JP2008523041A5 - - Google Patents

Download PDF

Info

Publication number
JP2008523041A5
JP2008523041A5 JP2007544984A JP2007544984A JP2008523041A5 JP 2008523041 A5 JP2008523041 A5 JP 2008523041A5 JP 2007544984 A JP2007544984 A JP 2007544984A JP 2007544984 A JP2007544984 A JP 2007544984A JP 2008523041 A5 JP2008523041 A5 JP 2008523041A5
Authority
JP
Japan
Prior art keywords
alkyl
amino
independently selected
alkoxy
imidazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007544984A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008523041A (ja
JP5197014B2 (ja
Filing date
Publication date
Priority claimed from GB0427138A external-priority patent/GB0427138D0/en
Priority claimed from GB0516435A external-priority patent/GB0516435D0/en
Application filed filed Critical
Priority claimed from PCT/GB2005/004743 external-priority patent/WO2006061638A2/en
Publication of JP2008523041A publication Critical patent/JP2008523041A/ja
Publication of JP2008523041A5 publication Critical patent/JP2008523041A5/ja
Application granted granted Critical
Publication of JP5197014B2 publication Critical patent/JP5197014B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2007544984A 2004-12-10 2005-12-09 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体 Expired - Lifetime JP5197014B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0427138.3 2004-12-10
GB0427138A GB0427138D0 (en) 2004-12-10 2004-12-10 Therapeutic compounds
GB0516435A GB0516435D0 (en) 2005-08-11 2005-08-11 Therapeutic compounds
GB0516435.5 2005-08-11
PCT/GB2005/004743 WO2006061638A2 (en) 2004-12-10 2005-12-09 Heterocycle derivatives as histone deacetylase (hdac) inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012251740A Division JP5878859B2 (ja) 2004-12-10 2012-11-16 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体

Publications (3)

Publication Number Publication Date
JP2008523041A JP2008523041A (ja) 2008-07-03
JP2008523041A5 true JP2008523041A5 (enExample) 2010-12-02
JP5197014B2 JP5197014B2 (ja) 2013-05-15

Family

ID=36424637

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007544984A Expired - Lifetime JP5197014B2 (ja) 2004-12-10 2005-12-09 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体
JP2012251740A Expired - Lifetime JP5878859B2 (ja) 2004-12-10 2012-11-16 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012251740A Expired - Lifetime JP5878859B2 (ja) 2004-12-10 2012-11-16 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体

Country Status (7)

Country Link
US (1) US7863294B2 (enExample)
EP (1) EP1828171B1 (enExample)
JP (2) JP5197014B2 (enExample)
AU (1) AU2005313108B2 (enExample)
CA (1) CA2590811C (enExample)
ES (1) ES2462341T3 (enExample)
WO (1) WO2006061638A2 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8017321B2 (en) 2004-01-23 2011-09-13 The Regents Of The University Of Colorado, A Body Corporate Gefitinib sensitivity-related gene expression and products and methods related thereto
ES2553264T3 (es) 2004-05-27 2015-12-07 The Regents Of The University Of Colorado Métodos para la predicción del resultado clínico para inhibidores del receptor del factor de crecimiento epidérmico para pacientes de cáncer
GB0518237D0 (en) 2005-09-07 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0522130D0 (en) 2005-10-31 2005-12-07 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2007070816A2 (en) * 2005-12-14 2007-06-21 Bristol-Myers Squibb Company Thiophene derivatives as factor xia inhibitors
US7626039B2 (en) 2005-12-14 2009-12-01 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, ayrlpropynamide, or arylmethylurea analogs as factor XIa inhibitors
GB0526107D0 (en) * 2005-12-22 2006-02-01 Angeletti P Ist Richerche Bio Therapeutic Compounds
WO2011053607A1 (en) 2009-10-26 2011-05-05 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
WO2009042646A1 (en) * 2007-09-24 2009-04-02 Curis, Inc. Anti-proliferative agents
KR20110079763A (ko) * 2008-10-29 2011-07-07 서트리스 파마슈티컬즈, 인코포레이티드 시르투인 조절제로서의 피리딘, 비시클릭 피리딘 및 관련 유사체
GB0900484D0 (en) 2009-01-13 2009-02-11 Angeletti P Ist Richerche Bio Therapeutic agent
GB0916608D0 (en) 2009-09-22 2009-11-04 Angeletti P Ist Richerche Bio Therapeutic compounds
AU2010306750B2 (en) 2009-10-15 2014-11-13 Children's Medical Center Corporation Sepiapterin reductase inhibitors for the treatment of pain
JP2013517281A (ja) 2010-01-13 2013-05-16 テンペロ、ファーマシューティカルズ、インコーポレイテッド 化合物及び方法
US20120322827A1 (en) * 2010-01-13 2012-12-20 Erkan Baloglu Compounds and methods
CN103221047B (zh) * 2010-01-13 2014-12-17 坦颇罗制药股份有限公司 化合物和方法
US8946223B2 (en) 2010-04-12 2015-02-03 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
EP2606033A1 (de) * 2010-08-20 2013-06-26 Grünenthal GmbH Substituierte cyclische carboxamid- und harnstoff-derivate als liganden des vanilloid-rezeptors
JP2013545740A (ja) * 2010-11-10 2013-12-26 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング バニロイド受容体リガンドとしての置換された複素芳香族カルボキサミド誘導体および尿素誘導体
WO2013006408A1 (en) * 2011-07-01 2013-01-10 Tempero Pharmaceuticals, Inc. Compounds and methods
WO2013005798A1 (ja) * 2011-07-06 2013-01-10 持田製薬株式会社 新規含窒素複素環誘導体
WO2013009810A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013009827A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013009830A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013009812A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc Methods of treatment
ITRM20120405A1 (it) 2012-08-09 2014-02-10 C N C C S Scarl Collezione Naziona Le Dei Compost Compounds for use in the treatment of disorders that are ameliorated by inhibition of hdac
JP6453218B2 (ja) 2012-08-24 2019-01-16 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 疾患を治療するためのｈｉｆ活性の複素環式修飾物質
ITRM20120530A1 (it) * 2012-10-31 2014-05-01 C N C C S S C A R L Collezione Na Zionale Dei Co Compounds for use in the treatment of parasitic diseases
CN103588761B (zh) * 2013-10-22 2015-05-27 湖南大学 N-[1-(苯并呋喃-5-基)-2-氧代乙基]苯并吡喃-4-酰胺的制备与应用
EP3291809B1 (en) 2015-05-07 2021-08-25 CHDI Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
MX378983B (es) 2015-05-07 2025-03-10 Chdi Foundation Inc Inhibidores de histona deacetilasa y composiciones y metodos para el uso de los mismos.
WO2018094005A1 (en) 2016-11-16 2018-05-24 The General Hospital Corporation Myeloperoxidase imaging agents
CN107226791B (zh) * 2017-06-13 2020-07-10 贵州医科大学 氮氧化物作为新型组蛋白去乙酰化酶抑制剂的抗肿瘤应用
US11731952B2 (en) 2017-08-31 2023-08-22 Musc Foundation For Research Development Indene derivatives and uses thereof
US12331044B2 (en) 2018-08-01 2025-06-17 Merck Sharp & Dohme Llc Inhibitors of histone deacetylase useful for the treatment or prevention of HIV infection
US20210403479A1 (en) * 2018-11-08 2021-12-30 Merck Sharp & Dohme Corp. Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection
WO2020150091A1 (en) * 2019-01-15 2020-07-23 Merck Sharp & Dohme Corp. Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection
WO2020190827A1 (en) 2019-03-21 2020-09-24 Merck Sharp & Dohme Corp. Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection
CN110776521A (zh) * 2019-10-24 2020-02-11 秦源生物医药科技(上海)有限公司 一种1,2,4-三唑-1,3,4-噻二唑类化合物及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001505585A (ja) * 1996-12-16 2001-04-24 藤沢薬品工業株式会社 新規アミド化合物およびそれらの一酸化窒素シンターゼ阻害剤としての用途
DK1086086T3 (da) * 1998-06-12 2005-01-24 Sod Conseils Rech Applic Imidazolylderivater og anvendelse deraf som somatostatinreceptorligander
TWI292316B (en) * 1999-10-11 2008-01-11 Sod Conseils Rech Applic Pharmaceutical composition of thiazole derivatives intended to inhibit mao and/or lipidic peroxidation and/or to act as modulators of sodium channels and the use thereof
ES2282275T3 (es) * 2000-08-01 2007-10-16 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivados de imidazolilo.
AU2003900608A0 (en) * 2003-02-11 2003-02-27 Fujisawa Pharmaceutical Co., Ltd. Hdac inhibitor
WO2004071448A2 (en) * 2003-02-12 2004-08-26 Transtech Pharma Inc. Substituted azole derivatives as inhibitors of protein tyrosine phosphatases
AU2005261487A1 (en) 2004-07-12 2006-01-19 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Amide derivatives as inhibitors of histone deacetylase
EP1768956A1 (en) 2004-07-12 2007-04-04 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Amide derivatives as inhibitors of histone deacetylase
GB0522130D0 (en) 2005-10-31 2005-12-07 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0526107D0 (en) 2005-12-22 2006-02-01 Angeletti P Ist Richerche Bio Therapeutic Compounds

Similar Documents

Publication Publication Date Title
JP2008523041A5 (enExample)
TWI579284B (zh) 咪唑并吡咯啶酮化合物
RU2436780C2 (ru) Производные 5-фенилтиазола и их применение в качестве ингибиторов рi3 киназы
CA2934137C (en) Novel carboxamides, method for the production thereof, pharmaceutical preparations comprising them, and use thereof for producing medicaments
DK2451794T3 (en) 1,2,4-thiazolidin-3-ONE DERIVATIVES AND THEIR USE IN CANCER TREATMENT
JP2010533158A5 (enExample)
CA2913223A1 (en) Pyrazolopyrrolidine derivatives and their use in the treatment of disease
JP2012525431A5 (enExample)
ES2967119T3 (es) Compuestos inhibidores de metaloenzimas
KR101363090B1 (ko) 아자비시클로 헥산 유도체의 용도
JP2017508766A5 (enExample)
JP2007505933A5 (enExample)
JP2016512511A5 (enExample)
WO2017191000A9 (en) Aromatic sulfonamide derivatives
JP2006504658A5 (enExample)
JP2011503166A5 (enExample)
CN103096718A (zh) 可溶性鸟苷酸环化酶活化剂
RU2012139828A (ru) Производные пиразолопиперидина в качестве ингибиторов nadph-оксидазы
JP2013532652A5 (enExample)
JP2017505762A5 (enExample)
MX2010013399A (es) Nuevos compuestos de 1,2,4-oxadiazol y sus metodos de uso.
WO2020009971A1 (en) Pikfyve inhibitors
JP2013515032A5 (enExample)
AU2023261964A1 (en) Compounds for inhibiting kif18a
RU2009123525A (ru) ПРОИЗВОДНЫЕ 5-СУЛЬФАНИЛМЕТИЛ[1,2,4}ТРИАЗОЛ[1,5-а]ПИРИМИДИН-7-ОЛА В КАЧЕСТВЕ АНТАГОНИСТОВ CXCR2