JP5197014B2 - ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体 - Google Patents

ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体 Download PDF

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JP5197014B2
JP5197014B2 JP2007544984A JP2007544984A JP5197014B2 JP 5197014 B2 JP5197014 B2 JP 5197014B2 JP 2007544984 A JP2007544984 A JP 2007544984A JP 2007544984 A JP2007544984 A JP 2007544984A JP 5197014 B2 JP5197014 B2 JP 5197014B2
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Prior art keywords
amino
alkyl
imidazol
methyl
ium
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Japanese (ja)
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JP2008523041A5 (enExample
JP2008523041A (ja
Inventor
アテンニ，バルバラ
フエリグノ，フエデリカ
ジヨーンズ，フイリツプ
インジエニト，ラフアエル
キンツエル，オラフ
リヤウヘル・ブフイ，ラウラ
オントリア・オントリア，ヘスス・マリア
ペスカトーレ，ジヨバンナ
ローリー，マイケル
スカルペツリ，リタ
シユルツ，カルステン
Original Assignee
イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ
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Priority claimed from GB0427138A external-priority patent/GB0427138D0/en
Priority claimed from GB0516435A external-priority patent/GB0516435D0/en
Application filed by イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ filed Critical イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ
Publication of JP2008523041A publication Critical patent/JP2008523041A/ja
Publication of JP2008523041A5 publication Critical patent/JP2008523041A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
JP2007544984A 2004-12-10 2005-12-09 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体 Expired - Lifetime JP5197014B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0427138.3 2004-12-10
GB0427138A GB0427138D0 (en) 2004-12-10 2004-12-10 Therapeutic compounds
GB0516435.5 2005-08-11
GB0516435A GB0516435D0 (en) 2005-08-11 2005-08-11 Therapeutic compounds
PCT/GB2005/004743 WO2006061638A2 (en) 2004-12-10 2005-12-09 Heterocycle derivatives as histone deacetylase (hdac) inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012251740A Division JP5878859B2 (ja) 2004-12-10 2012-11-16 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体

Publications (3)

Publication Number Publication Date
JP2008523041A JP2008523041A (ja) 2008-07-03
JP2008523041A5 JP2008523041A5 (enExample) 2010-12-02
JP5197014B2 true JP5197014B2 (ja) 2013-05-15

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JP2007544984A Expired - Lifetime JP5197014B2 (ja) 2004-12-10 2005-12-09 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体
JP2012251740A Expired - Lifetime JP5878859B2 (ja) 2004-12-10 2012-11-16 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体

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JP2012251740A Expired - Lifetime JP5878859B2 (ja) 2004-12-10 2012-11-16 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体

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US (1) US7863294B2 (enExample)
EP (1) EP1828171B1 (enExample)
JP (2) JP5197014B2 (enExample)
AU (1) AU2005313108B2 (enExample)
CA (1) CA2590811C (enExample)
ES (1) ES2462341T3 (enExample)
WO (1) WO2006061638A2 (enExample)

Families Citing this family (39)

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Publication number Priority date Publication date Assignee Title
WO2005070020A2 (en) 2004-01-23 2005-08-04 The Regents Of The University Of Colorado Gefitinib sensitivity-related gene expression and products and methods related thereto
WO2005117553A2 (en) 2004-05-27 2005-12-15 The Regents Of The University Of Colorado Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients
GB0518237D0 (en) 2005-09-07 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0522130D0 (en) 2005-10-31 2005-12-07 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2007070816A2 (en) * 2005-12-14 2007-06-21 Bristol-Myers Squibb Company Thiophene derivatives as factor xia inhibitors
EA014245B1 (ru) 2005-12-14 2010-10-29 Бристол-Маерс Сквибб Компани Аналоги арилпропионамида, арилакриламида, арилпропинамида или арилметилмочевины в качестве ингибиторов фактора xia
GB0526107D0 (en) * 2005-12-22 2006-02-01 Angeletti P Ist Richerche Bio Therapeutic Compounds
WO2011053607A1 (en) 2009-10-26 2011-05-05 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
WO2009042646A1 (en) * 2007-09-24 2009-04-02 Curis, Inc. Anti-proliferative agents
US20110263564A1 (en) * 2008-10-29 2011-10-27 Sirtris Pharmaceuticals, Inc. Pyridine, bicyclic pyridine and related analogs as sirtuin modulators
GB0900484D0 (en) 2009-01-13 2009-02-11 Angeletti P Ist Richerche Bio Therapeutic agent
GB0916608D0 (en) 2009-09-22 2009-11-04 Angeletti P Ist Richerche Bio Therapeutic compounds
AU2010306750B2 (en) 2009-10-15 2014-11-13 Children's Medical Center Corporation Sepiapterin reductase inhibitors for the treatment of pain
JP2013517281A (ja) 2010-01-13 2013-05-16 テンペロ、ファーマシューティカルズ、インコーポレイテッド 化合物及び方法
JP2013517279A (ja) * 2010-01-13 2013-05-16 テンペロ、ファーマシューティカルズ、インコーポレイテッド 化合物及び方法
KR101781663B1 (ko) * 2010-01-13 2017-09-25 템페로 파마슈티칼즈, 인크. 히스톤 데아세틸라제 효소를 억제하기 위한 화합물 및 이를 제조하는 방법
WO2011130163A1 (en) * 2010-04-12 2011-10-20 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
AR082498A1 (es) * 2010-08-20 2012-12-12 Gruenenthal Gmbh Derivados ciclicos de carboxamida y urea sustituidos como ligandos del receptor de vainiloide
EP2638034A1 (en) * 2010-11-10 2013-09-18 Grünenthal GmbH Substituted heteroaromatic carboxamide and urea derivatives as vanilloid receptor ligands
WO2013006408A1 (en) * 2011-07-01 2013-01-10 Tempero Pharmaceuticals, Inc. Compounds and methods
WO2013005798A1 (ja) * 2011-07-06 2013-01-10 持田製薬株式会社 新規含窒素複素環誘導体
WO2013009812A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc Methods of treatment
WO2013009810A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013009827A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013009830A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
ITRM20120405A1 (it) * 2012-08-09 2014-02-10 C N C C S Scarl Collezione Naziona Le Dei Compost Compounds for use in the treatment of disorders that are ameliorated by inhibition of hdac
WO2014031936A2 (en) 2012-08-24 2014-02-27 Philip Jones Heterocyclic modulators of hif activity for treatment of disease
ITRM20120530A1 (it) * 2012-10-31 2014-05-01 C N C C S S C A R L Collezione Na Zionale Dei Co Compounds for use in the treatment of parasitic diseases
CN103588761B (zh) * 2013-10-22 2015-05-27 湖南大学 N-[1-(苯并呋喃-5-基)-2-氧代乙基]苯并吡喃-4-酰胺的制备与应用
KR20180002730A (ko) * 2015-05-07 2018-01-08 씨에이치디아이 파운데이션, 인코포레이티드 히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법
AU2016258188B2 (en) 2015-05-07 2021-08-26 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
WO2018094005A1 (en) * 2016-11-16 2018-05-24 The General Hospital Corporation Myeloperoxidase imaging agents
CN107226791B (zh) * 2017-06-13 2020-07-10 贵州医科大学 氮氧化物作为新型组蛋白去乙酰化酶抑制剂的抗肿瘤应用
US10329269B2 (en) 2017-08-31 2019-06-25 Leukogene Therapeutics Incorporated Indene derivatives and uses thereof
WO2020028150A1 (en) 2018-08-01 2020-02-06 Merck Sharp & Dohme Corp. Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection
WO2020096916A2 (en) * 2018-11-08 2020-05-14 Merck Sharp & Dohme Corp. Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection
WO2020150091A1 (en) * 2019-01-15 2020-07-23 Merck Sharp & Dohme Corp. Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection
EP3941457A4 (en) * 2019-03-21 2023-04-26 Merck Sharp & Dohme LLC HISTONE-DEACETYLASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF HIV INFECTION
CN110776521A (zh) * 2019-10-24 2020-02-11 秦源生物医药科技(上海)有限公司 一种1,2,4-三唑-1,3,4-噻二唑类化合物及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998027108A2 (en) * 1996-12-16 1998-06-25 Fujisawa Pharmaceutical Co., Ltd. New amide compounds and their use as nitric oxide synthase inhibitors
WO1999064401A2 (en) * 1998-06-12 1999-12-16 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Imidazolyl derivatives and their use as somatostatin receptor ligands
TWI283577B (en) * 1999-10-11 2007-07-11 Sod Conseils Rech Applic Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof
NZ523774A (en) 2000-08-01 2004-09-24 Sod Conseils Rech Applic Imidazolyl derivatives
AU2003900608A0 (en) * 2003-02-11 2003-02-27 Fujisawa Pharmaceutical Co., Ltd. Hdac inhibitor
WO2004071448A2 (en) * 2003-02-12 2004-08-26 Transtech Pharma Inc. Substituted azole derivatives as inhibitors of protein tyrosine phosphatases
CN101133024A (zh) 2004-07-12 2008-02-27 P.安杰莱蒂分子生物学研究所 作为组蛋白脱乙酰酶抑制剂的酰胺衍生物
US20080221157A1 (en) 2004-07-12 2008-09-11 Istituto Di Ricerche Di Biologia Molecolare P Ange Amide Derivatives as Inhibitors of Histone Deacetylase
GB0522130D0 (en) 2005-10-31 2005-12-07 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0526107D0 (en) 2005-12-22 2006-02-01 Angeletti P Ist Richerche Bio Therapeutic Compounds

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