JP2008513464A5 - - Google Patents
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- Publication number
- JP2008513464A5 JP2008513464A5 JP2007532443A JP2007532443A JP2008513464A5 JP 2008513464 A5 JP2008513464 A5 JP 2008513464A5 JP 2007532443 A JP2007532443 A JP 2007532443A JP 2007532443 A JP2007532443 A JP 2007532443A JP 2008513464 A5 JP2008513464 A5 JP 2008513464A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- pyrazol
- optionally substituted
- urea
- methylpiperazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 *c1c(*)[n]nc1* Chemical compound *c1c(*)[n]nc1* 0.000 description 7
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- HMFDAWKQTIGMHE-GORDUTHDSA-N CN(CC1)CCN1c1ccc2nc(-c3n[nH]c(/C=C/c(cc4)ccc4O)c3)[nH]c2c1 Chemical compound CN(CC1)CCN1c1ccc2nc(-c3n[nH]c(/C=C/c(cc4)ccc4O)c3)[nH]c2c1 HMFDAWKQTIGMHE-GORDUTHDSA-N 0.000 description 2
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| AU (1) | AU2005287170B2 (https=) |
| CA (1) | CA2579313A1 (https=) |
| WO (1) | WO2006033943A2 (https=) |
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| BRPI0515482A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| MX2007003332A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| CA2618646A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| CN101058561B (zh) * | 2006-04-19 | 2011-01-26 | 苏州爱斯鹏药物研发有限责任公司 | 用于抑制蛋白激酶的二苯脲衍生物及其组合物和用途 |
| CL2009001214A1 (es) * | 2008-05-19 | 2010-12-31 | Schering Corp | Compuestos derivados de heterociclo, moduladores de serina proteasas composicion fa<rmacaeutica que los comprende; y su uso en el tratamiento de trastornos tromboembolicos |
| AU2009289649B2 (en) | 2008-09-03 | 2016-05-05 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
| WO2010045395A2 (en) * | 2008-10-14 | 2010-04-22 | Danyang Chen | Curcumin analog compositions and related methods |
| AU2011225095C1 (en) | 2010-03-11 | 2017-01-19 | Sumitomo Dainippon Pharma Co., Ltd. | N-Acyl cyclic amine derivative or pharmaceutically acceptable salt thereof |
| MX2012014958A (es) * | 2010-06-15 | 2013-02-12 | Bayer Ip Gmbh | Derivados de diamida antranilica. |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US9540395B2 (en) | 2011-02-28 | 2017-01-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| WO2012141228A1 (ja) * | 2011-04-11 | 2012-10-18 | 株式会社ファルマエイト | 新規ピラゾール誘導体 |
| US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
| US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
| CN104903297A (zh) * | 2012-10-10 | 2015-09-09 | 绿色科技株式会社 | 新型吡唑衍生物 |
| PL403149A1 (pl) * | 2013-03-14 | 2014-09-15 | Celon Pharma Spółka Akcyjna | Nowe związki pochodne pirazolilobenzo[d]imidazolu |
| DK2970139T3 (en) | 2013-03-15 | 2018-08-13 | Biomarin Pharm Inc | HDAC inhibitors |
| EP2944635B1 (en) * | 2014-05-15 | 2018-11-28 | Council of Scientific & Industrial Research | Pyrazole linked benzimidazole conjugates and a process for preparation thereof |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| EP3643705A1 (en) * | 2018-10-24 | 2020-04-29 | Basf Se | Pesticidal compounds |
| WO2022186362A1 (ja) * | 2021-03-03 | 2022-09-09 | 白鳥製薬株式会社 | ピラゾール化合物の製造方法 |
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| DE923028C (de) | 1952-04-02 | 1955-01-31 | Basf Ag | Verfahren zur Herstellung von Kuepenfarbstoffen |
| US3948937A (en) * | 1972-02-29 | 1976-04-06 | E. I. Du Pont De Nemours And Company | Pyrazole plant growth regulants |
| ZA744908B (en) * | 1973-09-17 | 1975-08-27 | American Cyanamid Co | Catalytic dehydrogenation process for the preparation of 3,5-disubstituted pyrazoles |
| GB1484615A (en) * | 1974-11-23 | 1977-09-01 | Lepetit Spa | Tricyclic n-containing derivatives |
| US4014896A (en) * | 1975-02-12 | 1977-03-29 | American Cyanamid Company | Catalytic dehydrogenation process for the preparation of 3,4,5-trisubstituted pyrazoles |
| IE59813B1 (en) * | 1986-05-09 | 1994-04-06 | Warner Lambert Co | Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them |
| US4877881A (en) * | 1987-04-06 | 1989-10-31 | Warner-Lambert Company | Process of preparing pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxygenase inhibitors |
| DE3903993A1 (de) * | 1989-02-10 | 1990-08-16 | Basf Ag | Diarylsubstituierte heterocyclische verbindungen, ihre herstellung und arzneimittel daraus |
| JPH04124178A (ja) * | 1990-09-12 | 1992-04-24 | Sds Biotech Kk | 複素環式化合物および該化合物を含有する除草剤 |
| EP0628563B1 (de) * | 1993-06-08 | 1999-03-03 | BASF Aktiengesellschaft | Verfahren zur Herstellung von N-substituierten Pyrazolen |
| US5783593A (en) * | 1993-11-04 | 1998-07-21 | Abbott Laboratories | Inhibitors of squalene synthetase and protein farnesyltransferase |
| DE19500838A1 (de) * | 1995-01-13 | 1996-07-18 | Basf Ag | Verfahren zur Herstellung von 3,5-Diarylpyrazolen |
| WO2000007996A2 (en) | 1998-08-07 | 2000-02-17 | Chiron Corporation | Pyrazoles as estrogen receptor modulators |
| AU1199600A (en) * | 1998-10-02 | 2000-04-26 | Board Of Trustees Of The University Of Illinois, The | Estrogen receptor ligands |
| DE19904397A1 (de) | 1999-02-04 | 2000-08-10 | Bayer Ag | Verwendung von Pyrazol-Carbonsäureamiden |
| AP2002002582A0 (en) | 1999-12-23 | 2002-09-30 | Nitromed Inc | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| IL152097A0 (en) | 2000-05-19 | 2003-05-29 | Applied Research Systems | Use of pyrazole derivatives for treating infertility |
| CN1259316C (zh) | 2001-04-05 | 2006-06-14 | 托伦脱药品有限公司 | 用于老龄相关性和糖尿病性血管系统并发症的杂环类化合物 |
| JP2005504014A (ja) | 2001-06-08 | 2005-02-10 | サイトビア インコーポレイテッド | カスパーゼの活性化因子およびアポトーシスの誘導因子としての置換された３−アリール−５−アリール−［１，２，４］−オキサジアゾール類および類似体、並びにその使用法 |
| BR0213562A (pt) | 2001-10-26 | 2004-08-31 | Aventis Pharma Inc | Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna |
| FR2831536A1 (fr) * | 2001-10-26 | 2003-05-02 | Aventis Pharma Sa | Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr |
| JP2005162612A (ja) * | 2002-01-09 | 2005-06-23 | Ajinomoto Co Inc | アシルスルホンアミド誘導体 |
| US6790979B2 (en) * | 2002-04-17 | 2004-09-14 | University Of North Carolina At Chapel Hill | Curcumin analogues and uses thereof |
| NI200300045A (es) * | 2002-04-26 | 2005-07-08 | Pfizer Prod Inc | Inhibidores de triariloxiariloxipirimidin-2,4,6-triona de metaloproteinasa. |
| AU2002314566A1 (en) * | 2002-06-17 | 2003-12-31 | Ho-Jeong Kwon | Novel curcumin derivatives |
| WO2004080972A1 (en) * | 2003-03-12 | 2004-09-23 | Vertex Pharmaceuticals Incorporated | Pirazole modulators of atp-binding cassette transporters |
| US7115642B2 (en) * | 2003-05-02 | 2006-10-03 | Rigel Pharmaceuticals, Inc. | Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection |
| GB0326601D0 (en) | 2003-11-14 | 2003-12-17 | Novartis Ag | Organic compounds |
| US7517910B2 (en) * | 2004-03-30 | 2009-04-14 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
| JPWO2005094823A1 (ja) * | 2004-03-30 | 2007-08-16 | 協和醗酵工業株式会社 | Ｆｌｔ−３阻害剤 |
-
2005
- 2005-09-15 EP EP05796701A patent/EP1797072A4/en not_active Withdrawn
- 2005-09-15 JP JP2007532443A patent/JP5063351B2/ja not_active Expired - Fee Related
- 2005-09-15 US US11/575,411 patent/US8710038B2/en not_active Expired - Fee Related
- 2005-09-15 CA CA002579313A patent/CA2579313A1/en not_active Abandoned
- 2005-09-15 WO PCT/US2005/032839 patent/WO2006033943A2/en not_active Ceased
- 2005-09-15 AU AU2005287170A patent/AU2005287170B2/en not_active Ceased
-
2012
- 2012-05-16 JP JP2012112312A patent/JP2012153720A/ja not_active Withdrawn
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