DK2343380T3 - Immunoglobulin variabel region kassetteudskiftning - Google Patents
Immunoglobulin variabel region kassetteudskiftning Download PDFInfo
- Publication number
- DK2343380T3 DK2343380T3 DK10014128.2T DK10014128T DK2343380T3 DK 2343380 T3 DK2343380 T3 DK 2343380T3 DK 10014128 T DK10014128 T DK 10014128T DK 2343380 T3 DK2343380 T3 DK 2343380T3
- Authority
- DK
- Denmark
- Prior art keywords
- variable region
- immunoglobulin variable
- cartridge replacement
- region cartridge
- replacement
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62858104P | 2004-11-16 | 2004-11-16 | |
| EP05851809.3A EP1824987B1 (en) | 2004-11-16 | 2005-11-16 | Immunoglobulin variable region cassette exchange |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2343380T3 true DK2343380T3 (da) | 2019-09-09 |
Family
ID=36407771
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10014128.2T DK2343380T3 (da) | 2004-11-16 | 2005-11-16 | Immunoglobulin variabel region kassetteudskiftning |
| DK19169135.1T DK3540062T3 (da) | 2004-11-16 | 2005-11-16 | Immunoglobulin-variabel region kassetteudskiftning |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19169135.1T DK3540062T3 (da) | 2004-11-16 | 2005-11-16 | Immunoglobulin-variabel region kassetteudskiftning |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20060134098A1 (https=) |
| EP (3) | EP2343380B1 (https=) |
| JP (1) | JP2008520586A (https=) |
| AU (1) | AU2005306502B2 (https=) |
| CA (1) | CA2587158C (https=) |
| DK (2) | DK2343380T3 (https=) |
| ES (3) | ES2881353T3 (https=) |
| PL (2) | PL3540062T3 (https=) |
| PT (2) | PT2343380T (https=) |
| WO (1) | WO2006055778A2 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8288322B2 (en) | 2000-04-17 | 2012-10-16 | Dyax Corp. | Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries |
| BRPI0506629A (pt) * | 2004-02-10 | 2007-05-02 | Univ Colorado | inibição do fator b, a via alternativa do sistema complemento e métodos relacionados |
| PT2343380T (pt) | 2004-11-16 | 2019-09-18 | Humanigen Inc | Permuta de cassetes da região variável de imunoglobulina |
| WO2006128006A1 (en) * | 2005-05-26 | 2006-11-30 | The Regents Of The University Of Colorado | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
| WO2008042024A2 (en) | 2006-06-01 | 2008-04-10 | Elan Pharmaceuticals, Inc. | Neuroactive fragments of app |
| WO2008063898A2 (en) * | 2006-11-08 | 2008-05-29 | Kalobios Pharmaceuticals, Inc. | Methods of treating idiopathic thrombocytopenia purpura using a gm-csf antagonist |
| EP2101780B1 (en) | 2006-11-21 | 2013-10-09 | Kalobios Pharmaceuticals, Inc. | Methods of treating chronic inflammatory diseases using a gm-csf antagonist |
| US8398972B2 (en) * | 2006-11-21 | 2013-03-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a GM-CSF antagonist |
| US20090075378A1 (en) * | 2007-02-20 | 2009-03-19 | Anaptysbio, Inc. | Somatic hypermutation systems |
| PL3199180T3 (pl) | 2007-03-08 | 2022-08-08 | Humanigen, Inc. | Przeciwciała przeciwko epha3 do leczenia guzów litych |
| CN101668773B (zh) * | 2007-03-14 | 2016-08-31 | 亚力史制药公司 | 人工程化抗b因子抗体 |
| WO2009012401A1 (en) * | 2007-07-17 | 2009-01-22 | Irm Llc | Antagonist antibodies of protease activated receptor-1 (par1) |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| BRPI0819598A2 (pt) | 2007-11-30 | 2017-05-09 | Kalobios Pharmaceuticals Inc | anticorpos para o antígeno pcrv da pseudomonas aeruginosa |
| WO2009114815A1 (en) | 2008-03-13 | 2009-09-17 | Dyax Corp | Libraries of genetic packages comprising novel hc cdr3 designs |
| JP5780951B2 (ja) | 2008-04-24 | 2015-09-16 | ダイアックス コーポレーション | 新規のhccdr1、cdr2、およびcdr3設計、ならびに新規のlccdr1、cdr2、およびcdr3設計を含む、遺伝子パッケージのライブラリ |
| WO2009134805A2 (en) * | 2008-04-28 | 2009-11-05 | Kalobios Pharmaceuticals, Inc. | Antibodies to granulocyte-macrophage colony-stimulating factor |
| CA2751433A1 (en) | 2009-02-04 | 2010-08-12 | Kalobios Pharmaceuticals, Inc. | Combination antibiotic and antibody therapy for the treatment of pseudomonas aeruginosa infection |
| US9079942B2 (en) | 2009-02-09 | 2015-07-14 | Epitomics, Inc. | CDR-anchored amplification method |
| WO2010093814A1 (en) | 2009-02-11 | 2010-08-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a gm-csf antagonist |
| AU2010221159B2 (en) | 2009-03-06 | 2015-11-26 | Humanigen, Inc. | Treatment of leukemias and chronic myeloproliferative diseases with antibodies to EphA3 |
| CN102459591B (zh) * | 2009-05-20 | 2015-05-13 | 诺维莫尼公司 | 合成性的多肽文库以及用于建立具有天然多样性的多肽变体的方法 |
| WO2011003098A1 (en) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
| CA2777068C (en) * | 2009-10-14 | 2020-05-26 | Humanigen, Inc. | Antibodies to epha3 |
| AR079336A1 (es) | 2009-12-11 | 2012-01-18 | Irm Llc | Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) |
| SG181893A1 (en) * | 2009-12-22 | 2012-08-30 | Hoffmann La Roche | Sequence dependent aggregation |
| AU2011217848B8 (en) | 2010-02-18 | 2015-09-24 | The Regents Of The University Of California | Integrin aVB8 neutralizing antibody |
| EP2553150A4 (en) * | 2010-04-02 | 2013-08-14 | Kalobios Pharmaceuticals Inc | GENERATION OF ANTIBODIES FOR CERTAIN EPITOPES |
| WO2012109530A1 (en) | 2011-02-11 | 2012-08-16 | Irm Llc | Pcsk9 antagonists |
| ES2926988T3 (es) | 2011-03-15 | 2022-10-31 | X Body Inc | Métodos de cribado de anticuerpos |
| WO2012168491A1 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Pharmaceutical formulations of pcsk9 antagonists |
| WO2012170607A2 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Use of pcsk9 antagonists |
| EP2764021A2 (en) * | 2011-10-05 | 2014-08-13 | Kalobios Pharmaceuticals, Inc. | Generation of antibodies to an epitope of interest that contains a phosphomimetic amino acid |
| AU2012328819B2 (en) | 2011-10-26 | 2017-08-03 | Elanco Tiergesundheit Ag | Monoclonal antibodies and methods of use |
| US9803005B2 (en) | 2012-05-24 | 2017-10-31 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
| WO2014084859A1 (en) | 2012-11-30 | 2014-06-05 | Novartis Ag | Molecules and methods for modulating tmem16a activities |
| AR096601A1 (es) | 2013-06-21 | 2016-01-20 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
| NZ720769A (en) | 2013-12-09 | 2022-10-28 | Allakos Inc | Anti-siglec-8 antibodies and methods of use thereof |
| DK3110446T3 (da) | 2014-02-28 | 2022-02-28 | Allakos Inc | Fremgangsmåder og sammensætninger til behandling af Siglec-8-associerede sygdomme |
| DK3157951T3 (da) * | 2014-06-17 | 2020-08-17 | Academia Sinica | Humaniserede anti-ige-antistoffer, der tværbinder cd23 på b-lymfocytter, men ikke sensibiliserer mastceller |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| US10774145B2 (en) | 2015-06-17 | 2020-09-15 | Allakos Inc. | Methods and compositions for treating fibrotic diseases |
| JP6654779B2 (ja) * | 2015-10-13 | 2020-02-26 | 株式会社バイオピーク | ターゲットを認識するタンパク質の発現スクリーニング法 |
| US10604577B2 (en) | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
| RU2018124307A (ru) | 2015-12-04 | 2020-01-14 | Новартис Аг | Антительно-цитокиновые привитые композиции и способы применения для иммунорегуляции |
| US11052111B2 (en) | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
| US20190270821A1 (en) | 2016-09-13 | 2019-09-05 | Humanigen, Inc. | Epha3 antibodies for the treatment of pulmonary fibrosis |
| US11078298B2 (en) | 2016-10-28 | 2021-08-03 | Banyan Biomarkers, Inc. | Antibodies to ubiquitin C-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) and related methods |
| WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
| EP3618868A4 (en) | 2017-05-05 | 2021-02-24 | Allakos Inc. | METHODS AND COMPOSITIONS FOR TREATING ALLERGIC EYE DISEASES |
| MY206158A (en) | 2017-05-24 | 2024-12-02 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer |
| WO2018215938A1 (en) | 2017-05-24 | 2018-11-29 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use |
| WO2018215937A1 (en) | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
| JOP20190271A1 (ar) | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
| US10927168B2 (en) | 2017-10-02 | 2021-02-23 | Humanicen, Inc. | Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab |
| AU2018345751A1 (en) | 2017-10-02 | 2020-05-07 | Humanigen, Inc. | Methods of treating immunotherapy-related toxicity using a GM-CSF antagonist |
| US10899831B2 (en) | 2017-10-02 | 2021-01-26 | Humanigen, Inc. | Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity |
| US11130805B2 (en) | 2017-10-02 | 2021-09-28 | Humanigen, Inc. | Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist |
| CA3122773A1 (en) | 2018-12-26 | 2020-07-02 | Xilio Development, Inc. | Anti-ctla4 antibodies and methods of use thereof |
| CA3209364A1 (en) | 2021-03-01 | 2022-09-09 | Jennifer O'neil | Combination of masked ctla4 and pd1/pdl1 antibodies for treating cancer |
| EP4301467A1 (en) | 2021-03-01 | 2024-01-10 | Xilio Development, Inc. | Combination of ctla4 and pd1/pdl1 antibodies for treating cancer |
Family Cites Families (33)
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| US3742105A (en) | 1970-05-05 | 1973-06-26 | S Kuroda | Method for producing a seamless tubing |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
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| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
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| PT2343380T (pt) | 2004-11-16 | 2019-09-18 | Humanigen Inc | Permuta de cassetes da região variável de imunoglobulina |
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-
2005
- 2005-11-16 PT PT10014128T patent/PT2343380T/pt unknown
- 2005-11-16 ES ES19169135T patent/ES2881353T3/es not_active Expired - Lifetime
- 2005-11-16 EP EP10014128.2A patent/EP2343380B1/en not_active Expired - Lifetime
- 2005-11-16 CA CA2587158A patent/CA2587158C/en not_active Expired - Lifetime
- 2005-11-16 ES ES10014128T patent/ES2744149T3/es not_active Expired - Lifetime
- 2005-11-16 EP EP05851809.3A patent/EP1824987B1/en not_active Revoked
- 2005-11-16 AU AU2005306502A patent/AU2005306502B2/en not_active Ceased
- 2005-11-16 WO PCT/US2005/041825 patent/WO2006055778A2/en not_active Ceased
- 2005-11-16 DK DK10014128.2T patent/DK2343380T3/da active
- 2005-11-16 PT PT191691351T patent/PT3540062T/pt unknown
- 2005-11-16 US US11/282,107 patent/US20060134098A1/en not_active Abandoned
- 2005-11-16 EP EP19169135.1A patent/EP3540062B1/en not_active Expired - Lifetime
- 2005-11-16 PL PL19169135T patent/PL3540062T3/pl unknown
- 2005-11-16 DK DK19169135.1T patent/DK3540062T3/da active
- 2005-11-16 JP JP2007541495A patent/JP2008520586A/ja active Pending
- 2005-11-16 PL PL10014128T patent/PL2343380T3/pl unknown
- 2005-11-16 ES ES05851809T patent/ES2429541T3/es not_active Expired - Lifetime
-
2015
- 2015-12-14 US US14/968,709 patent/US10919983B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005306502A1 (en) | 2006-05-26 |
| PL2343380T3 (pl) | 2020-03-31 |
| EP3540062B1 (en) | 2021-05-12 |
| DK3540062T3 (da) | 2021-06-28 |
| US10919983B2 (en) | 2021-02-16 |
| CA2587158A1 (en) | 2006-05-26 |
| AU2005306502B2 (en) | 2012-11-15 |
| US20160102152A1 (en) | 2016-04-14 |
| WO2006055778A3 (en) | 2006-11-23 |
| EP1824987A2 (en) | 2007-08-29 |
| JP2008520586A (ja) | 2008-06-19 |
| EP2343380B1 (en) | 2019-06-12 |
| US20060134098A1 (en) | 2006-06-22 |
| PT3540062T (pt) | 2021-07-06 |
| EP3540062A1 (en) | 2019-09-18 |
| ES2744149T3 (es) | 2020-02-21 |
| PT2343380T (pt) | 2019-09-18 |
| EP2343380A1 (en) | 2011-07-13 |
| CA2587158C (en) | 2016-01-12 |
| WO2006055778A2 (en) | 2006-05-26 |
| EP1824987A4 (en) | 2008-03-19 |
| EP1824987B1 (en) | 2013-08-21 |
| PL3540062T3 (pl) | 2021-12-27 |
| ES2881353T3 (es) | 2021-11-29 |
| ES2429541T3 (es) | 2013-11-15 |
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| ATE534013T1 (de) | Patrone | |
| DE602005019940D1 (de) | Linseneinrichtung | |
| DE602005019938D1 (de) | Linseneinrichtung | |
| DE602005022812D1 (de) | Gleitschienen | |
| DK1812475T3 (da) | Immunglobulinfraktioner | |
| FI20045334A0 (fi) | Kasettipatteri | |
| DE602005000846D1 (de) | Plattenkassette | |
| AT7367U3 (de) | Filterkartusche | |
| SE0400022D0 (sv) | New compounds | |
| UA10920S (uk) | Картридж бритви | |
| UA12032S (uk) | Тонер картридж | |
| UA12601S (uk) | Картридж бритви | |
| SE0400254D0 (sv) | New compounds | |
| IS8562A (is) | Ónæmisglóbúlín |