JP2008522968A5 - - Google Patents
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- Publication number
- JP2008522968A5 JP2008522968A5 JP2007544307A JP2007544307A JP2008522968A5 JP 2008522968 A5 JP2008522968 A5 JP 2008522968A5 JP 2007544307 A JP2007544307 A JP 2007544307A JP 2007544307 A JP2007544307 A JP 2007544307A JP 2008522968 A5 JP2008522968 A5 JP 2008522968A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- thioxo
- pyrrolo
- pyrimidin
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0402972A SE0402972D0 (sv) | 2004-12-06 | 2004-12-06 | Novel compounds |
| SE0402972-4 | 2004-12-06 | ||
| SE0501093-9 | 2005-05-13 | ||
| SE0501093 | 2005-05-13 | ||
| PCT/SE2005/001835 WO2006062465A1 (en) | 2004-12-06 | 2005-12-05 | Novel pyrrolo [3, 2-d] pyrimidin-4-one derivatives and their use in therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008522968A JP2008522968A (ja) | 2008-07-03 |
| JP2008522968A5 true JP2008522968A5 (https=) | 2009-01-22 |
| JP5028270B2 JP5028270B2 (ja) | 2012-09-19 |
Family
ID=36578191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007544307A Expired - Lifetime JP5028270B2 (ja) | 2004-12-06 | 2005-12-05 | 新規なピロロ［３，２−ｄ］ピリミジン−４−オン誘導体および治療でのその使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US7829707B2 (https=) |
| EP (1) | EP1824855B1 (https=) |
| JP (1) | JP5028270B2 (https=) |
| KR (3) | KR101557715B1 (https=) |
| CN (1) | CN101072778B (https=) |
| AR (1) | AR051698A1 (https=) |
| AU (1) | AU2005312388B2 (https=) |
| BR (1) | BRPI0518846B1 (https=) |
| CA (1) | CA2591314C (https=) |
| CY (1) | CY1113209T1 (https=) |
| DK (1) | DK1824855T3 (https=) |
| ES (1) | ES2390888T3 (https=) |
| HR (1) | HRP20120781T1 (https=) |
| IL (1) | IL183182A (https=) |
| ME (1) | ME01486B (https=) |
| MX (1) | MX2007006497A (https=) |
| MY (1) | MY140748A (https=) |
| NO (1) | NO20072399L (https=) |
| NZ (1) | NZ555046A (https=) |
| PL (1) | PL1824855T3 (https=) |
| PT (1) | PT1824855E (https=) |
| RS (1) | RS52490B (https=) |
| RU (2) | RU2409578C2 (https=) |
| SA (1) | SA05260385B1 (https=) |
| SI (1) | SI1824855T1 (https=) |
| TW (1) | TWI365189B (https=) |
| UA (1) | UA89968C2 (https=) |
| UY (1) | UY29246A1 (https=) |
| WO (1) | WO2006062465A1 (https=) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039385A1 (es) | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
| MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| JP5701485B2 (ja) * | 2006-02-21 | 2015-04-15 | テバ ファーマシューティカル インダストリーズ リミティド | 多系統萎縮症の治療のためのラサギリンの使用 |
| UY30267A1 (es) * | 2006-04-13 | 2007-11-30 | Astrazeneca Ab | Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones |
| JP2009533426A (ja) * | 2006-04-13 | 2009-09-17 | アストラゼネカ・アクチエボラーグ | チオキサンチン誘導体およびそれらのｍｐｏ阻害剤としての用途 |
| TW200804383A (en) | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
| US20090054468A1 (en) * | 2007-08-23 | 2009-02-26 | Astrazeneca Ab | New Use 938 |
| JP5201063B2 (ja) * | 2008-04-15 | 2013-06-05 | 信越化学工業株式会社 | 付加硬化型シリコーン組成物及びその硬化物 |
| SI2411393T1 (sl) | 2009-03-23 | 2014-03-31 | Glenmark Pharmaceuticals S.A. | Kondenzirani pirimidin-dionski derivati kot TRPA 1 modulatorji |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
| GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
| CN103917529B (zh) | 2011-11-11 | 2016-08-17 | 辉瑞大药厂 | 2-硫代嘧啶酮类 |
| WO2013150115A1 (en) * | 2012-04-05 | 2013-10-10 | Basf Se | N- substituted hetero - bicyclic compounds and derivatives for combating animal pests |
| RS58514B1 (sr) | 2012-06-13 | 2019-04-30 | Incyte Holdings Corp | Supstituisana triciklična jedinjenja kao inhibitori fgfr |
| US20150111868A1 (en) | 2012-06-15 | 2015-04-23 | Jansen R&D Ireland | Novel 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| PH12015502383B1 (en) | 2013-04-19 | 2023-02-03 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| US9920075B2 (en) | 2014-09-11 | 2018-03-20 | Bristol-Myers Squibb Company | Triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US9616063B2 (en) * | 2014-12-01 | 2017-04-11 | Astrazeneca Ab | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| TWI712601B (zh) | 2015-02-20 | 2020-12-11 | 美商英塞特公司 | 作為fgfr抑制劑之雙環雜環 |
| AU2016257179A1 (en) | 2015-05-05 | 2017-11-02 | Pfizer Inc. | 2-thiopyrimidinones |
| US10407422B2 (en) | 2015-09-03 | 2019-09-10 | Bristol-Myers Squibb Company | Triazolopyridine inhibitors of myeloperoxidase |
| WO2017040451A1 (en) * | 2015-09-03 | 2017-03-09 | Bristol-Myers Squibb Company | Triazolopyridine inhibitors of myeloperoxidase |
| WO2017160632A1 (en) * | 2016-03-14 | 2017-09-21 | Bristol-Myers Squibb Company | Triazolopyridine inhibitors of myeloperoxidase |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| AU2018304508B2 (en) | 2017-07-17 | 2021-06-10 | Astrazeneca Ab | MPO inhibitors for use in medicine |
| US10781226B2 (en) | 2017-10-19 | 2020-09-22 | Texas State University | Photoactivatable cancer prodrug |
| HRP20241288T1 (hr) | 2018-05-04 | 2024-12-06 | Incyte Corporation | Čvrsti oblici fgfr inhibitora i postupci za njihovu proizvodnju |
| AU2019262579B2 (en) | 2018-05-04 | 2024-09-12 | Incyte Corporation | Salts of an FGFR inhibitor |
| WO2020021300A1 (en) | 2018-07-24 | 2020-01-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of myeloperoxidase (mpo) inhibitors for the treatment of chemoresistant acute myeloid leukemia (aml) |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021013942A1 (en) | 2019-07-24 | 2021-01-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of myeloperoxidase inhibitors for the treatment of cardiovascular diseases in patients suffering from myeloproliferative neoplasms |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CA3157260A1 (en) * | 2019-10-10 | 2021-04-15 | Biohaven Therapeutics Ltd. | Prodrugs of myeloperoxidase inhibitors |
| CA3157361A1 (en) | 2019-10-14 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| JP7832891B2 (ja) | 2019-12-04 | 2026-03-18 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤の誘導体 |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021178734A1 (en) * | 2020-03-05 | 2021-09-10 | Biohaven Therapeutics Ltd. | Method of treating amyotrophic lateral sclerosis with myeloperoxidase inhibitor |
| WO2021176049A1 (en) | 2020-03-06 | 2021-09-10 | Bayer Aktiengesellschaft | Pyrazolopyrazines acting on cancers via inhibition of cdk12 |
| CA3181917A1 (en) * | 2020-05-06 | 2021-11-11 | Biohaven Therapeutics Ltd. | Process for the preparation of verdiperstat |
| EP4165034A1 (en) | 2020-06-11 | 2023-04-19 | Janssen Sciences Ireland Unlimited Company | Hemi (l)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2 yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one and pharmaceutical compositions comprising the same |
| WO2022221170A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| CN115403584B (zh) * | 2021-05-26 | 2024-04-02 | 长春金赛药业有限责任公司 | 2-硫代-2,3-二氢嘧啶-4-酮衍生物、药物组合物及其制备方法和应用 |
| US11939331B2 (en) | 2021-06-09 | 2024-03-26 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
| CA3220155A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| CN119894896A (zh) | 2022-08-18 | 2025-04-25 | 阿斯利康(瑞典)有限公司 | 绿过氧化物酶的抑制剂 |
| CN120265633A (zh) * | 2022-12-09 | 2025-07-04 | 深圳信立泰药业股份有限公司 | 一种吡咯并[3,2-d]嘧啶-4-酮类衍生物及其制备方法和医药用途 |
| WO2025107036A1 (en) * | 2023-11-23 | 2025-05-30 | Syntara Limited | Dual inhibitors of amine oxidases and peroxidases, and uses thereof |
| WO2025172474A1 (en) | 2024-02-15 | 2025-08-21 | Astrazeneca Ab | Inhibitors of myeloperoxidase |
| WO2025190901A1 (en) | 2024-03-13 | 2025-09-18 | Institut National de la Santé et de la Recherche Médicale | Use of myeloperoxidase (mpo) inhibitors for promoting cd8+ t cell responses |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3135753A (en) * | 1961-05-10 | 1964-06-02 | Burroughs Wellcome Co | Alkylthiopurines and method |
| US3652579A (en) | 1969-06-26 | 1972-03-28 | Hoffmann La Roche | 1-methyl-2-substituted 5-nitroimidazoles |
| SE7810947L (sv) | 1978-10-20 | 1980-04-21 | Draco Ab | 3-alkylxanthines |
| US4710503A (en) * | 1985-02-07 | 1987-12-01 | Euroceltique S.A. | 6-thioxanthine derivatives |
| WO1989006125A1 (en) | 1987-12-31 | 1989-07-13 | Smithkline Beckman Corporation | 4-aralkyl-5-substituted-1,2,4-triazole-5-thiols |
| DK440989A (da) | 1988-09-12 | 1990-03-13 | Smithkline Beecham Corp | Dopamin-beta-hydroxylase inhibitorer |
| JPH02160235A (ja) | 1988-12-13 | 1990-06-20 | Konica Corp | ハロゲン化銀カラー写真画像の形成方法 |
| EP0430300A3 (en) | 1989-12-01 | 1992-03-25 | Takeda Chemical Industries, Ltd. | Xanthine derivatives, their production and use |
| US5100906A (en) | 1990-04-19 | 1992-03-31 | Merrell Dow Pharmaceuticals Inc. | 5-aryl-4-alkyl-3h-1,2,4-triazole-3-thiones useful as memory enhancers |
| FR2665636B1 (fr) * | 1990-08-10 | 1994-10-07 | Adir | Utilisation d'un derive de la trimethyl-1,3,7 xanthine pour le traitement des troubles de la memoire, des troubles intellectuels de la senescence et de la maladie d'alzheimer. |
| US6046019A (en) * | 1991-07-09 | 2000-04-04 | Goumeniouk; Alexander P. | Diagnostic kits and methods for making granulocyte cell counts |
| US5281209A (en) | 1992-06-30 | 1994-01-25 | The Procter & Gamble Company | Absorbent article having tucked flaps |
| FI944933A7 (fi) | 1992-04-21 | 1994-10-20 | Biocryst Pharm Inc | 7-disubstitoitu metyyli-4-okso-3H,5H-pyrrolo(3,2-d) pyrimidiini ja sit ä sisältäviä farmaseuttisia käyttöjä ja koostumuksia |
| US6469017B1 (en) | 1998-01-16 | 2002-10-22 | Cell Therapeutics, Inc. | Method of inhibiting interleukin-12 signaling |
| GB9312853D0 (en) | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
| CN1046274C (zh) * | 1993-11-26 | 1999-11-10 | 辉瑞大药厂 | 用作消炎剂的异噁唑啉化合物 |
| US5489598A (en) * | 1994-06-08 | 1996-02-06 | Warner-Lambert Company | Cytoprotection utilizing aryltriazol-3-thiones |
| DE69531506T2 (de) * | 1994-12-13 | 2004-06-24 | Euroceltique S.A. | Arylthioxanthine |
| US6025361A (en) * | 1994-12-13 | 2000-02-15 | Euro-Celtique, S.A. | Trisubstituted thioxanthines |
| WO1996018400A1 (en) * | 1994-12-13 | 1996-06-20 | Euro-Celtique, S.A. | Trisubstituted thioxanthines |
| US5756511A (en) * | 1995-04-03 | 1998-05-26 | Cell Therapeutics, Inc. | Method for treating symptoms of a neurodegenerative condition |
| US6294541B1 (en) * | 1996-06-06 | 2001-09-25 | Euro-Celtique S.A. | Purine derivatives having phosphodiesterase IV inhibition activity |
| GB9626643D0 (en) | 1996-12-21 | 1997-02-12 | Astra Pharma Prod | Compounds |
| US5976823A (en) * | 1997-03-19 | 1999-11-02 | Integrated Biomedical Technology, Inc. | Low range total available chlorine test strip |
| DE69834500T2 (de) | 1997-09-05 | 2007-05-03 | Kyowa Hakko Kogyo Co., Ltd. | Xanthinderivative zur behandlung von hirnischämie |
| WO1999014204A1 (en) | 1997-09-16 | 1999-03-25 | G.D. Searle & Co. | Substituted 1,2,4-triazoles useful for inhibiting cholesteryl ester transfer protein activity |
| AR013669A1 (es) | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
| US6187777B1 (en) * | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| US6319928B1 (en) * | 1998-11-30 | 2001-11-20 | Euro-Celtique, S.A. | Purine derivatives having phosphodiesterase IV inhibition activity |
| DZ3019A1 (fr) | 1999-03-01 | 2005-05-20 | Smithkline Beecham Corp | Utilisation d'un inhibiteur de pde4 dans la préparation d'un médicament contre la copd. |
| CA2367143A1 (en) | 1999-04-02 | 2000-10-12 | Euro-Celtique S.A. | Purine derivatives having phosphodiesterase iv inhibition activity |
| GB2362101A (en) | 2000-05-12 | 2001-11-14 | Astrazeneca Ab | Treatment of chronic obstructive pulmonary disease |
| FR2811989A1 (fr) | 2000-07-18 | 2002-01-25 | Sanofi Synthelabo | Derives de polyfluoroalkytriazole, leur preparation et leur application en therapeutique |
| US6855817B2 (en) | 2000-07-21 | 2005-02-15 | Mark B. Lyles | Materials and methods for binding nucleic acids to surfaces |
| GB0100620D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical cokpounds V |
| GB0100623D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds IV |
| FR2819723B1 (fr) * | 2001-01-23 | 2006-11-17 | Arnaud Mainnemare | Composition halogene, son procede de preparation et ses utilisations |
| WO2002066447A1 (en) | 2001-02-21 | 2002-08-29 | Ono Pharmaceutical Co., Ltd. | 4h-1,2,4-triazole-3(2h)-thione deratives as sphingomyelinase inhibitors |
| SE0103766D0 (sv) * | 2001-11-09 | 2001-11-09 | Astrazeneca Ab | Novel assay |
| IL158462A0 (en) | 2001-05-08 | 2004-05-12 | Astrazeneca Ab | An assay for detecting inhibitors of the enzyme myeloperoxidase |
| ES2193839B1 (es) * | 2001-06-22 | 2005-02-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de 6-fenildihidropirrolpirimidindiona. |
| KR101098209B1 (ko) | 2002-01-28 | 2011-12-23 | 교와 핫꼬 기린 가부시키가이샤 | 운동성 질환에 걸린 환자의 치료 방법 |
| ES2208063B1 (es) * | 2002-04-01 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de la 4-(pirrolopirimidin-6-il)bencenosulfonamida. |
| AR039385A1 (es) * | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
| SE0301232D0 (sv) | 2003-04-25 | 2003-04-25 | Astrazeneca Ab | Novel use |
| SE0302756D0 (sv) * | 2003-10-17 | 2003-10-17 | Astrazeneca Ab | Novel Compounds |
| US7449473B2 (en) * | 2003-10-31 | 2008-11-11 | Cv Therapeutics, Inc. | Substituted pyrrolo[3,2-d]pyrimidin-2,4-diones as A2b adenosine receptor antagonists |
| PL1781657T3 (pl) | 2004-02-14 | 2013-08-30 | Glaxosmithkline Ip Dev Ltd | Leki o aktywności wobec receptora HM74A |
| WO2006045564A1 (en) | 2004-10-22 | 2006-05-04 | Smithkline Beecham Corporation | Xanthine derivatives with hm74a receptor activity |
| SE0402591D0 (sv) | 2004-10-25 | 2004-10-25 | Astrazeneca Ab | Novel use |
| MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| UY30267A1 (es) | 2006-04-13 | 2007-11-30 | Astrazeneca Ab | Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones |
| CN101460501A (zh) | 2006-06-05 | 2009-06-17 | 阿斯利康(瑞典)有限公司 | 作为髓过氧化物酶抑制剂的吡咯并[3，2-d]嘧啶-4-酮衍生物 |
| TW200804383A (en) | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
| AR066936A1 (es) | 2007-06-13 | 2009-09-23 | Astrazeneca Ab | 3 - (2r - tetrahidrofuril - metil) - 2 - tioxantina. composiciones farmaceuticas. |
| US20090054468A1 (en) | 2007-08-23 | 2009-02-26 | Astrazeneca Ab | New Use 938 |
-
2005
- 2005-12-02 MY MYPI20055659A patent/MY140748A/en unknown
- 2005-12-05 AR ARP050105071A patent/AR051698A1/es unknown
- 2005-12-05 PL PL05812036T patent/PL1824855T3/pl unknown
- 2005-12-05 NZ NZ555046A patent/NZ555046A/en not_active IP Right Cessation
- 2005-12-05 SA SA05260385A patent/SA05260385B1/ar unknown
- 2005-12-05 RU RU2007119307/04A patent/RU2409578C2/ru active
- 2005-12-05 ES ES05812036T patent/ES2390888T3/es not_active Expired - Lifetime
- 2005-12-05 DK DK05812036.1T patent/DK1824855T3/da active
- 2005-12-05 WO PCT/SE2005/001835 patent/WO2006062465A1/en not_active Ceased
- 2005-12-05 HR HRP20120781TT patent/HRP20120781T1/hr unknown
- 2005-12-05 MX MX2007006497A patent/MX2007006497A/es active IP Right Grant
- 2005-12-05 AU AU2005312388A patent/AU2005312388B2/en not_active Expired
- 2005-12-05 PT PT05812036T patent/PT1824855E/pt unknown
- 2005-12-05 KR KR1020137033109A patent/KR101557715B1/ko not_active Expired - Lifetime
- 2005-12-05 KR KR1020077012654A patent/KR101412786B1/ko not_active Expired - Lifetime
- 2005-12-05 EP EP05812036A patent/EP1824855B1/en not_active Expired - Lifetime
- 2005-12-05 CN CN2005800419194A patent/CN101072778B/zh not_active Expired - Lifetime
- 2005-12-05 RS RS20120426A patent/RS52490B/sr unknown
- 2005-12-05 ME MEP-2012-109A patent/ME01486B/me unknown
- 2005-12-05 JP JP2007544307A patent/JP5028270B2/ja not_active Expired - Lifetime
- 2005-12-05 BR BRPI0518846-6A patent/BRPI0518846B1/pt active IP Right Grant
- 2005-12-05 KR KR1020137005332A patent/KR101412939B1/ko not_active Expired - Lifetime
- 2005-12-05 CA CA2591314A patent/CA2591314C/en not_active Expired - Lifetime
- 2005-12-05 UY UY29246A patent/UY29246A1/es not_active Application Discontinuation
- 2005-12-05 RU RU2010139806/04A patent/RU2577858C2/ru active
- 2005-12-05 UA UAA200705136A patent/UA89968C2/uk unknown
- 2005-12-05 SI SI200631433T patent/SI1824855T1/sl unknown
- 2005-12-05 US US11/720,913 patent/US7829707B2/en active Active
- 2005-12-06 TW TW094143007A patent/TWI365189B/zh not_active IP Right Cessation
-
2007
- 2007-05-10 NO NO20072399A patent/NO20072399L/no unknown
- 2007-05-14 IL IL183182A patent/IL183182A/en not_active IP Right Cessation
-
2010
- 2010-11-03 US US12/938,490 patent/US8859568B2/en active Active
-
2012
- 2012-10-10 CY CY20121100939T patent/CY1113209T1/el unknown
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2014
- 2014-09-15 US US14/487,009 patent/US9580429B2/en not_active Expired - Lifetime
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