JP2008532477A5 - - Google Patents
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- JP2008532477A5 JP2008532477A5 JP2007535933A JP2007535933A JP2008532477A5 JP 2008532477 A5 JP2008532477 A5 JP 2008532477A5 JP 2007535933 A JP2007535933 A JP 2007535933A JP 2007535933 A JP2007535933 A JP 2007535933A JP 2008532477 A5 JP2008532477 A5 JP 2008532477A5
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- polypeptide
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- 229920001184 polypeptide Polymers 0.000 claims 77
- 102000004196 processed proteins & peptides Human genes 0.000 claims 77
- 108090000765 processed proteins & peptides Proteins 0.000 claims 77
- 108091033319 polynucleotide Proteins 0.000 claims 45
- 239000002157 polynucleotide Substances 0.000 claims 45
- 102000040430 polynucleotide Human genes 0.000 claims 45
- 125000003275 alpha amino acid group Chemical group 0.000 claims 38
- 239000002773 nucleotide Substances 0.000 claims 24
- 125000003729 nucleotide group Chemical group 0.000 claims 24
- 230000004071 biological effect Effects 0.000 claims 23
- 238000000034 method Methods 0.000 claims 19
- 150000001413 amino acids Chemical class 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 16
- 206010005003 Bladder cancer Diseases 0.000 claims 14
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 14
- 201000005112 urinary bladder cancer Diseases 0.000 claims 14
- 108091028664 Ribonucleotide Proteins 0.000 claims 12
- 230000000692 anti-sense effect Effects 0.000 claims 12
- 239000002336 ribonucleotide Substances 0.000 claims 12
- 125000002652 ribonucleotide group Chemical group 0.000 claims 12
- 108091081021 Sense strand Proteins 0.000 claims 9
- 108020004459 Small interfering RNA Proteins 0.000 claims 9
- 239000013598 vector Substances 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 238000012360 testing method Methods 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 6
- 239000004055 small Interfering RNA Substances 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 5
- 108700008625 Reporter Genes Proteins 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 238000012216 screening Methods 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 2
- 238000001890 transfection Methods 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 230000005809 anti-tumor immunity Effects 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65231805P | 2005-02-10 | 2005-02-10 | |
| US60/652,318 | 2005-02-10 | ||
| US70322505P | 2005-07-27 | 2005-07-27 | |
| US60/703,225 | 2005-07-27 | ||
| PCT/JP2006/302684 WO2006085684A2 (en) | 2005-02-10 | 2006-02-09 | Method of diagnosing bladder cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011256511A Division JP2012135301A (ja) | 2005-02-10 | 2011-11-24 | 膀胱癌を診断する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008532477A JP2008532477A (ja) | 2008-08-21 |
| JP2008532477A5 true JP2008532477A5 (https=) | 2009-03-19 |
| JP5109131B2 JP5109131B2 (ja) | 2012-12-26 |
Family
ID=36570700
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007535933A Expired - Fee Related JP5109131B2 (ja) | 2005-02-10 | 2006-02-09 | 膀胱癌を診断する方法 |
| JP2011256511A Ceased JP2012135301A (ja) | 2005-02-10 | 2011-11-24 | 膀胱癌を診断する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011256511A Ceased JP2012135301A (ja) | 2005-02-10 | 2011-11-24 | 膀胱癌を診断する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US7998695B2 (https=) |
| EP (5) | EP2011885B1 (https=) |
| JP (2) | JP5109131B2 (https=) |
| CN (1) | CN101175862A (https=) |
| WO (1) | WO2006085684A2 (https=) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005029067A2 (en) | 2003-09-24 | 2005-03-31 | Oncotherapy Science, Inc. | Method of diagnosing breast cancer |
| WO2006012522A1 (en) * | 2004-07-23 | 2006-02-02 | Pacific Edge Biotechnology Ltd. | Urine markers for detection of bladder cancer |
| WO2006090389A2 (en) | 2005-02-24 | 2006-08-31 | Compugen Ltd. | Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof |
| EP1871809A2 (en) * | 2005-04-22 | 2008-01-02 | Morphotek, Inc. | Antibodies with immune effector activity and that internalize in endosialin-positive cells |
| TW200741009A (en) * | 2005-07-01 | 2007-11-01 | Oncotherapy Science Inc | Methods of modulating SMYD3 for treatment of cancer |
| CN101432303A (zh) * | 2006-02-28 | 2009-05-13 | 肿瘤疗法科学股份有限公司 | 利用抗cdh3抗体的效应物功能来损伤细胞的方法 |
| JP5339291B2 (ja) | 2006-08-10 | 2013-11-13 | オンコセラピー・サイエンス株式会社 | 乳癌に関連する遺伝子およびポリペプチド |
| WO2008023842A1 (en) * | 2006-08-25 | 2008-02-28 | Oncotherapy Science, Inc. | Methods of screening for agents that inhibit binding between mphosph1 and prc1 |
| KR101543622B1 (ko) | 2006-10-17 | 2015-08-11 | 온코세라피 사이언스 가부시키가이샤 | Ｍｐｈｏｓｐｈ1 또는 ｄｅｐｄｃ1 폴리펩티드를 발현하는 암에 대한 펩티드 백신 |
| AU2013200566B2 (en) * | 2006-10-17 | 2014-10-09 | Oncotherapy Science, Inc. | Peptide vaccines for cancers expressing MPHOSPH1 or DEPDC1 polypeptides |
| EP2102360A2 (en) * | 2006-12-13 | 2009-09-23 | Oncotherapy Science, Inc. | Ttk as tumor marker and therapeutic target for lung cancer |
| CA2682726C (en) * | 2007-04-05 | 2017-05-09 | Morphotek, Inc. | Methods for inhibiting the binding of endosialin to ligands |
| EP2171082B1 (en) | 2007-06-14 | 2012-11-28 | Oncotherapy Science, Inc. | Methods of identifying agents that modulate methylation of vegfr1 by smyd3 |
| TW200908998A (en) * | 2007-06-27 | 2009-03-01 | Oncotherapy Science Inc | Compositions and methods of treating cancer |
| WO2009016691A1 (en) * | 2007-07-30 | 2009-02-05 | Oncotherapy Science, Inc. | Cancer associated gene ly6k |
| CN101827936B (zh) | 2007-08-20 | 2014-12-10 | 肿瘤疗法科学股份有限公司 | Cdh3肽以及含有cdh3肽的药剂 |
| US8569244B2 (en) | 2007-08-20 | 2013-10-29 | Oncotherapy Science, Inc. | FOXM1 peptide and medicinal agent comprising the same |
| PT2186889E (pt) * | 2007-08-20 | 2015-06-17 | Oncotherapy Science Inc | Péptido cdca1 e agente farmacêutico que o compreende |
| TW200920406A (en) * | 2007-08-24 | 2009-05-16 | Oncotherapy Science Inc | EBI3, DLX5, NPTX1 and CDKN3 for target genes of lung cancer therapy and diagnosis |
| US20120135875A1 (en) * | 2008-02-29 | 2012-05-31 | Bristol-Myers Squibb Company | Methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators |
| JP5445969B2 (ja) * | 2008-03-14 | 2014-03-19 | 学校法人北里研究所 | 膀胱癌の診断 |
| EP2297580B1 (en) | 2008-06-09 | 2015-03-04 | Oxford Biotherapeutics Ltd. | Antibody against Ephrin Type-A receptor 7 for treatment of bladder cancer |
| TW201000119A (en) * | 2008-06-10 | 2010-01-01 | Oncotherapy Science Inc | MYBL2 epitope peptides and vaccines containing the same |
| TW201000115A (en) * | 2008-06-11 | 2010-01-01 | Oncotherapy Science Inc | IQGAP3 epitope peptides and vaccines containing the same |
| TWI526219B (zh) * | 2008-06-19 | 2016-03-21 | 腫瘤療法 科學股份有限公司 | Ｃｄｃａ１抗原決定位胜肽及含此胜肽的疫苗 |
| US8435749B2 (en) | 2008-06-30 | 2013-05-07 | Oncotherapy Science, Inc. | Anti-CDH3 antibodies labeled with radioisotope label and uses thereof |
| TWI466680B (zh) | 2008-08-01 | 2015-01-01 | Oncotherapy Science Inc | Ｍｅｌｋ抗原決定位胜肽及含此胜肽的疫苗 |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
| TWI580431B (zh) | 2008-08-19 | 2017-05-01 | 腫瘤療法 科學股份有限公司 | Ｈｉｇ２與ｕｒｌｃ１０抗原決定位胜肽以及含此胜肽之疫苗 |
| BRPI0917350A2 (pt) * | 2008-08-28 | 2015-08-11 | Oncotherapy Science Inc | Oip5 como um gene alvo para terapia e diagnose de câncer |
| US8975086B2 (en) | 2008-08-28 | 2015-03-10 | Oncotherapy Science, Inc. | Method for treating or preventing bladder cancer using the DEPDC1 polypeptide |
| NZ592461A (en) * | 2008-10-22 | 2012-12-21 | Oncotherapy Science Inc | Rab6kifl/kif20a epitope peptide and vaccines containing the same |
| US20110301056A1 (en) * | 2008-12-12 | 2011-12-08 | Oncotherapy Science, Inc. | Nectin-4 for target genes of cancer therapy and diagnosis |
| GB0823445D0 (en) * | 2008-12-23 | 2009-01-28 | Univ Surrey | Biomarker |
| EP2382466B1 (en) * | 2008-12-30 | 2016-03-09 | Children's Medical Center Corporation | Method of predicting acute appendicitis |
| TWI469791B (zh) | 2009-02-18 | 2015-01-21 | Oncotherapy Science Inc | Ｆｏｘｍ１胜肽以及含此胜肽之疫苗 |
| TW201102081A (en) | 2009-05-11 | 2011-01-16 | Oncotherapy Science Inc | TTK peptides and vaccines including the same |
| CA2767914C (en) | 2009-07-24 | 2020-02-25 | Geadic Biotec, Aie. | Markers for endometrial cancer |
| US20120231472A1 (en) * | 2009-11-07 | 2012-09-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2011068839A1 (en) * | 2009-12-01 | 2011-06-09 | Compendia Bioscience, Inc. | Classification of cancers |
| WO2011069014A1 (en) * | 2009-12-04 | 2011-06-09 | Cedars-Sinai Medical Center | Tox3 as a biomarker for breast cancer |
| GB0922085D0 (en) * | 2009-12-17 | 2010-02-03 | Cambridge Entpr Ltd | Cancer diagnosis and treatment |
| US9017669B2 (en) | 2009-12-28 | 2015-04-28 | Oncotherapy Science, Inc. | Anti-CDH3 antibodies and uses thereof |
| TWI485245B (zh) | 2010-01-25 | 2015-05-21 | Oncotherapy Science Inc | 經修飾之ｍｅｌｋ胜肽及含此胜肽之疫苗 |
| TWI538685B (zh) | 2010-04-02 | 2016-06-21 | 腫瘤療法 科學股份有限公司 | Ｅｃｔ２胜肽及含此胜肽之疫苗 |
| EP2380991A1 (en) | 2010-04-20 | 2011-10-26 | Universitätsklinikum Hamburg-Eppendorf | Method of determining the metastatic potential of a tumor |
| US20110262921A1 (en) * | 2010-04-23 | 2011-10-27 | Sabichi Anita L | Test for the Detection of Bladder Cancer |
| WO2012009382A2 (en) * | 2010-07-12 | 2012-01-19 | The Regents Of The University Of Colorado | Molecular indicators of bladder cancer prognosis and prediction of treatment response |
| CA2806332C (en) | 2010-07-30 | 2017-11-14 | Oncotherapy Science, Inc. | Quinoline derivatives and melk inhibitors containing the same |
| EP2426216A1 (en) * | 2010-09-01 | 2012-03-07 | Institut Gustave Roussy (IGR) | Prognostic and/or predictive biomarkers and biological applications thereof |
| WO2012106559A1 (en) * | 2011-02-02 | 2012-08-09 | Translational Genomics Research Institute | Biomarkers and methods of use thereof |
| US20140154691A1 (en) * | 2011-06-22 | 2014-06-05 | Oncocyte Corporation | Methods and Compositions for the Treatment and Diagnosis of Bladder Cancer |
| JP6014904B2 (ja) | 2011-07-29 | 2016-10-26 | 国立大学法人徳島大学 | Ｅｒａｐ１由来ペプチド及びその使用 |
| JP5564730B2 (ja) | 2011-08-12 | 2014-08-06 | オンコセラピー・サイエンス株式会社 | Ｍｐｈｏｓｐｈ１ペプチドおよびそれを含むワクチン |
| CN104066746B (zh) | 2011-10-28 | 2017-12-05 | 肿瘤疗法科学股份有限公司 | Topk肽及包含它们的疫苗 |
| AU2012335781A1 (en) * | 2011-11-11 | 2014-05-29 | Metabolon, Inc. | Biomarkers for bladder cancer and methods using the same |
| IN2014DN05803A (https=) | 2011-12-14 | 2015-05-15 | Univ Texas | |
| WO2013109388A2 (en) | 2012-01-19 | 2013-07-25 | Oncotherapy Science, Inc. | 1,5-naphthyridine derivatives and melk inhibitors containing the same |
| US20150030615A1 (en) * | 2012-03-09 | 2015-01-29 | Verastem, Inc. | Biomarkers for cancer stem cells and related methods of use |
| EP2872532A4 (en) | 2012-07-10 | 2016-04-13 | Oncotherapy Science Inc | CDCA1-EPITOPPEPTIDES FOR TH1 CELLS AND VACCINES THEREWITH |
| JP6259983B2 (ja) | 2012-07-10 | 2018-01-17 | オンコセラピー・サイエンス株式会社 | Ｔｈ１細胞のＫＩＦ２０Ａエピトープペプチドおよびこれを含有するワクチン |
| WO2014010232A1 (en) | 2012-07-10 | 2014-01-16 | Oncotherapy Science, Inc. | Ly6k epitope peptides for th1 cells and vaccines containing the same |
| TWI606066B (zh) | 2012-09-27 | 2017-11-21 | 中外製藥股份有限公司 | FGFR3 Fusion Gene and Its Targeted Medicine |
| DE102012021222B4 (de) * | 2012-10-27 | 2015-02-05 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung einer nanoporösen Schicht auf einem Substrat |
| CN103033625B (zh) * | 2012-12-19 | 2014-12-24 | 中国科学院生物物理研究所 | 一种人膀胱癌细胞化学发光检测试剂盒及其制备方法 |
| ES2715874T3 (es) * | 2013-03-06 | 2019-06-06 | Cepheid | Métodos de detección del cáncer de la vejiga |
| EP3339450A3 (en) * | 2013-03-08 | 2018-08-08 | MDxHealth Research B.V. | Molecular markers in bladder cancer |
| TWI658049B (zh) | 2013-03-12 | 2019-05-01 | 腫瘤療法 科學股份有限公司 | Ｋｎｔｃ２胜肽及含此胜肽之疫苗 |
| KR101573467B1 (ko) * | 2013-04-10 | 2015-12-01 | (주)지노믹트리 | 방광암 특이적 후성유전적 마커 유전자를 이용한 방광암의 검출방법 |
| EP3066217A4 (en) * | 2013-11-04 | 2017-10-11 | The University Of British Columbia | Cancer biomarkers and classifiers and uses thereof |
| WO2016001810A1 (en) | 2014-07-01 | 2016-01-07 | Pfizer Inc. | Bispecific heterodimeric diabodies and uses thereof |
| JP6700512B2 (ja) | 2014-08-04 | 2020-05-27 | オンコセラピー・サイエンス株式会社 | Ｃｄｃａ１由来ペプチドおよびそれを含むワクチン |
| SG11201700838VA (en) | 2014-08-04 | 2017-03-30 | Oncotherapy Science Inc | Urlc10-derived peptide and vaccine containing same |
| US10851418B2 (en) | 2015-01-12 | 2020-12-01 | The George Washington University A Congressional Chartered Not-For-Profit Corporation | Blood biomarkers for respiratory infections |
| US20160378915A1 (en) * | 2015-03-24 | 2016-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and Methods for Multi-Scale, Annotation-Independent Detection of Functionally-Diverse Units of Recurrent Genomic Alteration |
| GB201511191D0 (en) * | 2015-06-25 | 2015-08-12 | Immatics Biotechnologies Gmbh | T-cell epitopes for the immunotherapy of myeloma |
| CA2994929A1 (en) | 2015-08-12 | 2017-02-16 | Oncotherapy Science, Inc. | Depdc1-derived peptide and vaccine containing same |
| BR112018005581A2 (pt) | 2015-10-08 | 2018-10-16 | Oncotherapy Science, Inc. | peptídeo derivado de foxm1 e vacina incluindo o mesmo |
| SG11201802286PA (en) | 2015-10-08 | 2018-04-27 | Oncotherapy Science Inc | Mphosph1-derived peptide, and vaccine including same |
| US10635909B2 (en) * | 2015-12-30 | 2020-04-28 | Texas Instruments Incorporated | Vehicle control with efficient iterative triangulation |
| WO2017126461A1 (ja) | 2016-01-19 | 2017-07-27 | 国立大学法人徳島大学 | がん治療用ペプチド及びそれを含む医薬組成物 |
| CN105886629B (zh) * | 2016-04-29 | 2019-09-27 | 北京泱深生物信息技术有限公司 | 分子标志物在诊治食管鳞癌中的应用 |
| CN107400704A (zh) * | 2016-05-20 | 2017-11-28 | 博尔诚（北京）科技有限公司 | 一种用于乳腺癌筛查的组合物及其应用 |
| JP6769596B2 (ja) * | 2016-05-30 | 2020-10-14 | 学校法人北里研究所 | 膀胱癌診断薬及び生体試料の判定方法 |
| RU2756982C2 (ru) | 2016-08-31 | 2021-10-07 | Онкотерапи Сайенс, Инк. | Моноклональное антитело против melk и его использование |
| TWI762516B (zh) | 2016-10-06 | 2022-05-01 | 日商腫瘤療法 科學股份有限公司 | 針對ｆｚｄ１０之單株抗體及其用途 |
| NL2020004B1 (en) | 2016-12-09 | 2018-07-02 | Ary Flohil Jacob | Treatment of diffuse intrinsic pontine glioma |
| CN111148752B (zh) | 2017-07-19 | 2024-01-16 | 国立大学法人德岛大学 | 肽衍生物和包含其的药物组合物 |
| CN110018309B (zh) * | 2018-01-08 | 2023-07-04 | 成都市第三人民医院 | 通过蛋白标志物判断结直肠癌预后的试剂盒 |
| KR102171774B1 (ko) * | 2018-06-04 | 2020-10-29 | 울산대학교 산학협력단 | 인산화된 tfcp2l1을 포함하는 고형암 예후 예측용 바이오마커 조성물 및 이의 용도 |
| WO2019236853A1 (en) * | 2018-06-06 | 2019-12-12 | Exosome Diagnostics, Inc. | Methods for developing urine biomarkers and for detecting bladder cancer |
| TW202023581A (zh) | 2018-08-02 | 2020-07-01 | 日商腫瘤療法 科學股份有限公司 | 來自cdca1的胜肽及含有此的疫苗 |
| CN111206093A (zh) * | 2018-11-21 | 2020-05-29 | 立森印迹诊断技术（无锡）有限公司 | 一种用于检测浸润性膀胱癌的标志物及其应用 |
| JP7525855B2 (ja) | 2018-11-30 | 2024-07-31 | 国立大学法人徳島大学 | Ｂｉｇ３－ｐｈｂ２相互作用阻害ｐｈｂ２由来ペプチドを含む乳がん治療薬 |
| CN110320369B (zh) * | 2019-07-31 | 2022-05-17 | 天津医科大学第二医院 | 一种诊断膀胱癌试剂盒 |
| CN112442499B (zh) * | 2019-08-30 | 2026-03-10 | 恩康药业科技（广州）有限公司 | 一种抑制MCM7的siRNA、组合物及其应用 |
| US20210379148A1 (en) * | 2020-05-12 | 2021-12-09 | University Of Maryland, Baltimore | Regulating muscle physiology and energy metabolism using crym |
| CA3186504A1 (en) * | 2020-08-17 | 2022-02-24 | Stephen J. Blakemore | Bicycle conjugates specific for nectin-4 and uses thereof |
| CN115501340B (zh) * | 2021-06-07 | 2024-04-12 | 中山大学附属第三医院（中山大学肝脏病医院） | CircPIAS1作为靶点在制备肝癌诊断试剂或治疗药物中的用途 |
| CN113322523B (zh) * | 2021-06-17 | 2024-03-19 | 翌圣生物科技(上海)股份有限公司 | Rna快速建库方法及其应用 |
| CN114854860A (zh) * | 2022-05-05 | 2022-08-05 | 北京化工大学 | 一种膀胱癌干细胞生物标志物组及其应用 |
| CN116121373A (zh) * | 2022-09-14 | 2023-05-16 | 中山大学孙逸仙纪念医院 | Etv4及其表达产物在制备诊断和治疗膀胱癌药物中的应用 |
| WO2024192018A1 (en) * | 2023-03-12 | 2024-09-19 | Novelna Inc. | Bladder cancer detection proteins and methods of use thereof |
| CN119633123A (zh) * | 2024-12-26 | 2025-03-18 | 中山大学附属第一医院 | Mettl2在消化系统肿瘤放疗增敏中的应用 |
| CN120064671B (zh) * | 2025-04-29 | 2025-07-29 | 吉林大学 | 用于检测幼儿唾液prb1含量的组合物及应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0239102A3 (en) | 1986-03-28 | 1989-07-12 | Tsuji, Kimiyoshi | Process for the formation of human-human hybridoma |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| WO1996033735A1 (en) | 1995-04-27 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ES2301158T3 (es) | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
| JPH08509612A (ja) | 1993-04-26 | 1996-10-15 | ジェンファーム インターナショナル インコーポレイテッド | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US7001999B1 (en) * | 1998-04-15 | 2006-02-21 | Ludwig Institute For Cancer Research | Tumor associated nucleic acids and uses therefor |
| US20020103360A1 (en) | 1998-09-01 | 2002-08-01 | Yang Pan | Novel protein related to melanoma-inhibiting protein and uses thereof |
| US20040241726A1 (en) * | 1999-01-06 | 2004-12-02 | Chondrogene Limited | Method for the detection of allergies related gene transcripts in blood |
| US20050123938A1 (en) * | 1999-01-06 | 2005-06-09 | Chondrogene Limited | Method for the detection of osteoarthritis related gene transcripts in blood |
| IL148798A0 (en) * | 1999-09-27 | 2002-09-12 | Quark Biotech Inc | Sequences characteristic of bladder cancer |
| CA2402563A1 (en) * | 1999-12-23 | 2001-07-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| AU2001231025A1 (en) | 2000-01-20 | 2001-07-31 | Cedars-Sinai Medical Center | Method of detecting neoplastic, hyperplastic, cytologically dysplastic and/or premalignant cellular growth or proliferation |
| WO2002031111A2 (en) | 2000-10-12 | 2002-04-18 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| US20030157561A1 (en) | 2001-11-19 | 2003-08-21 | Kolkman Joost A. | Combinatorial libraries of monomer domains |
| US20040076955A1 (en) * | 2001-07-03 | 2004-04-22 | Eos Biotechnology, Inc. | Methods of diagnosis of bladder cancer, compositions and methods of screening for modulators of bladder cancer |
| US7494646B2 (en) * | 2001-09-06 | 2009-02-24 | Agensys, Inc. | Antibodies and molecules derived therefrom that bind to STEAP-1 proteins |
| US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| AU2003222103A1 (en) * | 2002-03-28 | 2003-10-13 | Idec Pharmaceuticals Corporation | Novel gene targets and ligands that bind thereto for treatment and diagnosis of colon carcinomas |
| TW200413725A (en) * | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| DE602004032114D1 (de) | 2003-02-28 | 2011-05-19 | Oncotherapy Science Inc | Rna-interferenz für das gen znfn3a1 als verfahren zur hemmung des wachstums von krebszellen |
| US7700573B2 (en) | 2004-03-23 | 2010-04-20 | Oncotherapy Science, Inc. | Method for diagnosing non-small lung cancer |
| KR101543622B1 (ko) | 2006-10-17 | 2015-08-11 | 온코세라피 사이언스 가부시키가이샤 | Ｍｐｈｏｓｐｈ1 또는 ｄｅｐｄｃ1 폴리펩티드를 발현하는 암에 대한 펩티드 백신 |
| EP2171082B1 (en) * | 2007-06-14 | 2012-11-28 | Oncotherapy Science, Inc. | Methods of identifying agents that modulate methylation of vegfr1 by smyd3 |
-
2006
- 2006-02-09 CN CNA2006800115808A patent/CN101175862A/zh active Pending
- 2006-02-09 US US11/815,850 patent/US7998695B2/en not_active Expired - Fee Related
- 2006-02-09 JP JP2007535933A patent/JP5109131B2/ja not_active Expired - Fee Related
- 2006-02-09 WO PCT/JP2006/302684 patent/WO2006085684A2/en not_active Ceased
- 2006-02-09 EP EP20080013455 patent/EP2011885B1/en not_active Expired - Lifetime
- 2006-02-09 EP EP10176736A patent/EP2292796A1/en not_active Withdrawn
- 2006-02-09 EP EP10176747A patent/EP2295601A1/en not_active Withdrawn
- 2006-02-09 EP EP06713825A patent/EP1856278A2/en not_active Withdrawn
- 2006-02-09 EP EP10176741A patent/EP2311983A1/en not_active Withdrawn
-
2011
- 2011-06-24 US US13/168,720 patent/US20120014996A1/en not_active Abandoned
- 2011-11-24 JP JP2011256511A patent/JP2012135301A/ja not_active Ceased
-
2012
- 2012-06-28 US US13/536,327 patent/US8685641B2/en not_active Expired - Lifetime
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