JP2008508903A5 - - Google Patents

Info

Publication number

JP2008508903A5

JP2008508903A5 JP2007526144A JP2007526144A JP2008508903A5 JP 2008508903 A5 JP2008508903 A5 JP 2008508903A5 JP 2007526144 A JP2007526144 A JP 2007526144A JP 2007526144 A JP2007526144 A JP 2007526144A JP 2008508903 A5 JP2008508903 A5 JP 2008508903A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

acid sequence

protein

complementarity determining

Prior art date

2005-06-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 125000003275 alpha amino acid group Chemical group 0.000 claims 38
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 36
• 102000004169 proteins and genes Human genes 0.000 claims 25
• 108090000623 proteins and genes Proteins 0.000 claims 25
• 108091008324 binding proteins Proteins 0.000 claims 16
• 102000023732 binding proteins Human genes 0.000 claims 16
• 206010028980 Neoplasm Diseases 0.000 claims 12
• 201000011510 cancer Diseases 0.000 claims 12
• 229940127121 immunoconjugate Drugs 0.000 claims 12
• 239000000427 antigen Substances 0.000 claims 9
• 238000012360 testing method Methods 0.000 claims 9
• 102000036639 antigens Human genes 0.000 claims 6
• 108091007433 antigens Proteins 0.000 claims 6
• 102000013529 alpha-Fetoproteins Human genes 0.000 claims 5
• 108010026331 alpha-Fetoproteins Proteins 0.000 claims 5
• 230000027455 binding Effects 0.000 claims 5
• 150000007523 nucleic acids Chemical group 0.000 claims 5
• 239000003053 toxin Substances 0.000 claims 5
• 231100000765 toxin Toxicity 0.000 claims 5
• 210000004881 tumor cell Anatomy 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 4
• 102100032912 CD44 antigen Human genes 0.000 claims 3
• 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 3
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
• 230000015572 biosynthetic process Effects 0.000 claims 3
• 239000012830 cancer therapeutic Substances 0.000 claims 3
• -1 carrier Substances 0.000 claims 3
• 239000000032 diagnostic agent Substances 0.000 claims 3
• 229940039227 diagnostic agent Drugs 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 241000124008 Mammalia Species 0.000 claims 2
• 108700033844 Pseudomonas aeruginosa toxA Proteins 0.000 claims 2
• 108010039491 Ricin Proteins 0.000 claims 2
• 238000012875 competitive assay Methods 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• 238000003259 recombinant expression Methods 0.000 claims 2
• 239000003381 stabilizer Substances 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 101000669426 Aspergillus restrictus Ribonuclease mitogillin Proteins 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108700004714 Gelonium multiflorum GEL Proteins 0.000 claims 1
• 108090000829 Ribosome Inactivating Proteins Proteins 0.000 claims 1
• 108010084592 Saporins Proteins 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 108010049223 bryodin Proteins 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 239000002872 contrast media Substances 0.000 claims 1
• 239000000824 cytostatic agent Substances 0.000 claims 1
• 230000001085 cytostatic effect Effects 0.000 claims 1
• 231100000433 cytotoxic Toxicity 0.000 claims 1
• 230000001472 cytotoxic effect Effects 0.000 claims 1
• 239000000539 dimer Substances 0.000 claims 1
• 206010013023 diphtheria Diseases 0.000 claims 1
• 239000007850 fluorescent dye Substances 0.000 claims 1
• 229940051026 immunotoxin Drugs 0.000 claims 1
• 239000002596 immunotoxin Substances 0.000 claims 1
• 231100000608 immunotoxin Toxicity 0.000 claims 1
• 230000002637 immunotoxin Effects 0.000 claims 1
• 229910021645 metal ion Inorganic materials 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1