JP2008520586A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008520586A5 JP2008520586A5 JP2007541495A JP2007541495A JP2008520586A5 JP 2008520586 A5 JP2008520586 A5 JP 2008520586A5 JP 2007541495 A JP2007541495 A JP 2007541495A JP 2007541495 A JP2007541495 A JP 2007541495A JP 2008520586 A5 JP2008520586 A5 JP 2008520586A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- variable region
- library
- region
- hybrid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004602 germ cell Anatomy 0.000 claims description 7
- 238000000034 method Methods 0.000 claims 26
- 239000000427 antigen Substances 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 14
- 230000000295 complement effect Effects 0.000 claims 12
- 101150117115 V gene Proteins 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62858104P | 2004-11-16 | 2004-11-16 | |
| PCT/US2005/041825 WO2006055778A2 (en) | 2004-11-16 | 2005-11-16 | Immunoglobulin variable region cassette exchange |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008520586A JP2008520586A (ja) | 2008-06-19 |
| JP2008520586A5 true JP2008520586A5 (https=) | 2009-01-08 |
Family
ID=36407771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007541495A Pending JP2008520586A (ja) | 2004-11-16 | 2005-11-16 | 免疫グロブリン可変領域カセット交換 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20060134098A1 (https=) |
| EP (3) | EP2343380B1 (https=) |
| JP (1) | JP2008520586A (https=) |
| AU (1) | AU2005306502B2 (https=) |
| CA (1) | CA2587158C (https=) |
| DK (2) | DK2343380T3 (https=) |
| ES (3) | ES2881353T3 (https=) |
| PL (2) | PL3540062T3 (https=) |
| PT (2) | PT2343380T (https=) |
| WO (1) | WO2006055778A2 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8288322B2 (en) | 2000-04-17 | 2012-10-16 | Dyax Corp. | Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries |
| BRPI0506629A (pt) * | 2004-02-10 | 2007-05-02 | Univ Colorado | inibição do fator b, a via alternativa do sistema complemento e métodos relacionados |
| PT2343380T (pt) | 2004-11-16 | 2019-09-18 | Humanigen Inc | Permuta de cassetes da região variável de imunoglobulina |
| WO2006128006A1 (en) * | 2005-05-26 | 2006-11-30 | The Regents Of The University Of Colorado | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
| WO2008042024A2 (en) | 2006-06-01 | 2008-04-10 | Elan Pharmaceuticals, Inc. | Neuroactive fragments of app |
| WO2008063898A2 (en) * | 2006-11-08 | 2008-05-29 | Kalobios Pharmaceuticals, Inc. | Methods of treating idiopathic thrombocytopenia purpura using a gm-csf antagonist |
| EP2101780B1 (en) | 2006-11-21 | 2013-10-09 | Kalobios Pharmaceuticals, Inc. | Methods of treating chronic inflammatory diseases using a gm-csf antagonist |
| US8398972B2 (en) * | 2006-11-21 | 2013-03-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a GM-CSF antagonist |
| US20090075378A1 (en) * | 2007-02-20 | 2009-03-19 | Anaptysbio, Inc. | Somatic hypermutation systems |
| PL3199180T3 (pl) | 2007-03-08 | 2022-08-08 | Humanigen, Inc. | Przeciwciała przeciwko epha3 do leczenia guzów litych |
| CN101668773B (zh) * | 2007-03-14 | 2016-08-31 | 亚力史制药公司 | 人工程化抗b因子抗体 |
| WO2009012401A1 (en) * | 2007-07-17 | 2009-01-22 | Irm Llc | Antagonist antibodies of protease activated receptor-1 (par1) |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| BRPI0819598A2 (pt) | 2007-11-30 | 2017-05-09 | Kalobios Pharmaceuticals Inc | anticorpos para o antígeno pcrv da pseudomonas aeruginosa |
| WO2009114815A1 (en) | 2008-03-13 | 2009-09-17 | Dyax Corp | Libraries of genetic packages comprising novel hc cdr3 designs |
| JP5780951B2 (ja) | 2008-04-24 | 2015-09-16 | ダイアックス コーポレーション | 新規のhccdr1、cdr2、およびcdr3設計、ならびに新規のlccdr1、cdr2、およびcdr3設計を含む、遺伝子パッケージのライブラリ |
| WO2009134805A2 (en) * | 2008-04-28 | 2009-11-05 | Kalobios Pharmaceuticals, Inc. | Antibodies to granulocyte-macrophage colony-stimulating factor |
| CA2751433A1 (en) | 2009-02-04 | 2010-08-12 | Kalobios Pharmaceuticals, Inc. | Combination antibiotic and antibody therapy for the treatment of pseudomonas aeruginosa infection |
| US9079942B2 (en) | 2009-02-09 | 2015-07-14 | Epitomics, Inc. | CDR-anchored amplification method |
| WO2010093814A1 (en) | 2009-02-11 | 2010-08-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a gm-csf antagonist |
| AU2010221159B2 (en) | 2009-03-06 | 2015-11-26 | Humanigen, Inc. | Treatment of leukemias and chronic myeloproliferative diseases with antibodies to EphA3 |
| CN102459591B (zh) * | 2009-05-20 | 2015-05-13 | 诺维莫尼公司 | 合成性的多肽文库以及用于建立具有天然多样性的多肽变体的方法 |
| WO2011003098A1 (en) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
| CA2777068C (en) * | 2009-10-14 | 2020-05-26 | Humanigen, Inc. | Antibodies to epha3 |
| AR079336A1 (es) | 2009-12-11 | 2012-01-18 | Irm Llc | Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) |
| SG181893A1 (en) * | 2009-12-22 | 2012-08-30 | Hoffmann La Roche | Sequence dependent aggregation |
| AU2011217848B8 (en) | 2010-02-18 | 2015-09-24 | The Regents Of The University Of California | Integrin aVB8 neutralizing antibody |
| EP2553150A4 (en) * | 2010-04-02 | 2013-08-14 | Kalobios Pharmaceuticals Inc | GENERATION OF ANTIBODIES FOR CERTAIN EPITOPES |
| WO2012109530A1 (en) | 2011-02-11 | 2012-08-16 | Irm Llc | Pcsk9 antagonists |
| ES2926988T3 (es) | 2011-03-15 | 2022-10-31 | X Body Inc | Métodos de cribado de anticuerpos |
| WO2012168491A1 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Pharmaceutical formulations of pcsk9 antagonists |
| WO2012170607A2 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Use of pcsk9 antagonists |
| EP2764021A2 (en) * | 2011-10-05 | 2014-08-13 | Kalobios Pharmaceuticals, Inc. | Generation of antibodies to an epitope of interest that contains a phosphomimetic amino acid |
| AU2012328819B2 (en) | 2011-10-26 | 2017-08-03 | Elanco Tiergesundheit Ag | Monoclonal antibodies and methods of use |
| US9803005B2 (en) | 2012-05-24 | 2017-10-31 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
| WO2014084859A1 (en) | 2012-11-30 | 2014-06-05 | Novartis Ag | Molecules and methods for modulating tmem16a activities |
| AR096601A1 (es) | 2013-06-21 | 2016-01-20 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
| NZ720769A (en) | 2013-12-09 | 2022-10-28 | Allakos Inc | Anti-siglec-8 antibodies and methods of use thereof |
| DK3110446T3 (da) | 2014-02-28 | 2022-02-28 | Allakos Inc | Fremgangsmåder og sammensætninger til behandling af Siglec-8-associerede sygdomme |
| DK3157951T3 (da) * | 2014-06-17 | 2020-08-17 | Academia Sinica | Humaniserede anti-ige-antistoffer, der tværbinder cd23 på b-lymfocytter, men ikke sensibiliserer mastceller |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| US10774145B2 (en) | 2015-06-17 | 2020-09-15 | Allakos Inc. | Methods and compositions for treating fibrotic diseases |
| JP6654779B2 (ja) * | 2015-10-13 | 2020-02-26 | 株式会社バイオピーク | ターゲットを認識するタンパク質の発現スクリーニング法 |
| US10604577B2 (en) | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
| RU2018124307A (ru) | 2015-12-04 | 2020-01-14 | Новартис Аг | Антительно-цитокиновые привитые композиции и способы применения для иммунорегуляции |
| US11052111B2 (en) | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
| US20190270821A1 (en) | 2016-09-13 | 2019-09-05 | Humanigen, Inc. | Epha3 antibodies for the treatment of pulmonary fibrosis |
| US11078298B2 (en) | 2016-10-28 | 2021-08-03 | Banyan Biomarkers, Inc. | Antibodies to ubiquitin C-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) and related methods |
| WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
| EP3618868A4 (en) | 2017-05-05 | 2021-02-24 | Allakos Inc. | METHODS AND COMPOSITIONS FOR TREATING ALLERGIC EYE DISEASES |
| MY206158A (en) | 2017-05-24 | 2024-12-02 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer |
| WO2018215938A1 (en) | 2017-05-24 | 2018-11-29 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use |
| WO2018215937A1 (en) | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
| JOP20190271A1 (ar) | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
| US10927168B2 (en) | 2017-10-02 | 2021-02-23 | Humanicen, Inc. | Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab |
| AU2018345751A1 (en) | 2017-10-02 | 2020-05-07 | Humanigen, Inc. | Methods of treating immunotherapy-related toxicity using a GM-CSF antagonist |
| US10899831B2 (en) | 2017-10-02 | 2021-01-26 | Humanigen, Inc. | Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity |
| US11130805B2 (en) | 2017-10-02 | 2021-09-28 | Humanigen, Inc. | Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist |
| CA3122773A1 (en) | 2018-12-26 | 2020-07-02 | Xilio Development, Inc. | Anti-ctla4 antibodies and methods of use thereof |
| CA3209364A1 (en) | 2021-03-01 | 2022-09-09 | Jennifer O'neil | Combination of masked ctla4 and pd1/pdl1 antibodies for treating cancer |
| EP4301467A1 (en) | 2021-03-01 | 2024-01-10 | Xilio Development, Inc. | Combination of ctla4 and pd1/pdl1 antibodies for treating cancer |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3742105A (en) | 1970-05-05 | 1973-06-26 | S Kuroda | Method for producing a seamless tubing |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US6548640B1 (en) * | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| JPS6412935A (en) | 1987-07-02 | 1989-01-17 | Mitsubishi Electric Corp | Constant-speed travel device for vehicle |
| EP0368684B2 (en) * | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6969586B1 (en) * | 1989-05-16 | 2005-11-29 | Scripps Research Institute | Method for tapping the immunological repertoire |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| CA2082160C (en) | 1991-03-06 | 2003-05-06 | Mary M. Bendig | Humanised and chimeric monoclonal antibodies |
| US5565332A (en) * | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5714350A (en) * | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| ES2156149T3 (es) * | 1992-12-04 | 2001-06-16 | Medical Res Council | Proteinas de union multivalente y multiespecificas, su fabricacion y su uso. |
| US6309636B1 (en) * | 1995-09-14 | 2001-10-30 | Cancer Research Institute Of Contra Costa | Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides |
| ES2176484T3 (es) * | 1995-08-18 | 2002-12-01 | Morphosys Ag | Bancos de proteinas/(poli)peptidos. |
| DK1034298T3 (da) * | 1997-12-05 | 2012-01-30 | Scripps Research Inst | Humanisering af murint antistof |
| AU2001275267A1 (en) | 2000-06-05 | 2001-12-17 | Corixa Corporation | Leader peptides for enhancing secretion of recombinant protein from a host cell |
| AU2001268545A1 (en) | 2000-06-21 | 2002-01-08 | Alexion Pharmaceuticals, Inc. | Libraries displaying human antibody fragments with hybrid complementarity determining regions |
| MXPA05000511A (es) * | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
| JP4213586B2 (ja) | 2001-09-13 | 2009-01-21 | 株式会社抗体研究所 | ラクダ抗体ライブラリーの作製方法 |
| US20030219839A1 (en) * | 2001-09-20 | 2003-11-27 | Katherine Bowdish | Anti-PDGF antibodies and methods for producing engineered antibodies |
| AR038568A1 (es) * | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
| WO2003099999A2 (en) * | 2002-05-20 | 2003-12-04 | Abmaxis, Inc. | Generation and selection of protein library in silico |
| US7538195B2 (en) * | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US7541440B2 (en) * | 2002-09-30 | 2009-06-02 | Immunomedics, Inc. | Chimeric, human and humanized anti-granulocyte antibodies and methods of use |
| WO2004072266A2 (en) * | 2003-02-13 | 2004-08-26 | Kalobios Inc. | Antibody affinity engineering by serial epitope-guided complementarity replacement |
| EP1761561B1 (en) * | 2004-01-20 | 2015-08-26 | KaloBios Pharmaceuticals, Inc. | Antibody specificity transfer using minimal essential binding determinants |
| US7811563B2 (en) | 2004-10-25 | 2010-10-12 | Northwestern University | Anti-addl antibodies and uses thereof |
| PT2343380T (pt) | 2004-11-16 | 2019-09-18 | Humanigen Inc | Permuta de cassetes da região variável de imunoglobulina |
| PE20090329A1 (es) * | 2007-05-30 | 2009-03-27 | Abbott Lab | Anticuerpos humanizados contra el globulomero ab(20-42) y sus usos |
-
2005
- 2005-11-16 PT PT10014128T patent/PT2343380T/pt unknown
- 2005-11-16 ES ES19169135T patent/ES2881353T3/es not_active Expired - Lifetime
- 2005-11-16 EP EP10014128.2A patent/EP2343380B1/en not_active Expired - Lifetime
- 2005-11-16 CA CA2587158A patent/CA2587158C/en not_active Expired - Lifetime
- 2005-11-16 ES ES10014128T patent/ES2744149T3/es not_active Expired - Lifetime
- 2005-11-16 EP EP05851809.3A patent/EP1824987B1/en not_active Revoked
- 2005-11-16 AU AU2005306502A patent/AU2005306502B2/en not_active Ceased
- 2005-11-16 WO PCT/US2005/041825 patent/WO2006055778A2/en not_active Ceased
- 2005-11-16 DK DK10014128.2T patent/DK2343380T3/da active
- 2005-11-16 PT PT191691351T patent/PT3540062T/pt unknown
- 2005-11-16 US US11/282,107 patent/US20060134098A1/en not_active Abandoned
- 2005-11-16 EP EP19169135.1A patent/EP3540062B1/en not_active Expired - Lifetime
- 2005-11-16 PL PL19169135T patent/PL3540062T3/pl unknown
- 2005-11-16 DK DK19169135.1T patent/DK3540062T3/da active
- 2005-11-16 JP JP2007541495A patent/JP2008520586A/ja active Pending
- 2005-11-16 PL PL10014128T patent/PL2343380T3/pl unknown
- 2005-11-16 ES ES05851809T patent/ES2429541T3/es not_active Expired - Lifetime
-
2015
- 2015-12-14 US US14/968,709 patent/US10919983B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008520586A5 (https=) | ||
| CA2587158A1 (en) | Immunoglobulin variable region cassette exchange | |
| JP2009153527A5 (https=) | ||
| JP2019526622A5 (https=) | ||
| JP2007533304A5 (https=) | ||
| Shi et al. | De novo selection of high-affinity antibodies from synthetic fab libraries displayed on phage as pIX fusion proteins | |
| Smith et al. | Demystified… recombinant antibodies | |
| WO2012163520A4 (en) | Dual targeting | |
| JP2010536384A5 (https=) | ||
| WO2005069970A3 (en) | Antibody specificity transfer using minimal essential binding determinants | |
| NZ601342A (en) | Antibodies that bind il-4 and/or il-13 and their uses | |
| JP2010513539A5 (https=) | ||
| JP2012176953A5 (https=) | ||
| JP2019535254A5 (ja) | 抗pd−l1抗体および変異型 | |
| JP2007535471A5 (https=) | ||
| JP2009539348A5 (https=) | ||
| WO2005016111A3 (en) | Antibodies directed to parathyroid hormone (PTH) and uses thereof | |
| JP2020533016A5 (https=) | ||
| US12344959B2 (en) | Antibody libraries with maximized antibody developability characteristics | |
| JP2016516400A5 (https=) | ||
| US20200308256A1 (en) | Antibody phage display library | |
| JP2021500916A5 (https=) | ||
| JP2018505681A5 (https=) | ||
| JP2007501011A5 (https=) | ||
| JP2005512962A5 (https=) |