JP2008509658A5 - - Google Patents
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- Publication number
- JP2008509658A5 JP2008509658A5 JP2007521793A JP2007521793A JP2008509658A5 JP 2008509658 A5 JP2008509658 A5 JP 2008509658A5 JP 2007521793 A JP2007521793 A JP 2007521793A JP 2007521793 A JP2007521793 A JP 2007521793A JP 2008509658 A5 JP2008509658 A5 JP 2008509658A5
- Authority
- JP
- Japan
- Prior art keywords
- rhd
- cells
- cell
- antibody
- recombinant polyclonal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims 58
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 238000000034 method Methods 0.000 claims 11
- 238000004519 manufacturing process Methods 0.000 claims 10
- 239000013598 vector Substances 0.000 claims 9
- 239000013604 expression vector Substances 0.000 claims 7
- 102000018120 Recombinases Human genes 0.000 claims 5
- 108010091086 Recombinases Proteins 0.000 claims 5
- 210000004962 mammalian cell Anatomy 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 241000699802 Cricetulus griseus Species 0.000 claims 2
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 2
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 238000001890 transfection Methods 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 206010070834 Sensitisation Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000002949 hemolytic effect Effects 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000008313 sensitization Effects 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200401133 | 2004-07-20 | ||
| DKPA200401133 | 2004-07-20 | ||
| DKPA200401992 | 2004-12-22 | ||
| DKPA200401992 | 2004-12-22 | ||
| PCT/DK2005/000501 WO2006007850A1 (en) | 2004-07-20 | 2005-07-18 | Anti-rhesus d recombinant polyclonal antibody and methods of manufacture |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008509658A JP2008509658A (ja) | 2008-04-03 |
| JP2008509658A5 true JP2008509658A5 (https=) | 2008-07-03 |
| JP4926054B2 JP4926054B2 (ja) | 2012-05-09 |
Family
ID=35159789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007521793A Expired - Fee Related JP4926054B2 (ja) | 2004-07-20 | 2005-07-18 | 抗−ＲｈＤ組換えポリクローナル抗体及び製造方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8198415B2 (https=) |
| EP (2) | EP1771483A1 (https=) |
| JP (1) | JP4926054B2 (https=) |
| KR (1) | KR20070038556A (https=) |
| AU (1) | AU2005263331B8 (https=) |
| BR (1) | BRPI0513706A (https=) |
| CA (1) | CA2574062A1 (https=) |
| EA (1) | EA014182B1 (https=) |
| IL (1) | IL179658A (https=) |
| MX (1) | MX2007000644A (https=) |
| NO (1) | NO20070927L (https=) |
| NZ (1) | NZ552265A (https=) |
| WO (1) | WO2006007850A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| SI1583830T1 (sl) * | 2003-01-07 | 2006-12-31 | Symphogen As | Postopek za pripravo rekombinantnih poliklonskih proteinov |
| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| US8288109B2 (en) | 2004-07-20 | 2012-10-16 | Symphogen A/S | Procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line |
| US7850965B2 (en) | 2005-12-05 | 2010-12-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
| TW200846362A (en) * | 2007-02-09 | 2008-12-01 | Symphogen As | A polyclonal antibody product |
| BRPI0808551B1 (pt) | 2007-03-01 | 2022-04-05 | Symphogen A/S | Composições de anticorpo para o receptor do fator de crescimento antiepidérmico recombinante, molécula de ligação bi-específica e composição farmacêutica que os compreende |
| DK2121920T3 (da) * | 2007-03-01 | 2011-11-21 | Symphogen As | Fremgangsmåde til kloning af sammenhørende antistoffer |
| JP2010534057A (ja) * | 2007-03-06 | 2010-11-04 | シムフォゲン・アクティーゼルスカブ | 呼吸器合胞体ウイルス感染症を治療するための組換え抗体 |
| JP2008289483A (ja) * | 2007-05-25 | 2008-12-04 | Symphogen As | 真核生物系において発現可能な形質転換体のスクリーニング |
| MX2009012526A (es) * | 2007-05-25 | 2009-12-09 | Symphogen As | Metodo para fabricar una proteina policlonal recombinante. |
| CA2695309A1 (en) * | 2007-09-07 | 2009-03-12 | Symphogen A/S | Methods for recombinant manufacturing of anti-rsv antibodies |
| US20090093004A1 (en) * | 2007-10-04 | 2009-04-09 | Symphogen A/S | Potency assay |
| RU2476886C2 (ru) * | 2007-11-22 | 2013-02-27 | Симфоген А/С | Способ характеризации рекомбинантного поликлонального белка |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| KR102057826B1 (ko) * | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| NZ588651A (en) * | 2008-04-23 | 2012-04-27 | Symphogen As | Methods for manufacturing a polyclonal protein |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| US20110217317A1 (en) * | 2008-08-26 | 2011-09-08 | Symphogen A/S | Treatment of thrombocytopenia |
| WO2010022736A2 (en) | 2008-08-29 | 2010-03-04 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
| CN102137928A (zh) * | 2008-08-29 | 2011-07-27 | 西福根有限公司 | 克隆禽源抗体的方法 |
| BRPI0920032A2 (pt) * | 2008-10-06 | 2017-06-27 | Symphogen As | método para identificar e selecionar candidatos a fármacos para produtos farmacológicos combinatórios |
| FR2942799B1 (fr) * | 2009-03-06 | 2011-02-25 | Lfb Biotechnologies | Anticorps monoclonal anti-rhesus d |
| MX2012003538A (es) | 2009-10-09 | 2012-08-03 | Symphogen As | Cuantificacion multiple de proteinas recombinantes individuales en una mezcla mediante peptidos distintivos y espectrometria de masas. |
| MX352889B (es) | 2011-02-25 | 2017-12-13 | Chugai Pharmaceutical Co Ltd | Anticuerpo de fc especifico para fcyriib. |
| EP2864346B1 (en) * | 2012-06-21 | 2018-10-17 | Synthon Biopharmaceuticals B.V. | Method of purifying an antibody |
| EP2711428A1 (en) * | 2012-09-21 | 2014-03-26 | Lonza Biologics plc. | Site-specific integration |
| UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
| JP6595458B2 (ja) | 2013-09-20 | 2019-10-23 | ブリストル−マイヤーズ スクイブ カンパニー | 腫瘍を処置するための抗ｌａｇ−３抗体と抗ｐｄ−１抗体との組合せ |
| PE20170255A1 (es) | 2014-01-24 | 2017-03-22 | Dana Farber Cancer Inst Inc | Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas |
| KR102442436B1 (ko) | 2014-03-14 | 2022-09-15 | 노파르티스 아게 | Lag-3에 대한 항체 분자 및 그의 용도 |
| US9683017B2 (en) | 2014-07-17 | 2017-06-20 | University Tennessee Research Foundation | Inhibitory peptides of viral infection |
| US10213506B2 (en) | 2014-08-26 | 2019-02-26 | University Of Tennessee Research Foundation | Targeting immunotherapy for amyloidosis |
| HRP20211058T8 (hr) | 2015-07-29 | 2021-11-26 | Novartis Ag | Kombinirane terapije koje sadrže molekule antitijela protiv lag-3 |
| WO2017184973A1 (en) | 2016-04-22 | 2017-10-26 | University Of Tennessee Research Foundation | Identifying amyloidogenic proteins & amyloidogenic risk |
| CN110678200B (zh) | 2017-05-30 | 2024-05-17 | 百时美施贵宝公司 | 包含抗lag-3抗体或抗lag-3抗体和抗pd-1或抗pd-l1抗体的组合物 |
| ES2965352T3 (es) | 2017-05-30 | 2024-04-12 | Bristol Myers Squibb Co | Tratamiento de tumores positivos a gen 3 de activación de linfocitos (LAG-3) |
| EP3810649A1 (en) * | 2018-06-22 | 2021-04-28 | Genmab A/S | Method for producing a controlled mixture of two or more different antibodies |
| WO2020084034A1 (en) | 2018-10-26 | 2020-04-30 | F. Hoffmann-La Roche Ag | Multispecific antibody screening method using recombinase mediated cassette exchange |
| US12479908B2 (en) | 2019-03-29 | 2025-11-25 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Antibodies against programmed cell death protein 1 (PD1) and uses thereof |
| JP7250950B2 (ja) | 2019-03-29 | 2023-04-03 | エフ． ホフマン－ラ ロシュ アーゲー | 所定の構成の複数の発現カセットを標的指向組込みすることによってＦｃＲｎ発現細胞を作製するための方法 |
| CN118547004A (zh) | 2019-06-19 | 2024-08-27 | 豪夫迈·罗氏有限公司 | 通过使用Cre mRNA进行的靶向整合来产生蛋白质表达细胞的方法 |
| EP3986924A1 (en) | 2019-06-19 | 2022-04-27 | F. Hoffmann-La Roche AG | Method for the generation of a multivalent, multispecific antibody expressing cell by targeted integration of multiple expression cassettes in a defined organization |
| AU2020294879A1 (en) | 2019-06-19 | 2021-12-16 | F. Hoffmann-La Roche Ag | Method for the generation of a bivalent, bispecific antibody expressing cell by targeted integration of multiple expression cassettes in a defined organization |
| CA3140323A1 (en) | 2019-06-19 | 2020-12-24 | Johannes Auer | Method for the generation of a multivalent, bispecific antibody expressing cell by targeted integration of multiple expression cassettes in a defined organization |
| CN114008212B (zh) | 2019-06-19 | 2024-12-06 | 豪夫迈·罗氏有限公司 | 通过以限定的组织形式靶向整合多个表达盒来产生三价抗体表达细胞的方法 |
| KR20230093282A (ko) | 2020-10-23 | 2023-06-27 | 브리스톨-마이어스 스큅 컴퍼니 | 폐암에 대한 lag-3 길항제 요법 |
| WO2022150654A2 (en) * | 2021-01-08 | 2022-07-14 | 10X Genomics, Inc. | Antigen-binding polypeptides specific for coronaviruses and uses thereof |
| RU2770654C1 (ru) * | 2021-06-17 | 2022-04-20 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный педиатрический медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПбГПМУ Минздрава России) | Способ профилактики тяжелой формы гемолитической болезни новорожденных при резус-иммунизации у беременных с соматической патологией и потерями плода в анамнезе |
| WO2025039046A1 (en) * | 2023-08-23 | 2025-02-27 | The Walter And Eliza Hall Institute Of Medical Research | Anti-rhesus d human monoclonal antibodies |
| CN119176879B (zh) * | 2024-09-05 | 2025-08-05 | 西安市中心血站（陕西省血液中心） | 一种中和抗d抗体的抗独特型抗体及其应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985002413A1 (en) | 1983-11-28 | 1985-06-06 | The Board Of Trustees Of The Leland Stanford Jr. U | HUMAN MONOCLONAL ANTIBODY AGAINST Rh(D) ANTIGEN AND ITS USES |
| US5126130A (en) * | 1986-11-24 | 1992-06-30 | The Childrens Hospital Incorporated | Monoclonal antibodies reactive with specific antigenic sites on human cytomegalovirus glycoprotein a |
| GB8722020D0 (en) | 1987-09-18 | 1987-10-28 | Central Blood Lab Authority | Human anti-rh(d)monoclonal antibodies |
| GB8722019D0 (en) | 1987-09-18 | 1987-10-28 | Central Blood Lab Authority | Human anti-rh(d)monoclonal antibodies |
| GB8722018D0 (en) | 1987-09-18 | 1987-10-28 | Central Blood Lab Authority | Human anti-rh(d)monoclonal antibodies |
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| GB8906129D0 (en) | 1989-03-17 | 1989-05-04 | Central Blood Lab Authority | Pharmaceutical preparations |
| GB8919761D0 (en) | 1989-09-01 | 1989-10-18 | Central Blood Lab Authority | Chemical compounds |
| WO1992015694A1 (en) | 1991-03-08 | 1992-09-17 | The Salk Institute For Biological Studies | Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor |
| US5837268A (en) | 1991-10-16 | 1998-11-17 | University Of Saskatchewan | GnRH-leukotoxin chimeras |
| BR9305557A (pt) | 1992-06-26 | 1997-03-25 | Aetsrn | Anticorpos monoclonais humanos anti Rhesus-D e composiçao farmacêutica que os contém |
| JP3731891B2 (ja) | 1992-10-21 | 2006-01-05 | ミルテンイ，ステファン | 分泌生成物による細胞の直接選択 |
| US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| DE69534347T2 (de) * | 1994-01-31 | 2006-05-24 | Trustees Of Boston University, Boston | Bibliotheken aus Polyklonalen Antikörpern |
| FR2724182B1 (fr) * | 1994-09-02 | 1996-12-13 | Pasteur Institut | Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations |
| US6025155A (en) | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| AU722127B2 (en) | 1996-06-24 | 2000-07-20 | Zlb Behring Ag | Polypeptides capable of forming antigen binding structures with specificity for the rhesus D antigens, the DNA encoding them and the process for their preparation and use |
| US5876925A (en) * | 1996-10-11 | 1999-03-02 | The Trustees Of The University Of Pennsylvania | Magnetically activated cell sorting for production of proteins |
| US6255455B1 (en) * | 1996-10-11 | 2001-07-03 | The Trustees Of The University Of Pennsylvania | Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| WO1999025821A1 (en) | 1997-11-18 | 1999-05-27 | Pioneer Hi-Bred International, Inc. | Compositions and methods for genetic modification of plants |
| AU771111B2 (en) | 1998-07-21 | 2004-03-11 | Emd Millipore Corporation | A polynucleotide comprising a ubiquitous chromatin opening element (UCOE) |
| US20020155114A1 (en) * | 1998-08-31 | 2002-10-24 | James D. Marks | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| DK1234022T3 (da) | 1999-07-23 | 2010-07-19 | Univ California | DNA-rekombination i eukaryote celler med bakteriofag PHIC31-rekombinationssystemet |
| EP1106625A1 (en) | 1999-11-17 | 2001-06-13 | ZLB Bioplasma AG | Rhesus D specific peptide sequences |
| WO2001058925A2 (en) | 2000-02-08 | 2001-08-16 | The Regents Of The University Of Michigan | Protein separation and display |
| US7069151B2 (en) | 2000-02-08 | 2006-06-27 | Regents Of The University Of Michigan | Mapping of differential display of proteins |
| CA2401663C (en) | 2000-02-08 | 2008-11-25 | The Regents Of The University Of Michigan | Protein mapping |
| HK1052305B (en) | 2000-05-26 | 2007-10-12 | Symphogen A/S | Recombinant or purified polyclonal antibodies for treating allergy |
| BR0112633A (pt) | 2000-07-21 | 2003-09-16 | Us Agriculture | Método para substituir, translocar e empilhar dna em genomas eucarióticos |
| US6610472B1 (en) * | 2000-10-31 | 2003-08-26 | Genetastix Corporation | Assembly and screening of highly complex and fully human antibody repertoire in yeast |
| JP2004514444A (ja) * | 2000-11-28 | 2004-05-20 | アプライド モレキュラー エボリューション， インコーポレイテッド | 二重ｌｏｘ組換えに基づく真核生物発現ライブラリーおよび使用方法 |
| EP1739424B1 (en) | 2000-12-26 | 2011-08-24 | The Institute for Systems Biology | Rapid and quantitative proteome anaysis and related methods |
| US20040033591A1 (en) | 2002-05-31 | 2004-02-19 | The Regents Of The University Of Michigan | Automated protein analysis system |
| DK2314629T4 (da) | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| AU2003284227A1 (en) | 2002-10-15 | 2004-05-04 | The Regents Of The University Of Michigan | Multidimensional protein separation system |
| US20060275766A1 (en) * | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
| SI1583830T1 (sl) * | 2003-01-07 | 2006-12-31 | Symphogen As | Postopek za pripravo rekombinantnih poliklonskih proteinov |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| US8288109B2 (en) | 2004-07-20 | 2012-10-16 | Symphogen A/S | Procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line |
-
2005
- 2005-07-18 EA EA200700249A patent/EA014182B1/ru not_active IP Right Cessation
- 2005-07-18 AU AU2005263331A patent/AU2005263331B8/en not_active Ceased
- 2005-07-18 JP JP2007521793A patent/JP4926054B2/ja not_active Expired - Fee Related
- 2005-07-18 NZ NZ552265A patent/NZ552265A/en not_active IP Right Cessation
- 2005-07-18 CA CA002574062A patent/CA2574062A1/en not_active Abandoned
- 2005-07-18 WO PCT/DK2005/000501 patent/WO2006007850A1/en not_active Ceased
- 2005-07-18 MX MX2007000644A patent/MX2007000644A/es active IP Right Grant
- 2005-07-18 KR KR1020077003955A patent/KR20070038556A/ko not_active Ceased
- 2005-07-18 EP EP05760588A patent/EP1771483A1/en not_active Withdrawn
- 2005-07-18 BR BRPI0513706-3A patent/BRPI0513706A/pt not_active IP Right Cessation
- 2005-07-18 US US11/632,937 patent/US8198415B2/en not_active Expired - Fee Related
- 2005-07-18 EP EP08157871A patent/EP1967529A1/en not_active Withdrawn
-
2006
- 2006-11-28 IL IL179658A patent/IL179658A/en not_active IP Right Cessation
-
2007
- 2007-02-19 NO NO20070927A patent/NO20070927L/no not_active Application Discontinuation
-
2012
- 2012-06-11 US US13/493,623 patent/US20120322690A1/en not_active Abandoned
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