CN101460466B - 适用作蛋白激酶抑制剂的噻唑类、咪唑类和吡唑类 - Google Patents

适用作蛋白激酶抑制剂的噻唑类、咪唑类和吡唑类 Download PDF

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CN101460466B
CN101460466B CN2007800208154A CN200780020815A CN101460466B CN 101460466 B CN101460466 B CN 101460466B CN 2007800208154 A CN2007800208154 A CN 2007800208154A CN 200780020815 A CN200780020815 A CN 200780020815A CN 101460466 B CN101460466 B CN 101460466B
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compound
formula
define
disease
compounds
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CN101460466A (zh
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J-M·吉米内斯
R·克内戈泰尔
D·罗宾森
P·克里尔
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Vertex Pharmaceuticals Inc
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C07D277/593—Z being doubly bound oxygen or doubly bound nitrogen, which nitrogen is part of a possibly substituted oximino radical
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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CN2007800208154A 2006-04-11 2007-04-11 适用作蛋白激酶抑制剂的噻唑类、咪唑类和吡唑类 Expired - Fee Related CN101460466B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79108306P 2006-04-11 2006-04-11
US60/791,083 2006-04-11
PCT/US2007/008819 WO2007117692A2 (en) 2006-04-11 2007-04-11 Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases

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CN101460466A CN101460466A (zh) 2009-06-17
CN101460466B true CN101460466B (zh) 2012-06-13

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US (3) US7589214B2 (enExample)
EP (1) EP2007732B1 (enExample)
JP (1) JP2009536617A (enExample)
CN (1) CN101460466B (enExample)
AT (1) ATE534632T1 (enExample)
AU (1) AU2007235237B2 (enExample)
CA (1) CA2648923A1 (enExample)
ES (1) ES2376765T3 (enExample)
WO (1) WO2007117692A2 (enExample)

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US10301297B2 (en) 2013-09-30 2019-05-28 Guangzhou Innocare Pharma Tech Co., Ltd. Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
RU2810260C2 (ru) * 2019-02-25 2023-12-25 Бэйцзин Иннокэа Фарма Тек Ко., Лтд. Способ получения 6-(1-акрилоилпиперидин-4-ил)-2-(4-феноксифенил)никотинамида
TWI830876B (zh) 2019-02-25 2024-02-01 大陸商北京諾誠健華醫藥科技有限公司 6-(1-丙烯醯基呱啶-4-基)-2-(4-苯氧基苯基)尼克醯胺的製備工藝

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ATE534632T1 (de) * 2006-04-11 2011-12-15 Vertex Pharma Thiazole, imidazole und pyrazole als proteinkinasehemmer
AU2010240882B2 (en) * 2009-04-24 2014-10-23 Janssen Sciences Ireland Uc Diaryl ethers
AU2010331927B2 (en) 2009-12-17 2013-10-10 Merck Canada Inc. Aminopyrimidines as Syk inhibitors
EP2512246B1 (en) 2009-12-17 2015-09-30 Merck Sharp & Dohme Corp. Aminopyrimidines as syk inhibitors
WO2012154518A1 (en) 2011-05-10 2012-11-15 Merck Sharp & Dohme Corp. Bipyridylaminopyridines as syk inhibitors
CA2834062A1 (en) 2011-05-10 2012-11-15 Merck Sharp & Dohme Corp. Pyridyl aminopyridines as syk inhibitors
AU2012253885A1 (en) 2011-05-10 2013-10-31 Merck Sharp & Dohme Corp. Aminopyrimidines as Syk inhibitors
MX340033B (es) 2011-12-28 2016-06-21 Janssen Sciences Ireland Uc Derivados heterobiciclicos como inhibidores del virus de la hepatitis c.
CN104603124B (zh) 2012-08-10 2018-04-17 勃林格殷格翰国际有限公司 用作布鲁顿酪氨酸激酶(btk)抑制剂的杂芳族化合物
US20150291554A1 (en) 2012-11-02 2015-10-15 Pfizer Inc. Bruton's Tyrosine Kinase Inhibitors
CN103848810A (zh) * 2012-11-30 2014-06-11 北京赛林泰医药技术有限公司 鲁顿酪氨酸激酶抑制剂
WO2014151620A1 (en) * 2013-03-14 2014-09-25 Boehringer Ingelheim International Gmbh 5-thiazolecarboxamide dervatives and their use as btk inhibitors
WO2014152114A1 (en) 2013-03-15 2014-09-25 Boehringer Ingelheim International Gmbh Heteroaromatic compounds as btk inhibitors
US9624201B2 (en) 2013-12-13 2017-04-18 Hoffmann-La Roche Inc. Inhibitors of bruton's tyrosine kinase
JP6486954B2 (ja) * 2014-01-29 2019-03-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂｔｋ阻害剤としてのピラゾール化合物
CN105085474B (zh) * 2014-05-07 2018-05-18 北京赛林泰医药技术有限公司 鲁顿酪氨酸激酶抑制剂
WO2016008411A1 (en) * 2014-07-18 2016-01-21 Beigene, Ltd. 5-amino-4-carbamoyl-pyrazole compounds as selective and irreversible t790m over wt-egfr kinase inhibitors and use thereof
HRP20211845T1 (hr) 2015-12-16 2022-03-04 Boehringer Ingelheim International Gmbh Derivati bipirazolila korisni za liječenje autoimunih bolesti
US10570118B2 (en) 2016-01-13 2020-02-25 Boehringer Ingelheim International Gmbh Isoquinolones as BTK inhibitors
WO2022012550A1 (en) * 2020-07-13 2022-01-20 Henan Normal University Substituted 1h-imidazo [1, 2-b] pyrazole-3-carboxamide as bruton's tyrosine kinase inhibitors

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FR2881426B1 (fr) * 2005-02-03 2007-03-30 Aventis Pharma Sa Pyrolles et imidazoles substitues, compositions les contenant, procede de frabrication et utilisation
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US11345695B2 (en) 2013-09-30 2022-05-31 Guangzhou Innocare Pharma Tech Co., Ltd. Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
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RU2810260C2 (ru) * 2019-02-25 2023-12-25 Бэйцзин Иннокэа Фарма Тек Ко., Лтд. Способ получения 6-(1-акрилоилпиперидин-4-ил)-2-(4-феноксифенил)никотинамида
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EP2007732A2 (en) 2008-12-31
US20130090479A1 (en) 2013-04-11
US20090306155A1 (en) 2009-12-10
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US7589214B2 (en) 2009-09-15
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US8865751B2 (en) 2014-10-21
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