JP2020533016A5 - - Google Patents

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Publication number
JP2020533016A5
JP2020533016A5 JP2020529100A JP2020529100A JP2020533016A5 JP 2020533016 A5 JP2020533016 A5 JP 2020533016A5 JP 2020529100 A JP2020529100 A JP 2020529100A JP 2020529100 A JP2020529100 A JP 2020529100A JP 2020533016 A5 JP2020533016 A5 JP 2020533016A5
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JP
Japan
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amino acid
antigen
acid sequence
seq
region
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JP2020529100A
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English (en)
Japanese (ja)
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JP2020533016A (ja
JP7801095B2 (ja
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Priority claimed from PCT/US2018/044778 external-priority patent/WO2019028125A1/en
Publication of JP2020533016A publication Critical patent/JP2020533016A/ja
Publication of JP2020533016A5 publication Critical patent/JP2020533016A5/ja
Priority to JP2023105890A priority Critical patent/JP7685771B2/ja
Priority to JP2025072790A priority patent/JP2025111661A/ja
Application granted granted Critical
Publication of JP7801095B2 publication Critical patent/JP7801095B2/ja
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JP2020529100A 2017-08-01 2018-08-01 二重特異性抗体およびその使用 Active JP7801095B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023105890A JP7685771B2 (ja) 2017-08-01 2023-06-28 二重特異性抗体およびその使用
JP2025072790A JP2025111661A (ja) 2017-08-01 2025-04-25 二重特異性抗体およびその使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762539970P 2017-08-01 2017-08-01
US62/539,970 2017-08-01
US201862654112P 2018-04-06 2018-04-06
US62/654,112 2018-04-06
PCT/US2018/044778 WO2019028125A1 (en) 2017-08-01 2018-08-01 Bispecific antibodies and uses thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2023105890A Division JP7685771B2 (ja) 2017-08-01 2023-06-28 二重特異性抗体およびその使用
JP2025072790A Division JP2025111661A (ja) 2017-08-01 2025-04-25 二重特異性抗体およびその使用

Publications (3)

Publication Number Publication Date
JP2020533016A JP2020533016A (ja) 2020-11-19
JP2020533016A5 true JP2020533016A5 (https=) 2021-09-09
JP7801095B2 JP7801095B2 (ja) 2026-01-16

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ID=65233048

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020529100A Active JP7801095B2 (ja) 2017-08-01 2018-08-01 二重特異性抗体およびその使用
JP2023105890A Active JP7685771B2 (ja) 2017-08-01 2023-06-28 二重特異性抗体およびその使用
JP2025072790A Pending JP2025111661A (ja) 2017-08-01 2025-04-25 二重特異性抗体およびその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023105890A Active JP7685771B2 (ja) 2017-08-01 2023-06-28 二重特異性抗体およびその使用
JP2025072790A Pending JP2025111661A (ja) 2017-08-01 2025-04-25 二重特異性抗体およびその使用

Country Status (7)

Country Link
US (5) US12049517B2 (https=)
EP (2) EP3661555B1 (https=)
JP (3) JP7801095B2 (https=)
KR (2) KR102794369B1 (https=)
CN (3) CN113896797B (https=)
ES (1) ES3023158T3 (https=)
WO (1) WO2019028125A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3661555B1 (en) * 2017-08-01 2025-04-16 Ab Therapeutics, Inc. Bispecific antibodies and uses thereof
WO2020159918A2 (en) * 2019-01-28 2020-08-06 Ab Therapeutics, Inc. Bispecific antibodies and uses thereof
US20220185903A1 (en) * 2019-03-04 2022-06-16 Nantong Yichen Biopharma. Co. Ltd. Novel bispecific binding molecule and drug conjugate thereof
JP2022525275A (ja) 2019-03-28 2022-05-12 エービー ストゥーディオ インコーポレイテッド ヘテロ多量体タンパク質及びその使用法
JP7369297B2 (ja) * 2019-12-17 2023-10-25 ファイザー・インク Cd47、pd-l1に特異的な抗体、およびその使用
CN112062855B (zh) * 2020-08-26 2024-08-30 北京天诺健成医药科技有限公司 一种含有衔接器的药物治疗剂的开发和应用
CN114478770A (zh) * 2020-11-12 2022-05-13 迈威(上海)生物科技股份有限公司 抗体及其制备方法
CN112430271B (zh) * 2020-11-13 2021-09-03 武汉滨会生物科技股份有限公司 一种双特异性单链抗体及应用
US20250320309A1 (en) * 2021-11-25 2025-10-16 Shenghe (China) Biopharmaceutical Co., Ltd. Bispecific antigen binding protein
CN116143948A (zh) * 2023-02-14 2023-05-23 中国药科大学 一种以Jurkat为平台的靶向CD24和PD-L1双特异性嵌合抗原受体CAR及其应用
WO2024255756A1 (zh) * 2023-06-13 2024-12-19 南京维立志博生物科技股份有限公司 基于共同轻链产生双特异性抗体的方法
WO2026011331A1 (zh) * 2024-07-10 2026-01-15 嘉和生物药业有限公司 一种稳定的双特异性抗体组合物

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769330A (en) 1981-12-24 1988-09-06 Health Research, Incorporated Modified vaccinia virus and methods for making and using the same
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
GB8508845D0 (en) 1985-04-04 1985-05-09 Hoffmann La Roche Vaccinia dna
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4777127A (en) 1985-09-30 1988-10-11 Labsystems Oy Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
GB8702816D0 (en) 1987-02-07 1987-03-11 Al Sumidaie A M K Obtaining retrovirus-containing fraction
WO1989001973A2 (en) 1987-09-02 1989-03-09 Applied Biotechnology, Inc. Recombinant pox virus for immunization against tumor-associated antigens
AP129A (en) 1988-06-03 1991-04-17 Smithkline Biologicals S A Expression of retrovirus gag protein eukaryotic cells
JP4041535B2 (ja) 1989-08-18 2008-01-30 オックスフォード バイオメディカ(ユーケー)リミテッド 標的細胞にベクター構造体を運搬する組換レトロウィルス
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
KR101033196B1 (ko) * 2002-02-14 2011-05-09 이뮤노메딕스, 인코오포레이티드 항-cd20 항체 및 그 융합 단백질 및 이들의 이용방법
EP1545430A4 (en) 2002-09-16 2006-01-04 Elusys Therapeutics Inc BISPECIFIC MOLECULE COMPRISING ANTI-CR1TICTIC ANTIBODY TO ANTIGENIC BINDING ANTIBODY FRAGMENT
WO2004065611A1 (ja) 2003-01-21 2004-08-05 Chugai Seiyaku Kabushiki Kaisha 抗体の軽鎖スクリーニング方法
CA2522586C (en) 2003-05-31 2017-02-21 Micromet Ag Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders
CA2603264C (en) 2005-04-08 2017-03-21 Chugai Seiyaku Kabushiki Kaisha Antibody substituting for function of blood coagulation factor viii
LT1976880T (lt) 2005-12-21 2016-10-10 Amgen Research (Munich) Gmbh Farmacinės kompozicijos, pasižyminčios atsparumu tirpiam cea
US9670269B2 (en) 2006-03-31 2017-06-06 Chugai Seiyaku Kabushiki Kaisha Methods of modifying antibodies for purification of bispecific antibodies
SG10201504662WA (en) * 2006-06-14 2015-07-30 Macrogenics Inc Methods For The Treatment Of Autoimmune Disorders Using Immunosuppressive Monoclonal Antibodies With Reduced Toxicity
US20080226635A1 (en) 2006-12-22 2008-09-18 Hans Koll Antibodies against insulin-like growth factor I receptor and uses thereof
JP5816170B2 (ja) 2009-06-26 2015-11-18 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. 天然の免疫グロブリン形式を有する容易に単離される二重特異性抗体
HRP20201595T1 (hr) * 2011-11-28 2020-12-11 Merck Patent Gmbh Anti-pd-l1 protutijela i njihova uporaba
LT2794905T (lt) 2011-12-20 2020-07-10 Medimmune, Llc Modifikuoti polipeptidai, skirti bispecifinių antikūnų karkasams
PE20190658A1 (es) 2012-02-24 2019-05-08 Abbvie Stemcentrx Llc Moduladores y metodos de empleo novedosos
WO2013163427A1 (en) 2012-04-25 2013-10-31 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Antibodies to treat hiv-1 infection
DK2847231T3 (da) 2012-05-10 2019-10-14 Bioatla Llc Multispecifikke monoklonale antistoffer
WO2014012085A2 (en) 2012-07-13 2014-01-16 Zymeworks Inc. Bispecific asymmetric heterodimers comprising anti-cd3 constructs
AU2013302696B9 (en) * 2012-08-14 2018-08-09 Ibc Pharmaceuticals, Inc. T-cell redirecting bispecific antibodies for treatment of disease
WO2014075788A1 (en) 2012-11-13 2014-05-22 Biontech Ag Agents for treatment of claudin expressing cancer diseases
WO2014189973A2 (en) * 2013-05-20 2014-11-27 Genentech, Inc. Anti-transferrin receptor antibodies and methods of use
JP2016531100A (ja) * 2013-07-12 2016-10-06 ザイムワークス,インコーポレイテッド 二重特異的なcd3及びcd19抗原結合構築物
KR20160044060A (ko) * 2013-10-11 2016-04-22 에프. 호프만-라 로슈 아게 다중특이적 도메인 교환된 통상의 가변 경쇄 항체
EP3327038B1 (en) 2013-12-20 2020-09-23 F. Hoffmann-La Roche AG Bispecific her2 antibodies and methods of use
TWI680138B (zh) * 2014-01-23 2019-12-21 美商再生元醫藥公司 抗pd-l1之人類抗體
US10059761B2 (en) 2014-03-12 2018-08-28 Prothena Biosciences Limited Anti-Laminin4 antibodies specific for LG4-5
TWI754319B (zh) 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
MX2017006016A (es) 2014-11-11 2017-06-19 Amunix Operating Inc Composiciones conjugadas de xten direccionadas y metodos para producir las mismas.
CN110894240B (zh) * 2014-11-26 2022-04-15 森科股份有限公司 结合cd3和肿瘤抗原的异二聚体抗体
CN110655582B (zh) 2015-01-08 2022-12-16 江苏康宁杰瑞生物制药有限公司 具有共同轻链的双特异性抗体或抗体混合物
CN107660214B (zh) * 2015-01-08 2022-02-08 根马布股份公司 针对cd3和cd20的双特异性抗体
JP2018502859A (ja) 2015-01-09 2018-02-01 イミューノメディクス、インコーポレイテッドImmunomedics, Inc. 二重特異性抗体を用いた事前標的指向化による腫瘍の治療
US10464999B2 (en) * 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
SI3115376T1 (sl) * 2015-07-10 2018-12-31 Merus N.V. Humana protitelesa, ki vežejo CD3
PL3368572T3 (pl) * 2015-10-02 2022-09-12 Symphogen A/S Przeciwciała anty-PD-1 oraz kompozycje
JP7058219B2 (ja) * 2015-12-07 2022-04-21 ゼンコア インコーポレイテッド Cd3及びpsmaに結合するヘテロ二量体抗体
CN108601830B (zh) 2015-12-18 2023-02-03 比奥根Ma公司 双特异性抗体平台
EP3661555B1 (en) * 2017-08-01 2025-04-16 Ab Therapeutics, Inc. Bispecific antibodies and uses thereof

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