CN101044242B - 肿瘤特异性抗体 - Google Patents
肿瘤特异性抗体 Download PDFInfo
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- CN101044242B CN101044242B CN2005800272005A CN200580027200A CN101044242B CN 101044242 B CN101044242 B CN 101044242B CN 2005800272005 A CN2005800272005 A CN 2005800272005A CN 200580027200 A CN200580027200 A CN 200580027200A CN 101044242 B CN101044242 B CN 101044242B
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Abstract
Description
临床适应症 | 代表性肿瘤细胞系 | N1 | MF2 | 相对等级 |
乳房 | MCF-7,MDA-MB-231,MDA-MB-435S | 3 | 17.2 | 1 |
肺 | A-549,NCI-H460,NCI-H69 | 3 | 16.1 | 2 |
黑素瘤 | A-375,SK-MEL-5a,b,SK-MEL-28a | 3 | 15.6 | 3 |
前列腺 | DU-145a,b,f,PC-3a,b,g,LNCaPa,b,g | 3 | 14.2 | 4 |
卵巢 | SK-OV-3a,OVCar-3 | 2 | 10.8 | 5 |
肾 | Caki-1a,A498a,ACHNa | 3 | 10.5 | 6 |
肝 | SK-HEP-1,Hep-G2 | 2 | 8.3 | 7 |
直肠 | SW837,NCI-H630 | 2 | 7.5 | 8 |
结肠 | HT-29a,SW480,WiDr | 3 | 7.2 | 9 |
子宫颈 | HeLa,C-41,C-33A | 3 | 4.4 | 10 |
胃 | AGS,NCI-N-87,KATO III | 3 | 4.0 | 11 |
膀胱 | UM-UC-3,T24 | 2 | 3.9 | 12 |
子宫内膜 | RL-95-2,HEC-1-A | 2 | 3.9 | 12 |
胰腺 | PANC-1,BxPC-3,MIA PaCa-2 | 3 | 3.8 | 14 |
头&颈 | SCC-15,SCC-25 | 2 | 2.9 | 15 |
正常细胞类型 | 细胞系 | 肿瘤:正常 | ||
肾 | HRE | 1 | 6.1 | 1.7 |
肺 | NHLF | 1 | 5.6 | 2.9 |
内皮 | HUVEC | 1 | 1.6 | N/A |
乳房 | HMEC | 1 | 2.4 | 7.2 |
前列腺 | PrEC | 1 | 4.0 | 3.6 |
组织 | 膜染色 | 评分范围* |
脑 | 无(0/2) | 0 |
结肠 | 无(0/5) | 0 |
心脏 | 无(0/5) | 0 |
肾 | 2/3 | 0-1(10%) |
肝 | 无(0/5) | 0 |
肺 | 无(0/5) | 0 |
胰腺 | 1/5 | 1(30%) |
胃 | 1/5 | 1(70%) |
组织 | 膜染色 | 评分范围* |
肾上腺 | 无(0/2) | 0 |
大动脉 | 无(0/5) | 0 |
动脉 | 无(0/5) | 0 |
膀胱 | 无(0/5) | 0 |
脑 | 无(0/5) | 0 |
乳房 | 无(0/5) | 0 |
输卵管 | 3/4 | 1-2(30-60%) |
LN | 无(0/3) | 0 |
肌肉 | 无(0/4) | 0 |
卵巢 | 无(0/5) | 0 |
垂体 | 无(0/5) | 0 |
胎盘 | 无(0/4) | 0 |
前列腺 | 4/5 | 0-1(10-20%) |
皮肤 | ND | |
脊髓 | 无(0/1) | 0 |
脾 | 无(0/2) | 0 |
睾丸 | 3/5 | 1-2(95%) |
胸腺 | 无(0/1) | 0 |
甲状腺 | 无(0/5) | 0 |
输尿管 | 1/2 | |
子宫 | 无(0/5) | 0 |
组织 | 膜染色 | 评分范围* |
膀胱 | 6/6 | 1-2(100%) |
乳房 | 6/7 | 1-2(100%) |
子宫颈 | 2/7 | 1(100%) |
结肠 | 3/3 | 1-2(100%) |
肾 | 5/8 | 1-2(100%) |
肝 | 5/7 | 1-2(100%) |
肺 | 1/8 | 1(100%) |
卵巢 | 6/7 | 1-2(100%) |
胰腺 | 4/7 | 1(100%) |
前列腺 | 5/5 | 1-2(100%) |
直肠 | 4/6 | 1-2(100%) |
皮肤 | 1/4 | 1(100%) |
胃 | 4/5 | 1-2(100%) |
子宫 | 8/8 | 1-2(100%) |
头&颈 | 4/8 | 1(100%) |
细胞系 | MF* |
A-375 | 13.3 |
MDA-MB-435S | 15.8 |
MDA-MB-231 | 14.2 |
MCF-7 | 4.67 |
PANC-1 | 8.3 |
DAUDI | 1.1 |
RAMOS | 1.3 |
NLQNVDMK–Exon20(SEQ ID NO:38) |
YVQKGEYR–Exon5(SEQ ID NO:39) |
KPSGLNGEASK–Exon20(SEQ ID NO:40) |
YGFIEGHVVIPR–Exon3(SEQ ID NO:41) |
TEAADLCK–Exon2(SEQ ID NO:42) |
LVINSGNGAVEDR–Exon19(SEQ ID NO:43) |
ESSETPDQFMTADETR–Exon20(SEQ ID NO:44) |
TGPLSMTTQQSNSQSFSTSHEGLEED–Exon v8-v9(SEQ ID NO:45) |
细胞系 | VB1-008 | CD44抗体 | AFP抗体 | Ag强度 | EGFR抗体 |
MB435S | 15.8 | 773.5 | 1.95 | ++++ | 33.1 |
MB231 | 14.2 | 292 | 1.3 | ++ | 149 |
A-375 | 13.3 | 368 | 1.3 | +++ | 16 |
PANC-1 | 8.3 | 192.5 | 1.1 | - | 132.4 |
MCF-7 | 4.63 | 52 | 1.1 | + | 7 |
DAUDI | 1 | 1.6 | 1.4 | - | 1.1 |
RAMOS | 1.1 | 1.3 | 1.3 | +++ | 1.2 |
Claims (23)
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US57829104P | 2004-06-10 | 2004-06-10 | |
US60/578,291 | 2004-06-10 | ||
PCT/CA2005/000899 WO2005121341A1 (en) | 2004-06-10 | 2005-06-10 | Tumor specific antibody |
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CN101044242A CN101044242A (zh) | 2007-09-26 |
CN101044242B true CN101044242B (zh) | 2013-10-30 |
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US (3) | US8383117B2 (zh) |
EP (2) | EP2927322A1 (zh) |
JP (2) | JP5026268B2 (zh) |
CN (1) | CN101044242B (zh) |
AU (1) | AU2005252275B2 (zh) |
CA (1) | CA2569788C (zh) |
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IL (1) | IL179891A (zh) |
NZ (1) | NZ552476A (zh) |
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US20150197575A1 (en) | 2015-07-16 |
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AU2005252275B2 (en) | 2011-07-21 |
CA2569788A1 (en) | 2005-12-22 |
AU2005252275A1 (en) | 2005-12-22 |
IL179891A (en) | 2014-07-31 |
US8383117B2 (en) | 2013-02-26 |
IL179891A0 (en) | 2007-05-15 |
US8969540B2 (en) | 2015-03-03 |
EP1766017A4 (en) | 2009-12-02 |
CA2569788C (en) | 2014-03-18 |
US20130217865A1 (en) | 2013-08-22 |
EP1766017B1 (en) | 2015-01-21 |
US20070292441A1 (en) | 2007-12-20 |
WO2005121341A1 (en) | 2005-12-22 |
EP1766017A1 (en) | 2007-03-28 |
ES2535229T3 (es) | 2015-05-06 |
CN101044242A (zh) | 2007-09-26 |
JP2012187104A (ja) | 2012-10-04 |
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PL1766017T3 (pl) | 2015-08-31 |
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