CN101065109A - 形状－保持性凝胶粒子聚集体的生成方法和它们的用途 - Google Patents

形状－保持性凝胶粒子聚集体的生成方法和它们的用途 Download PDF

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Publication number
CN101065109A
CN101065109A CNA2005800402244A CN200580040224A CN101065109A CN 101065109 A CN101065109 A CN 101065109A CN A2005800402244 A CNA2005800402244 A CN A2005800402244A CN 200580040224 A CN200580040224 A CN 200580040224A CN 101065109 A CN101065109 A CN 101065109A
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Prior art keywords
particles
aggregates
phema
particle
liquid
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Pending
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CNA2005800402244A
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English (en)
Chinese (zh)
Inventor
D·G·莫罗
J·V·圣约翰
K·F·珊农
B·C·庞德
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Uluru Inc
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Uluru Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/513—Organic macromolecular compounds; Dendrimers
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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    • A—HUMAN NECESSITIES
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
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    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2312/00—Crosslinking
    • C—CHEMISTRY; METALLURGY
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    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers

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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
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  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Polymerisation Methods In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
CNA2005800402244A 2004-10-06 2005-10-06 形状－保持性凝胶粒子聚集体的生成方法和它们的用途 Pending CN101065109A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/960,461 2004-10-06
US10/960,461 US7811605B2 (en) 2002-11-06 2004-10-06 Method of formation of shape-retentive aggregates of gel particles and their uses

Publications (1)

Publication Number Publication Date
CN101065109A true CN101065109A (zh) 2007-10-31

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CNA2005800402244A Pending CN101065109A (zh) 2004-10-06 2005-10-06 形状－保持性凝胶粒子聚集体的生成方法和它们的用途

Country Status (14)

Country Link
US (2) US7811605B2 (https=)
EP (1) EP1814522A4 (https=)
JP (1) JP2008517878A (https=)
KR (1) KR20070083927A (https=)
CN (1) CN101065109A (https=)
AU (1) AU2005294311B2 (https=)
BR (1) BRPI0516095A (https=)
CA (1) CA2583341A1 (https=)
IL (1) IL182410A0 (https=)
MX (1) MX2007004169A (https=)
NZ (1) NZ554458A (https=)
RU (1) RU2395276C2 (https=)
WO (1) WO2006041967A1 (https=)
ZA (1) ZA200703563B (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7811605B2 (en) * 2002-11-06 2010-10-12 Uluru Inc. Method of formation of shape-retentive aggregates of gel particles and their uses
US7351430B2 (en) * 2002-11-06 2008-04-01 Uluru Inc. Shape-retentive hydrogel particle aggregates and their uses
DE10300271A1 (de) * 2003-01-08 2004-07-22 Mnemoscience Gmbh Photosensitive polymere Netzwerke
CA2633380A1 (en) * 2005-12-16 2007-07-05 University Of Kansas Nanoclusters for delivery of therapeutics
US8668676B2 (en) * 2006-06-19 2014-03-11 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
US7504366B2 (en) * 2006-08-16 2009-03-17 Halliburton Energy Services, Inc. Subterranean treatment fluids, friction reducing copolymers, and associated methods
US7910135B2 (en) 2006-10-13 2011-03-22 Uluru Inc. Hydrogel wound dressing and biomaterials formed in situ and their uses
EP2091584A2 (en) * 2006-12-12 2009-08-26 Bausch & Lomb Incorporated Ordered polymer system and intraocular lens
US20080228268A1 (en) * 2007-03-15 2008-09-18 Uluru, Inc. Method of Formation of Viscous, Shape Conforming Gels and Their Uses as Medical Prosthesis
WO2008137747A1 (en) * 2007-05-02 2008-11-13 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
US20080287633A1 (en) * 2007-05-18 2008-11-20 Drumheller Paul D Hydrogel Materials
WO2009117542A2 (en) * 2008-03-20 2009-09-24 E. I. Du Pont De Nemours And Company Dimensionally stable, shaped articles comprised of dried, aggregated, water-swellable hydrogel microspheres and method of making same
EP2306931B1 (en) * 2008-06-30 2013-06-26 Allergan, Inc. Fillable prosthetic breast prosthesis with gel-like properties
US8557288B2 (en) * 2008-08-15 2013-10-15 Washington University Hydrogel microparticle formation in aqueous solvent for biomedical applications
WO2010022131A1 (en) * 2008-08-20 2010-02-25 Allergan, Inc. Self-sealing shell for inflatable prostheses
US8636797B2 (en) 2010-02-05 2014-01-28 Allergan, Inc. Inflatable prostheses and methods of making same
KR20130004575A (ko) 2010-02-05 2013-01-11 알러간, 인코포레이티드 팽창성 보형물 및 그의 제작방법
US8207290B2 (en) 2010-03-26 2012-06-26 Cerulean Pharma Inc. Methods and systems for generating nanoparticles
US8546521B2 (en) 2011-01-28 2013-10-01 Cerulean Pharma Inc. Method for fabricating nanoparticles
KR101860485B1 (ko) * 2011-11-03 2018-07-02 (주)아모레퍼시픽 미세 유화 입자를 포함하는 미용 티슈, 그 제조방법 및 사용방법
EP2847249A4 (en) * 2012-03-14 2016-12-28 Medipacs Inc Smart polymer materials with excess reactive molecules
WO2016140716A1 (en) 2015-03-02 2016-09-09 The Trustees Of Columbia University In The City Of New York Injectable microtissue systems, devices, and methods
USD896383S1 (en) 2018-09-13 2020-09-15 Allergan, Inc. Tissue expansion device
CA3112634A1 (en) 2018-09-13 2020-03-19 Allergan, Inc. Tissue expansion device
CN113336536B (zh) * 2021-05-31 2022-11-15 大连理工大学 一种无机非金属纳米颗粒组装的水凝胶材料及其在增材制造技术中的应用
WO2025166277A1 (en) * 2024-02-02 2025-08-07 Slingshot Biosciences, Inc. Synthetic cell mimics with modified surface charges

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3822089A (en) 1968-09-25 1974-07-02 Akademie Ved Contact lens blank or replica made from anhydrous, sparingly cross-linked hydrophilic copolymers
CS153762B1 (https=) 1969-01-14 1974-03-29
JPS492189B1 (https=) 1970-10-28 1974-01-18
US3948841A (en) * 1972-05-22 1976-04-06 Karel Dusek Process for producing transparent gels with improved mechanical and sorption properties from copolymers of 2-hydroxyethyl methacrylate and amides of acrylic or methacrylic acid
CS163469B1 (https=) 1972-05-22 1975-09-15
US3963685A (en) * 1974-05-13 1976-06-15 Abrahams Robert A Alcohol soluble hydrophilic polymer via aqueous polymerization
JPS5340038A (en) 1976-09-27 1978-04-12 Japan Exlan Co Ltd Preparation of microhydrogel
US4272518A (en) * 1979-07-10 1981-06-09 Moro Daniel G Plastic wound bandage
EP0068684B1 (en) * 1981-06-12 1986-08-13 National Research Development Corporation Preparation of particulate gels
JPS58331A (ja) 1981-06-23 1983-01-05 Nec Corp プレス部品打抜き方法
JPS5911602B2 (ja) 1982-12-28 1984-03-16 東レ株式会社 診断用微粒子
US5122544A (en) * 1988-05-31 1992-06-16 Nalco Chemical Company Process for producing improved superabsorbent polymer aggregates from fines
US5840293A (en) * 1988-11-16 1998-11-24 Advanced Polymer Systems, Inc. Ionic beads for controlled release and adsorption
US4962133A (en) * 1989-09-05 1990-10-09 Dow Corning Corporation Method of making highly adsorptive copolymers
US5468811A (en) * 1989-11-02 1995-11-21 National Patent Development Corporation Hydrophilic composite polymer articles formed from a settable paste comprising a mixture of hydrophilic polymer and unsaturated monomer
US5045266A (en) * 1989-11-02 1991-09-03 National Patent Development Corporation Process of making a hearing aid earmold in situ
US5091443A (en) * 1990-02-07 1992-02-25 Becton, Dickinson And Company Composition for gelling liquids
US5266325A (en) * 1990-09-28 1993-11-30 Hydro Med Science Division Of National Patent Development Corp. Preparation of homogeneous hydrogel copolymers
AU651654B2 (en) * 1992-01-14 1994-07-28 Endo Pharmaceuticals Solutions Inc. Manufacture of water-swellable hydrophilic articles and drug delivery devices
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
JP2993801B2 (ja) 1992-07-09 1999-12-27 株式会社日本触媒 粒子状含水ゲル状重合体および吸水性樹脂の製造方法
EP0758244B2 (en) * 1994-05-06 2008-02-13 Pfizer Inc. Controlled-release dosage forms of azithromycin
US5840338A (en) * 1994-07-18 1998-11-24 Roos; Eric J. Loading of biologically active solutes into polymer gels
US5632774A (en) * 1995-01-17 1997-05-27 Babian; Hamik In-the-shell hydration to make implant filler material and prosthesis employing same
JP3156955B2 (ja) 1995-07-12 2001-04-16 大日精化工業株式会社 連結されたミクロゲル粒子の製造方法及びそれで処理された物品
AU676971B1 (en) * 1995-08-24 1997-03-27 Dainichiseika Color & Chemicals Mfg. Co. Ltd. Production process of connected microgel particles and articles treated with connected microgel particles
DE19601764A1 (de) 1996-01-19 1997-07-24 Hoechst Ag Verfahren zur Herstellung hydrophiler, hochquellfähiger Hydrogele
EP0873145A2 (en) * 1996-11-15 1998-10-28 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
JP2001517494A (ja) 1997-09-19 2001-10-09 リプロジェネシス・インコーポレーテッド 組織エンジニアリングのための改良されたヒドロゲル
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
US6521431B1 (en) * 1999-06-22 2003-02-18 Access Pharmaceuticals, Inc. Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments
JP2002284882A (ja) 2001-03-27 2002-10-03 Mitsubishi Chemicals Corp 高吸水性ポリマーの製造方法
JP4883844B2 (ja) 2001-04-05 2012-02-22 住友精化株式会社 カルボキシル基含有重合体粒子
MXPA04000156A (es) * 2001-06-29 2005-06-06 Medgraft Microtech Inc Implantes inyectables biodegradables y metodos relacionados de fabricacion y uso.
US20030138490A1 (en) * 2001-09-08 2003-07-24 Zhibing Hu Synthesis and uses of polymer gel nanoparticle networks
IL145576A0 (en) 2001-09-24 2002-06-30 A prosthesis for physical implant
JP2003261777A (ja) 2002-03-07 2003-09-19 Japan Science & Technology Corp 高圧により形成される分子複合体
US7351430B2 (en) * 2002-11-06 2008-04-01 Uluru Inc. Shape-retentive hydrogel particle aggregates and their uses
US7811605B2 (en) * 2002-11-06 2010-10-12 Uluru Inc. Method of formation of shape-retentive aggregates of gel particles and their uses
CN1522690A (zh) 2003-02-12 2004-08-25 罗姆和哈斯公司 消费产品中的聚合物纳米微粒

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