AU2005315770B2 - 4-cycloalkyl-substituted tetrahydrochinoline derivatives and use thereof as medicaments - Google Patents
4-cycloalkyl-substituted tetrahydrochinoline derivatives and use thereof as medicaments Download PDFInfo
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- AU2005315770B2 AU2005315770B2 AU2005315770A AU2005315770A AU2005315770B2 AU 2005315770 B2 AU2005315770 B2 AU 2005315770B2 AU 2005315770 A AU2005315770 A AU 2005315770A AU 2005315770 A AU2005315770 A AU 2005315770A AU 2005315770 B2 AU2005315770 B2 AU 2005315770B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/04—Anorexiants; Antiobesity agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004060997.7 | 2004-12-18 | ||
| DE102004060997A DE102004060997A1 (de) | 2004-12-18 | 2004-12-18 | Chemische Verbindung und ihre Verwendung |
| DE102004061000.2 | 2004-12-18 | ||
| DE102004061000A DE102004061000A1 (de) | 2004-12-18 | 2004-12-18 | Chemische Verbindung und ihre Verwendung |
| PCT/EP2005/013490 WO2006063828A1 (de) | 2004-12-18 | 2005-12-15 | 4-cycloalkyl-substituierte tetrahydrochinolinderivate und deren verwendung als medikamente |
Publications (2)
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| AU2005315770A1 AU2005315770A1 (en) | 2006-06-22 |
| AU2005315770B2 true AU2005315770B2 (en) | 2011-12-08 |
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| AU2005315770A Ceased AU2005315770B2 (en) | 2004-12-18 | 2005-12-15 | 4-cycloalkyl-substituted tetrahydrochinoline derivatives and use thereof as medicaments |
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|---|---|
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| EP (1) | EP1828137B1 (enExample) |
| JP (1) | JP5132317B2 (enExample) |
| KR (1) | KR20070090248A (enExample) |
| AR (1) | AR055011A1 (enExample) |
| AT (1) | ATE555097T1 (enExample) |
| AU (1) | AU2005315770B2 (enExample) |
| BR (1) | BRPI0519602A2 (enExample) |
| CA (1) | CA2591397A1 (enExample) |
| CU (1) | CU23452B7 (enExample) |
| CY (1) | CY1112887T1 (enExample) |
| DK (1) | DK1828137T3 (enExample) |
| DO (1) | DOP2005000259A (enExample) |
| ES (1) | ES2384980T3 (enExample) |
| GT (1) | GT200500377A (enExample) |
| IL (1) | IL184008A (enExample) |
| MA (1) | MA29100B1 (enExample) |
| MX (1) | MX2007007188A (enExample) |
| NO (1) | NO20073146L (enExample) |
| PE (1) | PE20060767A1 (enExample) |
| PL (1) | PL1828137T3 (enExample) |
| PT (1) | PT1828137E (enExample) |
| RU (1) | RU2393151C2 (enExample) |
| SI (1) | SI1828137T1 (enExample) |
| TW (1) | TW200635900A (enExample) |
| UY (1) | UY29276A1 (enExample) |
| WO (1) | WO2006063828A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005324127A1 (en) * | 2004-12-18 | 2006-07-13 | Bayer Healthcare Ag | (5S) -3-[(S)-fluoro (4-trifluoromethylphenyl) methyl]-5,6,7,8-tetrahydroquinoline-5-ol derivatives and use thereof as CETP inhibitors |
| DE102006012548A1 (de) * | 2006-03-18 | 2007-09-20 | Bayer Healthcare Ag | Substituierte Chromanol-Derivate und ihre Verwendung |
| ATE520696T1 (de) * | 2008-03-05 | 2011-09-15 | Boehringer Ingelheim Int | Tricyclische pyridinderivate, solche verbindungen enthaltende medikamente, ihre verwendung und verfahren zu ihrer herstellung |
| MA34007B1 (fr) | 2010-02-19 | 2013-02-01 | Boehringer Ingelheim Int | Derives de pyridine tricycliques medicaments contenant ces composes leur utilisation et leur procede de preparation |
| US9187450B2 (en) * | 2010-07-09 | 2015-11-17 | Daiichi Sankyo Company, Limited | Substituted pyridine compound |
| WO2012110599A1 (en) | 2011-02-17 | 2012-08-23 | Boehringer Ingelheim International Gmbh | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
| US9150583B2 (en) | 2011-08-17 | 2015-10-06 | Boehringer Ingelheim International Gmbh | Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation |
| US9321747B2 (en) | 2012-01-06 | 2016-04-26 | Daiichi Sankyo Company, Limited | Acid addition salt of substituted pyridine compound |
| WO2016016157A1 (en) | 2014-07-30 | 2016-02-04 | F. Hoffmann-La Roche Ag | Genetic markers for predicting responsiveness to therapy with hdl-raising or hdl mimicking agent |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6069148A (en) * | 1996-07-08 | 2000-05-30 | Bayer Aktiengesellschaft | Cycloalkano-pyridines |
| US6291477B1 (en) * | 1997-09-19 | 2001-09-18 | Bayer Aktiengesellschaft | Tetrahydroquinolines, processes for their preparation, pharmaceutical compositions containing them, and their use to prevent or treat hyperlipoproteinaemia |
| CA2462030A1 (en) * | 2001-10-01 | 2003-04-10 | Bayer Healthcare Ag | 3-`hydroxy-(-4-trifluoromethylphenyl)-methyl-7-spirocyclobutyl-5,6,7,8-tetrahydroquinolin-5-ol derivatives and the use of the same as cholesterol ester transfer protein (cetp) inhibitors |
| US6586613B1 (en) * | 1997-09-18 | 2003-07-01 | Bayer Aktiengellschaft | Substituted tetrahydronaphthaline and analogous compounds |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4128681A1 (de) * | 1991-08-29 | 1993-03-04 | Bayer Ag | Substituierte mandelsaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| DE19610932A1 (de) | 1996-03-20 | 1997-09-25 | Bayer Ag | 2-Aryl-substituierte Pyridine |
| DE19627430A1 (de) | 1996-07-08 | 1998-01-15 | Bayer Ag | Bicyclisch kondensierte Pyridine |
| US6207671B1 (en) | 1996-07-08 | 2001-03-27 | Bayer Aktiengesellschaft | Cycloalkano-pyridines |
| DE19627431A1 (de) | 1996-07-08 | 1998-01-15 | Bayer Ag | Heterocyclisch kondensierte Pyridine |
| DE19704244A1 (de) | 1997-02-05 | 1998-08-06 | Bayer Ag | 5-Hydroxy-alkyl substituierte Phenyle |
| DE19709125A1 (de) | 1997-03-06 | 1998-09-10 | Bayer Ag | Substituierte Chinoline |
| DE19741051A1 (de) | 1997-09-18 | 1999-03-25 | Bayer Ag | Hetero-Tetrahydrochinoline |
| DE19935966A1 (de) | 1999-07-30 | 2001-02-01 | Bayer Ag | Verfahren zur Reduktion von Ketoalkoholen |
| DE10250687A1 (de) | 2002-10-31 | 2004-05-13 | Bayer Ag | 7H-Dibenzo(b,g)(1,5)dioxocin-5-on-Derivate und ihre Verwendung |
| AU2005324127A1 (en) * | 2004-12-18 | 2006-07-13 | Bayer Healthcare Ag | (5S) -3-[(S)-fluoro (4-trifluoromethylphenyl) methyl]-5,6,7,8-tetrahydroquinoline-5-ol derivatives and use thereof as CETP inhibitors |
-
2005
- 2005-12-15 WO PCT/EP2005/013490 patent/WO2006063828A1/de not_active Ceased
- 2005-12-15 KR KR1020077016219A patent/KR20070090248A/ko not_active Ceased
- 2005-12-15 EP EP05820528A patent/EP1828137B1/de not_active Expired - Lifetime
- 2005-12-15 BR BRPI0519602-7A patent/BRPI0519602A2/pt not_active IP Right Cessation
- 2005-12-15 SI SI200531547T patent/SI1828137T1/sl unknown
- 2005-12-15 CA CA002591397A patent/CA2591397A1/en not_active Abandoned
- 2005-12-15 PL PL05820528T patent/PL1828137T3/pl unknown
- 2005-12-15 US US11/793,482 patent/US8124775B2/en not_active Expired - Fee Related
- 2005-12-15 JP JP2007545948A patent/JP5132317B2/ja not_active Expired - Fee Related
- 2005-12-15 RU RU2007127127/04A patent/RU2393151C2/ru not_active IP Right Cessation
- 2005-12-15 ES ES05820528T patent/ES2384980T3/es not_active Expired - Lifetime
- 2005-12-15 PT PT05820528T patent/PT1828137E/pt unknown
- 2005-12-15 DK DK05820528.7T patent/DK1828137T3/da active
- 2005-12-15 MX MX2007007188A patent/MX2007007188A/es active IP Right Grant
- 2005-12-15 AT AT05820528T patent/ATE555097T1/de active
- 2005-12-15 AU AU2005315770A patent/AU2005315770B2/en not_active Ceased
- 2005-12-16 TW TW094144588A patent/TW200635900A/zh unknown
- 2005-12-16 AR ARP050105313A patent/AR055011A1/es not_active Application Discontinuation
- 2005-12-16 PE PE2005001475A patent/PE20060767A1/es not_active Application Discontinuation
- 2005-12-16 DO DO2005P000259A patent/DOP2005000259A/es unknown
- 2005-12-19 GT GT200500377A patent/GT200500377A/es unknown
- 2005-12-20 UY UY29276A patent/UY29276A1/es not_active Application Discontinuation
-
2007
- 2007-06-18 IL IL184008A patent/IL184008A/en not_active IP Right Cessation
- 2007-06-18 CU CU20070140A patent/CU23452B7/es not_active IP Right Cessation
- 2007-06-18 MA MA30003A patent/MA29100B1/fr unknown
- 2007-06-19 NO NO20073146A patent/NO20073146L/no not_active Application Discontinuation
-
2012
- 2012-02-16 US US13/398,290 patent/US20120142728A1/en not_active Abandoned
- 2012-06-29 CY CY20121100588T patent/CY1112887T1/el unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6069148A (en) * | 1996-07-08 | 2000-05-30 | Bayer Aktiengesellschaft | Cycloalkano-pyridines |
| US6586613B1 (en) * | 1997-09-18 | 2003-07-01 | Bayer Aktiengellschaft | Substituted tetrahydronaphthaline and analogous compounds |
| US6291477B1 (en) * | 1997-09-19 | 2001-09-18 | Bayer Aktiengesellschaft | Tetrahydroquinolines, processes for their preparation, pharmaceutical compositions containing them, and their use to prevent or treat hyperlipoproteinaemia |
| CA2462030A1 (en) * | 2001-10-01 | 2003-04-10 | Bayer Healthcare Ag | 3-`hydroxy-(-4-trifluoromethylphenyl)-methyl-7-spirocyclobutyl-5,6,7,8-tetrahydroquinolin-5-ol derivatives and the use of the same as cholesterol ester transfer protein (cetp) inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| PE20060767A1 (es) | 2006-09-10 |
| IL184008A0 (en) | 2007-10-31 |
| US20080255068A1 (en) | 2008-10-16 |
| GT200500377A (es) | 2006-11-09 |
| MX2007007188A (es) | 2007-08-14 |
| DOP2005000259A (es) | 2006-11-15 |
| KR20070090248A (ko) | 2007-09-05 |
| ATE555097T1 (de) | 2012-05-15 |
| AR055011A1 (es) | 2007-08-01 |
| IL184008A (en) | 2012-03-29 |
| BRPI0519602A2 (pt) | 2009-02-25 |
| JP5132317B2 (ja) | 2013-01-30 |
| CY1112887T1 (el) | 2016-04-13 |
| TW200635900A (en) | 2006-10-16 |
| EP1828137B1 (de) | 2012-04-25 |
| PL1828137T3 (pl) | 2012-09-28 |
| EP1828137A1 (de) | 2007-09-05 |
| AU2005315770A1 (en) | 2006-06-22 |
| MA29100B1 (fr) | 2007-12-03 |
| CU23452B7 (es) | 2009-12-01 |
| NO20073146L (no) | 2007-09-18 |
| UY29276A1 (es) | 2006-07-31 |
| PT1828137E (pt) | 2012-07-04 |
| RU2393151C2 (ru) | 2010-06-27 |
| SI1828137T1 (sl) | 2012-08-31 |
| WO2006063828A1 (de) | 2006-06-22 |
| US8124775B2 (en) | 2012-02-28 |
| US20120142728A1 (en) | 2012-06-07 |
| CA2591397A1 (en) | 2006-06-22 |
| DK1828137T3 (da) | 2012-07-23 |
| RU2007127127A (ru) | 2009-01-27 |
| ES2384980T3 (es) | 2012-07-16 |
| JP2008524145A (ja) | 2008-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT Free format text: FORMER APPLICANT(S): BAYER HEALTHCARE AG |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |