JP2008513352A5 - - Google Patents
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- JP2008513352A5 JP2008513352A5 JP2007519460A JP2007519460A JP2008513352A5 JP 2008513352 A5 JP2008513352 A5 JP 2008513352A5 JP 2007519460 A JP2007519460 A JP 2007519460A JP 2007519460 A JP2007519460 A JP 2007519460A JP 2008513352 A5 JP2008513352 A5 JP 2008513352A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- optionally substituted
- nitrogen
- oxygen
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 64
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 38
- 229910052757 nitrogen Inorganic materials 0.000 claims 27
- 229910052760 oxygen Inorganic materials 0.000 claims 26
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 25
- 125000005842 heteroatom Chemical group 0.000 claims 25
- 239000001301 oxygen Chemical group 0.000 claims 25
- 229910052717 sulfur Inorganic materials 0.000 claims 24
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 23
- 239000011593 sulfur Chemical group 0.000 claims 23
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 18
- 229920006395 saturated elastomer Polymers 0.000 claims 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 13
- 201000010099 disease Diseases 0.000 claims 12
- 125000002950 monocyclic group Chemical group 0.000 claims 12
- 125000001931 aliphatic group Chemical group 0.000 claims 11
- 208000030507 AIDS Diseases 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 4
- 208000011580 syndromic disease Diseases 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- -1 2-phenoxyphenyl Chemical group 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 201000004624 Dermatitis Diseases 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 230000003463 hyperproliferative effect Effects 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 206010039083 rhinitis Diseases 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 206010015150 Erythema Diseases 0.000 claims 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims 2
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 2
- 206010042953 Systemic sclerosis Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 201000010105 allergic rhinitis Diseases 0.000 claims 2
- 231100000321 erythema Toxicity 0.000 claims 2
- 206010025135 lupus erythematosus Diseases 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000035939 Alveolitis allergic Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 206010014950 Eosinophilia Diseases 0.000 claims 1
- 206010014954 Eosinophilic fasciitis Diseases 0.000 claims 1
- 206010014989 Epidermolysis bullosa Diseases 0.000 claims 1
- 208000027445 Farmer Lung Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 201000003838 Idiopathic interstitial pneumonia Diseases 0.000 claims 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 1
- 206010024227 Lepromatous leprosy Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029164 Nephrotic syndrome Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 208000031481 Pathologic Constriction Diseases 0.000 claims 1
- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 241000721454 Pemphigus Species 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 206010036774 Proctitis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000033464 Reiter syndrome Diseases 0.000 claims 1
- 208000036284 Rhinitis seasonal Diseases 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims 1
- 208000009359 Sezary Syndrome Diseases 0.000 claims 1
- 208000021388 Sezary disease Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- NINIDFKCEFEMDL-RNFDNDRNSA-N Sulfur-36 Chemical group [36S] NINIDFKCEFEMDL-RNFDNDRNSA-N 0.000 claims 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 125000001118 alkylidene group Chemical group 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 208000000594 bullous pemphigoid Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000017760 chronic graft versus host disease Diseases 0.000 claims 1
- 201000009151 chronic rhinitis Diseases 0.000 claims 1
- 208000010247 contact dermatitis Diseases 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000001564 eosinophilic gastroenteritis Diseases 0.000 claims 1
- 208000022195 farmer lung disease Diseases 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000011486 lichen planus Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 208000008585 mastocytosis Diseases 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 201000005962 mycosis fungoides Diseases 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 201000009240 nasopharyngitis Diseases 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 208000002574 reactive arthritis Diseases 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 208000008742 seborrheic dermatitis Diseases 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 201000005671 spondyloarthropathy Diseases 0.000 claims 1
- 230000036262 stenosis Effects 0.000 claims 1
- 208000037804 stenosis Diseases 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58438304P | 2004-06-30 | 2004-06-30 | |
| US60/584,383 | 2004-06-30 | ||
| US58472104P | 2004-07-01 | 2004-07-01 | |
| US60/584,721 | 2004-07-01 | ||
| PCT/US2005/011358 WO2005103050A2 (en) | 2004-04-02 | 2005-04-04 | Azaindoles useful as inhibitors of rock and other protein kinases |
| US11/098,751 US7514448B2 (en) | 2004-04-02 | 2005-04-04 | Azaindoles useful as inhibitors of rock and other protein kinases |
| USPCT/US05/11358 | 2005-04-04 | ||
| US11/098,751 | 2005-04-04 | ||
| PCT/US2005/023429 WO2006004984A1 (en) | 2004-06-30 | 2005-06-29 | Azaindoles useful as inhibitors of protein kinases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011227135A Division JP2012012417A (ja) | 2004-06-30 | 2011-10-14 | タンパク質キナーゼのインヒビターとして有用なアザインドール |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008513352A JP2008513352A (ja) | 2008-05-01 |
| JP2008513352A5 true JP2008513352A5 (enExample) | 2008-08-14 |
| JP5122280B2 JP5122280B2 (ja) | 2013-01-16 |
Family
ID=37801682
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519460A Expired - Fee Related JP5122280B2 (ja) | 2004-06-30 | 2005-06-29 | タンパク質キナーゼのインヒビターとして有用なアザインドール |
| JP2011227135A Pending JP2012012417A (ja) | 2004-06-30 | 2011-10-14 | タンパク質キナーゼのインヒビターとして有用なアザインドール |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011227135A Pending JP2012012417A (ja) | 2004-06-30 | 2011-10-14 | タンパク質キナーゼのインヒビターとして有用なアザインドール |
Country Status (4)
| Country | Link |
|---|---|
| JP (2) | JP5122280B2 (enExample) |
| IL (1) | IL180303A0 (enExample) |
| MX (1) | MX2007000092A (enExample) |
| NO (1) | NO20070502L (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5122280B2 (ja) * | 2004-06-30 | 2013-01-16 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼのインヒビターとして有用なアザインドール |
| BRPI0515012A (pt) * | 2004-08-13 | 2008-07-01 | Genentech Inc | substáncia quìmica, composição e formulação farmacêutica, método de tratamento, método de inibição de pelo menos uma enzima que utiliza atp e uso |
| DE102008038221A1 (de) * | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | 7-Azaindolderivate |
| DE102009058280A1 (de) * | 2009-12-14 | 2011-06-16 | Merck Patent Gmbh | Thiazolderivate |
| ES2734552T3 (es) | 2010-04-16 | 2019-12-10 | Ac Immune Sa | Compuestos novedosos para el tratamiento de enfermedades asociadas a proteínas amiloides o de tipo amiloide |
| JP2013529643A (ja) * | 2010-06-23 | 2013-07-22 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用なピロロピラジン誘導体 |
| DE102011105469A1 (de) * | 2011-06-24 | 2012-12-27 | Merck Patent Gmbh | 7-Azaindolderivate |
| CN107007597A (zh) * | 2012-05-31 | 2017-08-04 | 菲尼克斯药品股份公司 | 作为孤儿核受体RORγ调节物的经甲酰胺或磺酰胺取代的噻唑及相关衍生物的制药用途 |
| ES2706306T3 (es) * | 2014-02-04 | 2019-03-28 | Taiho Pharmaceutical Co Ltd | Derivado de azaindol |
| WO2022076973A1 (en) * | 2020-10-05 | 2022-04-14 | Enliven Therapeutics, Inc. | 7-azaindole compounds for inhibition of bcr-abl tyrosine kinases |
| WO2023110843A1 (en) * | 2021-12-15 | 2023-06-22 | Almirall, S.A. | Heterobicyclic derivatives as itk inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6265403B1 (en) * | 1999-01-20 | 2001-07-24 | Merck & Co., Inc. | Angiogenesis inhibitors |
| CA2397661C (en) * | 2000-03-01 | 2012-01-03 | Janssen Pharmaceutica N.V. | 2,4-disubstituted thiazolyl derivatives |
| SE0202463D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
| US7514448B2 (en) * | 2004-04-02 | 2009-04-07 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of rock and other protein kinases |
| JP5122280B2 (ja) * | 2004-06-30 | 2013-01-16 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼのインヒビターとして有用なアザインドール |
-
2005
- 2005-06-29 JP JP2007519460A patent/JP5122280B2/ja not_active Expired - Fee Related
- 2005-06-29 MX MX2007000092A patent/MX2007000092A/es active IP Right Grant
-
2006
- 2006-12-25 IL IL180303A patent/IL180303A0/en unknown
-
2007
- 2007-01-26 NO NO20070502A patent/NO20070502L/no not_active Application Discontinuation
-
2011
- 2011-10-14 JP JP2011227135A patent/JP2012012417A/ja active Pending
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