JP5109131B2 - 膀胱癌を診断する方法 - Google Patents

膀胱癌を診断する方法 Download PDF

Info

Publication number
JP5109131B2
JP5109131B2 JP2007535933A JP2007535933A JP5109131B2 JP 5109131 B2 JP5109131 B2 JP 5109131B2 JP 2007535933 A JP2007535933 A JP 2007535933A JP 2007535933 A JP2007535933 A JP 2007535933A JP 5109131 B2 JP5109131 B2 JP 5109131B2
Authority
JP
Japan
Prior art keywords
seq
polypeptide
sequence
expression
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2007535933A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008532477A5 (https=
JP2008532477A (ja
Inventor
祐輔 中村
豊雅 片桐
修一 中鶴
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncotherapy Science Inc
Original Assignee
Oncotherapy Science Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncotherapy Science Inc filed Critical Oncotherapy Science Inc
Publication of JP2008532477A publication Critical patent/JP2008532477A/ja
Publication of JP2008532477A5 publication Critical patent/JP2008532477A5/ja
Application granted granted Critical
Publication of JP5109131B2 publication Critical patent/JP5109131B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2007535933A 2005-02-10 2006-02-09 膀胱癌を診断する方法 Expired - Fee Related JP5109131B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US65231805P 2005-02-10 2005-02-10
US60/652,318 2005-02-10
US70322505P 2005-07-27 2005-07-27
US60/703,225 2005-07-27
PCT/JP2006/302684 WO2006085684A2 (en) 2005-02-10 2006-02-09 Method of diagnosing bladder cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011256511A Division JP2012135301A (ja) 2005-02-10 2011-11-24 膀胱癌を診断する方法

Publications (3)

Publication Number Publication Date
JP2008532477A JP2008532477A (ja) 2008-08-21
JP2008532477A5 JP2008532477A5 (https=) 2009-03-19
JP5109131B2 true JP5109131B2 (ja) 2012-12-26

Family

ID=36570700

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007535933A Expired - Fee Related JP5109131B2 (ja) 2005-02-10 2006-02-09 膀胱癌を診断する方法
JP2011256511A Ceased JP2012135301A (ja) 2005-02-10 2011-11-24 膀胱癌を診断する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011256511A Ceased JP2012135301A (ja) 2005-02-10 2011-11-24 膀胱癌を診断する方法

Country Status (5)

Country Link
US (3) US7998695B2 (https=)
EP (5) EP2011885B1 (https=)
JP (2) JP5109131B2 (https=)
CN (1) CN101175862A (https=)
WO (1) WO2006085684A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018520653A (ja) * 2015-06-25 2018-08-02 イマティクス バイオテクノロジーズ ゲーエムベーハー 骨髄腫およびその他のがんの免疫療法において使用するための新規細胞エピトープおよび細胞エピトープ組み合わせ

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005029067A2 (en) 2003-09-24 2005-03-31 Oncotherapy Science, Inc. Method of diagnosing breast cancer
WO2006012522A1 (en) * 2004-07-23 2006-02-02 Pacific Edge Biotechnology Ltd. Urine markers for detection of bladder cancer
WO2006090389A2 (en) 2005-02-24 2006-08-31 Compugen Ltd. Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof
EP1871809A2 (en) * 2005-04-22 2008-01-02 Morphotek, Inc. Antibodies with immune effector activity and that internalize in endosialin-positive cells
TW200741009A (en) * 2005-07-01 2007-11-01 Oncotherapy Science Inc Methods of modulating SMYD3 for treatment of cancer
CN101432303A (zh) * 2006-02-28 2009-05-13 肿瘤疗法科学股份有限公司 利用抗cdh3抗体的效应物功能来损伤细胞的方法
JP5339291B2 (ja) 2006-08-10 2013-11-13 オンコセラピー・サイエンス株式会社 乳癌に関連する遺伝子およびポリペプチド
WO2008023842A1 (en) * 2006-08-25 2008-02-28 Oncotherapy Science, Inc. Methods of screening for agents that inhibit binding between mphosph1 and prc1
KR101543622B1 (ko) 2006-10-17 2015-08-11 온코세라피 사이언스 가부시키가이샤 Ｍｐｈｏｓｐｈ1 또는 ｄｅｐｄｃ1 폴리펩티드를 발현하는 암에 대한 펩티드 백신
AU2013200566B2 (en) * 2006-10-17 2014-10-09 Oncotherapy Science, Inc. Peptide vaccines for cancers expressing MPHOSPH1 or DEPDC1 polypeptides
EP2102360A2 (en) * 2006-12-13 2009-09-23 Oncotherapy Science, Inc. Ttk as tumor marker and therapeutic target for lung cancer
CA2682726C (en) * 2007-04-05 2017-05-09 Morphotek, Inc. Methods for inhibiting the binding of endosialin to ligands
EP2171082B1 (en) 2007-06-14 2012-11-28 Oncotherapy Science, Inc. Methods of identifying agents that modulate methylation of vegfr1 by smyd3
TW200908998A (en) * 2007-06-27 2009-03-01 Oncotherapy Science Inc Compositions and methods of treating cancer
WO2009016691A1 (en) * 2007-07-30 2009-02-05 Oncotherapy Science, Inc. Cancer associated gene ly6k
CN101827936B (zh) 2007-08-20 2014-12-10 肿瘤疗法科学股份有限公司 Cdh3肽以及含有cdh3肽的药剂
US8569244B2 (en) 2007-08-20 2013-10-29 Oncotherapy Science, Inc. FOXM1 peptide and medicinal agent comprising the same
PT2186889E (pt) * 2007-08-20 2015-06-17 Oncotherapy Science Inc Péptido cdca1 e agente farmacêutico que o compreende
TW200920406A (en) * 2007-08-24 2009-05-16 Oncotherapy Science Inc EBI3, DLX5, NPTX1 and CDKN3 for target genes of lung cancer therapy and diagnosis
US20120135875A1 (en) * 2008-02-29 2012-05-31 Bristol-Myers Squibb Company Methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators
JP5445969B2 (ja) * 2008-03-14 2014-03-19 学校法人北里研究所 膀胱癌の診断
EP2297580B1 (en) 2008-06-09 2015-03-04 Oxford Biotherapeutics Ltd. Antibody against Ephrin Type-A receptor 7 for treatment of bladder cancer
TW201000119A (en) * 2008-06-10 2010-01-01 Oncotherapy Science Inc MYBL2 epitope peptides and vaccines containing the same
TW201000115A (en) * 2008-06-11 2010-01-01 Oncotherapy Science Inc IQGAP3 epitope peptides and vaccines containing the same
TWI526219B (zh) * 2008-06-19 2016-03-21 腫瘤療法 科學股份有限公司 Ｃｄｃａ１抗原決定位胜肽及含此胜肽的疫苗
US8435749B2 (en) 2008-06-30 2013-05-07 Oncotherapy Science, Inc. Anti-CDH3 antibodies labeled with radioisotope label and uses thereof
TWI466680B (zh) 2008-08-01 2015-01-01 Oncotherapy Science Inc Ｍｅｌｋ抗原決定位胜肽及含此胜肽的疫苗
TW201008574A (en) 2008-08-19 2010-03-01 Oncotherapy Science Inc INHBB epitope peptides and vaccines containing the same
TWI580431B (zh) 2008-08-19 2017-05-01 腫瘤療法 科學股份有限公司 Ｈｉｇ２與ｕｒｌｃ１０抗原決定位胜肽以及含此胜肽之疫苗
BRPI0917350A2 (pt) * 2008-08-28 2015-08-11 Oncotherapy Science Inc Oip5 como um gene alvo para terapia e diagnose de câncer
US8975086B2 (en) 2008-08-28 2015-03-10 Oncotherapy Science, Inc. Method for treating or preventing bladder cancer using the DEPDC1 polypeptide
NZ592461A (en) * 2008-10-22 2012-12-21 Oncotherapy Science Inc Rab6kifl/kif20a epitope peptide and vaccines containing the same
US20110301056A1 (en) * 2008-12-12 2011-12-08 Oncotherapy Science, Inc. Nectin-4 for target genes of cancer therapy and diagnosis
GB0823445D0 (en) * 2008-12-23 2009-01-28 Univ Surrey Biomarker
EP2382466B1 (en) * 2008-12-30 2016-03-09 Children's Medical Center Corporation Method of predicting acute appendicitis
TWI469791B (zh) 2009-02-18 2015-01-21 Oncotherapy Science Inc Ｆｏｘｍ１胜肽以及含此胜肽之疫苗
TW201102081A (en) 2009-05-11 2011-01-16 Oncotherapy Science Inc TTK peptides and vaccines including the same
CA2767914C (en) 2009-07-24 2020-02-25 Geadic Biotec, Aie. Markers for endometrial cancer
US20120231472A1 (en) * 2009-11-07 2012-09-13 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2011068839A1 (en) * 2009-12-01 2011-06-09 Compendia Bioscience, Inc. Classification of cancers
WO2011069014A1 (en) * 2009-12-04 2011-06-09 Cedars-Sinai Medical Center Tox3 as a biomarker for breast cancer
GB0922085D0 (en) * 2009-12-17 2010-02-03 Cambridge Entpr Ltd Cancer diagnosis and treatment
US9017669B2 (en) 2009-12-28 2015-04-28 Oncotherapy Science, Inc. Anti-CDH3 antibodies and uses thereof
TWI485245B (zh) 2010-01-25 2015-05-21 Oncotherapy Science Inc 經修飾之ｍｅｌｋ胜肽及含此胜肽之疫苗
TWI538685B (zh) 2010-04-02 2016-06-21 腫瘤療法 科學股份有限公司 Ｅｃｔ２胜肽及含此胜肽之疫苗
EP2380991A1 (en) 2010-04-20 2011-10-26 Universitätsklinikum Hamburg-Eppendorf Method of determining the metastatic potential of a tumor
US20110262921A1 (en) * 2010-04-23 2011-10-27 Sabichi Anita L Test for the Detection of Bladder Cancer
WO2012009382A2 (en) * 2010-07-12 2012-01-19 The Regents Of The University Of Colorado Molecular indicators of bladder cancer prognosis and prediction of treatment response
CA2806332C (en) 2010-07-30 2017-11-14 Oncotherapy Science, Inc. Quinoline derivatives and melk inhibitors containing the same
EP2426216A1 (en) * 2010-09-01 2012-03-07 Institut Gustave Roussy (IGR) Prognostic and/or predictive biomarkers and biological applications thereof
WO2012106559A1 (en) * 2011-02-02 2012-08-09 Translational Genomics Research Institute Biomarkers and methods of use thereof
US20140154691A1 (en) * 2011-06-22 2014-06-05 Oncocyte Corporation Methods and Compositions for the Treatment and Diagnosis of Bladder Cancer
JP6014904B2 (ja) 2011-07-29 2016-10-26 国立大学法人徳島大学 Ｅｒａｐ１由来ペプチド及びその使用
JP5564730B2 (ja) 2011-08-12 2014-08-06 オンコセラピー・サイエンス株式会社 Ｍｐｈｏｓｐｈ１ペプチドおよびそれを含むワクチン
CN104066746B (zh) 2011-10-28 2017-12-05 肿瘤疗法科学股份有限公司 Topk肽及包含它们的疫苗
AU2012335781A1 (en) * 2011-11-11 2014-05-29 Metabolon, Inc. Biomarkers for bladder cancer and methods using the same
IN2014DN05803A (https=) 2011-12-14 2015-05-15 Univ Texas
WO2013109388A2 (en) 2012-01-19 2013-07-25 Oncotherapy Science, Inc. 1,5-naphthyridine derivatives and melk inhibitors containing the same
US20150030615A1 (en) * 2012-03-09 2015-01-29 Verastem, Inc. Biomarkers for cancer stem cells and related methods of use
EP2872532A4 (en) 2012-07-10 2016-04-13 Oncotherapy Science Inc CDCA1-EPITOPPEPTIDES FOR TH1 CELLS AND VACCINES THEREWITH
JP6259983B2 (ja) 2012-07-10 2018-01-17 オンコセラピー・サイエンス株式会社 Ｔｈ１細胞のＫＩＦ２０Ａエピトープペプチドおよびこれを含有するワクチン
WO2014010232A1 (en) 2012-07-10 2014-01-16 Oncotherapy Science, Inc. Ly6k epitope peptides for th1 cells and vaccines containing the same
TWI606066B (zh) 2012-09-27 2017-11-21 中外製藥股份有限公司 FGFR3 Fusion Gene and Its Targeted Medicine
DE102012021222B4 (de) * 2012-10-27 2015-02-05 Forschungszentrum Jülich GmbH Verfahren zur Herstellung einer nanoporösen Schicht auf einem Substrat
CN103033625B (zh) * 2012-12-19 2014-12-24 中国科学院生物物理研究所 一种人膀胱癌细胞化学发光检测试剂盒及其制备方法
ES2715874T3 (es) * 2013-03-06 2019-06-06 Cepheid Métodos de detección del cáncer de la vejiga
EP3339450A3 (en) * 2013-03-08 2018-08-08 MDxHealth Research B.V. Molecular markers in bladder cancer
TWI658049B (zh) 2013-03-12 2019-05-01 腫瘤療法 科學股份有限公司 Ｋｎｔｃ２胜肽及含此胜肽之疫苗
KR101573467B1 (ko) * 2013-04-10 2015-12-01 (주)지노믹트리 방광암 특이적 후성유전적 마커 유전자를 이용한 방광암의 검출방법
EP3066217A4 (en) * 2013-11-04 2017-10-11 The University Of British Columbia Cancer biomarkers and classifiers and uses thereof
WO2016001810A1 (en) 2014-07-01 2016-01-07 Pfizer Inc. Bispecific heterodimeric diabodies and uses thereof
JP6700512B2 (ja) 2014-08-04 2020-05-27 オンコセラピー・サイエンス株式会社 Ｃｄｃａ１由来ペプチドおよびそれを含むワクチン
SG11201700838VA (en) 2014-08-04 2017-03-30 Oncotherapy Science Inc Urlc10-derived peptide and vaccine containing same
US10851418B2 (en) 2015-01-12 2020-12-01 The George Washington University A Congressional Chartered Not-For-Profit Corporation Blood biomarkers for respiratory infections
US20160378915A1 (en) * 2015-03-24 2016-12-29 The Board Of Trustees Of The Leland Stanford Junior University Systems and Methods for Multi-Scale, Annotation-Independent Detection of Functionally-Diverse Units of Recurrent Genomic Alteration
CA2994929A1 (en) 2015-08-12 2017-02-16 Oncotherapy Science, Inc. Depdc1-derived peptide and vaccine containing same
BR112018005581A2 (pt) 2015-10-08 2018-10-16 Oncotherapy Science, Inc. peptídeo derivado de foxm1 e vacina incluindo o mesmo
SG11201802286PA (en) 2015-10-08 2018-04-27 Oncotherapy Science Inc Mphosph1-derived peptide, and vaccine including same
US10635909B2 (en) * 2015-12-30 2020-04-28 Texas Instruments Incorporated Vehicle control with efficient iterative triangulation
WO2017126461A1 (ja) 2016-01-19 2017-07-27 国立大学法人徳島大学 がん治療用ペプチド及びそれを含む医薬組成物
CN105886629B (zh) * 2016-04-29 2019-09-27 北京泱深生物信息技术有限公司 分子标志物在诊治食管鳞癌中的应用
CN107400704A (zh) * 2016-05-20 2017-11-28 博尔诚（北京）科技有限公司 一种用于乳腺癌筛查的组合物及其应用
JP6769596B2 (ja) * 2016-05-30 2020-10-14 学校法人北里研究所 膀胱癌診断薬及び生体試料の判定方法
RU2756982C2 (ru) 2016-08-31 2021-10-07 Онкотерапи Сайенс, Инк. Моноклональное антитело против melk и его использование
TWI762516B (zh) 2016-10-06 2022-05-01 日商腫瘤療法 科學股份有限公司 針對ｆｚｄ１０之單株抗體及其用途
NL2020004B1 (en) 2016-12-09 2018-07-02 Ary Flohil Jacob Treatment of diffuse intrinsic pontine glioma
CN111148752B (zh) 2017-07-19 2024-01-16 国立大学法人德岛大学 肽衍生物和包含其的药物组合物
CN110018309B (zh) * 2018-01-08 2023-07-04 成都市第三人民医院 通过蛋白标志物判断结直肠癌预后的试剂盒
KR102171774B1 (ko) * 2018-06-04 2020-10-29 울산대학교 산학협력단 인산화된 tfcp2l1을 포함하는 고형암 예후 예측용 바이오마커 조성물 및 이의 용도
WO2019236853A1 (en) * 2018-06-06 2019-12-12 Exosome Diagnostics, Inc. Methods for developing urine biomarkers and for detecting bladder cancer
TW202023581A (zh) 2018-08-02 2020-07-01 日商腫瘤療法 科學股份有限公司 來自cdca1的胜肽及含有此的疫苗
CN111206093A (zh) * 2018-11-21 2020-05-29 立森印迹诊断技术（无锡）有限公司 一种用于检测浸润性膀胱癌的标志物及其应用
JP7525855B2 (ja) 2018-11-30 2024-07-31 国立大学法人徳島大学 Ｂｉｇ３－ｐｈｂ２相互作用阻害ｐｈｂ２由来ペプチドを含む乳がん治療薬
CN110320369B (zh) * 2019-07-31 2022-05-17 天津医科大学第二医院 一种诊断膀胱癌试剂盒
CN112442499B (zh) * 2019-08-30 2026-03-10 恩康药业科技（广州）有限公司 一种抑制MCM7的siRNA、组合物及其应用
US20210379148A1 (en) * 2020-05-12 2021-12-09 University Of Maryland, Baltimore Regulating muscle physiology and energy metabolism using crym
CA3186504A1 (en) * 2020-08-17 2022-02-24 Stephen J. Blakemore Bicycle conjugates specific for nectin-4 and uses thereof
CN115501340B (zh) * 2021-06-07 2024-04-12 中山大学附属第三医院（中山大学肝脏病医院） CircPIAS1作为靶点在制备肝癌诊断试剂或治疗药物中的用途
CN113322523B (zh) * 2021-06-17 2024-03-19 翌圣生物科技(上海)股份有限公司 Rna快速建库方法及其应用
CN114854860A (zh) * 2022-05-05 2022-08-05 北京化工大学 一种膀胱癌干细胞生物标志物组及其应用
CN116121373A (zh) * 2022-09-14 2023-05-16 中山大学孙逸仙纪念医院 Etv4及其表达产物在制备诊断和治疗膀胱癌药物中的应用
WO2024192018A1 (en) * 2023-03-12 2024-09-19 Novelna Inc. Bladder cancer detection proteins and methods of use thereof
CN119633123A (zh) * 2024-12-26 2025-03-18 中山大学附属第一医院 Mettl2在消化系统肿瘤放疗增敏中的应用
CN120064671B (zh) * 2025-04-29 2025-07-29 吉林大学 用于检测幼儿唾液prb1含量的组合物及应用

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0239102A3 (en) 1986-03-28 1989-07-12 Tsuji, Kimiyoshi Process for the formation of human-human hybridoma
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
WO1996033735A1 (en) 1995-04-27 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
ATE158021T1 (de) 1990-08-29 1997-09-15 Genpharm Int Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
ES2301158T3 (es) 1992-07-24 2008-06-16 Amgen Fremont Inc. Produccion de anticuerpos xenogenicos.
JPH08509612A (ja) 1993-04-26 1996-10-15 ジェンファーム インターナショナル インコーポレイテッド 異種抗体を産生することができるトランスジェニック非ヒト動物
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US7001999B1 (en) * 1998-04-15 2006-02-21 Ludwig Institute For Cancer Research Tumor associated nucleic acids and uses therefor
US20020103360A1 (en) 1998-09-01 2002-08-01 Yang Pan Novel protein related to melanoma-inhibiting protein and uses thereof
US20040241726A1 (en) * 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of allergies related gene transcripts in blood
US20050123938A1 (en) * 1999-01-06 2005-06-09 Chondrogene Limited Method for the detection of osteoarthritis related gene transcripts in blood
IL148798A0 (en) * 1999-09-27 2002-09-12 Quark Biotech Inc Sequences characteristic of bladder cancer
CA2402563A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
AU2001231025A1 (en) 2000-01-20 2001-07-31 Cedars-Sinai Medical Center Method of detecting neoplastic, hyperplastic, cytologically dysplastic and/or premalignant cellular growth or proliferation
WO2002031111A2 (en) 2000-10-12 2002-04-18 Hyseq, Inc. Novel nucleic acids and polypeptides
US20030157561A1 (en) 2001-11-19 2003-08-21 Kolkman Joost A. Combinatorial libraries of monomer domains
US20040076955A1 (en) * 2001-07-03 2004-04-22 Eos Biotechnology, Inc. Methods of diagnosis of bladder cancer, compositions and methods of screening for modulators of bladder cancer
US7494646B2 (en) * 2001-09-06 2009-02-24 Agensys, Inc. Antibodies and molecules derived therefrom that bind to STEAP-1 proteins
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
AU2003222103A1 (en) * 2002-03-28 2003-10-13 Idec Pharmaceuticals Corporation Novel gene targets and ligands that bind thereto for treatment and diagnosis of colon carcinomas
TW200413725A (en) * 2002-09-30 2004-08-01 Oncotherapy Science Inc Method for diagnosing non-small cell lung cancers
DE602004032114D1 (de) 2003-02-28 2011-05-19 Oncotherapy Science Inc Rna-interferenz für das gen znfn3a1 als verfahren zur hemmung des wachstums von krebszellen
US7700573B2 (en) 2004-03-23 2010-04-20 Oncotherapy Science, Inc. Method for diagnosing non-small lung cancer
KR101543622B1 (ko) 2006-10-17 2015-08-11 온코세라피 사이언스 가부시키가이샤 Ｍｐｈｏｓｐｈ1 또는 ｄｅｐｄｃ1 폴리펩티드를 발현하는 암에 대한 펩티드 백신
EP2171082B1 (en) * 2007-06-14 2012-11-28 Oncotherapy Science, Inc. Methods of identifying agents that modulate methylation of vegfr1 by smyd3

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018520653A (ja) * 2015-06-25 2018-08-02 イマティクス バイオテクノロジーズ ゲーエムベーハー 骨髄腫およびその他のがんの免疫療法において使用するための新規細胞エピトープおよび細胞エピトープ組み合わせ

Also Published As

Publication number Publication date
EP1856278A2 (en) 2007-11-21
EP2011885A2 (en) 2009-01-07
US7998695B2 (en) 2011-08-16
US8685641B2 (en) 2014-04-01
EP2011885B1 (en) 2015-04-22
WO2006085684A2 (en) 2006-08-17
CN101175862A (zh) 2008-05-07
US20120014996A1 (en) 2012-01-19
US20130011933A1 (en) 2013-01-10
EP2295601A1 (en) 2011-03-16
EP2011885A3 (en) 2009-06-24
WO2006085684A3 (en) 2007-03-29
US20090175844A1 (en) 2009-07-09
EP2292796A1 (en) 2011-03-09
EP2311983A1 (en) 2011-04-20
JP2012135301A (ja) 2012-07-19
JP2008532477A (ja) 2008-08-21
WO2006085684A9 (en) 2006-10-19

Similar Documents

Publication Publication Date Title
JP5109131B2 (ja) 膀胱癌を診断する方法
JP4579246B2 (ja) 乳癌を診断する方法
JP4679149B2 (ja) ヒト膵癌に関連する遺伝子およびポリペプチド
JP2006517783A (ja) ヒト骨髄性白血病に関連する遺伝子およびポリペプチド
WO2004031413A2 (en) Method for diagnosing non-small cell lung cancers
CN101835894A (zh) Ebi3、dlx5、nptx1和cdkn3用作肺癌治疗和诊断的靶基因
JP2006518186A (ja) 前立腺癌関連遺伝子およびポリペプチド
EP1907580A2 (en) Method for diagnosing and treating renal cell carcinoma
WO2012090479A1 (en) Mcm7 as a target gene for cancer therapy and diagnosis
JP2009505632A (ja) 膵臓癌関連遺伝子であるｃｓｔ６およびｇａｂｒｐ
US8067153B2 (en) Genes and polypeptides relating to prostate cancers
JP5109063B2 (ja) 乳癌に関連する遺伝子およびポリペプチド
US20120022131A1 (en) Breast cancer related gene rqcd1
WO2011024433A1 (en) Lung and esophageal cancer related gene adamts18
US20110313018A1 (en) Cancer related gene, lgn/gpsm2
JP2009505631A (ja) 癌関連遺伝子ｒａｓｇｅｆ１ａ
JP2010500004A (ja) 前立腺癌関連遺伝子ｓｔｙｋ１
JP2008505601A (ja) 前立腺癌に関連した遺伝子及びポリペプチド
WO2011024428A1 (en) Breast cancer related gene c12orf32

Legal Events

Date Code Title Description
A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20080711

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090126

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090126

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110929

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111124

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120627

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120817

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120910

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120913

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20151019

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 5109131

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20151019

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

LAPS Cancellation because of no payment of annual fees