WO2005117939A3 - Use of GPCR54 ligands for the treatment of infertility - Google Patents

Use of GPCR54 ligands for the treatment of infertility Download PDF

Info

Publication number
WO2005117939A3
WO2005117939A3 PCT/US2005/013339 US2005013339W WO2005117939A3 WO 2005117939 A3 WO2005117939 A3 WO 2005117939A3 US 2005013339 W US2005013339 W US 2005013339W WO 2005117939 A3 WO2005117939 A3 WO 2005117939A3
Authority
WO
WIPO (PCT)
Prior art keywords
infertility
treatment
gpcr54
ligands
compositions
Prior art date
Application number
PCT/US2005/013339
Other languages
French (fr)
Other versions
WO2005117939A2 (en
WO2005117939A9 (en
Inventor
Robert K Campbell
Xuliang Jian
Shoji Nagatani
Original Assignee
Applied Research Systems
Campell Robert K
Jiang Xuliang
Shoji Nagatani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems, Campell Robert K, Jiang Xuliang, Shoji Nagatani filed Critical Applied Research Systems
Priority to AU2005249373A priority Critical patent/AU2005249373A1/en
Priority to US11/547,293 priority patent/US20070270339A1/en
Priority to EP05804783A priority patent/EP1750513A4/en
Priority to JP2007509576A priority patent/JP2007533748A/en
Priority to CA002562676A priority patent/CA2562676A1/en
Publication of WO2005117939A2 publication Critical patent/WO2005117939A2/en
Publication of WO2005117939A9 publication Critical patent/WO2005117939A9/en
Publication of WO2005117939A3 publication Critical patent/WO2005117939A3/en
Priority to IL178795A priority patent/IL178795A0/en
Priority to NO20065297A priority patent/NO20065297L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Abstract

The present invention is directed to methods and compositions for the treatment of infertility.
PCT/US2005/013339 2004-04-23 2005-04-19 Use of gpcr54 ligands for the treatment of infertility WO2005117939A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2005249373A AU2005249373A1 (en) 2004-04-23 2005-04-19 Use of GPCR54 ligands for the treatment of infertility
US11/547,293 US20070270339A1 (en) 2004-04-23 2005-04-19 Use of GPCR54 Ligands for the Treatment of Infertility
EP05804783A EP1750513A4 (en) 2004-04-23 2005-04-19 Use of gpcr54 ligands for the treatment of infertility
JP2007509576A JP2007533748A (en) 2004-04-23 2005-04-19 Use of GPCR54 ligand for the treatment of infertility
CA002562676A CA2562676A1 (en) 2004-04-23 2005-04-19 Use of gpcr54 ligands for the treatment of infertility
IL178795A IL178795A0 (en) 2004-04-23 2006-10-22 Gpcr54 ligands in infertility
NO20065297A NO20065297L (en) 2004-04-23 2006-11-17 Use of GPCR54 ligands to treat infertility

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56475604P 2004-04-23 2004-04-23
US60/564,756 2004-04-23

Publications (3)

Publication Number Publication Date
WO2005117939A2 WO2005117939A2 (en) 2005-12-15
WO2005117939A9 WO2005117939A9 (en) 2006-04-20
WO2005117939A3 true WO2005117939A3 (en) 2006-06-01

Family

ID=35463344

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/013339 WO2005117939A2 (en) 2004-04-23 2005-04-19 Use of gpcr54 ligands for the treatment of infertility

Country Status (7)

Country Link
EP (1) EP1750513A4 (en)
JP (1) JP2007533748A (en)
AU (1) AU2005249373A1 (en)
CA (1) CA2562676A1 (en)
IL (1) IL178795A0 (en)
NO (1) NO20065297L (en)
WO (1) WO2005117939A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG153865A1 (en) 2004-06-25 2009-07-29 Takeda Pharmaceutical Metastin derivatives and use thereof
US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
TWI404726B (en) 2006-10-25 2013-08-11 Takeda Pharmaceutical Metastin derivatives and use thereof
KR20100058548A (en) * 2007-09-11 2010-06-03 몬도바이오테크 래보래토리즈 아게 Use of octreotide as a therapeutic agent
GB0719592D0 (en) 2007-10-08 2007-11-14 Medical Res Council Compound, use and method
WO2010013762A1 (en) * 2008-07-30 2010-02-04 武田薬品工業株式会社 Metastin derivative and use thereof
US8680263B2 (en) 2008-09-19 2014-03-25 Nektar Therapeutics Carbohydrate-based drug delivery polymers and conjugates thereof
EP2340047A1 (en) * 2008-09-19 2011-07-06 Nektar Therapeutics Polymer conjugates of kiss1 peptides
US9127038B2 (en) 2011-08-04 2015-09-08 Merck Sharp & Dohme Corp. Kisspeptide-pentasaccharide conjugates
US20150087610A1 (en) * 2012-03-20 2015-03-26 Monell Chemcial Senses Center Method of Modifying Fertility
FR3001455B1 (en) 2013-01-31 2017-10-06 Agronomique Inst Nat Rech AGONIST COMPOUNDS OF THE KISS1R RECEPTOR AND THEIR USE IN INDUCING OVULATION IN MAMMALS
TW201605907A (en) * 2014-08-12 2016-02-16 國立臺灣大學 Use of a short-chain peptide capable of controlling spermatozoa fertilization performance to increasing success rates of in vitro fertilization
JP6982621B2 (en) 2016-09-30 2021-12-17 マイオバント サイエンシズ ゲーエムベーハー How to treat female infertility
CN109125307B (en) * 2018-09-03 2021-05-07 河南牧翔动物药业有限公司 Clomidinol-polypeptide compound, pharmaceutical preparation, and preparation methods and applications thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004063221A1 (en) * 2002-12-26 2004-07-29 Takeda Pharmaceutical Company Limited Metastin derivative and use thereof
WO2004080479A1 (en) * 2003-03-12 2004-09-23 Takeda Pharmaceutical Company Limited Gonadal function improving agents

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
COLLEDGE W.H.: "PGPR54 and puberty", TRENDS IN ENDOCRINOLOGY AND METABOLISM, vol. 15, no. 9, November 2004 (2004-11-01), pages 448 - 453, XP004618466 *
JENNINGS J.C. ET AL: "In Vitro Fertilisation. A Review of Drug Therapy and Clinical Management", DRUGS, vol. 52, September 1996 (1996-09-01), pages 312 - 343, XP008062377 *
MATSUI H. ET AL: "Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat", BIOCHEM. AND BIOPHYS. RESEARCH COMMUN., vol. 32, no. 2, July 2004 (2004-07-01), pages 383 - 388, XP004516641 *
NAVARRO V.M. ET AL: "Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54", J. PHYSIOL., vol. 561, no. 2, December 2004 (2004-12-01), pages 379 - 386, XP002996184 *
ROUX DE N. ET AL: "Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 100, no. 19, 16 September 2003 (2003-09-16), pages 10972 - 10976, XP002262289 *
THOMPSON E.L. ET AL: "Central and Peripheral Administration of Kisspeptin-10 Stimulates the Hypothalamic-Pituitary-Gonadal Axis", J NEUROENDOCRINOL., vol. 16, no. 10, October 2004 (2004-10-01), pages 850 - 858, XP002996183 *

Also Published As

Publication number Publication date
WO2005117939A2 (en) 2005-12-15
NO20065297L (en) 2006-11-17
WO2005117939A9 (en) 2006-04-20
AU2005249373A1 (en) 2005-12-15
IL178795A0 (en) 2007-03-08
CA2562676A1 (en) 2005-12-15
JP2007533748A (en) 2007-11-22
EP1750513A2 (en) 2007-02-14
EP1750513A4 (en) 2009-07-22

Similar Documents

Publication Publication Date Title
WO2005117939A3 (en) Use of GPCR54 ligands for the treatment of infertility
HUS2100051I1 (en) Compositions and methods of treating cell proliferation disorders
IL257622B (en) Methods and compositions for the treatment of persistent infections
WO2006029183A3 (en) Compositions and methods for the diagnosis and treatment of tumor
WO2007001851A3 (en) Compositions and methods for the diagnosis and treatment of tumor
WO2006023651A3 (en) Extended treatment of multiple sclerosis
EP1628530B8 (en) Methods and compositions for the prevention and treatment of sepsis
IL233634A0 (en) Methods, compositions, and kits for the treatment of medical conditions
IL181896A0 (en) Methods and compositions for the treatment of hyperlipidemia
WO2006024018A3 (en) Compositions for treating nociceptive pain
TW200716525A (en) Process for preparation of sulfamide derivatives
IL174627A0 (en) Compositions and methods for treatment of burns
WO2007011759A3 (en) Inhibitors of mitotic kinesin
ZA200703087B (en) Methods and compositions for the treatment of hyperlipidemia
WO2007121125A3 (en) Hcv inhibitors
WO2006128143A3 (en) Hydantoin compounds
EP1740221A4 (en) Methods and compositions for the treatment of polycystic diseases
WO2006130493A3 (en) Heterocycles useful as modulators of ion channels
SI1812797T1 (en) Compositions and methods for the treatment and prevention of hyperproliferative diseases
WO2004096124A3 (en) Compositions and methods for the diagnosis and treatment of tumor
EP1755581A4 (en) Methods and compositions for the treatment of myocardial conditions
EP1781318A4 (en) Methods and compositions for the treatment of polycystic diseases
WO2005077019A3 (en) Protease inhibitors for treatment of wrinkles
WO2006081272A3 (en) Compositions and methods for the diagnosis and treatment of tumor
GB0313630D0 (en) Compositions for the enhanced treatment of depression

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
COP Corrected version of pamphlet

Free format text: PAGES 1/3-3/3, DRAWINGS, REPLACED BY NEW PAGES 1/4-4/4

WWE Wipo information: entry into national phase

Ref document number: 2562676

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2005249373

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2007509576

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 178795

Country of ref document: IL

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

ENP Entry into the national phase

Ref document number: 2005249373

Country of ref document: AU

Date of ref document: 20050419

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2005249373

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2005804783

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2005804783

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 11547293

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 11547293

Country of ref document: US