JP2008526760A - 種々の腫瘍関連抗原を含む組成物の抗癌ワクチンとしての使用 - Google Patents
種々の腫瘍関連抗原を含む組成物の抗癌ワクチンとしての使用 Download PDFInfo
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013513659A (ja) * | 2009-12-15 | 2013-04-22 | セラヴァック ファーマスウティカルズ エイ ビー | 腫瘍治療における有効なツールとしての腫瘍血管をターゲティングする新規なワクチン |
| KR101807162B1 (ko) * | 2011-04-21 | 2017-12-11 | 주식회사 보령바이젠셀 | 폴로-유사 키나아제 1의 종양항원 단백질 또는 유전자 |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6977074B2 (en) | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
| US7178491B2 (en) * | 2003-06-05 | 2007-02-20 | Caterpillar Inc | Control system and method for engine valve actuator |
| EP2332971B1 (en) * | 2004-06-17 | 2016-02-17 | MannKind Corporation | Epitope analogs |
| EP1838342A2 (en) * | 2004-12-29 | 2007-10-03 | Mannkind Corporation | Methods to bypass cd+4 cells in the induction of an immune response |
| KR101294290B1 (ko) * | 2004-12-29 | 2013-08-07 | 맨카인드 코포레이션 | 예방 또는 치료를 위해 제ｉ류 주조직 적합성복합체〔ｍｈｃ〕-제한 에피토프에 대한 면역 반응을 유발,향상 및 지속하는 방법 |
| EP2351576A1 (en) * | 2004-12-29 | 2011-08-03 | Mannkind Corporation | Methods to trigger, maintain and manipulate immune responses by targeted administration of biological response modifiers into lymphoid organs |
| EP3130350A1 (en) | 2005-06-08 | 2017-02-15 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (pd-1)pathway |
| CA2612516C (en) | 2005-06-17 | 2015-03-24 | Mannkind Corporation | Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma |
| US7511119B2 (en) * | 2005-06-17 | 2009-03-31 | Mannkind Corporation | PRAME peptide analogues |
| KR20080033271A (ko) * | 2005-06-17 | 2008-04-16 | 맨카인드 코포레이션 | 암종을 위한 다가 동반이행 및 증폭형 면역치료제 |
| US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
| US20080014211A1 (en) * | 2006-07-14 | 2008-01-17 | Mannkind Corporation | Methods to elicit, enhance and sustain immune responses against MHC class I-restricted epitopes, for prophylactic and therapeutic purposes |
| EP2129389B1 (en) | 2007-02-15 | 2014-10-08 | MannKind Corporation | A method for enhancing t cell response |
| EP2281004A4 (en) * | 2008-04-14 | 2012-02-15 | Proscan Rx Pharma Inc | PROSTATE-SPECIFIC MEMBRANANT ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS |
| WO2011050344A2 (en) | 2009-10-23 | 2011-04-28 | Mannkind Corporation | Cancer immunotherapy and method of treatment |
| MX2013008252A (es) * | 2011-01-18 | 2014-04-14 | Everist Genomics Inc | Firma de pronostico para la recurrencia de cancer colorrectal. |
| KR20120116518A (ko) * | 2011-04-11 | 2012-10-23 | 한국생명공학연구원 | 폐암 조기 진단용 ＸＡＧＥ-1ａ 마커 및 이의 용도 |
| BR112014004779B1 (pt) | 2011-08-30 | 2022-01-18 | Astex Pharmaceuticals, Inc | Formulações de derivados de decitabina, kit e processos relacionados |
| RU2019138702A (ru) | 2013-03-01 | 2020-01-27 | Астекс Фармасьютикалз, Инк. | Комбинации лекарственных средств |
| MX2018000016A (es) | 2015-07-02 | 2019-01-31 | Otsuka Pharma Co Ltd | Composiciones farmaceuticas liofilizadas. |
| MX2020001233A (es) | 2017-08-03 | 2020-07-20 | Otsuka Pharma Co Ltd | Compuesto farmaceutico y metodos de purificacion del mismo. |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001085932A2 (en) * | 2000-05-10 | 2001-11-15 | Aventis Pasteur Limited | Immunogenic polypeptides encoded by mage minigenes and uses thereof |
| JP2003512335A (ja) * | 1999-10-18 | 2003-04-02 | セント ビンセンツ ホスピタル アンド メディカル センター オブ ニューヨーク | メラノーマワクチン並びにその製造方法及び使用方法 |
| WO2003034903A2 (en) * | 2001-10-23 | 2003-05-01 | Psma Development Company, L.L.C. | Psma antibodies and protein multimers |
| JP2003535824A (ja) * | 2000-04-28 | 2003-12-02 | シーティーエル イムノセラピーズ コーポレーション | 抗原提示細胞におけるエピトープ同調 |
| US20030228634A1 (en) * | 2001-11-07 | 2003-12-11 | Simard John J.L. | Expression vectors encoding epitopes of target-associated antigens and methods for their design |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US568388A (en) | 1896-09-29 | Antirefilling bottle | ||
| US5804381A (en) * | 1996-10-03 | 1998-09-08 | Cornell Research Foundation | Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5342774A (en) * | 1991-05-23 | 1994-08-30 | Ludwig Institute For Cancer Research | Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1 |
| EP1757694A3 (en) * | 1992-11-05 | 2008-02-27 | Sloan Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
| US5747271A (en) * | 1992-12-22 | 1998-05-05 | Ludwig Institute For Cancer Research | Method for identifying individuals suffering from a cellular abnormality some of whose abnormal cells present complexes of HLA-A2/tyrosinase derived peptides, and methods for treating said individuals |
| US5620886A (en) | 1993-03-18 | 1997-04-15 | Ludwig Institute For Cancer Research | Isolated nucleic acid sequence coding for a tumor rejection antigen precursor processed to at least one tumor rejection antigen presented by HLA-A2 |
| US5571711A (en) * | 1993-06-17 | 1996-11-05 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors |
| US6013481A (en) | 1993-07-22 | 2000-01-11 | Ludwig Institute For Cancer Research | Isolated, nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof |
| US5648226A (en) | 1993-07-22 | 1997-07-15 | Ludwig Institute For Cancer Research | Isolated peptides derived from tumor rejection antigens, and their use |
| US5610013A (en) * | 1993-07-22 | 1997-03-11 | Ludwig Institute For Cancer Research | Method for diagnosing a disorder by determining expression of gage tumor rejection antigen precursors |
| US5858689A (en) * | 1993-07-22 | 1999-01-12 | Ludwig Institute For Cancer Research | Isolated peptides derived from the gage tumor rejection antigen precursor and uses thereof |
| US5679647A (en) * | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| US5935818A (en) | 1995-02-24 | 1999-08-10 | Sloan-Kettering Institute For Cancer Research | Isolated nucleic acid molecule encoding alternatively spliced prostate-specific membrane antigen and uses thereof |
| US5874560A (en) | 1994-04-22 | 1999-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Melanoma antigens and their use in diagnostic and therapeutic methods |
| US5830753A (en) * | 1994-09-30 | 1998-11-03 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof. |
| US6025191A (en) | 1995-06-07 | 2000-02-15 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules which encode a melanoma specific antigen and uses thereof |
| US5856136A (en) | 1996-07-03 | 1999-01-05 | Incyte Pharmaceuticals, Inc. | Human stem cell antigens |
| US6977074B2 (en) * | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
| IL133912A0 (en) | 1997-07-10 | 2001-04-30 | Ctl Immunotherapies Corp | A method of inducing ctl response |
| US6994851B1 (en) | 1997-07-10 | 2006-02-07 | Mannkind Corporation | Method of inducing a CTL response |
| US6709844B1 (en) | 2000-11-16 | 2004-03-23 | Mannkind Corporation | Avoidance of undesirable replication intermediates in plasmid propagation |
| US20030138808A1 (en) * | 1998-02-19 | 2003-07-24 | Simard John J.L. | Expression vectors encoding epitopes of target-associated antigens |
| GB9804121D0 (en) | 1998-02-26 | 1998-04-22 | Cancer Res Campaign Tech | Anti-angiogenic vaccines: materials and methods relating thereto |
| CN1308347C (zh) | 1999-04-28 | 2007-04-04 | 德克萨斯大学董事会 | 用于通过选择性抑制vegf来治疗癌症的组合物和方法 |
| US20030215425A1 (en) * | 2001-12-07 | 2003-11-20 | Simard John J. L. | Epitope synchronization in antigen presenting cells |
| US6861234B1 (en) | 2000-04-28 | 2005-03-01 | Mannkind Corporation | Method of epitope discovery |
| EP1595548A3 (en) * | 2001-03-07 | 2006-02-22 | Mannkind Corporation | Anti-neovasculature preparations for treating cancer |
| EP1372736A4 (en) | 2001-03-07 | 2004-11-17 | Mannkind Corp | PREPARATIONS AGAINST CANCER FORMATION |
| WO2003008537A2 (en) * | 2001-04-06 | 2003-01-30 | Mannkind Corporation | Epitope sequences |
| CN1691964A (zh) | 2002-09-06 | 2005-11-02 | 曼康公司 | 表位序列 |
| ATE546153T1 (de) * | 2003-06-17 | 2012-03-15 | Mannkind Corp | Kombinationen von tumor-assoziierten antigenen zur behandlung von verschiedenen krebstypen |
| MXPA05013973A (es) | 2003-06-17 | 2006-03-02 | Mannkind Corp | Metodos para producir, mejorar y sustentar respuestas inmunes contra epitopes restringidos mhc clase i, para propositos profilacticos o terapeuticos. |
| US20060008468A1 (en) | 2004-06-17 | 2006-01-12 | Chih-Sheng Chiang | Combinations of tumor-associated antigens in diagnostics for various types of cancers |
| JP2008503494A (ja) | 2004-06-17 | 2008-02-07 | マンカインド コーポレイション | 診断方法を治療方法と統合することによる免疫療法の効力改善 |
| DK1782070T3 (da) * | 2004-06-17 | 2011-01-03 | Mannkind Corp | Tumorassocieret antigenprofiler i cancerdiagnostik og immunterapi |
| US20060159689A1 (en) * | 2004-06-17 | 2006-07-20 | Chih-Sheng Chiang | Combinations of tumor-associated antigens in diagnostics for various types of cancers |
| EP2332971B1 (en) * | 2004-06-17 | 2016-02-17 | MannKind Corporation | Epitope analogs |
| US20080206270A1 (en) * | 2004-07-08 | 2008-08-28 | Minev Boris R | Enhancing Class I Antigen Presentation With Synthetic Sequences |
| EP2351576A1 (en) * | 2004-12-29 | 2011-08-03 | Mannkind Corporation | Methods to trigger, maintain and manipulate immune responses by targeted administration of biological response modifiers into lymphoid organs |
| KR101294290B1 (ko) * | 2004-12-29 | 2013-08-07 | 맨카인드 코포레이션 | 예방 또는 치료를 위해 제ｉ류 주조직 적합성복합체〔ｍｈｃ〕-제한 에피토프에 대한 면역 반응을 유발,향상 및 지속하는 방법 |
| KR20080033271A (ko) * | 2005-06-17 | 2008-04-16 | 맨카인드 코포레이션 | 암종을 위한 다가 동반이행 및 증폭형 면역치료제 |
| CA2612516C (en) * | 2005-06-17 | 2015-03-24 | Mannkind Corporation | Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma |
| US7511119B2 (en) * | 2005-06-17 | 2009-03-31 | Mannkind Corporation | PRAME peptide analogues |
-
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- 2007-06-28 IL IL184277A patent/IL184277A/en not_active IP Right Cessation
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003512335A (ja) * | 1999-10-18 | 2003-04-02 | セント ビンセンツ ホスピタル アンド メディカル センター オブ ニューヨーク | メラノーマワクチン並びにその製造方法及び使用方法 |
| JP2003535824A (ja) * | 2000-04-28 | 2003-12-02 | シーティーエル イムノセラピーズ コーポレーション | 抗原提示細胞におけるエピトープ同調 |
| WO2001085932A2 (en) * | 2000-05-10 | 2001-11-15 | Aventis Pasteur Limited | Immunogenic polypeptides encoded by mage minigenes and uses thereof |
| WO2003034903A2 (en) * | 2001-10-23 | 2003-05-01 | Psma Development Company, L.L.C. | Psma antibodies and protein multimers |
| US20030228634A1 (en) * | 2001-11-07 | 2003-12-11 | Simard John J.L. | Expression vectors encoding epitopes of target-associated antigens and methods for their design |
| US20040132088A1 (en) * | 2001-11-07 | 2004-07-08 | Simard John J.L. | Expression vectors encoding epitopes of target-associated antigens and methods for their design |
Non-Patent Citations (9)
| Title |
|---|
| JPN6011036730; ＲＥＹＮＯＬＤＳ，Ｓ．Ｒ． ｅｔ ａｌ: 'Ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ｏｆ ＨＬＡ-Ａ＊０３， Ａ＊１１ ａｎｄ Ｂ＊０７-ｒｅｓｔｒｉｃｔｅｄ ｍｅｌａｎｏｍａ-ａｓｓｏｃｉａｔｅｄ ｐｅｐｔｉｄｅｓ ｔｈａｔ ａｒｅ ｉｍｍｕｎｏｇｅｎ' Ｊ Ｉｍｍｕｎｏｌ Ｍｅｔｈｏｄｓ Ｖｏｌ．２４４， Ｎｏ．１-２, 2000, ｐ．５９-６７ * |
| JPN6011036732; ＳＭＩＴＨ，Ｓ．Ｇ． ｅｔ ａｌ: 'Ｈｕｍａｎ ｄｅｎｄｒｉｔｉｃ ｃｅｌｌｓ ｇｅｎｅｔｉｃａｌｌｙ ｅｎｇｉｎｅｅｒｅｄ ｔｏ ｅｘｐｒｅｓｓ ａ ｍｅｌａｎｏｍａ ｐｏｌｙｅｐｉｔｏｐｅ ＤＮＡ ｖａｃｃｉｎｅ ｉｎｄｕｃｅ ｍｕ' Ｃｌｉｎ Ｃａｎｃｅｒ Ｒｅｓ Ｖｏｌ．７， Ｎｏ．１２, 2001, ｐ．４２５３-６１ * |
| JPN6011036734; ＣＨＡＮＧ，Ｓ．Ｓ． ｅｔ ａｌ: 'Ｆｉｖｅ ｄｉｆｆｅｒｅｎｔ ａｎｔｉ-ｐｒｏｓｔａｔｅ-ｓｐｅｃｉｆｉｃ ｍｅｍｂｒａｎｅ ａｎｔｉｇｅｎ （ＰＳＭＡ） ａｎｔｉｂｏｄｉｅｓ ｃｏｎｆｉｒｍ ＰＳＭＡ ｅｘｐｒｅｓｓｉｏｎ ｉｎ' Ｃａｎｃｅｒ Ｒｅｓ Ｖｏｌ．５９， Ｎｏ．１３, 1999, ｐ．３１９２-８ * |
| JPN6011036736; ＣＨＡＮＧ，Ｓ．Ｓ． ｅｔ ａｌ: 'Ｐｒｏｓｔａｔｅ-ｓｐｅｃｉｆｉｃ ｍｅｍｂｒａｎｅ ａｎｔｉｇｅｎ ｉｓ ｐｒｏｄｕｃｅｄ ｉｎ ｔｕｍｏｒ-ａｓｓｏｃｉａｔｅｄ ｎｅｏｖａｓｃｕｌａｔｕｒｅ' Ｃｌｉｎ Ｃａｎｃｅｒ Ｒｅｓ Ｖｏｌ．５， Ｎｏ．１０, 1999, ｐ．２６７４-８１ * |
| JPN6011036740; ＫＥＳＳＬＥＲ，Ｊ．Ｈ． ｅｔ ａｌ: 'Ｅｆｆｉｃｉｅｎｔ ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ｏｆ ｎｏｖｅｌ ＨＬＡ-Ａ（＊）０２０１-ｐｒｅｓｅｎｔｅｄ ｃｙｔｏｔｏｘｉｃ Ｔ ｌｙｍｐｈｏｃｙｔｅ ｅｐｉｔｏｐｅｓ ｉｎ ｔｈｅ ｗｉｄｅ' Ｊ Ｅｘｐ Ｍｅｄ Ｖｏｌ．１９３， Ｎｏ．１, 2001, ｐ．７３-８８ * |
| JPN6011036742; ＭＯＩＮＧＥＯＮ，Ｐ．: 'Ｃａｎｃｅｒ ｖａｃｃｉｎｅｓ' Ｖａｃｃｉｎｅ Ｖｏｌ．１９， Ｎｏ．１１-１２, 2001, ｐ．１３０５-２６ * |
| JPN6011036746; ＭＡＴＳＵＳＨＩＴＡ，Ｍ． ｅｔ ａｌ: 'Ｐｒｅｆｅｒｅｎｔｉａｌｌｙ ｅｘｐｒｅｓｓｅｄ ａｎｔｉｇｅｎ ｏｆ ｍｅｌａｎｏｍａ （ＰＲＡＭＥ） ｉｎ ｔｈｅ ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ｄｉａｇｎｏｓｔｉｃ ａｎｄ ｔｈｅｒａｐｅｕｔｉ' Ｌｅｕｋ Ｌｙｍｐｈｏｍａ Ｖｏｌ．４４， Ｎｏ．３, 2003, ｐ．４３９-４４ * |
| JPN6012031857; ＣＨＡＮＧ，Ｓ．Ｓ．: 'Ｍｏｎｏｃｌｏｎａｌ ａｎｔｉｂｏｄｉｅｓ ａｎｄ ｐｒｏｓｔａｔｅ-ｓｐｅｃｉｆｉｃ ｍｅｍｂｒａｎｅ ａｎｔｉｇｅｎ' Ｃｕｒｒ Ｏｐｉｎ Ｉｎｖｅｓｔｉｇ Ｄｒｕｇｓ Ｖｏｌ．５， Ｎｏ．６, 2004, ｐ．６１１-５ * |
| JPN6012031859; 池田英之ら: 'ＰＲＡＭＥ蛋白を標的とした抗白血病免疫療法の可能性' 今日の移植 Ｖｏｌ．１５， Ｎｏ．１, 2002, ２７-３２ * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013513659A (ja) * | 2009-12-15 | 2013-04-22 | セラヴァック ファーマスウティカルズ エイ ビー | 腫瘍治療における有効なツールとしての腫瘍血管をターゲティングする新規なワクチン |
| KR101807162B1 (ko) * | 2011-04-21 | 2017-12-11 | 주식회사 보령바이젠셀 | 폴로-유사 키나아제 1의 종양항원 단백질 또는 유전자 |
Also Published As
| Publication number | Publication date |
|---|---|
| PL1833506T3 (pl) | 2016-01-29 |
| AU2005321898A1 (en) | 2006-07-06 |
| EP1833506A2 (en) | 2007-09-19 |
| WO2006071983A3 (en) | 2007-03-08 |
| EP1833506B1 (en) | 2015-08-26 |
| WO2006071983A2 (en) | 2006-07-06 |
| WO2006071983A9 (en) | 2007-04-19 |
| US20060159694A1 (en) | 2006-07-20 |
| CA2592968A1 (en) | 2006-07-06 |
| IL184277A0 (en) | 2007-10-31 |
| IL184277A (en) | 2013-02-28 |
| AU2005321898B2 (en) | 2012-07-19 |
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