JP5122280B2 - タンパク質キナーゼのインヒビターとして有用なアザインドール - Google Patents

タンパク質キナーゼのインヒビターとして有用なアザインドール Download PDF

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Publication number
JP5122280B2
JP5122280B2 JP2007519460A JP2007519460A JP5122280B2 JP 5122280 B2 JP5122280 B2 JP 5122280B2 JP 2007519460 A JP2007519460 A JP 2007519460A JP 2007519460 A JP2007519460 A JP 2007519460A JP 5122280 B2 JP5122280 B2 JP 5122280B2
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JP
Japan
Prior art keywords
compound
compounds
substituted
nitrogen
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2007519460A
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English (en)
Japanese (ja)
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JP2008513352A (ja
JP2008513352A5 (enExample
Inventor
フランソワ ピラール，
ジャン−ミゲル ヒメネス，
ロナルド ケンテル，
ガイ ブレンチレイ，
マイケル モルティモア，
フランセスカ マッツェイ，
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Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2005/011358 external-priority patent/WO2005103050A2/en
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Priority claimed from PCT/US2005/023429 external-priority patent/WO2006004984A1/en
Publication of JP2008513352A publication Critical patent/JP2008513352A/ja
Publication of JP2008513352A5 publication Critical patent/JP2008513352A5/ja
Application granted granted Critical
Publication of JP5122280B2 publication Critical patent/JP5122280B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2007519460A 2004-06-30 2005-06-29 タンパク質キナーゼのインヒビターとして有用なアザインドール Expired - Fee Related JP5122280B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US58438304P 2004-06-30 2004-06-30
US60/584,383 2004-06-30
US58472104P 2004-07-01 2004-07-01
US60/584,721 2004-07-01
PCT/US2005/011358 WO2005103050A2 (en) 2004-04-02 2005-04-04 Azaindoles useful as inhibitors of rock and other protein kinases
US11/098,751 US7514448B2 (en) 2004-04-02 2005-04-04 Azaindoles useful as inhibitors of rock and other protein kinases
US11/098,751 2005-04-04
USPCT/US05/11358 2005-04-04
PCT/US2005/023429 WO2006004984A1 (en) 2004-06-30 2005-06-29 Azaindoles useful as inhibitors of protein kinases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011227135A Division JP2012012417A (ja) 2004-06-30 2011-10-14 タンパク質キナーゼのインヒビターとして有用なアザインドール

Publications (3)

Publication Number Publication Date
JP2008513352A JP2008513352A (ja) 2008-05-01
JP2008513352A5 JP2008513352A5 (enExample) 2008-08-14
JP5122280B2 true JP5122280B2 (ja) 2013-01-16

Family

ID=37801682

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007519460A Expired - Fee Related JP5122280B2 (ja) 2004-06-30 2005-06-29 タンパク質キナーゼのインヒビターとして有用なアザインドール
JP2011227135A Pending JP2012012417A (ja) 2004-06-30 2011-10-14 タンパク質キナーゼのインヒビターとして有用なアザインドール

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011227135A Pending JP2012012417A (ja) 2004-06-30 2011-10-14 タンパク質キナーゼのインヒビターとして有用なアザインドール

Country Status (4)

Country Link
JP (2) JP5122280B2 (enExample)
IL (1) IL180303A0 (enExample)
MX (1) MX2007000092A (enExample)
NO (1) NO20070502L (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012012417A (ja) * 2004-06-30 2012-01-19 Vertex Pharmaceuticals Inc タンパク質キナーゼのインヒビターとして有用なアザインドール

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG155222A1 (en) * 2004-08-13 2009-09-30 Genentech Inc Thiazole based inhibitors of atp-utilizing enzymes
DE102008038221A1 (de) * 2008-08-18 2010-02-25 Merck Patent Gmbh 7-Azaindolderivate
DE102009058280A1 (de) * 2009-12-14 2011-06-16 Merck Patent Gmbh Thiazolderivate
PH12012502079A1 (en) 2010-04-16 2013-02-11 Ac Immune Sa Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
MX2013000103A (es) * 2010-06-23 2013-06-13 Vertex Pharma Derivados de pirrolo-pirazina utiles como inhibidores de cinasa art.
DE102011105469A1 (de) * 2011-06-24 2012-12-27 Merck Patent Gmbh 7-Azaindolderivate
WO2013178362A1 (en) * 2012-05-31 2013-12-05 Phenex Pharmaceuticals Ag Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ror[gamma]
RU2649575C1 (ru) * 2014-02-04 2018-04-04 Тайхо Фармасьютикал Ко., Лтд. Азаиндольное производное
MX2023003996A (es) * 2020-10-05 2023-06-15 Enliven Inc Compuestos de 7-azaindol para la inhibicion de tirosina cinasas bcr-abl.
WO2023110843A1 (en) * 2021-12-15 2023-06-22 Almirall, S.A. Heterobicyclic derivatives as itk inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265403B1 (en) * 1999-01-20 2001-07-24 Merck & Co., Inc. Angiogenesis inhibitors
DE60136530D1 (de) * 2000-03-01 2008-12-24 Janssen Pharmaceutica Nv 2,4-disubstituierte thiazolyl derivate
SE0202463D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab Novel compounds
AR049333A1 (es) * 2004-04-02 2006-07-19 Vertex Pharma Azaindoles inhibidores de proteinquinasas rock y otras proteinas quinasas. composiciones farmaceuticas.
MX2007000092A (es) * 2004-06-30 2007-03-07 Vertex Pharma Azaindoles utiles como inhibidores de proteinas cinasas.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012012417A (ja) * 2004-06-30 2012-01-19 Vertex Pharmaceuticals Inc タンパク質キナーゼのインヒビターとして有用なアザインドール

Also Published As

Publication number Publication date
NO20070502L (no) 2007-01-26
JP2008513352A (ja) 2008-05-01
IL180303A0 (en) 2007-06-03
MX2007000092A (es) 2007-03-07
JP2012012417A (ja) 2012-01-19

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