JP2008531470A5 - - Google Patents

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Publication number
JP2008531470A5
JP2008531470A5 JP2007547106A JP2007547106A JP2008531470A5 JP 2008531470 A5 JP2008531470 A5 JP 2008531470A5 JP 2007547106 A JP2007547106 A JP 2007547106A JP 2007547106 A JP2007547106 A JP 2007547106A JP 2008531470 A5 JP2008531470 A5 JP 2008531470A5
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JP
Japan
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substituted
alkyl
phenyl
benzyl
aryl
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JP2007547106A
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English (en)
Japanese (ja)
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JP4966202B2 (ja
JP2008531470A (ja
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Priority claimed from PCT/AU2005/001975 external-priority patent/WO2006066361A1/en
Publication of JP2008531470A publication Critical patent/JP2008531470A/ja
Publication of JP2008531470A5 publication Critical patent/JP2008531470A5/ja
Application granted granted Critical
Publication of JP4966202B2 publication Critical patent/JP4966202B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2007547106A 2004-12-24 2005-12-23 治療または予防のための方法 Expired - Lifetime JP4966202B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2004907332 2004-12-24
AU2004907332A AU2004907332A0 (en) 2004-12-24 Method of Treatment or Prophylaxis
PCT/AU2005/001975 WO2006066361A1 (en) 2004-12-24 2005-12-23 Method of treatment or prophylaxis

Publications (3)

Publication Number Publication Date
JP2008531470A JP2008531470A (ja) 2008-08-14
JP2008531470A5 true JP2008531470A5 (https=) 2008-12-25
JP4966202B2 JP4966202B2 (ja) 2012-07-04

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ID=36601295

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007547106A Expired - Lifetime JP4966202B2 (ja) 2004-12-24 2005-12-23 治療または予防のための方法

Country Status (16)

Country Link
US (5) US7795275B2 (https=)
EP (3) EP1830869B1 (https=)
JP (1) JP4966202B2 (https=)
CN (3) CN101087619B (https=)
CY (1) CY1114424T1 (https=)
DK (1) DK1830869T3 (https=)
ES (1) ES2425567T3 (https=)
HR (1) HRP20130738T1 (https=)
ME (1) ME01597B (https=)
NZ (1) NZ555334A (https=)
PL (1) PL1830869T3 (https=)
PT (1) PT1830869E (https=)
RS (1) RS52927B (https=)
SI (1) SI1830869T1 (https=)
WO (1) WO2006066361A1 (https=)
ZA (3) ZA200704909B (https=)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1830869E (pt) 2004-12-24 2013-08-22 Spinifex Pharm Pty Ltd Método de tratamento ou profilaxia
CA2646379C (en) 2006-03-20 2014-12-23 The University Of Queensland Method of treatment or prophylaxis inflammatory pain
CN101522676A (zh) * 2006-10-05 2009-09-02 Cv医药有限公司 用作硬脂酰-CoA脱氢酶抑制剂的双环含氮杂环化合物
US20090105283A1 (en) * 2007-04-11 2009-04-23 Dmitry Koltun 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
US20080255161A1 (en) * 2007-04-11 2008-10-16 Dmitry Koltun 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
US7828840B2 (en) * 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
WO2010056230A1 (en) * 2008-10-15 2010-05-20 Cv Therapeutics, Inc. 3-hydroquinazolin-4-one derivatives for use as stearoyl coa desaturase inhibitors
WO2010045374A1 (en) * 2008-10-15 2010-04-22 Gilead Palo Alto, Inc. 3-hydroquinazolin-4-one derivatives for use as stearoyl coa desaturase inhibitors
US9095587B2 (en) 2010-01-19 2015-08-04 Spinifex Pharmaceuticals Pty Ltd Methods and compositions for improved nerve conduction velocity
DE102010013075A1 (de) 2010-03-26 2011-09-29 B. Braun Melsungen Ag Antimikrobielle Wundauflage
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
ES2570135T3 (es) 2010-07-21 2016-05-17 Novartis Ag Sal y solvatos de un derivado de tetrahidroisoquinolina
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
ES2969977T3 (es) 2011-08-23 2024-05-23 Libertas Bio Inc Compuestos de pirimido-piridazinona y uso de los mismos
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
AU2013202982C1 (en) 2012-01-06 2017-01-05 Novartis Ag Heterocyclic compounds and methods for their use
PT2807171T (pt) 2012-01-25 2020-11-03 Novartis Ag Compostos heterocíclicos e métodos para a sua utilização
PL2807153T3 (pl) * 2012-01-25 2020-09-07 Novartis Ag Związki heterocykliczne i sposoby ich zastosowania
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
NZ630908A (en) 2013-07-08 2017-08-25 Novartis Ag Heterocyclic compounds and methods of their use
EP3051944B1 (en) 2013-09-30 2023-11-01 FMC Corporation Method of delivering an agriculturally active ingredient
EP3126329B1 (en) 2014-01-17 2019-05-29 Cardioxyl Pharmaceuticals Inc. N-hydroxymethanesulfonamide nitroxyl donors
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
MX373150B (es) 2014-03-26 2020-04-21 Astex Therapeutics Ltd Combinaciones de un inhibidor del factor de crecimiento de fibroblasto (fgfr) y un inhibidor del receptor del factor de crecimiento 1 similar a insulina (igf1r).
JP6752715B2 (ja) 2014-03-26 2020-09-09 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 組合せ
AR100936A1 (es) 2014-06-24 2016-11-09 Fmc Corp Formulaciones de espumas y concentrados emulsionables
CN107001337B (zh) 2015-01-13 2021-05-04 诺华股份有限公司 作为血管紧张素ii型拮抗剂的吡咯烷衍生物
TWI719960B (zh) 2015-02-10 2021-03-01 英商阿斯迪克治療公司 新穎組成物
PL3268356T3 (pl) 2015-03-12 2022-01-24 Novartis Ag Związki heterocykliczne i sposoby ich stosowania
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
CN106478502B (zh) * 2015-08-29 2021-04-27 上海翰森生物医药科技有限公司 1,2,3,4-四氢异喹啉衍生物、其制备方法和应用
DK3353177T3 (da) 2015-09-23 2020-08-24 Janssen Pharmaceutica Nv Tricykliske heterocykler til behandling af cancer
AU2016328693B2 (en) 2015-09-23 2021-03-11 Janssen Pharmaceutica Nv Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
US11632959B2 (en) 2015-12-23 2023-04-25 Fmc Corporation In situ treatment of seed in furrow
WO2018001997A1 (en) 2016-06-27 2018-01-04 Ratiopharm Gmbh Crystalline calcium salt of (s)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid
JP2019514862A (ja) 2017-03-23 2019-06-06 ノバルティス アーゲー （ｓ）−２−（ジフェニルアセチル）−１，２，３，４−テトラヒドロ−６−メトキシ−５−（フェニルメトキシ）−３−イソキノリンカルボン酸ナトリウムの無水結晶形
KR20190140011A (ko) 2017-04-28 2019-12-18 아사나 바이오사이언시스 엘엘씨 아토피성 피부염을 치료하고, 활성 약학적 성분의 안정성을 개선하기 위한 제형물, 방법, 키트, 및 투여형
WO2018224037A1 (zh) * 2017-06-09 2018-12-13 南京明德新药研发股份有限公司 作为at2r受体拮抗剂的羧酸衍生物
GB201710906D0 (en) * 2017-07-06 2017-08-23 Vicore Pharma Ab Compounds and methods for treating peripheral neuropathy
CA3091300A1 (en) * 2018-02-23 2019-08-29 Beijing Tide Pharmaceutical Co., Ltd. Receptor inhibitors, pharmaceutical compositions comprising the same, and usage thereof
AU2019236882B2 (en) * 2018-03-23 2023-08-10 Beijing Tide Pharmaceutical Co., Ltd. Receptor inhibitor, pharmaceutical composition comprising same, and use thereof
EP3820498A1 (en) * 2018-06-14 2021-05-19 University College Cork-National University of Ireland Cork Peptide for disease treatment
WO2020012266A1 (en) 2018-07-12 2020-01-16 Novartis Ag Biocatalytic synthesis of olodanrigan (ema401) from 3-(2-(benzyloxy)-3-methoxyphenyl)propenoic acid with phenylalanine ammonia lyase
WO2023006893A1 (en) 2021-07-30 2023-02-02 Confo Therapeutics N.V. Compounds for the treatment of pain, in particular neuropathic pain, and/or other diseases or disorders that are associated with at2r and/or at2r mediated signaling
CA3254395A1 (en) 2022-05-17 2023-11-23 Eli Lilly And Company AT2R'S ANTAGONISTS AND THEIR USES

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3531485A (en) 1967-08-14 1970-09-29 American Home Prod Aryl-substituted diazabicycloalkanes
US3957795A (en) 1974-01-28 1976-05-18 Delmar Chemicals Limited Novel cyclopentene and cyclopentane derivatives
US3975795A (en) 1975-01-20 1976-08-24 Union Carbide Corporation Product stuffing apparatus and method
US4812462A (en) 1986-04-01 1989-03-14 Warner-Lambert Company 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
US5091390A (en) 1990-09-20 1992-02-25 E. I. Du Pont De Nemours And Company Treatment of CNS disorders with 4,5,6,7-tetrahydro-1H-imidazo (4,5-)-pyridines and analogs
WO1992005784A1 (en) 1990-10-02 1992-04-16 Warner-Lambert Company 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine derivatives and analogues as angiotensin ii receptor antagonists
US5385894A (en) 1991-03-06 1995-01-31 Merck & Co., Inc. Disubstituted 6-aminoquinazolinones
US5238942A (en) 1991-05-10 1993-08-24 Merck & Co., Inc. Substituted quinazolinones bearing acidic functional groups as angiotensin ii antagonists
WO1992020661A1 (en) * 1991-05-22 1992-11-26 Merck & Co., Inc. N, n-diacylpiperazines
US5204354A (en) * 1992-02-14 1993-04-20 Merck & Co., Inc. Substituted quinazolinones as neurotensin antagonists useful in the treatment of CNS disorders
NZ251741A (en) 1992-04-13 1997-06-24 Zeneca Ltd Use of angiotensin ii antagonists for treating disease conditions associated with impaired neuronal conduction velocity
GB9208116D0 (en) 1992-04-13 1992-05-27 Ici Plc Therapeutic agents
US5246943A (en) 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
US5236934A (en) 1992-08-26 1993-08-17 E. I. Du Pont De Nemours And Company 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders
US5344830A (en) 1992-12-10 1994-09-06 Merck & Co., Inc. N,N-diacylpiperazine tachykinin antagonists
NZ258888A (en) 1992-12-11 1997-02-24 Ciba Geigy Ag Benzazepin-2-one derivatives; preparations and pharmaceutical compositions
US5395844A (en) 1993-06-10 1995-03-07 The Du Pont Merck Pharmaceutical Company Imidazole 5-position substituted angiotensin II antagonists
US5348955A (en) 1993-06-22 1994-09-20 Merck & Co., Inc. N,N-diacylpiperazines
US5338740A (en) 1993-07-13 1994-08-16 Pfizer Inc. Angiotensin II receptor antagonists
AP9400651A0 (en) 1993-07-15 1995-12-30 Pfizer Azacyclic-heterocyclic compounds as angiotensin II receptor antagonists.
US5409926A (en) 1993-07-19 1995-04-25 Merck & Co., Inc. AT-2 antagonist inhibition of vascular restenosis
US5610165A (en) 1994-02-17 1997-03-11 Merck & Co., Inc. N-acylpiperidine tachykinin antagonists
FR2739625B1 (fr) 1995-10-09 1997-12-05 Atochem Elf Sa Copolymeres hydrosolubles associatifs triblocs
GB2323783A (en) 1997-04-02 1998-10-07 Ferring Bv Group Holdings Inhibitors of farnesyl protein transferase
WO1999007413A1 (en) 1997-08-11 1999-02-18 Algos Pharmaceutical Corporation Substance p inhibitors in combination with nmda-blockers for treating pain
US6277839B1 (en) 1998-10-07 2001-08-21 Merck Frosst Canada & Co. Biphenylene lactams as prostaglandin receptor ligands
ATE524176T1 (de) * 1998-12-23 2011-09-15 Novartis Pharma Gmbh Valsartan tablette
DE60030764T2 (de) * 1999-12-15 2007-09-13 Bristol-Myers Squibb Co. Biphenyl - sulfonamide als duale angiotensin - endothelin - rezeptor - antagonisten
AU1793101A (en) 1999-12-16 2001-06-25 University Of Southern California Methods for treating and preventing damage to mucosal tissue
WO2001082916A2 (en) 2000-05-03 2001-11-08 Tularik Inc. Combination therapeutic compositions and methods of use
AU2001282886A1 (en) 2000-07-13 2002-01-30 Pharmacia Corporation Combination of a cox-2 inhibitor and a vasomodulator for treating pain and headache pain
DE60113290D1 (de) 2000-11-17 2005-10-13 Warner Lambert Co Behandlung von sexueller funktionsstörung mit bombesin rezeptor antagonisten
EG23054A (en) 2001-01-22 2004-02-29 Sankyo Co Pyrrole derivatives their preparation and their therapeutic uses
US20030170222A1 (en) 2001-01-29 2003-09-11 University Of Utah Research Foundation Beta-superfamily conotoxins
EP1356815A4 (en) 2001-01-29 2007-03-07 Takeda Pharmaceutical ANALGESIC AND ANTI-INFLAMMATORY DRUGS
EP1463481A4 (en) 2001-12-14 2008-06-25 Targacept Inc METHOD AND COMPOSITIONS FOR TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM
WO2003064414A1 (en) 2002-01-29 2003-08-07 Vicore Pharma Ab. Tricyclic compounds useful as angiotensin ii agonists
TWI259079B (en) 2002-02-08 2006-08-01 Merck & Co Inc N-biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives
US20030199424A1 (en) 2002-03-20 2003-10-23 Smith Maree Therese Method of treatment and/or prophylaxis
JP2006500399A (ja) 2002-04-30 2006-01-05 メルク　エンド　カムパニー　インコーポレーテッド ナトリウムチャンネルブロッカーとしての、アリール−結合−アリール置換された、チアゾリジン−ジオンおよびオキサゾリジン−ジオン
WO2003097024A1 (en) 2002-05-17 2003-11-27 Faust Pharmaceuticals Methods for the prevention and/or the treatment of neurological disorders
AU2003237224A1 (en) 2002-05-29 2003-12-19 Merck And Co., Inc. 1,2 diamido cycloalkyl sodium channel blockers
GB0212412D0 (en) 2002-05-29 2002-07-10 Novartis Ag Combination of organic compounds
WO2004006959A1 (en) 2002-07-16 2004-01-22 Elan Pharma International, Ltd Liquid dosage compositions of stable nanoparticulate active agents
JO2397B1 (en) 2002-12-20 2007-06-17 ميرك شارب اند دوم كوربوريشن Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
DE10300973A1 (de) 2003-01-14 2004-07-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Carbonsäuren und deren Ester, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
PA8597401A1 (es) 2003-03-14 2005-05-24 Pfizer Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep
WO2004099248A2 (en) 2003-05-05 2004-11-18 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor agtr2 (agtr2)
US7157584B2 (en) 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
PT1830869E (pt) * 2004-12-24 2013-08-22 Spinifex Pharm Pty Ltd Método de tratamento ou profilaxia
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin

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