JP2008536496A5 - - Google Patents
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- Publication number
- JP2008536496A5 JP2008536496A5 JP2008505707A JP2008505707A JP2008536496A5 JP 2008536496 A5 JP2008536496 A5 JP 2008536496A5 JP 2008505707 A JP2008505707 A JP 2008505707A JP 2008505707 A JP2008505707 A JP 2008505707A JP 2008536496 A5 JP2008536496 A5 JP 2008536496A5
- Authority
- JP
- Japan
- Prior art keywords
- deletion
- mtdna
- prostate cancer
- pcr analysis
- detecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020005196 Mitochondrial DNA Proteins 0.000 claims 18
- 230000037430 deletion Effects 0.000 claims 15
- 238000012217 deletion Methods 0.000 claims 15
- 238000000034 method Methods 0.000 claims 15
- 206010060862 Prostate cancer Diseases 0.000 claims 9
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 8
- 238000010222 PCR analysis Methods 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 238000003753 real-time PCR Methods 0.000 claims 5
- 230000035772 mutation Effects 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 239000007790 solid phase Substances 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 108010035095 NADH dehydrogenase subunit 4 Proteins 0.000 claims 1
- 102100021506 NADH-ubiquinone oxidoreductase chain 4 Human genes 0.000 claims 1
- 102100021452 NADH-ubiquinone oxidoreductase chain 4L Human genes 0.000 claims 1
- 101710151478 NADH-ubiquinone oxidoreductase chain 4L Proteins 0.000 claims 1
- 101710106577 NADH-ubiquinone oxidoreductase chain 5 Proteins 0.000 claims 1
- 102100036971 NADH-ubiquinone oxidoreductase chain 5 Human genes 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 108020004566 Transfer RNA Proteins 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 238000013507 mapping Methods 0.000 claims 1
- 238000013188 needle biopsy Methods 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 208000023958 prostate neoplasm Diseases 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000036561 sun exposure Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67201605P | 2005-04-18 | 2005-04-18 | |
| US60/672,016 | 2005-04-18 | ||
| US72152205P | 2005-09-29 | 2005-09-29 | |
| US60/721,522 | 2005-09-29 | ||
| US78987206P | 2006-04-07 | 2006-04-07 | |
| US60/789,872 | 2006-04-07 | ||
| PCT/CA2006/000652 WO2006111029A1 (en) | 2005-04-18 | 2006-04-18 | Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012101409A Division JP6134890B2 (ja) | 2005-04-18 | 2012-04-26 | 日光曝露、前立腺癌および他の癌の検出用の診断ツールとしての、ミトコンドリアの突然変異および再配置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008536496A JP2008536496A (ja) | 2008-09-11 |
| JP2008536496A5 true JP2008536496A5 (https=) | 2009-05-28 |
| JP5537804B2 JP5537804B2 (ja) | 2014-07-02 |
Family
ID=37114687
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008505707A Expired - Fee Related JP5537804B2 (ja) | 2005-04-18 | 2006-04-18 | 日光曝露、前立腺癌および他の癌の検出用の診断ツールとしての、ミトコンドリアの突然変異および再配置 |
| JP2012101409A Expired - Fee Related JP6134890B2 (ja) | 2005-04-18 | 2012-04-26 | 日光曝露、前立腺癌および他の癌の検出用の診断ツールとしての、ミトコンドリアの突然変異および再配置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012101409A Expired - Fee Related JP6134890B2 (ja) | 2005-04-18 | 2012-04-26 | 日光曝露、前立腺癌および他の癌の検出用の診断ツールとしての、ミトコンドリアの突然変異および再配置 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US8008008B2 (https=) |
| EP (2) | EP1877559B1 (https=) |
| JP (2) | JP5537804B2 (https=) |
| KR (1) | KR101363032B1 (https=) |
| CN (2) | CN101248180B (https=) |
| AT (1) | ATE484589T1 (https=) |
| AU (1) | AU2006238390B2 (https=) |
| CA (2) | CA2606156C (https=) |
| DE (1) | DE602006017534D1 (https=) |
| DK (1) | DK1877559T3 (https=) |
| ES (1) | ES2354452T3 (https=) |
| NZ (2) | NZ587665A (https=) |
| PT (1) | PT1877559E (https=) |
| SG (1) | SG2014011837A (https=) |
| WO (1) | WO2006111029A1 (https=) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101248180B (zh) * | 2005-04-18 | 2013-09-25 | 米托米克斯公司 | 作为检测日光照射、前列腺癌和其它癌症的诊断工具的线粒体突变及重排 |
| US20130022979A1 (en) * | 2005-04-18 | 2013-01-24 | Genesis Genomics Inc. | 3.4kb MITOCHONDRIAL DNA DELETION FOR USE IN THE DETECTION OF CANCER |
| CN100526453C (zh) * | 2005-05-20 | 2009-08-12 | 麦克奥迪实业集团有限公司 | 激光显微切割后细胞收集方法 |
| AU2005333512A1 (en) * | 2005-06-16 | 2006-12-28 | Biotools Biotechnological & Medical Laboratories, S.A. | Nucleic acid detection method involving the direct generation of a measurable signal |
| US20080254530A1 (en) * | 2007-02-27 | 2008-10-16 | Gettysburg College | Isolation and characterization of a single mitochondrion |
| CN101874119B (zh) * | 2007-09-26 | 2015-01-28 | 米托米克斯公司 | 3.4kb线粒体DNA缺失用于检测癌症 |
| NZ584595A (en) * | 2007-10-11 | 2012-12-21 | Mitomics Inc | Methods for assaying melanocortin 1 receptor variants utilysing a mitochondrial DNA abberration which is a 3895 bp mtDNA deletion between nucleic acid 546 to 4444 of the mtDNA genome |
| WO2009046514A1 (en) * | 2007-10-11 | 2009-04-16 | Genesis Genomics Inc. | Methods for non-invasive collection of skin cells for dna analysis |
| JP5481383B2 (ja) * | 2007-11-09 | 2014-04-23 | ミトミクス インコーポレイテッド | 癌の検出に使用するための、約１２３１７残基〜約１６２５４残基の間のミトコンドリアｄｎａの欠失 |
| AU2009227935B2 (en) * | 2008-03-28 | 2015-07-09 | Mdna Life Sciences Inc. | Aberrant mitochondrial DNA, associated fusion transcripts and hybridization probes therefor |
| JP2012501456A (ja) * | 2008-08-28 | 2012-01-19 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後のための方法および組成物 |
| EP2324354B1 (en) * | 2008-08-29 | 2014-07-16 | Astute Medical, Inc. | Methods for prognosis of acute renal failure |
| CA2740923A1 (en) * | 2008-10-21 | 2010-04-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| ES2836218T3 (es) | 2008-10-21 | 2021-06-24 | Astute Medical Inc | Procedimientos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal |
| EP2913676A1 (en) | 2008-11-10 | 2015-09-02 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| AU2009316387B2 (en) * | 2008-11-22 | 2015-01-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| AU2010279249B2 (en) | 2009-02-06 | 2015-08-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US9229010B2 (en) | 2009-02-06 | 2016-01-05 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| AU2010234238B2 (en) * | 2009-03-27 | 2016-07-28 | Mdna Life Sciences Inc. | Aberrant mitochondrial DNA, associated fusion transcripts and translation products and hybridization probes therefor |
| US12129514B2 (en) | 2009-04-30 | 2024-10-29 | Molecular Loop Biosolutions, Llc | Methods and compositions for evaluating genetic markers |
| EP2425240A4 (en) | 2009-04-30 | 2012-12-12 | Good Start Genetics Inc | METHOD AND COMPOSITION FOR EVALUATING GENETIC MARKERS |
| AU2010315008B2 (en) | 2009-11-07 | 2015-12-03 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| JP2011115098A (ja) * | 2009-12-04 | 2011-06-16 | Nippon Menaade Keshohin Kk | 加齢による皮膚明度の低下を予測する皮膚評価方法 |
| WO2011075744A1 (en) | 2009-12-20 | 2011-06-23 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| AU2011213684B2 (en) | 2010-02-05 | 2014-11-20 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| NZ701807A (en) | 2010-02-26 | 2015-05-29 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| JP6008743B2 (ja) * | 2010-03-01 | 2016-10-19 | エムディーエヌエー ライフ サイエンシズ インコーポレイテッド | ＵＶに関連するｍｔＤＮＡの融合転写物ならびにその方法および使用 |
| NZ605698A (en) | 2010-06-23 | 2015-03-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| IN2012MN02812A (https=) | 2010-06-23 | 2015-05-22 | Astute Medical Inc | |
| US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
| ES2625288T3 (es) | 2011-04-15 | 2017-07-19 | The Johns Hopkins University | Sistema de secuenciación segura |
| CA2852665A1 (en) | 2011-10-17 | 2013-04-25 | Good Start Genetics, Inc. | Analysis methods |
| US10935548B2 (en) | 2011-12-08 | 2021-03-02 | Astute Medical, Inc. | Methods for diagnosis and prognosis of renal injury and renal failure using insulin-like growth factor-binding protein 7 and metalloproteinase inhibitor 2 |
| US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
| US8812422B2 (en) | 2012-04-09 | 2014-08-19 | Good Start Genetics, Inc. | Variant database |
| US10227635B2 (en) | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
| AU2013292610B2 (en) * | 2012-07-17 | 2018-05-17 | Myriad Women's Health, Inc. | System and methods for detecting genetic variation |
| AU2013338393C1 (en) | 2012-10-29 | 2024-07-25 | The Johns Hopkins University | Papanicolaou test for ovarian and endometrial cancers |
| US9868946B2 (en) * | 2012-11-05 | 2018-01-16 | Icahn School Of Medicine At Mount Sinai | Method of isolating pure mitochondrial DNA |
| ES2482866B1 (es) * | 2012-11-22 | 2015-05-12 | Consejo Superior De Investigaciones Científicas (Csic) | Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas. |
| EP3361255B1 (en) | 2013-01-17 | 2020-03-11 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2014152421A1 (en) | 2013-03-14 | 2014-09-25 | Good Start Genetics, Inc. | Methods for analyzing nucleic acids |
| US8847799B1 (en) | 2013-06-03 | 2014-09-30 | Good Start Genetics, Inc. | Methods and systems for storing sequence read data |
| US11041203B2 (en) | 2013-10-18 | 2021-06-22 | Molecular Loop Biosolutions, Inc. | Methods for assessing a genomic region of a subject |
| US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
| US9745611B2 (en) * | 2014-05-06 | 2017-08-29 | Genewiz Inc. | Methods and kits for identifying microorganisms in a sample |
| US11053548B2 (en) | 2014-05-12 | 2021-07-06 | Good Start Genetics, Inc. | Methods for detecting aneuploidy |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| CN104062294A (zh) * | 2014-07-11 | 2014-09-24 | 青岛千士医疗科技有限公司 | 一种支气管/肺上皮细胞线粒体损伤的检测方法 |
| US20160048608A1 (en) | 2014-08-15 | 2016-02-18 | Good Start Genetics, Inc. | Systems and methods for genetic analysis |
| US11408024B2 (en) | 2014-09-10 | 2022-08-09 | Molecular Loop Biosciences, Inc. | Methods for selectively suppressing non-target sequences |
| US10429399B2 (en) | 2014-09-24 | 2019-10-01 | Good Start Genetics, Inc. | Process control for increased robustness of genetic assays |
| KR20210013299A (ko) | 2014-10-17 | 2021-02-03 | 코디악 사이언시스 인코포레이티드 | 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트 |
| EP4095261B1 (en) | 2015-01-06 | 2025-05-28 | Molecular Loop Biosciences, Inc. | Screening for structural variants |
| EP3091083B1 (en) | 2015-05-07 | 2017-11-08 | Latvian Biomedical Research and Study Centre | A kit for detecting mutation or polymorphism in the human mitochondrial dna |
| JP6841609B2 (ja) | 2015-07-10 | 2021-03-10 | ３スキャン インコーポレイテッド | 組織学的染色の空間的多重化 |
| US11286531B2 (en) | 2015-08-11 | 2022-03-29 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| EP3465201A4 (en) | 2016-06-06 | 2020-08-26 | Astute Medical, Inc. | MANAGEMENT OF ACUTE KIDNEY DAMAGE USING INSULINOMIMETIC GROWTH FACTOR BINDING PROTEIN 7 AND TISSUE METALLOPROTEINASE 2 INHIBITOR |
| IL319255A (en) | 2017-08-07 | 2025-04-01 | Univ Johns Hopkins | Methods and materials for cancer assessment and treatment |
| CN108827887B (zh) * | 2018-03-19 | 2021-05-18 | 陕西学前师范学院 | 一种商陆基因组大小估计方法及基因组大小测量系统 |
| EP3578671A1 (en) * | 2018-06-05 | 2019-12-11 | Universitat Autònoma De Barcelona | Method for evaluating risk of cardiovascular disease |
| CN109360656B (zh) * | 2018-08-20 | 2021-11-02 | 安徽大学 | 一种基于多目标演化算法的癌症检测方法 |
| EP3966323A4 (en) * | 2019-05-06 | 2024-04-24 | The Regents Of The University Of Michigan | TARGETED THERAPY |
| CN110378881B (zh) * | 2019-07-05 | 2020-03-24 | 北京航空航天大学 | 一种基于深度学习的肿瘤定位系统 |
| CN110358856B (zh) * | 2019-07-23 | 2023-04-07 | 四川省农业科学院生物技术核技术研究所 | 侧耳属线粒体nad4L基因的扩增引物及其在鉴定侧耳属物种中的应用 |
| CN113025633B (zh) * | 2019-12-09 | 2024-08-27 | 武汉纽福斯生物科技有限公司 | 编码人nadh脱氢酶亚单位1蛋白的核酸及其应用 |
| JP2023513606A (ja) | 2020-02-14 | 2023-03-31 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 核酸を評価するための方法および材料 |
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| CN117070511B (zh) * | 2023-08-16 | 2024-02-02 | 广州卿泽生物科技有限公司 | 一种用于扩增人类线粒体全基因组的引物组及其应用 |
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-
2006
- 2006-04-18 CN CN2006800219031A patent/CN101248180B/zh not_active Expired - Fee Related
- 2006-04-18 CN CN201310399746.XA patent/CN103789405B/zh not_active Expired - Fee Related
- 2006-04-18 ES ES06741413T patent/ES2354452T3/es not_active Expired - Lifetime
- 2006-04-18 PT PT06741413T patent/PT1877559E/pt unknown
- 2006-04-18 DE DE602006017534T patent/DE602006017534D1/de not_active Expired - Lifetime
- 2006-04-18 KR KR1020077026442A patent/KR101363032B1/ko not_active Expired - Fee Related
- 2006-04-18 CA CA2606156A patent/CA2606156C/en not_active Expired - Lifetime
- 2006-04-18 EP EP06741413A patent/EP1877559B1/en not_active Expired - Lifetime
- 2006-04-18 EP EP10013553.2A patent/EP2339032B1/en not_active Expired - Lifetime
- 2006-04-18 WO PCT/CA2006/000652 patent/WO2006111029A1/en not_active Ceased
- 2006-04-18 NZ NZ587665A patent/NZ587665A/en not_active IP Right Cessation
- 2006-04-18 SG SG2014011837A patent/SG2014011837A/en unknown
- 2006-04-18 NZ NZ562928A patent/NZ562928A/en not_active IP Right Cessation
- 2006-04-18 DK DK06741413.6T patent/DK1877559T3/da active
- 2006-04-18 JP JP2008505707A patent/JP5537804B2/ja not_active Expired - Fee Related
- 2006-04-18 AU AU2006238390A patent/AU2006238390B2/en not_active Ceased
- 2006-04-18 CA CA2792443A patent/CA2792443A1/en not_active Abandoned
- 2006-04-18 AT AT06741413T patent/ATE484589T1/de active
-
2007
- 2007-10-18 US US11/975,390 patent/US8008008B2/en active Active
-
2011
- 2011-08-30 US US13/221,618 patent/US20120058483A1/en not_active Abandoned
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2012
- 2012-04-26 JP JP2012101409A patent/JP6134890B2/ja not_active Expired - Fee Related
-
2014
- 2014-08-27 US US14/470,627 patent/US9745632B2/en not_active Expired - Fee Related
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2017
- 2017-08-29 US US15/690,147 patent/US10907213B2/en active Active
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