JP2009536617A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009536617A5 JP2009536617A5 JP2009505430A JP2009505430A JP2009536617A5 JP 2009536617 A5 JP2009536617 A5 JP 2009536617A5 JP 2009505430 A JP2009505430 A JP 2009505430A JP 2009505430 A JP2009505430 A JP 2009505430A JP 2009536617 A5 JP2009536617 A5 JP 2009536617A5
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- compound
- disease
- formula
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*C1=NC(C)=C(C)*1 Chemical compound C*C1=NC(C)=C(C)*1 0.000 description 4
- QZFLYWCLTRUQCM-UHFFFAOYSA-N CC1(CC1)C(C)=N Chemical compound CC1(CC1)C(C)=N QZFLYWCLTRUQCM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79108306P | 2006-04-11 | 2006-04-11 | |
| PCT/US2007/008819 WO2007117692A2 (en) | 2006-04-11 | 2007-04-11 | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009536617A JP2009536617A (ja) | 2009-10-15 |
| JP2009536617A5 true JP2009536617A5 (enExample) | 2011-05-12 |
Family
ID=38508761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009505430A Pending JP2009536617A (ja) | 2006-04-11 | 2007-04-11 | タンパク質キナーゼの阻害剤として有用なチアゾール、イミダゾール、およびピラゾール |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7589214B2 (enExample) |
| EP (1) | EP2007732B1 (enExample) |
| JP (1) | JP2009536617A (enExample) |
| CN (1) | CN101460466B (enExample) |
| AT (1) | ATE534632T1 (enExample) |
| AU (1) | AU2007235237B2 (enExample) |
| CA (1) | CA2648923A1 (enExample) |
| ES (1) | ES2376765T3 (enExample) |
| WO (1) | WO2007117692A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE534632T1 (de) * | 2006-04-11 | 2011-12-15 | Vertex Pharma | Thiazole, imidazole und pyrazole als proteinkinasehemmer |
| AU2010240882B2 (en) * | 2009-04-24 | 2014-10-23 | Janssen Sciences Ireland Uc | Diaryl ethers |
| AU2010331927B2 (en) | 2009-12-17 | 2013-10-10 | Merck Canada Inc. | Aminopyrimidines as Syk inhibitors |
| EP2512246B1 (en) | 2009-12-17 | 2015-09-30 | Merck Sharp & Dohme Corp. | Aminopyrimidines as syk inhibitors |
| WO2012154518A1 (en) | 2011-05-10 | 2012-11-15 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridines as syk inhibitors |
| CA2834062A1 (en) | 2011-05-10 | 2012-11-15 | Merck Sharp & Dohme Corp. | Pyridyl aminopyridines as syk inhibitors |
| AU2012253885A1 (en) | 2011-05-10 | 2013-10-31 | Merck Sharp & Dohme Corp. | Aminopyrimidines as Syk inhibitors |
| MX340033B (es) | 2011-12-28 | 2016-06-21 | Janssen Sciences Ireland Uc | Derivados heterobiciclicos como inhibidores del virus de la hepatitis c. |
| CN104603124B (zh) | 2012-08-10 | 2018-04-17 | 勃林格殷格翰国际有限公司 | 用作布鲁顿酪氨酸激酶(btk)抑制剂的杂芳族化合物 |
| US20150291554A1 (en) | 2012-11-02 | 2015-10-15 | Pfizer Inc. | Bruton's Tyrosine Kinase Inhibitors |
| CN103848810A (zh) * | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| WO2014151620A1 (en) * | 2013-03-14 | 2014-09-25 | Boehringer Ingelheim International Gmbh | 5-thiazolecarboxamide dervatives and their use as btk inhibitors |
| WO2014152114A1 (en) | 2013-03-15 | 2014-09-25 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as btk inhibitors |
| RU2677884C2 (ru) * | 2013-09-30 | 2019-01-22 | Гуанчжоу Иннокэа Фарма Тек Ко., Лтд. | Замещенные никотинимидные ингибиторы втк, их получение и применение в терапии раковых, воспалительных и аутоиммунных заболеваний |
| US9624201B2 (en) | 2013-12-13 | 2017-04-18 | Hoffmann-La Roche Inc. | Inhibitors of bruton's tyrosine kinase |
| JP6486954B2 (ja) * | 2014-01-29 | 2019-03-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｔｋ阻害剤としてのピラゾール化合物 |
| CN105085474B (zh) * | 2014-05-07 | 2018-05-18 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| WO2016008411A1 (en) * | 2014-07-18 | 2016-01-21 | Beigene, Ltd. | 5-amino-4-carbamoyl-pyrazole compounds as selective and irreversible t790m over wt-egfr kinase inhibitors and use thereof |
| HRP20211845T1 (hr) | 2015-12-16 | 2022-03-04 | Boehringer Ingelheim International Gmbh | Derivati bipirazolila korisni za liječenje autoimunih bolesti |
| US10570118B2 (en) | 2016-01-13 | 2020-02-25 | Boehringer Ingelheim International Gmbh | Isoquinolones as BTK inhibitors |
| SG11202109213RA (en) * | 2019-02-25 | 2021-09-29 | Beijing Innocare Pharma Tech Co Ltd | Process for preparing 6- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide |
| WO2022012550A1 (en) * | 2020-07-13 | 2022-01-20 | Henan Normal University | Substituted 1h-imidazo [1, 2-b] pyrazole-3-carboxamide as bruton's tyrosine kinase inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
| US6288061B1 (en) * | 1997-12-26 | 2001-09-11 | Welfide Corporation | Imidazole derivatives |
| AU2001290912A1 (en) * | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| AU2002241966A1 (en) * | 2001-01-26 | 2002-08-28 | Chugai Seiyaku Kabushiki Kaisha | Malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
| EP2256106B1 (en) | 2003-07-22 | 2015-05-06 | Astex Therapeutics Limited | 3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators |
| WO2005123671A1 (ja) * | 2004-06-22 | 2005-12-29 | Taisho Pharmaceutical Co., Ltd. | ピロール誘導体 |
| FR2881426B1 (fr) * | 2005-02-03 | 2007-03-30 | Aventis Pharma Sa | Pyrolles et imidazoles substitues, compositions les contenant, procede de frabrication et utilisation |
| ATE534632T1 (de) * | 2006-04-11 | 2011-12-15 | Vertex Pharma | Thiazole, imidazole und pyrazole als proteinkinasehemmer |
-
2007
- 2007-04-11 AT AT07755181T patent/ATE534632T1/de active
- 2007-04-11 EP EP07755181A patent/EP2007732B1/en not_active Not-in-force
- 2007-04-11 CN CN2007800208154A patent/CN101460466B/zh not_active Expired - Fee Related
- 2007-04-11 ES ES07755181T patent/ES2376765T3/es active Active
- 2007-04-11 AU AU2007235237A patent/AU2007235237B2/en not_active Ceased
- 2007-04-11 CA CA002648923A patent/CA2648923A1/en not_active Abandoned
- 2007-04-11 JP JP2009505430A patent/JP2009536617A/ja active Pending
- 2007-04-11 US US11/786,464 patent/US7589214B2/en not_active Expired - Fee Related
- 2007-04-11 WO PCT/US2007/008819 patent/WO2007117692A2/en not_active Ceased
-
2009
- 2009-08-10 US US12/538,396 patent/US8236832B2/en not_active Expired - Fee Related
-
2012
- 2012-07-03 US US13/540,651 patent/US8865751B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111315737B (zh) | 经砜吡啶烷基酰胺取代的杂芳基化合物 | |
| JP7369769B2 (ja) | アミノピリミジン誘導体又はその塩を含む経口投与用医薬組成物 | |
| ES2543216T3 (es) | Moduladores de tiazolopirimidina como agentes inmunosupresores | |
| EA028079B1 (ru) | Определенные аминопиримидины, композиции на их основе и способы их использования | |
| CN113423685A (zh) | 整合应激通路的前药调节剂 | |
| JP2020528889A5 (enExample) | ||
| JP2007519742A5 (enExample) | ||
| JP2021501779A (ja) | 統合的ストレス経路の調節剤 | |
| BR112020008839A2 (pt) | moduladores da via de estresse integrada | |
| JP2022526854A (ja) | ホスファチジルイノシトール３－キナーゼ阻害剤 | |
| KR20090013804A (ko) | 할로아릴 치환된 아미노퓨린, 이의 조성물 및 이를 이용한 치료 방법 | |
| JP2016538257A5 (enExample) | ||
| CN108553467A (zh) | 改善膈肌功能的方法 | |
| TW201106951A (en) | 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]octane-or heptane-nitrile as JAK inhibitors | |
| JP2013502431A5 (enExample) | ||
| JP6655608B2 (ja) | ６−（（６，７−ジメトキシキナゾリン−４−イル）オキシ）−ｎ，２−ジメチルベンゾフラン−３−カルボキサミドの結晶形 | |
| WO2017025814A1 (en) | Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on btk occupancy and btk resynthesis rate | |
| CN101945655A (zh) | 作为p2x7调节剂的5-氧代-3-吡咯烷甲酰胺衍生物 | |
| JP7672372B2 (ja) | ４－アミノ－ｎ－（１－（（３－クロロ－２－フルオロフェニル）アミノ）－６－メチルイソキノリン－５－イル）チエノ［３，２－ｄ］ピリミジン－７－カルボキサミドの塩とその結晶形態 | |
| KR20170031786A (ko) | 다발성 골수종을 치료하기 위한 약물 병용물 | |
| JP7025555B2 (ja) | 一過性受容体電位ａ１イオンチャネルの阻害 | |
| JP2019512534A5 (enExample) | ||
| CA3176994A1 (en) | Treatments of inflammatory bowel disease | |
| CN105813643A (zh) | 利用含有噻吩并三唑二氮杂*化合物的药物制剂治疗非小细胞肺癌的方法 | |
| US20200009175A1 (en) | Nucleobase analogue derivatives and their applications |