JP2008510789A - トリアゾロベンゾジアゼピン及びバゾプレシンアンタゴニストとしてのそれらの使用 - Google Patents

トリアゾロベンゾジアゼピン及びバゾプレシンアンタゴニストとしてのそれらの使用 Download PDF

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Publication number
JP2008510789A
JP2008510789A JP2007529032A JP2007529032A JP2008510789A JP 2008510789 A JP2008510789 A JP 2008510789A JP 2007529032 A JP2007529032 A JP 2007529032A JP 2007529032 A JP2007529032 A JP 2007529032A JP 2008510789 A JP2008510789 A JP 2008510789A
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JP
Japan
Prior art keywords
compound
mmol
formula
disease
dysmenorrhea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2007529032A
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English (en)
Japanese (ja)
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JP2008510789A5 (https=
Inventor
スティーブン ジョンソン,パトリック
Original Assignee
ファイザー・インク
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Priority claimed from GB0418980A external-priority patent/GB0418980D0/en
Application filed by ファイザー・インク filed Critical ファイザー・インク
Publication of JP2008510789A publication Critical patent/JP2008510789A/ja
Publication of JP2008510789A5 publication Critical patent/JP2008510789A5/ja
Withdrawn legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06Antiabortive agents; Labour repressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2007529032A 2004-08-25 2005-08-12 トリアゾロベンゾジアゼピン及びバゾプレシンアンタゴニストとしてのそれらの使用 Withdrawn JP2008510789A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0418980A GB0418980D0 (en) 2004-08-25 2004-08-25 Triazole compounds useful in therapy
US61660104P 2004-10-05 2004-10-05
PCT/IB2005/002711 WO2006021882A1 (en) 2004-08-25 2005-08-12 Triazolobenzodiazepines and their use as vasopressin antagonists

Publications (2)

Publication Number Publication Date
JP2008510789A true JP2008510789A (ja) 2008-04-10
JP2008510789A5 JP2008510789A5 (https=) 2008-07-24

Family

ID=35355092

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007529032A Withdrawn JP2008510789A (ja) 2004-08-25 2005-08-12 トリアゾロベンゾジアゼピン及びバゾプレシンアンタゴニストとしてのそれらの使用

Country Status (7)

Country Link
US (1) US7456170B2 (https=)
EP (1) EP1784408A1 (https=)
JP (1) JP2008510789A (https=)
BR (1) BRPI0514458A (https=)
CA (1) CA2578370A1 (https=)
MX (1) MX2007002248A (https=)
WO (1) WO2006021882A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012508711A (ja) * 2008-11-13 2012-04-12 エフ.ホフマン−ラ ロシュ アーゲー スピロ−5,6−ジヒドロ−4H−2,3,5,10b−テトラアザ−ベンゾ[e]アズレン
JP2013523675A (ja) * 2010-03-31 2013-06-17 エフ.ホフマン−ラ ロシュ アーゲー アリール−シクロヘキシル−テトラアザベンゾ[e]アズレン
JP2013523853A (ja) * 2010-04-13 2013-06-17 エフ.ホフマン−ラ ロシュ アーゲー バソプレシンアンタゴニストとしてのアリール−/ヘテロアリール−シクロヘキセニル−テトラアザベンゾ[e]アズレン
JP2013525396A (ja) * 2010-04-26 2013-06-20 エフ.ホフマン−ラ ロシュ アーゲー ヘテロビアリール−シクロヘキシル−テトラアザベンゾ[e]アズレン
JP2013525319A (ja) * 2010-04-21 2013-06-20 エフ.ホフマン−ラ ロシュ アーゲー バソプレシンV1a受容体アンタゴニストとしてのヘテロアリール−シクロヘキシル−テトラアザベンゾ[e]アズレン

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101385433B1 (ko) 2008-11-18 2014-04-14 에프. 호프만-라 로슈 아게 다이하이드로테트라아자벤조아줄렌의 알킬사이클로헥실에터
HRP20131067T1 (hr) * 2008-11-28 2013-12-06 F. Hoffmann - La Roche Ag Arilcikloheksileteri od dihidrotetraazabenzoazulena za primjenu kao antagonista receptora vazopresina v1a
US8513238B2 (en) * 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
US8828989B2 (en) * 2011-09-26 2014-09-09 Hoffmann-La Roche Inc. Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
HUE034118T2 (en) 2012-03-06 2018-01-29 Pfizer Macrocyclic derivatives for the treatment of proliferative diseases
CA2919738A1 (en) * 2013-08-19 2015-02-26 F. Hoffmann-La Roche Ag V1a antagonists to treat phase shift sleep disorders
NZ720340A (en) 2013-12-05 2020-03-27 Hoffmann La Roche Synthesis of trans-8-chloro-5-methyl-1 -[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulene and crystalline forms thereof
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素V1a受體拮抗劑之三環化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69826487T2 (de) 1997-07-30 2005-12-01 Wyeth Trizyclische vasopressin-agonisten
CN100379723C (zh) * 2002-02-19 2008-04-09 特瓦制药工业有限公司 阿托伐他汀半钙脱溶剂的方法和基本上不含有机溶剂的阿托伐他汀半钙
GB0303852D0 (en) * 2003-02-19 2003-03-26 Pfizer Ltd Triazole compounds useful in therapy
US7119088B2 (en) * 2003-02-19 2006-10-10 Pfizer Inc. Triazole compounds useful in therapy

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012508711A (ja) * 2008-11-13 2012-04-12 エフ.ホフマン−ラ ロシュ アーゲー スピロ−5,6−ジヒドロ−4H−2,3,5,10b−テトラアザ−ベンゾ[e]アズレン
JP2013523675A (ja) * 2010-03-31 2013-06-17 エフ.ホフマン−ラ ロシュ アーゲー アリール−シクロヘキシル−テトラアザベンゾ[e]アズレン
JP2013523853A (ja) * 2010-04-13 2013-06-17 エフ.ホフマン−ラ ロシュ アーゲー バソプレシンアンタゴニストとしてのアリール−/ヘテロアリール−シクロヘキセニル−テトラアザベンゾ[e]アズレン
JP2013525319A (ja) * 2010-04-21 2013-06-20 エフ.ホフマン−ラ ロシュ アーゲー バソプレシンV1a受容体アンタゴニストとしてのヘテロアリール−シクロヘキシル−テトラアザベンゾ[e]アズレン
JP2013525396A (ja) * 2010-04-26 2013-06-20 エフ.ホフマン−ラ ロシュ アーゲー ヘテロビアリール−シクロヘキシル−テトラアザベンゾ[e]アズレン

Also Published As

Publication number Publication date
MX2007002248A (es) 2008-10-02
BRPI0514458A (pt) 2008-06-10
EP1784408A1 (en) 2007-05-16
CA2578370A1 (en) 2006-03-02
US20070249585A1 (en) 2007-10-25
WO2006021882A1 (en) 2006-03-02
US7456170B2 (en) 2008-11-25

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