JP2008517878A5 - - Google Patents
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- JP2008517878A5 JP2008517878A5 JP2007535791A JP2007535791A JP2008517878A5 JP 2008517878 A5 JP2008517878 A5 JP 2008517878A5 JP 2007535791 A JP2007535791 A JP 2007535791A JP 2007535791 A JP2007535791 A JP 2007535791A JP 2008517878 A5 JP2008517878 A5 JP 2008517878A5
- Authority
- JP
- Japan
- Prior art keywords
- suspension system
- gel particles
- working substance
- liquid
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000725 suspension Substances 0.000 claims 65
- 239000007788 liquid Substances 0.000 claims 24
- 239000007863 gel particle Substances 0.000 claims 22
- 239000000126 substance Substances 0.000 claims 22
- 239000003814 drug Substances 0.000 claims 9
- 239000000178 monomer Substances 0.000 claims 8
- 238000006116 polymerization reaction Methods 0.000 claims 8
- 210000001519 tissue Anatomy 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- XFCMNSHQOZQILR-UHFFFAOYSA-N 2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOC(=O)C(C)=C XFCMNSHQOZQILR-UHFFFAOYSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 210000002808 connective tissue Anatomy 0.000 claims 3
- 239000002537 cosmetic Substances 0.000 claims 3
- 239000003431 cross linking reagent Substances 0.000 claims 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims 3
- 210000003205 muscle Anatomy 0.000 claims 3
- 229920005862 polyol Polymers 0.000 claims 3
- 150000003077 polyols Chemical class 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims 2
- LEJBBGNFPAFPKQ-UHFFFAOYSA-N 2-(2-prop-2-enoyloxyethoxy)ethyl prop-2-enoate Chemical compound C=CC(=O)OCCOCCOC(=O)C=C LEJBBGNFPAFPKQ-UHFFFAOYSA-N 0.000 claims 2
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 claims 2
- VHSHLMUCYSAUQU-UHFFFAOYSA-N 2-hydroxypropyl methacrylate Chemical compound CC(O)COC(=O)C(C)=C VHSHLMUCYSAUQU-UHFFFAOYSA-N 0.000 claims 2
- KUDUQBURMYMBIJ-UHFFFAOYSA-N 2-prop-2-enoyloxyethyl prop-2-enoate Chemical group C=CC(=O)OCCOC(=O)C=C KUDUQBURMYMBIJ-UHFFFAOYSA-N 0.000 claims 2
- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 2
- 230000003416 augmentation Effects 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 claims 2
- 210000000845 cartilage Anatomy 0.000 claims 2
- 210000000981 epithelium Anatomy 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000008207 working material Substances 0.000 claims 2
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 claims 1
- QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 claims 1
- OLQFXOWPTQTLDP-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCO OLQFXOWPTQTLDP-UHFFFAOYSA-N 0.000 claims 1
- RWXMAAYKJDQVTF-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl prop-2-enoate Chemical compound OCCOCCOC(=O)C=C RWXMAAYKJDQVTF-UHFFFAOYSA-N 0.000 claims 1
- ZKLMKZINKNMVKA-UHFFFAOYSA-N 2-(2-hydroxypropoxy)propan-1-ol;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CC(O)COC(C)CO ZKLMKZINKNMVKA-UHFFFAOYSA-N 0.000 claims 1
- YATYDCQGPUOZGZ-UHFFFAOYSA-N 2-(2-hydroxypropoxy)propan-1-ol;prop-2-enoic acid Chemical compound OC(=O)C=C.CC(O)COC(C)CO YATYDCQGPUOZGZ-UHFFFAOYSA-N 0.000 claims 1
- JJBFVQSGPLGDNX-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)propyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC(C)COC(=O)C(C)=C JJBFVQSGPLGDNX-UHFFFAOYSA-N 0.000 claims 1
- IPDYIFGHKYLTOM-UHFFFAOYSA-N 2-(2-prop-2-enoyloxypropoxy)propyl prop-2-enoate Chemical compound C=CC(=O)OCC(C)OCC(C)OC(=O)C=C IPDYIFGHKYLTOM-UHFFFAOYSA-N 0.000 claims 1
- JFZBUNLOTDDXNY-UHFFFAOYSA-N 2-[2-(2-methylprop-2-enoyloxy)propoxy]propyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(C)OCC(C)OC(=O)C(C)=C JFZBUNLOTDDXNY-UHFFFAOYSA-N 0.000 claims 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 claims 1
- HXDLWJWIAHWIKI-UHFFFAOYSA-N 2-hydroxyethyl acetate Chemical compound CC(=O)OCCO HXDLWJWIAHWIKI-UHFFFAOYSA-N 0.000 claims 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims 1
- GWZMWHWAWHPNHN-UHFFFAOYSA-N 2-hydroxypropyl prop-2-enoate Chemical compound CC(O)COC(=O)C=C GWZMWHWAWHPNHN-UHFFFAOYSA-N 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- QZPSOSOOLFHYRR-UHFFFAOYSA-N 3-hydroxypropyl prop-2-enoate Chemical compound OCCCOC(=O)C=C QZPSOSOOLFHYRR-UHFFFAOYSA-N 0.000 claims 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- UXDDRFCJKNROTO-UHFFFAOYSA-N Glycerol 1,2-diacetate Chemical compound CC(=O)OCC(CO)OC(C)=O UXDDRFCJKNROTO-UHFFFAOYSA-N 0.000 claims 1
- 239000004348 Glyceryl diacetate Substances 0.000 claims 1
- 239000004347 Glyceryl monoacetate Substances 0.000 claims 1
- 229920000877 Melamine resin Polymers 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000005888 Periodontal Pocket Diseases 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 claims 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- -1 allyl vinyl maleate Chemical compound 0.000 claims 1
- KGDPCYLOLUTZEO-UHFFFAOYSA-N bis(2-hydroxyethyl) 2-methylidenebutanedioate Chemical compound OCCOC(=O)CC(=C)C(=O)OCCO KGDPCYLOLUTZEO-UHFFFAOYSA-N 0.000 claims 1
- DWSNCSCTZIYPNV-UHFFFAOYSA-N bis(3-hydroxypropyl) oxalate Chemical compound OCCCOC(=O)C(=O)OCCCO DWSNCSCTZIYPNV-UHFFFAOYSA-N 0.000 claims 1
- VGSLORJPNYOXGN-SREVYHEPSA-N bis(ethenyl) (z)-2-methylbut-2-enedioate Chemical compound C=COC(=O)C(/C)=C\C(=O)OC=C VGSLORJPNYOXGN-SREVYHEPSA-N 0.000 claims 1
- BFHRUCFCIXWADD-UHFFFAOYSA-N bis(ethenyl) 2,3-dihydroxybutanedioate Chemical compound C=COC(=O)C(O)C(O)C(=O)OC=C BFHRUCFCIXWADD-UHFFFAOYSA-N 0.000 claims 1
- ZPOLOEWJWXZUSP-AATRIKPKSA-N bis(prop-2-enyl) (e)-but-2-enedioate Chemical compound C=CCOC(=O)\C=C\C(=O)OCC=C ZPOLOEWJWXZUSP-AATRIKPKSA-N 0.000 claims 1
- ZPOLOEWJWXZUSP-WAYWQWQTSA-N bis(prop-2-enyl) (z)-but-2-enedioate Chemical compound C=CCOC(=O)\C=C/C(=O)OCC=C ZPOLOEWJWXZUSP-WAYWQWQTSA-N 0.000 claims 1
- VPPSHXIFIAJKMX-UHFFFAOYSA-N bis(prop-2-enyl) 2,3-dihydroxybutanedioate Chemical compound C=CCOC(=O)C(O)C(O)C(=O)OCC=C VPPSHXIFIAJKMX-UHFFFAOYSA-N 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- PRXKHZGEIIFEBU-UHFFFAOYSA-N butane-1,4-diol;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CC(=C)C(O)=O.OCCCCO PRXKHZGEIIFEBU-UHFFFAOYSA-N 0.000 claims 1
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 229920006037 cross link polymer Polymers 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 210000004268 dentin Anatomy 0.000 claims 1
- 150000001991 dicarboxylic acids Chemical class 0.000 claims 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000001033 ether group Chemical group 0.000 claims 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 235000019443 glyceryl diacetate Nutrition 0.000 claims 1
- 235000019442 glyceryl monoacetate Nutrition 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- PYGSKMBEVAICCR-UHFFFAOYSA-N hexa-1,5-diene Chemical group C=CCCC=C PYGSKMBEVAICCR-UHFFFAOYSA-N 0.000 claims 1
- XXMIOPMDWAUFGU-UHFFFAOYSA-N hexane-1,6-diol Chemical compound OCCCCCCO XXMIOPMDWAUFGU-UHFFFAOYSA-N 0.000 claims 1
- OHMBHFSEKCCCBW-UHFFFAOYSA-N hexane-2,5-diol Chemical compound CC(O)CCC(C)O OHMBHFSEKCCCBW-UHFFFAOYSA-N 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- JDSHMPZPIAZGSV-UHFFFAOYSA-N melamine Chemical compound NC1=NC(N)=NC(N)=N1 JDSHMPZPIAZGSV-UHFFFAOYSA-N 0.000 claims 1
- RIEABXYBQSLTFR-UHFFFAOYSA-N monobutyrin Chemical compound CCCC(=O)OCC(O)CO RIEABXYBQSLTFR-UHFFFAOYSA-N 0.000 claims 1
- 150000002763 monocarboxylic acids Chemical class 0.000 claims 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- RPQRDASANLAFCM-UHFFFAOYSA-N oxiran-2-ylmethyl prop-2-enoate Chemical compound C=CC(=O)OCC1CO1 RPQRDASANLAFCM-UHFFFAOYSA-N 0.000 claims 1
- DBSDMAPJGHBWAL-UHFFFAOYSA-N penta-1,4-dien-3-ylbenzene Chemical compound C=CC(C=C)C1=CC=CC=C1 DBSDMAPJGHBWAL-UHFFFAOYSA-N 0.000 claims 1
- 210000002379 periodontal ligament Anatomy 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001515 polyalkylene glycol Polymers 0.000 claims 1
- 229940113115 polyethylene glycol 200 Drugs 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 230000008467 tissue growth Effects 0.000 claims 1
- 150000003628 tricarboxylic acids Chemical class 0.000 claims 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims 1
- XHDRYKHQTDSTRY-UHFFFAOYSA-N tris(2-hydroxyethyl) 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound OCCOC(=O)CC(O)(C(=O)OCCO)CC(=O)OCCO XHDRYKHQTDSTRY-UHFFFAOYSA-N 0.000 claims 1
- NZHHDFRSEQSGLN-ZRDIBKRKSA-N tris(prop-2-enyl) (e)-prop-1-ene-1,2,3-tricarboxylate Chemical compound C=CCOC(=O)C\C(C(=O)OCC=C)=C/C(=O)OCC=C NZHHDFRSEQSGLN-ZRDIBKRKSA-N 0.000 claims 1
- KJWHEZXBZQXVSA-UHFFFAOYSA-N tris(prop-2-enyl) phosphite Chemical compound C=CCOP(OCC=C)OCC=C KJWHEZXBZQXVSA-UHFFFAOYSA-N 0.000 claims 1
- 229960000834 vinyl ether Drugs 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/960,461 US7811605B2 (en) | 2002-11-06 | 2004-10-06 | Method of formation of shape-retentive aggregates of gel particles and their uses |
| PCT/US2005/035905 WO2006041967A1 (en) | 2004-10-06 | 2005-10-06 | Method of formation of the shape-retentive aggregates of gel particles and their uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008517878A JP2008517878A (ja) | 2008-05-29 |
| JP2008517878A5 true JP2008517878A5 (https=) | 2008-11-06 |
Family
ID=36148658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007535791A Pending JP2008517878A (ja) | 2004-10-06 | 2005-10-06 | ゲル粒子の形状保持凝集塊の形成の方法とその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7811605B2 (https=) |
| EP (1) | EP1814522A4 (https=) |
| JP (1) | JP2008517878A (https=) |
| KR (1) | KR20070083927A (https=) |
| CN (1) | CN101065109A (https=) |
| AU (1) | AU2005294311B2 (https=) |
| BR (1) | BRPI0516095A (https=) |
| CA (1) | CA2583341A1 (https=) |
| IL (1) | IL182410A0 (https=) |
| MX (1) | MX2007004169A (https=) |
| NZ (1) | NZ554458A (https=) |
| RU (1) | RU2395276C2 (https=) |
| WO (1) | WO2006041967A1 (https=) |
| ZA (1) | ZA200703563B (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7811605B2 (en) * | 2002-11-06 | 2010-10-12 | Uluru Inc. | Method of formation of shape-retentive aggregates of gel particles and their uses |
| US7351430B2 (en) * | 2002-11-06 | 2008-04-01 | Uluru Inc. | Shape-retentive hydrogel particle aggregates and their uses |
| DE10300271A1 (de) * | 2003-01-08 | 2004-07-22 | Mnemoscience Gmbh | Photosensitive polymere Netzwerke |
| CA2633380A1 (en) * | 2005-12-16 | 2007-07-05 | University Of Kansas | Nanoclusters for delivery of therapeutics |
| US8668676B2 (en) * | 2006-06-19 | 2014-03-11 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
| US7504366B2 (en) * | 2006-08-16 | 2009-03-17 | Halliburton Energy Services, Inc. | Subterranean treatment fluids, friction reducing copolymers, and associated methods |
| US7910135B2 (en) | 2006-10-13 | 2011-03-22 | Uluru Inc. | Hydrogel wound dressing and biomaterials formed in situ and their uses |
| EP2091584A2 (en) * | 2006-12-12 | 2009-08-26 | Bausch & Lomb Incorporated | Ordered polymer system and intraocular lens |
| US20080228268A1 (en) * | 2007-03-15 | 2008-09-18 | Uluru, Inc. | Method of Formation of Viscous, Shape Conforming Gels and Their Uses as Medical Prosthesis |
| WO2008137747A1 (en) * | 2007-05-02 | 2008-11-13 | The Regents Of The University Of Michigan | Nanoemulsion therapeutic compositions and methods of using the same |
| US20080287633A1 (en) * | 2007-05-18 | 2008-11-20 | Drumheller Paul D | Hydrogel Materials |
| WO2009117542A2 (en) * | 2008-03-20 | 2009-09-24 | E. I. Du Pont De Nemours And Company | Dimensionally stable, shaped articles comprised of dried, aggregated, water-swellable hydrogel microspheres and method of making same |
| EP2306931B1 (en) * | 2008-06-30 | 2013-06-26 | Allergan, Inc. | Fillable prosthetic breast prosthesis with gel-like properties |
| US8557288B2 (en) * | 2008-08-15 | 2013-10-15 | Washington University | Hydrogel microparticle formation in aqueous solvent for biomedical applications |
| WO2010022131A1 (en) * | 2008-08-20 | 2010-02-25 | Allergan, Inc. | Self-sealing shell for inflatable prostheses |
| US8636797B2 (en) | 2010-02-05 | 2014-01-28 | Allergan, Inc. | Inflatable prostheses and methods of making same |
| KR20130004575A (ko) | 2010-02-05 | 2013-01-11 | 알러간, 인코포레이티드 | 팽창성 보형물 및 그의 제작방법 |
| US8207290B2 (en) | 2010-03-26 | 2012-06-26 | Cerulean Pharma Inc. | Methods and systems for generating nanoparticles |
| US8546521B2 (en) | 2011-01-28 | 2013-10-01 | Cerulean Pharma Inc. | Method for fabricating nanoparticles |
| KR101860485B1 (ko) * | 2011-11-03 | 2018-07-02 | (주)아모레퍼시픽 | 미세 유화 입자를 포함하는 미용 티슈, 그 제조방법 및 사용방법 |
| EP2847249A4 (en) * | 2012-03-14 | 2016-12-28 | Medipacs Inc | Smart polymer materials with excess reactive molecules |
| WO2016140716A1 (en) | 2015-03-02 | 2016-09-09 | The Trustees Of Columbia University In The City Of New York | Injectable microtissue systems, devices, and methods |
| USD896383S1 (en) | 2018-09-13 | 2020-09-15 | Allergan, Inc. | Tissue expansion device |
| CA3112634A1 (en) | 2018-09-13 | 2020-03-19 | Allergan, Inc. | Tissue expansion device |
| CN113336536B (zh) * | 2021-05-31 | 2022-11-15 | 大连理工大学 | 一种无机非金属纳米颗粒组装的水凝胶材料及其在增材制造技术中的应用 |
| WO2025166277A1 (en) * | 2024-02-02 | 2025-08-07 | Slingshot Biosciences, Inc. | Synthetic cell mimics with modified surface charges |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CS163469B1 (https=) | 1972-05-22 | 1975-09-15 | ||
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| US5091443A (en) * | 1990-02-07 | 1992-02-25 | Becton, Dickinson And Company | Composition for gelling liquids |
| US5266325A (en) * | 1990-09-28 | 1993-11-30 | Hydro Med Science Division Of National Patent Development Corp. | Preparation of homogeneous hydrogel copolymers |
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| IT1243390B (it) * | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
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| DE19601764A1 (de) | 1996-01-19 | 1997-07-24 | Hoechst Ag | Verfahren zur Herstellung hydrophiler, hochquellfähiger Hydrogele |
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| US6521431B1 (en) * | 1999-06-22 | 2003-02-18 | Access Pharmaceuticals, Inc. | Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments |
| JP2002284882A (ja) | 2001-03-27 | 2002-10-03 | Mitsubishi Chemicals Corp | 高吸水性ポリマーの製造方法 |
| JP4883844B2 (ja) | 2001-04-05 | 2012-02-22 | 住友精化株式会社 | カルボキシル基含有重合体粒子 |
| MXPA04000156A (es) * | 2001-06-29 | 2005-06-06 | Medgraft Microtech Inc | Implantes inyectables biodegradables y metodos relacionados de fabricacion y uso. |
| US20030138490A1 (en) * | 2001-09-08 | 2003-07-24 | Zhibing Hu | Synthesis and uses of polymer gel nanoparticle networks |
| IL145576A0 (en) | 2001-09-24 | 2002-06-30 | A prosthesis for physical implant | |
| JP2003261777A (ja) | 2002-03-07 | 2003-09-19 | Japan Science & Technology Corp | 高圧により形成される分子複合体 |
| US7351430B2 (en) * | 2002-11-06 | 2008-04-01 | Uluru Inc. | Shape-retentive hydrogel particle aggregates and their uses |
| US7811605B2 (en) * | 2002-11-06 | 2010-10-12 | Uluru Inc. | Method of formation of shape-retentive aggregates of gel particles and their uses |
| CN1522690A (zh) | 2003-02-12 | 2004-08-25 | 罗姆和哈斯公司 | 消费产品中的聚合物纳米微粒 |
-
2004
- 2004-10-06 US US10/960,461 patent/US7811605B2/en active Active
-
2005
- 2005-10-06 RU RU2007116975/15A patent/RU2395276C2/ru not_active IP Right Cessation
- 2005-10-06 JP JP2007535791A patent/JP2008517878A/ja active Pending
- 2005-10-06 BR BRPI0516095-2A patent/BRPI0516095A/pt not_active IP Right Cessation
- 2005-10-06 KR KR1020077010042A patent/KR20070083927A/ko not_active Ceased
- 2005-10-06 AU AU2005294311A patent/AU2005294311B2/en not_active Ceased
- 2005-10-06 ZA ZA200703563A patent/ZA200703563B/xx unknown
- 2005-10-06 EP EP05804247A patent/EP1814522A4/en not_active Withdrawn
- 2005-10-06 WO PCT/US2005/035905 patent/WO2006041967A1/en not_active Ceased
- 2005-10-06 CN CNA2005800402244A patent/CN101065109A/zh active Pending
- 2005-10-06 NZ NZ554458A patent/NZ554458A/en not_active IP Right Cessation
- 2005-10-06 CA CA002583341A patent/CA2583341A1/en not_active Abandoned
- 2005-10-06 MX MX2007004169A patent/MX2007004169A/es unknown
-
2007
- 2007-04-10 IL IL182410A patent/IL182410A0/en unknown
- 2007-10-30 US US11/929,531 patent/US20080063716A1/en not_active Abandoned
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