JP2008521908A5 - - Google Patents

Info

Publication number

JP2008521908A5

JP2008521908A5 JP2007544442A JP2007544442A JP2008521908A5 JP 2008521908 A5 JP2008521908 A5 JP 2008521908A5 JP 2007544442 A JP2007544442 A JP 2007544442A JP 2007544442 A JP2007544442 A JP 2007544442A JP 2008521908 A5 JP2008521908 A5 JP 2008521908A5

Authority

JP

Japan

Prior art keywords

optionally substituted

substituted

group

hydrogen

aryl

Prior art date

2005-11-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 229910052739 hydrogen Inorganic materials 0.000 claims 23
• 239000001257 hydrogen Substances 0.000 claims 23
• 125000001072 heteroaryl group Chemical group 0.000 claims 20
• 150000002431 hydrogen Chemical class 0.000 claims 19
• 125000001188 haloalkyl group Chemical group 0.000 claims 17
• 229910052736 halogen Inorganic materials 0.000 claims 17
• 150000002367 halogens Chemical class 0.000 claims 17
• 125000004438 haloalkoxy group Chemical group 0.000 claims 16
• 239000008194 pharmaceutical composition Substances 0.000 claims 14
• 125000000217 alkyl group Chemical group 0.000 claims 13
• 150000001875 compounds Chemical class 0.000 claims 13
• 125000003118 aryl group Chemical group 0.000 claims 12
• 150000001336 alkenes Chemical class 0.000 claims 11
• 150000001345 alkine derivatives Chemical group 0.000 claims 11
• 125000003710 aryl alkyl group Chemical group 0.000 claims 11
• 125000004475 heteroaralkyl group Chemical group 0.000 claims 10
• 125000003107 substituted aryl group Chemical group 0.000 claims 7
• 125000000753 cycloalkyl group Chemical group 0.000 claims 5
• 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 4
• 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
• MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 4
• 125000004423 acyloxy group Chemical group 0.000 claims 4
• 125000003545 alkoxy group Chemical group 0.000 claims 4
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 4
• 150000002148 esters Chemical class 0.000 claims 4
• 125000000623 heterocyclic group Chemical group 0.000 claims 4
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 4
• 239000000651 prodrug Substances 0.000 claims 4
• 229940002612 prodrug Drugs 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 125000000547 substituted alkyl group Chemical group 0.000 claims 4
• 229910052760 oxygen Inorganic materials 0.000 claims 3
• 125000005415 substituted alkoxy group Chemical group 0.000 claims 3
• 102000008299 Nitric Oxide Synthase Human genes 0.000 claims 2
• 108010021487 Nitric Oxide Synthase Proteins 0.000 claims 2
• 102000011779 Nitric Oxide Synthase Type II Human genes 0.000 claims 2
• 108010076864 Nitric Oxide Synthase Type II Proteins 0.000 claims 2
• 208000002193 Pain Diseases 0.000 claims 2
• 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 2
• 230000005856 abnormality Effects 0.000 claims 2
• 230000001668 ameliorated effect Effects 0.000 claims 2
• 238000006471 dimerization reaction Methods 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 230000005764 inhibitory process Effects 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• 208000004296 neuralgia Diseases 0.000 claims 2
• 208000021722 neuropathic pain Diseases 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
• 238000011200 topical administration Methods 0.000 claims 2
• 125000006164 6-membered heteroaryl group Chemical group 0.000 claims 1
• 229910003844 NSO2 Inorganic materials 0.000 claims 1
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
• FTTMCCMCBNEPQX-UHFFFAOYSA-N n-(1,3-benzodioxol-5-ylmethyl)-2-[2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)pyrrolidin-1-yl]ethanamine Chemical compound N=1C(C)=CC(C2N(CCC2)CCNCC=2C=C3OCOC3=CC=2)=NC=1N1C=CN=C1 FTTMCCMCBNEPQX-UHFFFAOYSA-N 0.000 claims 1
• ZJFFPGMGWOEQLF-UHFFFAOYSA-N n-(1,3-benzodioxol-5-ylmethyl)-n'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-n'-methylpropane-1,3-diamine Chemical compound C=1C=C2OCOC2=CC=1CNCCCN(C)C(SN=1)=NC=1N1C=CN=C1 ZJFFPGMGWOEQLF-UHFFFAOYSA-N 0.000 claims 1
• 125000001424 substituent group Chemical group 0.000 claims 1
• 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1