JP2020533016A5 - - Google Patents
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- JP2020533016A5 JP2020533016A5 JP2020529100A JP2020529100A JP2020533016A5 JP 2020533016 A5 JP2020533016 A5 JP 2020533016A5 JP 2020529100 A JP2020529100 A JP 2020529100A JP 2020529100 A JP2020529100 A JP 2020529100A JP 2020533016 A5 JP2020533016 A5 JP 2020533016A5
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- Prior art keywords
- amino acid
- antigen
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023105890A JP7685771B2 (ja) | 2017-08-01 | 2023-06-28 | 二重特異性抗体およびその使用 |
| JP2025072790A JP2025111661A (ja) | 2017-08-01 | 2025-04-25 | 二重特異性抗体およびその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762539970P | 2017-08-01 | 2017-08-01 | |
| US62/539,970 | 2017-08-01 | ||
| US201862654112P | 2018-04-06 | 2018-04-06 | |
| US62/654,112 | 2018-04-06 | ||
| PCT/US2018/044778 WO2019028125A1 (en) | 2017-08-01 | 2018-08-01 | Bispecific antibodies and uses thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023105890A Division JP7685771B2 (ja) | 2017-08-01 | 2023-06-28 | 二重特異性抗体およびその使用 |
| JP2025072790A Division JP2025111661A (ja) | 2017-08-01 | 2025-04-25 | 二重特異性抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020533016A JP2020533016A (ja) | 2020-11-19 |
| JP2020533016A5 true JP2020533016A5 (https=) | 2021-09-09 |
| JP7801095B2 JP7801095B2 (ja) | 2026-01-16 |
Family
ID=65233048
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020529100A Active JP7801095B2 (ja) | 2017-08-01 | 2018-08-01 | 二重特異性抗体およびその使用 |
| JP2023105890A Active JP7685771B2 (ja) | 2017-08-01 | 2023-06-28 | 二重特異性抗体およびその使用 |
| JP2025072790A Pending JP2025111661A (ja) | 2017-08-01 | 2025-04-25 | 二重特異性抗体およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023105890A Active JP7685771B2 (ja) | 2017-08-01 | 2023-06-28 | 二重特異性抗体およびその使用 |
| JP2025072790A Pending JP2025111661A (ja) | 2017-08-01 | 2025-04-25 | 二重特異性抗体およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US12049517B2 (https=) |
| EP (2) | EP3661555B1 (https=) |
| JP (3) | JP7801095B2 (https=) |
| KR (2) | KR102794369B1 (https=) |
| CN (3) | CN113896797B (https=) |
| ES (1) | ES3023158T3 (https=) |
| WO (1) | WO2019028125A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3661555B1 (en) * | 2017-08-01 | 2025-04-16 | Ab Therapeutics, Inc. | Bispecific antibodies and uses thereof |
| WO2020159918A2 (en) * | 2019-01-28 | 2020-08-06 | Ab Therapeutics, Inc. | Bispecific antibodies and uses thereof |
| US20220185903A1 (en) * | 2019-03-04 | 2022-06-16 | Nantong Yichen Biopharma. Co. Ltd. | Novel bispecific binding molecule and drug conjugate thereof |
| JP2022525275A (ja) | 2019-03-28 | 2022-05-12 | エービー ストゥーディオ インコーポレイテッド | ヘテロ多量体タンパク質及びその使用法 |
| JP7369297B2 (ja) * | 2019-12-17 | 2023-10-25 | ファイザー・インク | Cd47、pd-l1に特異的な抗体、およびその使用 |
| CN112062855B (zh) * | 2020-08-26 | 2024-08-30 | 北京天诺健成医药科技有限公司 | 一种含有衔接器的药物治疗剂的开发和应用 |
| CN114478770A (zh) * | 2020-11-12 | 2022-05-13 | 迈威(上海)生物科技股份有限公司 | 抗体及其制备方法 |
| CN112430271B (zh) * | 2020-11-13 | 2021-09-03 | 武汉滨会生物科技股份有限公司 | 一种双特异性单链抗体及应用 |
| US20250320309A1 (en) * | 2021-11-25 | 2025-10-16 | Shenghe (China) Biopharmaceutical Co., Ltd. | Bispecific antigen binding protein |
| CN116143948A (zh) * | 2023-02-14 | 2023-05-23 | 中国药科大学 | 一种以Jurkat为平台的靶向CD24和PD-L1双特异性嵌合抗原受体CAR及其应用 |
| WO2024255756A1 (zh) * | 2023-06-13 | 2024-12-19 | 南京维立志博生物科技股份有限公司 | 基于共同轻链产生双特异性抗体的方法 |
| WO2026011331A1 (zh) * | 2024-07-10 | 2026-01-15 | 嘉和生物药业有限公司 | 一种稳定的双特异性抗体组合物 |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US4777127A (en) | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
| GB8702816D0 (en) | 1987-02-07 | 1987-03-11 | Al Sumidaie A M K | Obtaining retrovirus-containing fraction |
| WO1989001973A2 (en) | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Recombinant pox virus for immunization against tumor-associated antigens |
| AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
| JP4041535B2 (ja) | 1989-08-18 | 2008-01-30 | オックスフォード バイオメディカ(ユーケー)リミテッド | 標的細胞にベクター構造体を運搬する組換レトロウィルス |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| KR101033196B1 (ko) * | 2002-02-14 | 2011-05-09 | 이뮤노메딕스, 인코오포레이티드 | 항-cd20 항체 및 그 융합 단백질 및 이들의 이용방법 |
| EP1545430A4 (en) | 2002-09-16 | 2006-01-04 | Elusys Therapeutics Inc | BISPECIFIC MOLECULE COMPRISING ANTI-CR1TICTIC ANTIBODY TO ANTIGENIC BINDING ANTIBODY FRAGMENT |
| WO2004065611A1 (ja) | 2003-01-21 | 2004-08-05 | Chugai Seiyaku Kabushiki Kaisha | 抗体の軽鎖スクリーニング方法 |
| CA2522586C (en) | 2003-05-31 | 2017-02-21 | Micromet Ag | Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders |
| CA2603264C (en) | 2005-04-08 | 2017-03-21 | Chugai Seiyaku Kabushiki Kaisha | Antibody substituting for function of blood coagulation factor viii |
| LT1976880T (lt) | 2005-12-21 | 2016-10-10 | Amgen Research (Munich) Gmbh | Farmacinės kompozicijos, pasižyminčios atsparumu tirpiam cea |
| US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
| SG10201504662WA (en) * | 2006-06-14 | 2015-07-30 | Macrogenics Inc | Methods For The Treatment Of Autoimmune Disorders Using Immunosuppressive Monoclonal Antibodies With Reduced Toxicity |
| US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
| JP5816170B2 (ja) | 2009-06-26 | 2015-11-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 天然の免疫グロブリン形式を有する容易に単離される二重特異性抗体 |
| HRP20201595T1 (hr) * | 2011-11-28 | 2020-12-11 | Merck Patent Gmbh | Anti-pd-l1 protutijela i njihova uporaba |
| LT2794905T (lt) | 2011-12-20 | 2020-07-10 | Medimmune, Llc | Modifikuoti polipeptidai, skirti bispecifinių antikūnų karkasams |
| PE20190658A1 (es) | 2012-02-24 | 2019-05-08 | Abbvie Stemcentrx Llc | Moduladores y metodos de empleo novedosos |
| WO2013163427A1 (en) | 2012-04-25 | 2013-10-31 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Antibodies to treat hiv-1 infection |
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| WO2014012085A2 (en) | 2012-07-13 | 2014-01-16 | Zymeworks Inc. | Bispecific asymmetric heterodimers comprising anti-cd3 constructs |
| AU2013302696B9 (en) * | 2012-08-14 | 2018-08-09 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| WO2014075788A1 (en) | 2012-11-13 | 2014-05-22 | Biontech Ag | Agents for treatment of claudin expressing cancer diseases |
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| JP2016531100A (ja) * | 2013-07-12 | 2016-10-06 | ザイムワークス,インコーポレイテッド | 二重特異的なcd3及びcd19抗原結合構築物 |
| KR20160044060A (ko) * | 2013-10-11 | 2016-04-22 | 에프. 호프만-라 로슈 아게 | 다중특이적 도메인 교환된 통상의 가변 경쇄 항체 |
| EP3327038B1 (en) | 2013-12-20 | 2020-09-23 | F. Hoffmann-La Roche AG | Bispecific her2 antibodies and methods of use |
| TWI680138B (zh) * | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
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| MX2017006016A (es) | 2014-11-11 | 2017-06-19 | Amunix Operating Inc | Composiciones conjugadas de xten direccionadas y metodos para producir las mismas. |
| CN110894240B (zh) * | 2014-11-26 | 2022-04-15 | 森科股份有限公司 | 结合cd3和肿瘤抗原的异二聚体抗体 |
| CN110655582B (zh) | 2015-01-08 | 2022-12-16 | 江苏康宁杰瑞生物制药有限公司 | 具有共同轻链的双特异性抗体或抗体混合物 |
| CN107660214B (zh) * | 2015-01-08 | 2022-02-08 | 根马布股份公司 | 针对cd3和cd20的双特异性抗体 |
| JP2018502859A (ja) | 2015-01-09 | 2018-02-01 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | 二重特異性抗体を用いた事前標的指向化による腫瘍の治療 |
| US10464999B2 (en) * | 2015-01-28 | 2019-11-05 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| SI3115376T1 (sl) * | 2015-07-10 | 2018-12-31 | Merus N.V. | Humana protitelesa, ki vežejo CD3 |
| PL3368572T3 (pl) * | 2015-10-02 | 2022-09-12 | Symphogen A/S | Przeciwciała anty-PD-1 oraz kompozycje |
| JP7058219B2 (ja) * | 2015-12-07 | 2022-04-21 | ゼンコア インコーポレイテッド | Cd3及びpsmaに結合するヘテロ二量体抗体 |
| CN108601830B (zh) | 2015-12-18 | 2023-02-03 | 比奥根Ma公司 | 双特异性抗体平台 |
| EP3661555B1 (en) * | 2017-08-01 | 2025-04-16 | Ab Therapeutics, Inc. | Bispecific antibodies and uses thereof |
-
2018
- 2018-08-01 EP EP18840836.3A patent/EP3661555B1/en active Active
- 2018-08-01 CN CN202111079150.2A patent/CN113896797B/zh active Active
- 2018-08-01 ES ES18840836T patent/ES3023158T3/es active Active
- 2018-08-01 CN CN201880062833.7A patent/CN111356477B/zh active Active
- 2018-08-01 EP EP22160823.5A patent/EP4088783A1/en active Pending
- 2018-08-01 KR KR1020207006195A patent/KR102794369B1/ko active Active
- 2018-08-01 JP JP2020529100A patent/JP7801095B2/ja active Active
- 2018-08-01 US US16/635,878 patent/US12049517B2/en active Active
- 2018-08-01 CN CN202411097878.1A patent/CN119019564A/zh active Pending
- 2018-08-01 WO PCT/US2018/044778 patent/WO2019028125A1/en not_active Ceased
- 2018-08-01 KR KR1020257011307A patent/KR20250052490A/ko active Pending
-
2021
- 2021-08-10 US US17/398,807 patent/US11566083B2/en active Active
- 2021-08-10 US US17/398,853 patent/US11440972B2/en active Active
-
2023
- 2023-06-28 JP JP2023105890A patent/JP7685771B2/ja active Active
-
2024
- 2024-06-14 US US18/743,295 patent/US20240336702A1/en not_active Abandoned
-
2025
- 2025-04-25 JP JP2025072790A patent/JP2025111661A/ja active Pending
- 2025-08-20 US US19/304,720 patent/US20260085131A1/en active Pending
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