JP2008521908A - 誘導型一酸化窒素シンターゼ阻害剤 - Google Patents

誘導型一酸化窒素シンターゼ阻害剤 Download PDF

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Publication number
JP2008521908A
JP2008521908A JP2007544442A JP2007544442A JP2008521908A JP 2008521908 A JP2008521908 A JP 2008521908A JP 2007544442 A JP2007544442 A JP 2007544442A JP 2007544442 A JP2007544442 A JP 2007544442A JP 2008521908 A JP2008521908 A JP 2008521908A
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Japan
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optionally substituted
group
compound
hydrogen
haloalkyl
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JP2007544442A
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Japanese (ja)
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JP2008521908A5 (enExample
Inventor
ティモシー・シー・ガーマン
ヘンギュアン・ラング
マーク・アール・ハーバート
アンジェリーナ・エム・タイアー
クリスティアン・エイ・ハッシグ
スチュアート・エイ・ノーブル
ラッセル・ディ・カズンズ
フイ・ズアン
クリストファー・アール・サントス
シャオホン・チェン
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カリプシス・インコーポレーテッド
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Publication of JP2008521908A publication Critical patent/JP2008521908A/ja
Publication of JP2008521908A5 publication Critical patent/JP2008521908A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2007544442A 2004-12-01 2005-11-28 誘導型一酸化窒素シンターゼ阻害剤 Pending JP2008521908A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63197104P 2004-12-01 2004-12-01
US67200105P 2005-04-14 2005-04-14
PCT/US2005/043190 WO2006060424A2 (en) 2004-12-01 2005-11-28 Inducible nitric oxide synthase dimerization inhibitors

Publications (2)

Publication Number Publication Date
JP2008521908A true JP2008521908A (ja) 2008-06-26
JP2008521908A5 JP2008521908A5 (enExample) 2009-01-22

Family

ID=36215758

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007544442A Pending JP2008521908A (ja) 2004-12-01 2005-11-28 誘導型一酸化窒素シンターゼ阻害剤

Country Status (11)

Country Link
US (1) US7825256B2 (enExample)
EP (1) EP1817030A2 (enExample)
JP (1) JP2008521908A (enExample)
KR (1) KR20070084574A (enExample)
AR (1) AR055287A1 (enExample)
AU (1) AU2005311985A1 (enExample)
BR (1) BRPI0518096A (enExample)
CA (1) CA2589433A1 (enExample)
IL (1) IL183392A0 (enExample)
TW (1) TW200635587A (enExample)
WO (1) WO2006060424A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014021408A1 (ja) * 2012-08-01 2014-02-06 アステラス製薬株式会社 抗癌剤の併用による癌治療方法
JP2016102079A (ja) * 2014-11-28 2016-06-02 株式会社豊田自動織機 飽和ヘテロ環含有化合物、並びにこれを用いた二次電池用電極及び二次電池、結着剤、蛍光物質

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US20070123572A1 (en) * 2005-11-28 2007-05-31 Kalypsys, Inc. Novel method of preparation of 5-chloro-3-imidazol-1-yl-[1,2,4]thiadiazole and (3-imidazol-1-yl-[1,2,4]thiadiazol-5yl)-dialkyl-amines
WO2007062417A1 (en) * 2005-11-28 2007-05-31 Kalypsys, Inc. Methods of preparing 2-imidazol-1-yl-4-methyl-6-pyrrolidin-2-yl-pyrimidine and 4-(1-alkylpyrrolidin-2-yl)-2-(1h-imidazol-1-yl)-6-methylpyrimidine derivatives
JP2009517483A (ja) * 2005-11-28 2009-04-30 カリプシス・インコーポレーテッド 一酸化窒素シンターゼの二量化の抑制剤としてのイミダゾール誘導体
FR2903405B1 (fr) 2006-07-04 2011-09-09 Pasteur Institut Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications
JP2010510245A (ja) * 2006-11-21 2010-04-02 スミスクライン ビーチャム コーポレーション 抗ウイルス化合物
EP1939181A1 (en) * 2006-12-27 2008-07-02 sanofi-aventis Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase
WO2008086176A2 (en) * 2007-01-08 2008-07-17 Kalypsys, Inc. Topical pharmaceutical formulation comprising an inos inhibitor for the treatment of disease
US20100311776A1 (en) * 2008-01-30 2010-12-09 Smithkline Beecham Corporation Novel sEH Inhibitors and their Use
JP2011510996A (ja) * 2008-01-30 2011-04-07 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 新規ｓＥＨ阻害剤およびその使用
US8578892B2 (en) * 2008-06-13 2013-11-12 Air Products And Chemicals, Inc. Oxygen control system for oxygen enhanced combustion of solid fuels
US8478446B2 (en) 2008-06-13 2013-07-02 Air Products And Chemicals, Inc. Oxygen control system for oxygen enhanced combustion
EP3129015B1 (en) 2014-04-08 2021-07-14 The Methodist Hospital Inos-inhibitory compositions and their use as breast cancer therapeutics
US9701661B2 (en) 2014-07-11 2017-07-11 Northwestern University 2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase
GB201512635D0 (en) 2015-07-17 2015-08-26 Ucl Business Plc Uses of therapeutic compounds
CA3049464A1 (en) 2017-02-14 2018-08-23 Research Triangle Institute Proline-based neuropeptide ff receptor modulators

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999000430A1 (en) * 1997-06-27 1999-01-07 Bp Chemicals Limited Polymerisation process
JP2002515058A (ja) * 1997-02-19 2002-05-21 バーレツクス ラボラトリーズ インコーポレーテツド Ｎｏｓ抑制剤としてのｎ−複素環誘導体
JP2003507476A (ja) * 1999-08-26 2003-02-25 バーレックス ラボラトリーズ，インコーポレイティド Ｎｏｓ阻害剤としてのｎ−複素環式誘導体
WO2004019986A1 (en) * 2002-08-29 2004-03-11 Schering Aktiengesellschaft Methods of treating acute respiratory distress syndrome
JP2009517483A (ja) * 2005-11-28 2009-04-30 カリプシス・インコーポレーテッド 一酸化窒素シンターゼの二量化の抑制剤としてのイミダゾール誘導体

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IT1161237B (it) 1983-04-26 1987-03-18 Montedison Spa 1,4-dichetoni-insaturi ad attivita' fungicida
DE3433953A1 (de) 1984-09-15 1986-03-27 A. Nattermann & Cie GmbH, 5000 Köln Neue, eine imidazol-gruppe enthaltende 3,4-dihydro-2(1h)-pyridone und2(1h)-pyridone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US5795905A (en) 1995-06-06 1998-08-18 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
DE19541146A1 (de) * 1995-10-25 1997-04-30 Schering Ag Imidazolderivate und deren Verwendung als Stickstoffmonoxid-Synthase-Inhibitoren
US5874452A (en) 1996-04-03 1999-02-23 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
CA2619901A1 (en) 1996-05-31 1997-12-04 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
DE19627310A1 (de) 1996-06-27 1998-01-02 Schering Ag Imidazolderivate als Stickstoffmonoxid-Synthase-Inhibitoren
US6861448B2 (en) 1998-01-14 2005-03-01 Virtual Drug Development, Inc. NAD synthetase inhibitors and uses thereof
US20030191279A1 (en) 1999-08-27 2003-10-09 Goldstein Steven Wayne Urea derivatives useful as anticancer agents
US6723743B1 (en) 1999-09-28 2004-04-20 Neurogen Corporation High affinity small molecule C5a receptor modulators
IL154993A0 (en) 2000-09-29 2003-10-31 Neurogen Corp High affinity small molecule c5a receptor modulators
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
FR2827286A1 (fr) 2001-07-11 2003-01-17 Aventis Cropscience Sa Nouveaux composes fongicides
JP2006512280A (ja) 2002-03-27 2006-04-13 スミスクライン・ビーチャム・コーポレイション 化合物および方法
US7186734B2 (en) 2002-03-29 2007-03-06 Neurogen Corporation Aryl imidazoles and related compounds as C5a receptor modulators
WO2003084524A1 (en) 2002-03-29 2003-10-16 Neurogen Corporation Combination therapy for the treatment of conditions with pathogenic inflammatory components
CN1894241A (zh) 2002-08-09 2007-01-10 阿斯利康(瑞典)有限公司 作为代谢型谷氨酸受体－5调节剂的“1,2,4” 噁二唑
CN100357297C (zh) * 2003-02-06 2007-12-26 巴斯福股份公司 嘧啶、其生产方法及其用途

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JP2002515058A (ja) * 1997-02-19 2002-05-21 バーレツクス ラボラトリーズ インコーポレーテツド Ｎｏｓ抑制剤としてのｎ−複素環誘導体
WO1999000430A1 (en) * 1997-06-27 1999-01-07 Bp Chemicals Limited Polymerisation process
JP2003507476A (ja) * 1999-08-26 2003-02-25 バーレックス ラボラトリーズ，インコーポレイティド Ｎｏｓ阻害剤としてのｎ−複素環式誘導体
WO2004019986A1 (en) * 2002-08-29 2004-03-11 Schering Aktiengesellschaft Methods of treating acute respiratory distress syndrome
JP2009517483A (ja) * 2005-11-28 2009-04-30 カリプシス・インコーポレーテッド 一酸化窒素シンターゼの二量化の抑制剤としてのイミダゾール誘導体

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014021408A1 (ja) * 2012-08-01 2014-02-06 アステラス製薬株式会社 抗癌剤の併用による癌治療方法
JP2016102079A (ja) * 2014-11-28 2016-06-02 株式会社豊田自動織機 飽和ヘテロ環含有化合物、並びにこれを用いた二次電池用電極及び二次電池、結着剤、蛍光物質

Also Published As

Publication number Publication date
IL183392A0 (en) 2007-09-20
TW200635587A (en) 2006-10-16
CA2589433A1 (en) 2006-06-08
AR055287A1 (es) 2007-08-15
BRPI0518096A (pt) 2008-10-28
US20060116515A1 (en) 2006-06-01
EP1817030A2 (en) 2007-08-15
WO2006060424A2 (en) 2006-06-08
AU2005311985A1 (en) 2006-06-08
WO2006060424A3 (en) 2007-03-29
KR20070084574A (ko) 2007-08-24
US7825256B2 (en) 2010-11-02

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