|
CA2529510A1
(en)
|
2003-07-01 |
2005-01-13 |
President And Fellows Of Harvard College |
Compositions for manipulating the lifespan and stress response of cells and organisms
|
|
US20050158376A1
(en)
*
|
2003-10-23 |
2005-07-21 |
Sardi William F. |
Dietary supplement and method of processing same
|
|
US20090169585A1
(en)
*
|
2003-10-23 |
2009-07-02 |
Resveratrol Partners, Llc |
Resveratrol-Containing Compositions And Their Use In Modulating Gene Product Concentration Or Activity
|
|
US8017634B2
(en)
|
2003-12-29 |
2011-09-13 |
President And Fellows Of Harvard College |
Compositions for treating obesity and insulin resistance disorders
|
|
EP1708689A2
(en)
|
2003-12-29 |
2006-10-11 |
The President and Fellows of Harvard College |
Compositions for treating or preventing obesity and insulin resistance disorders
|
|
US7714161B2
(en)
*
|
2004-01-20 |
2010-05-11 |
Brigham Young University |
Sirtuin activating compounds and methods for making the same
|
|
JP2008501343A
(ja)
*
|
2004-06-04 |
2008-01-24 |
ワシントン・ユニバーシティ |
神経障害を治療するための方法および組成物
|
|
UA91341C2
(ru)
|
2004-07-15 |
2010-07-26 |
Амр Текнолоджи, Інк. |
Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
|
|
JP2008527002A
(ja)
*
|
2005-01-13 |
2008-07-24 |
サートリス ファーマシューティカルズ， インコーポレイテッド |
神経変性障害および血液凝固障害を予防および処置するための新規組成物
|
|
US20090142335A1
(en)
*
|
2005-02-15 |
2009-06-04 |
Joslin Diabetes Center |
Methods of diagnosis and treatment of metabolic disorders
|
|
US20090215681A1
(en)
*
|
2005-02-15 |
2009-08-27 |
Joslin Diabetes Center |
Methods of Diagnosis and Treatment of Metabolic Disorders
|
|
US20070014833A1
(en)
*
|
2005-03-30 |
2007-01-18 |
Sirtris Pharmaceuticals, Inc. |
Treatment of eye disorders with sirtuin modulators
|
|
US20060229265A1
(en)
*
|
2005-03-30 |
2006-10-12 |
Sirtris Pharmaceuticals, Inc. |
Nicotinamide riboside and analogues thereof
|
|
ES2524922T3
(es)
|
2005-05-10 |
2014-12-15 |
Intermune, Inc. |
Derivados de piridona para modular el sistema de proteína cinasa activada por estrés
|
|
US8546423B2
(en)
|
2005-05-18 |
2013-10-01 |
Mpex Pharmaceuticals, Inc. |
Aerosolized fluoroquinolones and uses thereof
|
|
US20060292099A1
(en)
*
|
2005-05-25 |
2006-12-28 |
Michael Milburn |
Treatment of eye disorders with sirtuin modulators
|
|
WO2006138418A2
(en)
|
2005-06-14 |
2006-12-28 |
President And Fellows Of Harvard College |
Improvement of cognitive performance with sirtuin activators
|
|
US20070149466A1
(en)
*
|
2005-07-07 |
2007-06-28 |
Michael Milburn |
Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
|
|
CN101176786A
(zh)
*
|
2006-11-08 |
2008-05-14 |
中国科学院上海生命科学研究院 |
增加胰岛素敏感性的方法和组合物
|
|
US20080249103A1
(en)
*
|
2006-11-15 |
2008-10-09 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin polymorphisms and methods of use thereof
|
|
CA2675638C
(en)
*
|
2007-01-16 |
2015-11-24 |
Ipintl, Llc |
Composition comprising serotonin for treating metabolic syndrome
|
|
US20100210692A1
(en)
*
|
2007-03-28 |
2010-08-19 |
Farmer Stephen R |
Methods of treatment using sirt modulators and compositions containing sirt1 modulators
|
|
US8404275B2
(en)
*
|
2007-07-01 |
2013-03-26 |
Vitalis Llc |
Combination tablet with chewable outer layer
|
|
CA2690956C
(en)
*
|
2007-07-01 |
2017-01-03 |
Joseph Peter Habboushe |
Combination tablet with chewable outer layer
|
|
EP2018861A1
(en)
*
|
2007-07-26 |
2009-01-28 |
Laboratorios del Dr. Esteve S.A. |
5HT6-Ligands such as sulfonamide derivatives in drug-induced weight-gain
|
|
JP5337405B2
(ja)
|
2007-09-17 |
2013-11-06 |
ザ・ホスピタル・フォー・シック・チルドレン |
ゴーシェ病の治療方法
|
|
US9339500B2
(en)
*
|
2008-03-04 |
2016-05-17 |
Intra-Cellular Therapies, Inc. |
Methods of treating vasomotor symptoms
|
|
EP2291182A1
(en)
*
|
2008-05-13 |
2011-03-09 |
Genmedica Therapeutics SL |
Salicylate conjugates useful for treating metabolic disorders
|
|
CA2666036C
(en)
*
|
2008-05-16 |
2017-09-12 |
Chien-Hung Chen |
Novel compositions and methods for treating hyperproliferative diseases
|
|
CA2726588C
(en)
|
2008-06-03 |
2019-04-16 |
Karl Kossen |
Compounds and methods for treating inflammatory and fibrotic disorders
|
|
US9156812B2
(en)
|
2008-06-04 |
2015-10-13 |
Bristol-Myers Squibb Company |
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
|
|
CA2731849C
(en)
*
|
2008-07-25 |
2017-07-11 |
Emory University |
Use of 7,8-dihydroxyflavone and derivatives thereof as neuroprotectants and antidepressants
|
|
JP2012505223A
(ja)
*
|
2008-10-07 |
2012-03-01 |
エムペックス・ファーマシューティカルズ・インコーポレーテッド |
薬物動態の改善のためのエアゾールフルオロキノロン配合物
|
|
EP2346509B1
(en)
|
2008-10-07 |
2020-05-13 |
Horizon Orphan LLC |
Inhalation of levofloxacin for reducing lung inflammation
|
|
CA2755069A1
(en)
*
|
2009-03-16 |
2010-09-23 |
Genmedica Therapeutics Sl |
Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
|
|
CN102421424A
(zh)
*
|
2009-03-16 |
2012-04-18 |
根梅迪卡治疗公司 |
用于治疗代谢性疾病的组合疗法
|
|
US8377947B2
(en)
*
|
2009-03-16 |
2013-02-19 |
Chien-Hung Chen |
Treating alzheimer's disease and osteoporosis and reducing aging
|
|
US8815894B2
(en)
*
|
2009-05-12 |
2014-08-26 |
Bristol-Myers Squibb Company |
Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
|
|
AU2010247763B2
(en)
*
|
2009-05-12 |
2015-12-24 |
Albany Molecular Research, Inc. |
7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
|
|
EP2429295B1
(en)
*
|
2009-05-12 |
2013-12-25 |
Albany Molecular Research, Inc. |
Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
|
|
US8980843B2
(en)
|
2009-07-01 |
2015-03-17 |
Temple University—Of the Commonwealth System of Higher Education |
Leptin agonist and methods of use
|
|
PH12012500382A1
(en)
|
2009-09-03 |
2012-10-22 |
Bioenergenix |
Heterocyclic compounds for the inhibition of pask
|
|
RU2563809C2
(ru)
|
2009-09-04 |
2015-09-20 |
Мпекс Фармасьютикалс, Инк. |
Применение левофлоксацина в форме аэрозоля для лечения муковисцидоза
|
|
FI20106119A0
(fi)
*
|
2010-10-27 |
2010-10-27 |
Sirtuin Valley Oy |
Energia-aineenvaihduntaan vaikuttava koostumus
|
|
US8466197B2
(en)
|
2010-12-14 |
2013-06-18 |
Genmedica Therapeutics Sl |
Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
|
|
CA2823753C
(en)
|
2011-01-05 |
2019-03-12 |
Bioenergenix Llc |
Heterocyclic compounds for the inhibition of pask
|
|
BR112013022147A2
(pt)
|
2011-03-02 |
2017-04-25 |
Bioenergenix |
composto, composição farmacêutica, método de inibição da pask, método de tratamento de uma doença, método para alcançar um efeito em um paciente e método de tratamento de uma doença mediada pela pask
|
|
US8916561B2
(en)
|
2011-03-02 |
2014-12-23 |
Bioenergenix, Llc |
Substituted quinoxaline compounds for the inhibition of PASK
|
|
EP2898923A3
(en)
*
|
2011-04-15 |
2015-10-07 |
Nestec S.A. |
Isoflavones for regulating sirtuin gene expression
|
|
JP2012236793A
(ja)
*
|
2011-05-11 |
2012-12-06 |
Kikkoman Corp |
Ａｍｐｋ活性化剤
|
|
US8623924B2
(en)
|
2011-07-15 |
2014-01-07 |
Nusirt Sciences, Inc. |
Compositions and methods for modulating metabolic pathways
|
|
CA2853804C
(en)
|
2011-10-28 |
2021-06-01 |
Vitalis Llc |
Anti-flush compositions
|
|
WO2013074948A1
(en)
|
2011-11-16 |
2013-05-23 |
Resveratrol Partners, Llc |
Compositions containing resveratrol and nucleotides
|
|
JP6417630B2
(ja)
*
|
2011-12-27 |
2018-11-07 |
株式会社常磐植物化学研究所 |
サーチュイン活性化剤
|
|
JO3407B1
(ar)
|
2012-05-31 |
2019-10-20 |
Eisai R&D Man Co Ltd |
مركبات رباعي هيدرو بيرازولو بيريميدين
|
|
AR092742A1
(es)
|
2012-10-02 |
2015-04-29 |
Intermune Inc |
Piridinonas antifibroticas
|
|
TWI485145B
(zh)
|
2012-10-26 |
2015-05-21 |
財團法人工業技術研究院 |
Ｐ型有機半導體材料與光電元件
|
|
MX2015006023A
(es)
|
2012-11-13 |
2016-03-31 |
Nusirt Sciences Inc |
Composiciones y metodos para incrementar el metabolismo energetico.
|
|
CN105228627B
(zh)
*
|
2013-03-15 |
2018-07-13 |
纽斯尔特科学公司 |
亮氨酸和烟酸降低脂质水平
|
|
EP2801357A1
(en)
|
2013-05-10 |
2014-11-12 |
IMD Natural Solutions GmbH |
Carboxylated stilbenes for activating AMPK and sirtuins
|
|
MX382781B
(es)
|
2014-04-02 |
2025-03-13 |
Intermune Inc |
Piridinonas anti-fibroticas.
|
|
CN107613965A
(zh)
*
|
2015-02-19 |
2018-01-19 |
普渡制药公司 |
用于减少胃排空的方法和组合物
|
|
CN105153090A
(zh)
*
|
2015-07-17 |
2015-12-16 |
浙江海洋学院 |
4′-溴-7-异戊烯氧基-2,3-二氢黄酮和制备方法以及在制备抗抑郁药物中的应用
|
|
CN105380955A
(zh)
*
|
2015-09-24 |
2016-03-09 |
成都普瑞法科技开发有限公司 |
土大黄苷在治疗溃疡性结肠炎药物中的应用
|
|
US20180169085A1
(en)
*
|
2016-12-19 |
2018-06-21 |
Augusta University Reserch Institute, Inc. |
Combination Therapy for Hemorrhagic Injury
|
|
US11254700B2
(en)
|
2017-12-01 |
2022-02-22 |
University Of Hawaii |
GSK-3β inhibitors and use thereof in methods of treatment
|
|
US20210393621A1
(en)
|
2018-10-26 |
2021-12-23 |
The Research Foundation For The State University Of New York |
Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
|
|
IT201900003325A1
(it)
*
|
2019-03-07 |
2020-09-07 |
C I A M S R L |
Composizione per la prevenzione e trattamento della dermatite atopica
|
|
WO2021096882A1
(en)
*
|
2019-11-11 |
2021-05-20 |
Nusirt Sciences, Inc. |
Compositions, methods and kits for altering adipocytes
|
|
WO2023064857A1
(en)
|
2021-10-14 |
2023-04-20 |
Incyte Corporation |
Quinoline compounds as inhibitors of kras
|
|
WO2025049514A1
(en)
*
|
2023-08-30 |
2025-03-06 |
Sirona Biosciences Inc. |
Compositions and methods with flavonoids
|