene glycol in the presence of guanidine or an alkyl guanidine |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4425112A (en) | 1976-02-25 | 1984-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Flow-through centrifuge |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4235601A (en) | 1979-01-12 | 1980-11-25 | Thyroid Diagnostics, Inc. | Test device and method for its use |
| US4391904A (en) | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4517288A (en) | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
| US4472509A (en) | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| US4703017C1 (en) | 1984-02-14 | 2001-12-04 | Becton Dickinson Co | Solid phase assay with visual readout |
| US4938948A (en) | 1985-10-07 | 1990-07-03 | Cetus Corporation | Method for imaging breast tumors using labeled monoclonal anti-human breast cancer antibodies |
| CA1291031C (en) | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5763262A (en) | 1986-09-18 | 1998-06-09 | Quidel Corporation | Immunodiagnostic device |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| ES2150428T3 (es) | 1987-04-27 | 2000-12-01 | Unilever Nv | Ensayos de union especifica. |
| US4943522A (en) | 1987-06-01 | 1990-07-24 | Quidel | Lateral flow, non-bibulous membrane assay protocols |
| US5120643A (en) | 1987-07-13 | 1992-06-09 | Abbott Laboratories | Process for immunochromatography with colloidal particles |
| US4818677A (en) | 1987-12-03 | 1989-04-04 | Monoclonal Antibodies, Inc. | Membrane assay using focused sample application |
| AU2684488A (en) | 1988-06-27 | 1990-01-04 | Carter-Wallace, Inc. | Test device and method for colored particle immunoassay |
| US5221616A (en) | 1988-07-15 | 1993-06-22 | Quidel Corporation | Prevention of spontaneous complement activation in mammalian biological fluids |
| US5118630A (en) | 1988-11-04 | 1992-06-02 | Quidel Corporation | Method for determining periodic infertility in females |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6352862B1 (en) | 1989-02-17 | 2002-03-05 | Unilever Patent Holdings B.V. | Analytical test device for imuno assays and methods of using same |
| US5084828A (en) | 1989-09-29 | 1992-01-28 | Healthtech Services Corp. | Interactive medication delivery system |
| US5252496A (en) | 1989-12-18 | 1993-10-12 | Princeton Biomeditech Corporation | Carbon black immunochemical label |
| US5096837A (en) | 1990-02-08 | 1992-03-17 | Pacific Biotech, Inc. | Immunochromatographic assay and method of using same |
| US5223220A (en) | 1990-03-27 | 1993-06-29 | Pacific Biotech, Inc. | Solid phase immunoassay device and method of making same |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5118428A (en) | 1990-11-13 | 1992-06-02 | Quidel | Method to remove red blood cells from whole blood samples |
| DE4139840B4 (de) | 1990-12-04 | 2005-06-02 | Quidel Corp., San Diego | Antigen-Zubereitung zum Nachweis von H. pylori |
| WO1992012428A1 (en) | 1991-01-11 | 1992-07-23 | Quidel Corporation | A one-step lateral flow nonbibulous assay |
| US5225328A (en) | 1991-05-30 | 1993-07-06 | Quidel Corporation | Stable alkaline phosphatase compositions with color enhancement and their use in assays |
| US5686315A (en) | 1991-06-14 | 1997-11-11 | Quidel Corporation | Assay device for one step detection of analyte |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| JPH07503543A (ja) | 1992-02-04 | 1995-04-13 | クイデル コーポレイション | 乾燥試薬を用いる細菌抗原の簡易化抽出法 |
| US5541069A (en) | 1992-02-28 | 1996-07-30 | Quidel Corporation | Assay having improved dose response curve |
| ES2151902T3 (es) | 1992-03-10 | 2001-01-16 | Quidel Corp | Medio de separacion de globulos rojos para dosificarlos mediante union especifica. |
| DK0678122T3 (da) | 1993-01-12 | 2000-03-06 | Biogen Inc | Rekombinante anti-VLA4 antistofmolekyler |
| WO1994017828A2 (en) | 1993-02-09 | 1994-08-18 | Biogen, Inc. | Treatment for insulin dependent diabetes |
| US5415994A (en) | 1993-08-02 | 1995-05-16 | Quidel Corporation | Lateral flow medical diagnostic assay device with sample extraction means |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US5840299A (en) * | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
| US5434057A (en) | 1994-02-02 | 1995-07-18 | Quidel Corporation | Sperm motility assay and devices |
| US5521102A (en) | 1994-08-08 | 1996-05-28 | Quidel Corporation | Controlled sensitivity immunochromatographic assay |
| US5845255A (en) | 1994-10-28 | 1998-12-01 | Advanced Health Med-E-Systems Corporation | Prescription management system |
| US5712172A (en) | 1995-05-18 | 1998-01-27 | Wyntek Diagnostics, Inc. | One step immunochromatographic device and method of use |
| US5804452A (en) | 1995-04-27 | 1998-09-08 | Quidel Corporation | One step urine creatinine assays |
| US5786220A (en) | 1995-04-28 | 1998-07-28 | Quidel Corporation | Assays and devices for distinguishing between normal and abnormal pregnancy |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| US20010051350A1 (en) | 1995-05-02 | 2001-12-13 | Albert Nazareth | Diagnostic detection device and method |
| US5773234A (en) | 1995-08-07 | 1998-06-30 | Quidel Corporation | Method and device for chlamydia detection |
| DE19541844C1 (de) | 1995-11-09 | 1997-07-24 | Gsf Forschungszentrum Umwelt | Verfahren zur Herstellung von menschlichen Antikörpern und deren Verwendung |
| DE19543553B4 (de) | 1995-11-22 | 2009-04-09 | Deutsches Primatenzentrum Gmbh | VP-Antigene des JC-Virus |
| DE69738539T2 (de) | 1996-12-03 | 2009-03-26 | Amgen Fremont Inc. | Vollkommen humane Antikörper die EGFR binden |
| US6305377B1 (en) | 1996-12-12 | 2001-10-23 | Michael T. Portwood | System and method for improving compliance of a medical regimen |
| US6306642B1 (en) | 1997-11-24 | 2001-10-23 | Quidel Corporation | Enzyme substrate delivery and product registration in one step enzyme immunoassays |
| US6623981B2 (en) | 1998-01-27 | 2003-09-23 | Bristol-Myers Squibb Company | Detection of patients at risk for developing integrin antagonist/agonist mediated disease states |
| US6014631A (en) | 1998-04-02 | 2000-01-11 | Merck-Medco Managed Care, Llc | Computer implemented patient medication review system and process for the managed care, health care and/or pharmacy industry |
| US6045501A (en) | 1998-08-28 | 2000-04-04 | Celgene Corporation | Methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug |
| US7171371B2 (en) | 1999-09-03 | 2007-01-30 | Smg Trust | Method and system for providing pre and post operative support and care |
| EP1232392B2 (de) | 1999-10-12 | 2014-04-02 | Oxoid (Ely) Limited | Verbessertes verfahren zum nachweis von säure-resistenten bakterien der gattung helicobacter im stuhl |
| US6612032B1 (en) | 2000-01-31 | 2003-09-02 | Lexmark International, Inc. | Manufacturing method for ink jet pen |
| AU4465001A (en) | 2000-03-30 | 2001-10-15 | Nippon Kayaku Kabushiki Kaisha | Method of examining cancer by assaying autoantibody against mdm2 and reagent therefor |
| US8288322B2 (en) | 2000-04-17 | 2012-10-16 | Dyax Corp. | Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries |
| US7018847B2 (en) | 2000-05-05 | 2006-03-28 | Pharmacia Diagnostics Ab | Assay device with timer function |
| US6620626B1 (en) | 2000-08-09 | 2003-09-16 | Mission Research Corp. | Antigen detection device and method |
| JP2004511807A (ja) | 2000-10-17 | 2004-04-15 | ベッスト−テスト アンパーツゼルスカブ | 体液サンプル中のｒｓウイルスに関連した生物学的細胞の直接的検出のためのアッセイ |
| US6315720B1 (en) | 2000-10-23 | 2001-11-13 | Celgene Corporation | Methods for delivering a drug to a patient while avoiding the occurrence of an adverse side effect known or suspected of being caused by the drug |
| US6485460B2 (en) | 2001-01-12 | 2002-11-26 | Bracco Diagnostics, Inc. | Tamper evident syringe barrel |
| US7291477B2 (en) | 2001-07-03 | 2007-11-06 | Xenotope Diagnostics, Inc. | Method and device for trichomonas detection |
| AU2002331408B2 (en) | 2001-08-20 | 2008-05-08 | Proteome Systems Ltd | Diagnostic testing process and apparatus |
| EP1578361B1 (en) * | 2002-09-12 | 2011-04-20 | The Regents of The University of California | Immunogens and corresponding antibodies specific for high molecular weight aggregation intermediates common to amyloids formed from proteins of differing sequence |
| US7238538B2 (en) | 2003-09-19 | 2007-07-03 | Freitag Helmut E | Chromatographic assay device and methods |
| EP1664781B1 (en) | 2003-09-22 | 2013-05-08 | Quidel Corporation | Devices for the detection of multiple analytes in a sample |
| JP4672263B2 (ja) | 2004-01-27 | 2011-04-20 | デンカ生研株式会社 | 簡便な検出法、検出装置及び検出キットとその製法 |
| US7419666B1 (en) | 2004-02-23 | 2008-09-02 | Massachusetts Eye And Ear Infirmary | Treatment of ocular disorders |
| US20050283385A1 (en) | 2004-06-21 | 2005-12-22 | The Permanente Medical Group, Inc. | Individualized healthcare management system |
| US8445293B2 (en) | 2005-02-09 | 2013-05-21 | Rapid Pathogen Screening, Inc. | Method to increase specificity and/or accuracy of lateral flow immunoassays |
| WO2006112951A2 (en) | 2005-03-03 | 2006-10-26 | Seedlings Life Science Ventures, Llc | Method of risk management for patients undergoing natalizumab treatment |
| DK2645106T4 (da) * | 2005-04-04 | 2024-12-02 | Biogen Ma Inc | Fremgangsmåder til evaluering af et immunrespons på et terapeutisk middel |
| US20060246513A1 (en) | 2005-05-02 | 2006-11-02 | Bohannon Robert C | Method and device to detect the presence of analytes in a sample |
| WO2007100770A2 (en) | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
| US8410115B2 (en) | 2006-02-28 | 2013-04-02 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
| RS20080391A (sr) | 2006-03-03 | 2009-07-15 | Elan Pharmaceuticals Inc., | Postupci lečenja zapaljenskih i autoimunih bolesti natalizumabom |
| WO2008014709A1 (en) | 2006-07-26 | 2008-02-07 | Abon Biopharm (Hangzhou) Co., Ltd. | Analysis device for biologicla sample |
| US7704702B2 (en) | 2006-08-10 | 2010-04-27 | Inverness Medical Switzerland Gmbh | Test strip for lateral flow assays |
| US20080233150A1 (en) | 2006-11-16 | 2008-09-25 | Gale Smith | Respiratory syncytial virus-virus like particle (vlps) |
| EP1933140B1 (en) | 2006-12-11 | 2011-08-17 | AraGen Biotechnology Co. Ltd. | Antibody detection method involving an oligonucleotide enhanced collodial gold signal |
| CA2702118A1 (en) | 2007-08-30 | 2009-03-12 | President And Fellows Of Harvard College | Compliant surface multi-well culture plate |
| RS63744B1 (sr) | 2010-01-11 | 2022-12-30 | Biogen Ma Inc | Test za antitela protiv jc virusa |
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11190734A (ja) * | 1997-12-26 | 1999-07-13 | Wakamoto Pharmaceut Co Ltd | クローン病の検査方法および検査用キット |
| JP2002071694A (ja) * | 2000-08-25 | 2002-03-12 | Wakamoto Pharmaceut Co Ltd | 炎症性腸疾患の検査方法及び検査用キット |
| WO2003016909A1 (en) * | 2001-08-16 | 2003-02-27 | Ludwig Institute For Cancer Research | Method for determining protein component in a biological sample |
| WO2003072040A2 (en) * | 2002-02-25 | 2003-09-04 | Elan Pharmaceuticals, Inc. | Administration of agents for the treatment of inflammation |
| JP2005526045A (ja) * | 2002-02-25 | 2005-09-02 | エラン ファーマシューティカルズ，インコーポレイテッド | 炎症の治療用薬剤の投与 |
| WO2004043237A2 (en) * | 2002-11-08 | 2004-05-27 | Barnes-Jewish Hospital | Uncoupled collagen synthesis and degradation assays |
| JP2007500844A (ja) * | 2003-07-29 | 2007-01-18 | ジェネンテック・インコーポレーテッド | ヒト抗ｃｄ２０抗体のアッセイとその用途 |
Non-Patent Citations (1)
| Title |
|---|
| ROSKOS L K, MEASURING IMMUNITY, JPN5008003394, December 2004 (2004-12-01), NL, pages 172 - 186, ISSN: 0001881197 * |
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| JP2011510291A (ja) * | 2008-01-15 | 2011-03-31 | スティヒティンク サンクイン ブロイドフォーツィーニンク | 治療用抗体に対する抗体を検出する方法およびキット |
| JP2013536419A (ja) * | 2010-08-19 | 2013-09-19 | エフ．ホフマン−ラ ロシュ アーゲー | 療法用モノクローナル抗体に結合する抗体の測定のためのアッセイ |
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| JP2015215363A (ja) * | 2010-10-25 | 2015-12-03 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | ｓＶＣＡＭおよび／またはｓＭＡｄＣＡＭレベルの差を関連付けることにより、アルファ−４インテグリン活性の差を決定するための方法 |
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