JP2008512538A5 - - Google Patents
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- Publication number
- JP2008512538A5 JP2008512538A5 JP2007530739A JP2007530739A JP2008512538A5 JP 2008512538 A5 JP2008512538 A5 JP 2008512538A5 JP 2007530739 A JP2007530739 A JP 2007530739A JP 2007530739 A JP2007530739 A JP 2007530739A JP 2008512538 A5 JP2008512538 A5 JP 2008512538A5
- Authority
- JP
- Japan
- Prior art keywords
- glucopyranosyl
- methyl
- sulfonato
- tri
- biotinylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002402 hexoses Chemical class 0.000 claims 8
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- -1 6-biotinamidohexanoyl Chemical group 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 238000013171 endarterectomy Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000003132 pyranosyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000009424 thromboembolic effect Effects 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 1
- 108090001008 Avidin Proteins 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 230000002785 anti-thrombosis Effects 0.000 claims 1
- 230000023555 blood coagulation Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 239000003248 enzyme activator Substances 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 238000001631 haemodialysis Methods 0.000 claims 1
- 230000000322 hemodialysis Effects 0.000 claims 1
- 230000013632 homeostatic process Effects 0.000 claims 1
- 230000007574 infarction Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000002537 thrombolytic effect Effects 0.000 claims 1
- 230000001732 thrombotic effect Effects 0.000 claims 1
- 230000005748 tumor development Effects 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 208000004043 venous thromboembolism Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0409557A FR2874924B1 (fr) | 2004-09-09 | 2004-09-09 | Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique |
| FR0409557 | 2004-09-09 | ||
| PCT/FR2005/002218 WO2006030104A1 (fr) | 2004-09-09 | 2005-09-07 | Hexadecasaccharides biotinyles, leur preparation et leur utilisation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008512538A JP2008512538A (ja) | 2008-04-24 |
| JP2008512538A5 true JP2008512538A5 (https=) | 2012-08-09 |
| JP5108519B2 JP5108519B2 (ja) | 2012-12-26 |
Family
ID=34948342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530739A Expired - Fee Related JP5108519B2 (ja) | 2004-09-09 | 2005-09-07 | ビオチニル化十六糖、この調製及び使用 |
Country Status (38)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2912409B1 (fr) * | 2007-02-14 | 2012-08-24 | Sanofi Aventis | Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation |
| FR2912408A1 (fr) * | 2007-02-14 | 2008-08-15 | Sanofi Aventis Sa | Heparine comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine,leur procede de preparation,leur utilisation |
| TW201006479A (en) * | 2008-07-18 | 2010-02-16 | Sanofi Aventis | Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment |
| EP2145624A1 (en) * | 2008-07-18 | 2010-01-20 | Sanofi-Aventis | Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment |
| EP2233143A1 (en) * | 2009-03-24 | 2010-09-29 | Sanofi-Aventis | Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment |
| FR2935387B1 (fr) * | 2008-08-26 | 2010-09-10 | Sanofi Aventis | Hexadecasaccharides a activite antithrombotique comprenant une liaison covalente avec une chaine amine |
| FR2952935B1 (fr) | 2009-11-20 | 2011-12-02 | Sanofi Aventis | Procede de preparation du n-biotinyl-6-aminocaproate de n succinimidyle |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU563351C (en) | 1982-01-15 | 2003-06-19 | Glaxo Group Limited | Synthesis of oligosaccharides |
| EP0300099A1 (en) | 1987-07-20 | 1989-01-25 | Akzo N.V. | New pentasaccharides |
| IL102758A (en) | 1991-08-23 | 1997-03-18 | Akzo Nv | Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them |
| FR2704226B1 (fr) | 1993-04-22 | 1995-07-21 | Sanofi Elf | 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| NZ264340A (en) | 1993-09-01 | 1995-04-27 | Akzo Nobel Nv | Bisconjugate comprising two saccharides and a spacer, use in pharmaceutical compositions |
| FR2751334B1 (fr) | 1996-07-19 | 1998-10-16 | Sanofi Sa | Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant |
| FR2773801B1 (fr) | 1998-01-19 | 2000-05-12 | Sanofi Sa | Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant |
| FR2773804B1 (fr) | 1998-01-19 | 2000-02-18 | Sanofi Sa | Polysaccharides de synthese, procede pour leur preparation et compositions pharmaceutiques le contenant |
| FR2814463B1 (fr) * | 2000-09-22 | 2002-11-15 | Sanofi Synthelabo | Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine |
-
2004
- 2004-09-09 FR FR0409557A patent/FR2874924B1/fr not_active Expired - Fee Related
-
2005
- 2005-09-06 UY UY29102A patent/UY29102A1/es not_active Application Discontinuation
- 2005-09-06 HN HN2005000518A patent/HN2005000518A/es unknown
- 2005-09-07 CN CN2005800344450A patent/CN101039963B/zh not_active Expired - Fee Related
- 2005-09-07 SI SI200530615T patent/SI1791872T1/sl unknown
- 2005-09-07 PL PL05805571T patent/PL1791872T3/pl unknown
- 2005-09-07 AT AT05805571T patent/ATE420118T1/de active
- 2005-09-07 RS RSP-2009/0153A patent/RS50762B/sr unknown
- 2005-09-07 AR ARP050103730A patent/AR051286A1/es active IP Right Grant
- 2005-09-07 ZA ZA200702255A patent/ZA200702255B/xx unknown
- 2005-09-07 CA CA2577258A patent/CA2577258C/fr not_active Expired - Fee Related
- 2005-09-07 DE DE602005012287T patent/DE602005012287D1/de not_active Expired - Lifetime
- 2005-09-07 MX MX2007002875A patent/MX2007002875A/es active IP Right Grant
- 2005-09-07 DK DK05805571T patent/DK1791872T3/da active
- 2005-09-07 ES ES05805571T patent/ES2320576T3/es not_active Expired - Lifetime
- 2005-09-07 HR HR20090180T patent/HRP20090180T1/xx unknown
- 2005-09-07 MY MYPI20054213A patent/MY140666A/en unknown
- 2005-09-07 BR BRPI0515078-7A patent/BRPI0515078A/pt not_active Application Discontinuation
- 2005-09-07 EA EA200700594A patent/EA012587B1/ru not_active IP Right Cessation
- 2005-09-07 JP JP2007530739A patent/JP5108519B2/ja not_active Expired - Fee Related
- 2005-09-07 AU AU2005284080A patent/AU2005284080B2/en not_active Ceased
- 2005-09-07 PA PA20058644201A patent/PA8644201A1/es unknown
- 2005-09-07 PT PT05805571T patent/PT1791872E/pt unknown
- 2005-09-07 WO PCT/FR2005/002218 patent/WO2006030104A1/fr not_active Ceased
- 2005-09-07 KR KR1020077005500A patent/KR101223364B1/ko not_active Expired - Fee Related
- 2005-09-07 EP EP05805571A patent/EP1791872B1/fr not_active Expired - Lifetime
- 2005-09-08 PE PE2005001046A patent/PE20060663A1/es not_active Application Discontinuation
- 2005-09-08 SV SV2005002221A patent/SV2006002221A/es unknown
- 2005-09-08 GT GT200500250A patent/GT200500250A/es unknown
- 2005-09-08 TW TW094130817A patent/TW200612970A/zh unknown
-
2007
- 2007-02-12 TN TNP2007000053A patent/TNSN07053A1/fr unknown
- 2007-02-23 EC EC2007007272A patent/ECSP077272A/es unknown
- 2007-02-26 IL IL181569A patent/IL181569A/en not_active IP Right Cessation
- 2007-02-27 NI NI200700063A patent/NI200700063A/es unknown
- 2007-03-09 US US11/684,239 patent/US20070270342A1/en not_active Abandoned
- 2007-03-14 MA MA29753A patent/MA28859B1/fr unknown
- 2007-04-02 NO NO20071754A patent/NO20071754L/no not_active Application Discontinuation
-
2009
- 2009-03-23 CY CY20091100343T patent/CY1109126T1/el unknown
-
2010
- 2010-07-16 US US12/837,861 patent/US8557968B2/en not_active Expired - Fee Related
-
2012
- 2012-09-12 US US13/611,753 patent/US8703738B2/en not_active Expired - Fee Related
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