JP2008520586A5 - - Google Patents
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- Publication number
- JP2008520586A5 JP2008520586A5 JP2007541495A JP2007541495A JP2008520586A5 JP 2008520586 A5 JP2008520586 A5 JP 2008520586A5 JP 2007541495 A JP2007541495 A JP 2007541495A JP 2007541495 A JP2007541495 A JP 2007541495A JP 2008520586 A5 JP2008520586 A5 JP 2008520586A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- variable region
- library
- region
- hybrid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004602 germ cell Anatomy 0.000 claims description 7
- 238000000034 method Methods 0.000 claims 26
- 239000000427 antigen Substances 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 14
- 230000000295 complement effect Effects 0.000 claims 12
- 101150117115 V gene Proteins 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62858104P | 2004-11-16 | 2004-11-16 | |
| PCT/US2005/041825 WO2006055778A2 (en) | 2004-11-16 | 2005-11-16 | Immunoglobulin variable region cassette exchange |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008520586A JP2008520586A (ja) | 2008-06-19 |
| JP2008520586A5 true JP2008520586A5 (https=) | 2009-01-08 |
Family
ID=36407771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007541495A Pending JP2008520586A (ja) | 2004-11-16 | 2005-11-16 | 免疫グロブリン可変領域カセット交換 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20060134098A1 (https=) |
| EP (3) | EP3540062B1 (https=) |
| JP (1) | JP2008520586A (https=) |
| AU (1) | AU2005306502B2 (https=) |
| CA (1) | CA2587158C (https=) |
| DK (2) | DK3540062T3 (https=) |
| ES (3) | ES2744149T3 (https=) |
| PL (2) | PL3540062T3 (https=) |
| PT (2) | PT2343380T (https=) |
| WO (1) | WO2006055778A2 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8288322B2 (en) | 2000-04-17 | 2012-10-16 | Dyax Corp. | Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries |
| ES2432112T3 (es) * | 2004-02-10 | 2013-11-29 | The Regents Of The University Of Colorado, A Body Corporate | Inhibición del factor B, de la vía alternativa del complemento y métodos relacionados |
| US20060134098A1 (en) | 2004-11-16 | 2006-06-22 | Kalobios, Inc. | Immunoglobulin variable region cassette exchange |
| CA2610340C (en) * | 2005-05-26 | 2016-02-16 | Vernon Michael Holers | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
| US8357781B2 (en) | 2006-06-01 | 2013-01-22 | Janssen Alzheimer Immunotherapy | Neuroactive fragments of APP |
| US20080171038A1 (en) * | 2006-11-08 | 2008-07-17 | Kalobios Pharmaceuticals, Inc. | Methods of treating idiopathic thrombocytopenia purpura using a gm-csf antagonist |
| US20080206241A1 (en) * | 2006-11-21 | 2008-08-28 | Kalobios Pharmaceuticals Inc. | Methods of Treating Chronic Inflammatory Diseases Using a GM-CSF Antagonist |
| US8398972B2 (en) * | 2006-11-21 | 2013-03-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a GM-CSF antagonist |
| BRPI0807952A2 (pt) | 2007-02-20 | 2014-06-10 | Anaptysbio Inc | Sistemas de hipermutação somática |
| AU2008226905C1 (en) * | 2007-03-08 | 2014-11-06 | Humanigen, Inc. | EphA3 antibodies for the treatment of solid tumors |
| CA2680344A1 (en) | 2007-03-14 | 2008-11-20 | Woodruff Emlen | Humaneered anti-factor b antibody |
| WO2009012401A1 (en) * | 2007-07-17 | 2009-01-22 | Irm Llc | Antagonist antibodies of protease activated receptor-1 (par1) |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| EP2220117A2 (en) | 2007-11-30 | 2010-08-25 | Kalobios Pharmaceuticals, Inc. | Antibodies to the pcrv antigen of pseudomonas aeruginosa |
| US9873957B2 (en) * | 2008-03-13 | 2018-01-23 | Dyax Corp. | Libraries of genetic packages comprising novel HC CDR3 designs |
| ES2528963T3 (es) | 2008-04-24 | 2015-02-13 | Dyax Corp. | Bibliotecas de paquetes genéticos que comprenden nuevos diseños de CDR1, CDR2, y CDR3 de HC y nuevos diseños de CDR1, CDR2, y CDR3 de LC |
| NZ588850A (en) | 2008-04-28 | 2012-12-21 | Kalobios Pharmaceuticals Inc | Antibodies to granulocyte-macrophage colony-stimulating factor |
| WO2010091189A1 (en) | 2009-02-04 | 2010-08-12 | Kalobios Pharmaceuticals, Inc. | Combination antibiotic and antibody therapy for the treatment of pseudomonas aeruginosa infection |
| US9079942B2 (en) | 2009-02-09 | 2015-07-14 | Epitomics, Inc. | CDR-anchored amplification method |
| WO2010093814A1 (en) | 2009-02-11 | 2010-08-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a gm-csf antagonist |
| AU2010221159B2 (en) | 2009-03-06 | 2015-11-26 | Humanigen, Inc. | Treatment of leukemias and chronic myeloproliferative diseases with antibodies to EphA3 |
| CA2762837C (en) * | 2009-05-20 | 2021-08-03 | Novimmune S.A. | Synthetic polypeptide libraries and methods for generating naturally diversified polypeptide variants |
| JP5871798B2 (ja) | 2009-07-02 | 2016-03-01 | エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント | 肝再生を刺激する方法 |
| US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
| DK2488554T3 (da) | 2009-10-14 | 2019-09-02 | Humanigen Inc | Antistoffer mod epha3 |
| AR079336A1 (es) | 2009-12-11 | 2012-01-18 | Irm Llc | Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) |
| ES2535393T3 (es) * | 2009-12-22 | 2015-05-11 | F. Hoffmann-La Roche Ag | Agregación dependiente de secuencia |
| MX342270B (es) | 2010-02-18 | 2016-09-21 | The Regents Of The Univ Of California * | ANTICUERPO NEUTRALIZANTE DE LA INTEGRINA AVß8. |
| CA2794851A1 (en) * | 2010-04-02 | 2011-10-06 | Kalobios Pharmaceuticals, Inc. | Generation of antibodies to an epitope of interest |
| AU2012214251A1 (en) | 2011-02-11 | 2013-09-12 | Novartis Ag | PCSK9 antagonists |
| ES2873375T3 (es) | 2011-03-15 | 2021-11-03 | X Body Inc | Métodos de cribado de anticuerpos |
| WO2012170607A2 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Use of pcsk9 antagonists |
| WO2012168491A1 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Pharmaceutical formulations of pcsk9 antagonists |
| EP2764021A2 (en) * | 2011-10-05 | 2014-08-13 | Kalobios Pharmaceuticals, Inc. | Generation of antibodies to an epitope of interest that contains a phosphomimetic amino acid |
| CA2853637C (en) | 2011-10-26 | 2023-04-04 | Novartis Ag | Anti-canine cd20 monoclonal antibodies and methods of use |
| EP2855529A4 (en) | 2012-05-24 | 2015-12-09 | Alexion Pharma Inc | HUMANIZED ANTI-FACTOR B ANTIBODIES |
| WO2014084859A1 (en) | 2012-11-30 | 2014-06-05 | Novartis Ag | Molecules and methods for modulating tmem16a activities |
| AR096601A1 (es) | 2013-06-21 | 2016-01-20 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
| KR102311761B1 (ko) | 2013-12-09 | 2021-10-13 | 알라코스 인크. | 항-Siglec-8 항체 및 그의 사용 방법 |
| CA2939931C (en) | 2014-02-28 | 2025-04-22 | Allakos Inc. | METHODS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH SIGLEC8 |
| WO2015195631A1 (en) * | 2014-06-17 | 2015-12-23 | Academia Sinica | HUMANIZED ANTI-IgE ANTIBODIES THAT CROSSLINK CD23 ON B LYMPHOCYTES BUT DO NOT SENSITIZE MAST CELLS |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| US10774145B2 (en) | 2015-06-17 | 2020-09-15 | Allakos Inc. | Methods and compositions for treating fibrotic diseases |
| JP6654779B2 (ja) * | 2015-10-13 | 2020-02-26 | 株式会社バイオピーク | ターゲットを認識するタンパク質の発現スクリーニング法 |
| US10604577B2 (en) | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
| UY37003A (es) | 2015-12-04 | 2017-06-30 | Novartis Ag | Composiciones de anticuerpo injertado con citoquina y métodos para su uso en inmunorregulacion |
| US11052111B2 (en) | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
| WO2018053032A1 (en) | 2016-09-13 | 2018-03-22 | Humanigen, Inc. | Epha3 antibodies for the treatment of pulmonary fibrosis |
| WO2018081649A1 (en) | 2016-10-28 | 2018-05-03 | Banyan Biomarkers, Inc. | Antibodies to ubiquitin c-terminal hydrolase l1 (uch-l1) and glial fibrillary acidic protein (gfap) and related methods |
| WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
| KR20200016232A (ko) | 2017-05-05 | 2020-02-14 | 알라코스 인크. | 알레르기성 안구 질환을 치료하기 위한 방법 및 조성물 |
| BR112019024556A2 (pt) | 2017-05-24 | 2020-06-23 | Novartis Ag | Proteínas enxertadas com citocina de anticorpo e métodos para uso no tratamento de câncer |
| JOP20190271A1 (ar) | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
| EP3630162A1 (en) | 2017-05-24 | 2020-04-08 | Novartis AG | Antibody-cytokine engrafted proteins and methods of use |
| WO2018215937A1 (en) | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
| EP3691663A4 (en) | 2017-10-02 | 2021-08-18 | Humanigen, Inc. | METHODS OF TREATMENT OF TOXICITY ASSOCIATED WITH IMMUNOTHERAPIES USING A GM-CSF ANTAGONIST |
| US11130805B2 (en) | 2017-10-02 | 2021-09-28 | Humanigen, Inc. | Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist |
| US10899831B2 (en) | 2017-10-02 | 2021-01-26 | Humanigen, Inc. | Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity |
| US10927168B2 (en) | 2017-10-02 | 2021-02-23 | Humanicen, Inc. | Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab |
| BR112021012536A2 (pt) | 2018-12-26 | 2021-09-14 | City Of Hope | Proteínas de ligação anti-ctla4 mascaradas ativáveis |
| WO2022187270A1 (en) | 2021-03-01 | 2022-09-09 | Xilio Development, Inc. | Combination of ctla4 and pd1/pdl1 antibodies for treating cancer |
| EP4301781A1 (en) | 2021-03-01 | 2024-01-10 | Xilio Development, Inc. | Combination of masked ctla4 and pd1/pdl1 antibodies for treating cancer |
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| EP0368684B2 (en) * | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
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-
2005
- 2005-11-16 US US11/282,107 patent/US20060134098A1/en not_active Abandoned
- 2005-11-16 DK DK19169135.1T patent/DK3540062T3/da active
- 2005-11-16 PT PT10014128T patent/PT2343380T/pt unknown
- 2005-11-16 AU AU2005306502A patent/AU2005306502B2/en not_active Ceased
- 2005-11-16 ES ES10014128T patent/ES2744149T3/es not_active Expired - Lifetime
- 2005-11-16 PT PT191691351T patent/PT3540062T/pt unknown
- 2005-11-16 ES ES05851809T patent/ES2429541T3/es not_active Expired - Lifetime
- 2005-11-16 PL PL19169135T patent/PL3540062T3/pl unknown
- 2005-11-16 WO PCT/US2005/041825 patent/WO2006055778A2/en not_active Ceased
- 2005-11-16 DK DK10014128.2T patent/DK2343380T3/da active
- 2005-11-16 PL PL10014128T patent/PL2343380T3/pl unknown
- 2005-11-16 ES ES19169135T patent/ES2881353T3/es not_active Expired - Lifetime
- 2005-11-16 JP JP2007541495A patent/JP2008520586A/ja active Pending
- 2005-11-16 EP EP19169135.1A patent/EP3540062B1/en not_active Expired - Lifetime
- 2005-11-16 EP EP10014128.2A patent/EP2343380B1/en not_active Expired - Lifetime
- 2005-11-16 CA CA2587158A patent/CA2587158C/en not_active Expired - Lifetime
- 2005-11-16 EP EP05851809.3A patent/EP1824987B1/en not_active Revoked
-
2015
- 2015-12-14 US US14/968,709 patent/US10919983B2/en active Active
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