JP2008524145A5 - - Google Patents

Info

Publication number

JP2008524145A5

JP2008524145A5 JP2007545948A JP2007545948A JP2008524145A5 JP 2008524145 A5 JP2008524145 A5 JP 2008524145A5 JP 2007545948 A JP2007545948 A JP 2007545948A JP 2007545948 A JP2007545948 A JP 2007545948A JP 2008524145 A5 JP2008524145 A5 JP 2008524145A5

Authority

JP

Japan

Prior art keywords

formula

compound

protecting group

hydroxyl protecting

inhibitor

Prior art date

2005-12-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims 28
• 150000003839 salts Chemical class 0.000 claims 10
• 239000012453 solvate Substances 0.000 claims 10
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
• 239000003814 drug Substances 0.000 claims 7
• 208000008589 Obesity Diseases 0.000 claims 6
• 238000000034 method Methods 0.000 claims 6
• 235000020824 obesity Nutrition 0.000 claims 6
• 208000032928 Dyslipidaemia Diseases 0.000 claims 4
• 208000017170 Lipid metabolism disease Diseases 0.000 claims 4
• 238000011917 diastereoselective reduction Methods 0.000 claims 4
• 239000003112 inhibitor Substances 0.000 claims 4
• 206010003210 Arteriosclerosis Diseases 0.000 claims 3
• 208000035150 Hypercholesterolemia Diseases 0.000 claims 3
• 208000031226 Hyperlipidaemia Diseases 0.000 claims 3
• 208000011775 arteriosclerosis disease Diseases 0.000 claims 3
• 208000029078 coronary artery disease Diseases 0.000 claims 3
• 206010012601 diabetes mellitus Diseases 0.000 claims 3
• 208000006575 hypertriglyceridemia Diseases 0.000 claims 3
• 230000009862 primary prevention Effects 0.000 claims 3
• 208000037803 restenosis Diseases 0.000 claims 3
• 230000009863 secondary prevention Effects 0.000 claims 3
• 208000023516 stroke disease Diseases 0.000 claims 3
• HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 2
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
• 208000024827 Alzheimer disease Diseases 0.000 claims 2
• 206010021024 Hypolipidaemia Diseases 0.000 claims 2
• 241001465754 Metazoa Species 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• 239000005557 antagonist Substances 0.000 claims 2
• 239000003613 bile acid Substances 0.000 claims 2
• 238000007796 conventional method Methods 0.000 claims 2
• 239000012025 fluorinating agent Substances 0.000 claims 2
• 208000026621 hypolipoproteinemia Diseases 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 238000002360 preparation method Methods 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 238000006722 reduction reaction Methods 0.000 claims 2
• 239000002904 solvent Substances 0.000 claims 2
• ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 claims 1
• 239000005541 ACE inhibitor Substances 0.000 claims 1
• 208000006989 Alzheimer disease 9 Diseases 0.000 claims 1
• 102000015427 Angiotensins Human genes 0.000 claims 1
• 108010064733 Angiotensins Proteins 0.000 claims 1
• 229940127291 Calcium channel antagonist Drugs 0.000 claims 1
• 101000783577 Dendroaspis angusticeps Thrombostatin Proteins 0.000 claims 1
• 101000783578 Dendroaspis jamesoni kaimosae Dendroaspin Proteins 0.000 claims 1
• 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
• 229940127470 Lipase Inhibitors Drugs 0.000 claims 1
• 102000057248 Lipoprotein(a) Human genes 0.000 claims 1
• 108010033266 Lipoprotein(a) Proteins 0.000 claims 1
• 102000004895 Lipoproteins Human genes 0.000 claims 1
• 108090001030 Lipoproteins Proteins 0.000 claims 1
• 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims 1
• 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims 1
• 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims 1
• 229940119502 Squalene cyclase inhibitor Drugs 0.000 claims 1
• 229940123185 Squalene epoxidase inhibitor Drugs 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 239000003463 adsorbent Substances 0.000 claims 1
• 239000000556 agonist Substances 0.000 claims 1
• 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
• 239000003146 anticoagulant agent Substances 0.000 claims 1
• 229940127219 anticoagulant drug Drugs 0.000 claims 1
• 239000003472 antidiabetic agent Substances 0.000 claims 1
• 229940125708 antidiabetic agent Drugs 0.000 claims 1
• 229940127218 antiplatelet drug Drugs 0.000 claims 1
• 239000002876 beta blocker Substances 0.000 claims 1
• 229940097320 beta blocking agent Drugs 0.000 claims 1
• 239000000480 calcium channel blocker Substances 0.000 claims 1
• 230000001906 cholesterol absorption Effects 0.000 claims 1
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
• 230000006806 disease prevention Effects 0.000 claims 1
• 239000002934 diuretic Substances 0.000 claims 1
• 230000001882 diuretic effect Effects 0.000 claims 1
• 239000003623 enhancer Substances 0.000 claims 1
• 229940125753 fibrate Drugs 0.000 claims 1
• 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 231100000252 nontoxic Toxicity 0.000 claims 1
• 230000003000 nontoxic effect Effects 0.000 claims 1
• 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 1
• 239000000106 platelet aggregation inhibitor Substances 0.000 claims 1
• 230000009103 reabsorption Effects 0.000 claims 1
• 239000000018 receptor agonist Substances 0.000 claims 1
• 229940044601 receptor agonist Drugs 0.000 claims 1
• 230000001568 sexual effect Effects 0.000 claims 1
• 229940127296 soluble guanylate cyclase stimulator Drugs 0.000 claims 1
• 239000004059 squalene synthase inhibitor Substances 0.000 claims 1
• 108090000721 thyroid hormone receptors Proteins 0.000 claims 1
• 102000004217 thyroid hormone receptors Human genes 0.000 claims 1
• BHKIPHICFOJGLD-HOFKKMOUSA-N CC(C)(C1)Cc2nc(C3CCCC3)c([C@H](c3ccc(C(F)(F)F)cc3)F)c(C3CCCCC3)c2[C@H]1O Chemical compound CC(C)(C1)Cc2nc(C3CCCC3)c([C@H](c3ccc(C(F)(F)F)cc3)F)c(C3CCCCC3)c2[C@H]1O BHKIPHICFOJGLD-HOFKKMOUSA-N 0.000 description 1
• 0 CC(C)(C1)Cc2nc(C3CCCC3)c([C@](c3ccc(C(F)(F)F)cc3)F)c(C3CCCCC3)c2[C@]1O* Chemical compound CC(C)(C1)Cc2nc(C3CCCC3)c([C@](c3ccc(C(F)(F)F)cc3)F)c(C3CCCCC3)c2[C@]1O* 0.000 description 1