TW200635587A - Inducible nitric oxide synthase dimerization inhibitors - Google Patents
Inducible nitric oxide synthase dimerization inhibitorsInfo
- Publication number
- TW200635587A TW200635587A TW094141754A TW94141754A TW200635587A TW 200635587 A TW200635587 A TW 200635587A TW 094141754 A TW094141754 A TW 094141754A TW 94141754 A TW94141754 A TW 94141754A TW 200635587 A TW200635587 A TW 200635587A
- Authority
- TW
- Taiwan
- Prior art keywords
- nitric oxide
- oxide synthase
- inducible nitric
- dimerization inhibitors
- synthase dimerization
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000011779 Nitric Oxide Synthase Type II Human genes 0.000 title 1
- 108010076864 Nitric Oxide Synthase Type II Proteins 0.000 title 1
- 238000006471 dimerization reaction Methods 0.000 title 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63197104P | 2004-12-01 | 2004-12-01 | |
| US67200105P | 2005-04-14 | 2005-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200635587A true TW200635587A (en) | 2006-10-16 |
Family
ID=36215758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094141754A TW200635587A (en) | 2004-12-01 | 2005-11-28 | Inducible nitric oxide synthase dimerization inhibitors |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7825256B2 (enExample) |
| EP (1) | EP1817030A2 (enExample) |
| JP (1) | JP2008521908A (enExample) |
| KR (1) | KR20070084574A (enExample) |
| AR (1) | AR055287A1 (enExample) |
| AU (1) | AU2005311985A1 (enExample) |
| BR (1) | BRPI0518096A (enExample) |
| CA (1) | CA2589433A1 (enExample) |
| IL (1) | IL183392A0 (enExample) |
| TW (1) | TW200635587A (enExample) |
| WO (1) | WO2006060424A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070123572A1 (en) * | 2005-11-28 | 2007-05-31 | Kalypsys, Inc. | Novel method of preparation of 5-chloro-3-imidazol-1-yl-[1,2,4]thiadiazole and (3-imidazol-1-yl-[1,2,4]thiadiazol-5yl)-dialkyl-amines |
| WO2007062417A1 (en) * | 2005-11-28 | 2007-05-31 | Kalypsys, Inc. | Methods of preparing 2-imidazol-1-yl-4-methyl-6-pyrrolidin-2-yl-pyrimidine and 4-(1-alkylpyrrolidin-2-yl)-2-(1h-imidazol-1-yl)-6-methylpyrimidine derivatives |
| EP1954694A1 (en) * | 2005-11-28 | 2008-08-13 | Kalypsys, Inc. | Imidazole derivatives as nitric oxide synthase dimerisation inhibitor |
| FR2903405B1 (fr) | 2006-07-04 | 2011-09-09 | Pasteur Institut | Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications |
| JP2010510245A (ja) * | 2006-11-21 | 2010-04-02 | スミスクライン ビーチャム コーポレーション | 抗ウイルス化合物 |
| EP1939181A1 (en) * | 2006-12-27 | 2008-07-02 | sanofi-aventis | Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase |
| WO2008086176A2 (en) * | 2007-01-08 | 2008-07-17 | Kalypsys, Inc. | Topical pharmaceutical formulation comprising an inos inhibitor for the treatment of disease |
| JP2011510996A (ja) * | 2008-01-30 | 2011-04-07 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 新規ｓＥＨ阻害剤およびその使用 |
| US20100311776A1 (en) * | 2008-01-30 | 2010-12-09 | Smithkline Beecham Corporation | Novel sEH Inhibitors and their Use |
| US8478446B2 (en) | 2008-06-13 | 2013-07-02 | Air Products And Chemicals, Inc. | Oxygen control system for oxygen enhanced combustion |
| US8578892B2 (en) * | 2008-06-13 | 2013-11-12 | Air Products And Chemicals, Inc. | Oxygen control system for oxygen enhanced combustion of solid fuels |
| JP2015180606A (ja) * | 2012-08-01 | 2015-10-15 | アステラス製薬株式会社 | 抗癌剤の併用による癌治療方法 |
| AU2015243537B2 (en) | 2014-04-08 | 2020-10-22 | The Methodist Hospital | INOS-inhibitory compositions and their use as breast cancer therapeutics |
| US9701661B2 (en) | 2014-07-11 | 2017-07-11 | Northwestern University | 2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase |
| JP6460382B2 (ja) * | 2014-11-28 | 2019-01-30 | 株式会社豊田自動織機 | 飽和ヘテロ環含有化合物、並びにこれを用いた二次電池用電極及び二次電池、結着剤、蛍光物質 |
| GB201512635D0 (en) | 2015-07-17 | 2015-08-26 | Ucl Business Plc | Uses of therapeutic compounds |
| US11491136B2 (en) | 2017-02-14 | 2022-11-08 | Research Triangle Institute | Proline-based neuropeptide FF receptor modulators |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1161237B (it) * | 1983-04-26 | 1987-03-18 | Montedison Spa | 1,4-dichetoni-insaturi ad attivita' fungicida |
| DE3433953A1 (de) * | 1984-09-15 | 1986-03-27 | A. Nattermann & Cie GmbH, 5000 Köln | Neue, eine imidazol-gruppe enthaltende 3,4-dihydro-2(1h)-pyridone und2(1h)-pyridone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US5795905A (en) | 1995-06-06 | 1998-08-18 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| DE19541146A1 (de) * | 1995-10-25 | 1997-04-30 | Schering Ag | Imidazolderivate und deren Verwendung als Stickstoffmonoxid-Synthase-Inhibitoren |
| US5874452A (en) * | 1996-04-03 | 1999-02-23 | Merck & Co., Inc. | Biheteroaryl inhibitors of farnesyl-protein transferase |
| SK285854B6 (sk) | 1996-05-31 | 2007-09-06 | Allelix Neuroscience Inc. | Substituovaný amín, spôsoby jeho prípravy a použitie, farmaceutický prostriedok a jeho použitie |
| DE19627310A1 (de) * | 1996-06-27 | 1998-01-02 | Schering Ag | Imidazolderivate als Stickstoffmonoxid-Synthase-Inhibitoren |
| GB2338957B (en) * | 1997-02-19 | 2001-08-01 | Berlex Lab | N-heterocyclic derivatives as nos inhibitors |
| US6432947B1 (en) | 1997-02-19 | 2002-08-13 | Berlex Laboratories, Inc. | N-heterocyclic derivatives as NOS inhibitors |
| ID23510A (id) * | 1997-06-27 | 2000-04-27 | Bp Chem Int Ltd | Proses polimerisasi |
| US6861448B2 (en) * | 1998-01-14 | 2005-03-01 | Virtual Drug Development, Inc. | NAD synthetase inhibitors and uses thereof |
| US20030191279A1 (en) * | 1999-08-27 | 2003-10-09 | Goldstein Steven Wayne | Urea derivatives useful as anticancer agents |
| US6723743B1 (en) * | 1999-09-28 | 2004-04-20 | Neurogen Corporation | High affinity small molecule C5a receptor modulators |
| JP5260818B2 (ja) | 2000-09-29 | 2013-08-14 | ノバルティス・インターナショナル・ファーマシューティカル・リミテッド | 高親和性低分子Ｃ５ａ受容体調節物質 |
| DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| FR2827286A1 (fr) | 2001-07-11 | 2003-01-17 | Aventis Cropscience Sa | Nouveaux composes fongicides |
| EP1575495A4 (en) | 2002-03-27 | 2009-12-02 | Smithkline Beecham Corp | COMPOUNDS AND METHODS |
| KR20040093487A (ko) | 2002-03-29 | 2004-11-05 | 뉴로젠 코포레이션 | Ｃ5ａ 수용체 조절자로서의 신규 아릴이미다졸 및 관련화합물 |
| CA2480082A1 (en) | 2002-03-29 | 2003-10-16 | Neurogen Corporation | Combination therapy for the treatment of conditions with pathogenic inflammatory components |
| WO2004014881A2 (en) * | 2002-08-09 | 2004-02-19 | Astra Zeneca Ab | '1,2,4'oxadiazoles as modulators of metabotropic glutamate receptor-5 |
| AU2003260033A1 (en) * | 2002-08-29 | 2004-03-19 | Schering Aktiengesellschaft | Methods of treating acute respiratory distress syndrome |
| US20060058326A1 (en) * | 2003-02-06 | 2006-03-16 | Basf Aktiengesllschaft | Pyrimidines, methods for the production thereof, and use thereof |
| EP1954694A1 (en) * | 2005-11-28 | 2008-08-13 | Kalypsys, Inc. | Imidazole derivatives as nitric oxide synthase dimerisation inhibitor |
-
2005
- 2005-11-28 WO PCT/US2005/043190 patent/WO2006060424A2/en not_active Ceased
- 2005-11-28 CA CA002589433A patent/CA2589433A1/en not_active Abandoned
- 2005-11-28 KR KR1020077011898A patent/KR20070084574A/ko not_active Withdrawn
- 2005-11-28 TW TW094141754A patent/TW200635587A/zh unknown
- 2005-11-28 US US11/288,888 patent/US7825256B2/en not_active Expired - Fee Related
- 2005-11-28 JP JP2007544442A patent/JP2008521908A/ja active Pending
- 2005-11-28 BR BRPI0518096-1A patent/BRPI0518096A/pt not_active IP Right Cessation
- 2005-11-28 AU AU2005311985A patent/AU2005311985A1/en not_active Abandoned
- 2005-11-28 AR ARP050104970A patent/AR055287A1/es unknown
- 2005-11-28 EP EP05852447A patent/EP1817030A2/en not_active Withdrawn
-
2007
- 2007-05-24 IL IL183392A patent/IL183392A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005311985A1 (en) | 2006-06-08 |
| JP2008521908A (ja) | 2008-06-26 |
| AR055287A1 (es) | 2007-08-15 |
| BRPI0518096A (pt) | 2008-10-28 |
| WO2006060424A3 (en) | 2007-03-29 |
| IL183392A0 (en) | 2007-09-20 |
| EP1817030A2 (en) | 2007-08-15 |
| WO2006060424A2 (en) | 2006-06-08 |
| US7825256B2 (en) | 2010-11-02 |
| KR20070084574A (ko) | 2007-08-24 |
| US20060116515A1 (en) | 2006-06-01 |
| CA2589433A1 (en) | 2006-06-08 |
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