JP2008508882A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008508882A5 JP2008508882A5 JP2007524977A JP2007524977A JP2008508882A5 JP 2008508882 A5 JP2008508882 A5 JP 2008508882A5 JP 2007524977 A JP2007524977 A JP 2007524977A JP 2007524977 A JP2007524977 A JP 2007524977A JP 2008508882 A5 JP2008508882 A5 JP 2008508882A5
- Authority
- JP
- Japan
- Prior art keywords
- rage
- fusion protein
- seq
- fragment
- set forth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59836204P | 2004-08-03 | 2004-08-03 | |
| PCT/US2005/027694 WO2006017643A1 (en) | 2004-08-03 | 2005-08-03 | Rage fusion proteins and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008508882A JP2008508882A (ja) | 2008-03-27 |
| JP2008508882A5 true JP2008508882A5 (https=) | 2008-09-18 |
Family
ID=35427536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007524977A Withdrawn JP2008508882A (ja) | 2004-08-03 | 2005-08-03 | Rage融合タンパク質及び使用方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20090060925A1 (https=) |
| EP (1) | EP1776459A1 (https=) |
| JP (1) | JP2008508882A (https=) |
| KR (1) | KR20070057818A (https=) |
| CN (1) | CN101010430A (https=) |
| AP (1) | AP2007003893A0 (https=) |
| AU (2) | AU2005271449A1 (https=) |
| BR (1) | BRPI0514013A (https=) |
| CA (1) | CA2575830A1 (https=) |
| CR (2) | CR8897A (https=) |
| EA (1) | EA012586B1 (https=) |
| EC (1) | ECSP077297A (https=) |
| GE (1) | GEP20105111B (https=) |
| IL (1) | IL180555A0 (https=) |
| MA (1) | MA28781B1 (https=) |
| MX (1) | MX2007001556A (https=) |
| NO (1) | NO20070062L (https=) |
| NZ (1) | NZ552842A (https=) |
| SG (1) | SG161242A1 (https=) |
| TN (1) | TNSN07040A1 (https=) |
| UA (1) | UA92154C2 (https=) |
| WO (1) | WO2006017643A1 (https=) |
| ZA (1) | ZA200700641B (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7258857B2 (en) * | 1996-11-22 | 2007-08-21 | The Trustees Of Columbia University In The City Of New York | Rage-related methods for treating inflammation |
| US6790443B2 (en) * | 1996-11-22 | 2004-09-14 | The Trustees Of Columbia University In The City Of New York | Method for treating symptoms of diabetes |
| US6465422B1 (en) * | 1998-04-17 | 2002-10-15 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting tumor invasion or spreading in a subject |
| AU765719B2 (en) * | 1998-10-06 | 2003-09-25 | Trustees Of Columbia University In The City Of New York, The | Extracellular novel rage binding protein (EN-RAGE) and uses thereof |
| AU2002213192A1 (en) * | 2000-10-13 | 2002-04-22 | The Trustees Of Columbia University In The City Of New York | A method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury |
| EP1575513A4 (en) * | 2002-08-16 | 2007-04-04 | Wyeth Corp | COMPOSITIONS AND METHODS FOR TREATING RAGE-ASSOCIATED DISEASES |
| US8067371B2 (en) | 2003-05-09 | 2011-11-29 | The Trustees Of Columbia University In The City Of New York | RAGE G82S-related methods and compositions for treating inflammatory disorders |
| EP1771565B1 (en) * | 2004-07-20 | 2012-09-05 | The Feinstein Institute for Medical Research | Rage protein derivatives |
| SG161242A1 (en) * | 2004-08-03 | 2010-05-27 | Transtech Pharma Inc | Rage fusion proteins and methods of use |
| GEP20105110B (en) * | 2004-08-03 | 2010-11-10 | Transtech Pharma Inc | Rage fusion proteins and their use |
| WO2006036922A2 (en) | 2004-09-27 | 2006-04-06 | Centocor, Inc. | Srage mimetibody, compositions, methods and uses |
| BRPI0608401A2 (pt) * | 2005-03-17 | 2010-11-16 | Columbia Univ New York | polipeptìdeo, composição farmacêutica, ácido nucleico, vetor de expressão, célula, métodos para inibir a ligação entre diáfano e o domìnio citoplasmático de rage, para identificar um agente que inibe a ligação entre o diáfano e o domìnio citoplasmático de rage, e, uso de um agente que inibe a ligação entre diáfano e o domìnio citoplasmático de rage |
| WO2006119510A2 (en) * | 2005-05-04 | 2006-11-09 | Receptor Biologix, Inc. | Isoforms of receptor for advanced glycation end products (rage) and methods of identifying and using same |
| US20080207499A1 (en) * | 2005-06-29 | 2008-08-28 | Gaetano Barile | Rage-related methods for treating and preventing diabetic retinopathy |
| JP5314428B2 (ja) * | 2005-12-23 | 2013-10-16 | ジーコデール システムズ アクチボラゲット | 測位用パターン |
| EP1989227A2 (en) * | 2006-02-09 | 2008-11-12 | Transtech Pharma, Inc. | Rage fusion proteins and methods of use |
| SG171670A1 (en) * | 2006-05-05 | 2011-06-29 | Transtech Pharma Inc | Rage fusion proteins, formulations, and methods of use thereof |
| EP2450368A1 (en) | 2007-01-30 | 2012-05-09 | Epivax, Inc. | Regulatory t cell epitopes, compositions and uses thereof |
| WO2008100470A2 (en) * | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Rage - immunoglobulin fusion proteins |
| US20100254983A1 (en) * | 2007-06-07 | 2010-10-07 | Ann Marie Schmidt | Uses of rage antagonists for treating obesity and related diseases |
| KR101595634B1 (ko) * | 2007-06-14 | 2016-02-18 | 갈락티카 파마슈티칼스, 인크. | Rage 융합 단백질 |
| NL2001554C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| NL2001557C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| NL2001552C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| NL2001555C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| NL2001556C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| NL2001553C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| NL2001551C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| NL2001558C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| AU2010240569A1 (en) | 2009-04-20 | 2011-10-20 | Pfizer Inc. | Control of protein glycosylation and compositions and methods relating thereto |
| WO2013103688A1 (en) * | 2012-01-03 | 2013-07-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human soluble receptors for advanced glycation end products (srage), methods of preparing human srage, and treatment methods using srage |
| CN103376328A (zh) * | 2013-07-18 | 2013-10-30 | 上海交通大学医学院附属瑞金医院 | 血清sRAGE水平的检测试剂在筛选改善胰岛素β细胞功能的糖尿病治疗药物中的应用 |
| KR101645654B1 (ko) * | 2014-05-02 | 2016-08-05 | 서울대학교산학협력단 | Rage로부터 유래된 폴리펩티드 및 이를 유효성분으로 포함하는 뇌혈관질환의 예방 또는 치료용 약학적 조성물 |
| JP7307178B2 (ja) | 2018-09-14 | 2023-07-11 | バイオエイジ ラブス, インコーポレイテッド | 改善された安定性およびリガンド結合親和性を有するrage融合タンパク質ならびにその使用 |
| JP7477141B2 (ja) * | 2019-02-21 | 2024-05-01 | 国立研究開発法人農業・食品産業技術総合研究機構 | 肝疾患診断技術 |
| JP7479039B2 (ja) * | 2019-02-21 | 2024-05-08 | 国立研究開発法人農業・食品産業技術総合研究機構 | 糖尿病診断技術 |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) * | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4356108A (en) * | 1979-12-20 | 1982-10-26 | The Mead Corporation | Encapsulation process |
| US4265874A (en) * | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
| US5567584A (en) * | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
| US6018026A (en) * | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
| NZ235148A (en) * | 1989-09-05 | 1991-12-23 | Immunex Corp | Tumour necrosis factor receptor protein and dna sequences |
| MX9204374A (es) * | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
| SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
| DE69629176T2 (de) * | 1995-01-18 | 2004-06-03 | Alteon Inc. | Verwendung von thiazoliumverbindungen zum verhindern und umkehren der bildung von endprodukten der fortgeschrittenen glykosylierung |
| FI119756B (fi) * | 1995-01-18 | 2009-03-13 | Alteon Inc | Tiatsoliumyhdisteiden käyttö pitkälle edenneen glykosylaation lopputuotteiden muodostumisen estossa ja suunnan muutoksessa |
| US5656261A (en) * | 1995-01-18 | 1997-08-12 | The Picower Institute For Medical Research | Preventing and reversing advanced glycosylation endproducts |
| CA2217572A1 (en) * | 1995-04-05 | 1996-10-10 | The Picower Institute For Medical Research | Agents for binding to advanced glycosylation endproducts, and methods of their use |
| US5747035A (en) * | 1995-04-14 | 1998-05-05 | Genentech, Inc. | Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor |
| US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US5864018A (en) * | 1996-04-16 | 1999-01-26 | Schering Aktiengesellschaft | Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor |
| US7258857B2 (en) * | 1996-11-22 | 2007-08-21 | The Trustees Of Columbia University In The City Of New York | Rage-related methods for treating inflammation |
| US6555651B2 (en) * | 1997-10-09 | 2003-04-29 | The Trustees Of Columbia University In The City Of New York | Ligand binding site of rage and uses thereof |
| US6790443B2 (en) * | 1996-11-22 | 2004-09-14 | The Trustees Of Columbia University In The City Of New York | Method for treating symptoms of diabetes |
| US7081241B1 (en) * | 1998-10-06 | 2006-07-25 | The Trustees Of Columbia University In The City Of New York | Extracellular rage binding protein (EN-RAGE) and uses thereof |
| US7101838B2 (en) * | 1997-08-05 | 2006-09-05 | The Trustees Of Columbia University In The City Of New York | Method to prevent accelerated atherosclerosis using (sRAGE) soluble receptor for advanced glycation endproducts |
| MY131805A (en) * | 1997-09-18 | 2007-09-28 | Biogen Idec Inc | Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis. |
| US6380165B1 (en) * | 1997-09-19 | 2002-04-30 | The Picower Institute For Medical Research | Immunological advanced glycation endproduct crosslink |
| US6761888B1 (en) * | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US6323218B1 (en) * | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
| US7198789B2 (en) * | 1998-03-17 | 2007-04-03 | Genetics Institute, Llc | Methods and compositions for modulating interleukin-21 receptor activity |
| US6465422B1 (en) * | 1998-04-17 | 2002-10-15 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting tumor invasion or spreading in a subject |
| US6753150B2 (en) * | 1998-10-05 | 2004-06-22 | The Trustees Of Columbia University In The City Of New York | Method for determining whether a compound is capable of inhibiting the interaction of a peptide with rage |
| AU765719B2 (en) * | 1998-10-06 | 2003-09-25 | Trustees Of Columbia University In The City Of New York, The | Extracellular novel rage binding protein (EN-RAGE) and uses thereof |
| US6787566B2 (en) * | 1999-04-05 | 2004-09-07 | City Of Hope | Breakers of advanced glycation endproducts |
| US6605642B2 (en) * | 1999-04-05 | 2003-08-12 | City Of Hope | Inhibitors of formation of advanced glycation endproducts (AGES) |
| US6939545B2 (en) * | 1999-04-28 | 2005-09-06 | Genetics Institute, Llc | Composition and method for treating inflammatory disorders |
| CA2382095A1 (en) * | 1999-08-13 | 2001-02-22 | The Trustees Of Columbia University In The City Of New York | Methods of inhibiting binding of .beta.-sheet fibril to rage and consequences thereof |
| US20050170382A1 (en) * | 1999-10-06 | 2005-08-04 | The Trustees Of Columbia University In The City Of New York. | RAGE-related compositions |
| JP2003516150A (ja) * | 1999-12-08 | 2003-05-13 | ジェンセット | 潜在性分泌タンパク質をコードする全長ヒトcDNA |
| US6716635B2 (en) * | 2000-04-14 | 2004-04-06 | University Of Kentucky Research Foundation | Method for identifying regulators of protein-advanced glycation end product (protein-AGE) formation |
| US6613801B2 (en) * | 2000-05-30 | 2003-09-02 | Transtech Pharma, Inc. | Method for the synthesis of compounds of formula I and their uses thereof |
| US7423177B2 (en) * | 2001-03-05 | 2008-09-09 | Transtech Pharma, Inc. | Carboxamide derivatives as therapeutic agents |
| US6563015B1 (en) * | 2000-08-14 | 2003-05-13 | The Trustees Of Columbia University In The City Of New York | Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) and mutant APP in brain and uses thereof |
| US6825164B1 (en) * | 2000-08-14 | 2004-11-30 | The Trustees Of Columbia University In The City Of New York | Method to increase cerebral blood flow in amyloid angiopathy |
| CA2424246A1 (en) * | 2000-10-02 | 2002-04-11 | Shianlen Cahoon | Methods and compositions for the treatment of inflammatory diseases |
| AU2002213192A1 (en) * | 2000-10-13 | 2002-04-22 | The Trustees Of Columbia University In The City Of New York | A method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury |
| US20050244849A1 (en) * | 2000-12-15 | 2005-11-03 | Genetics Institute, Llc | Screening assays for rheumatoid arthritis |
| PL366250A1 (en) * | 2000-12-29 | 2005-01-24 | Reddy Us Therapeutics, Inc. | Detection of compounds that modulate inflammatory responses |
| CN100522242C (zh) * | 2001-02-19 | 2009-08-05 | 默克专利有限公司 | 具有降低的免疫原性的人工蛋白质 |
| CN1235583C (zh) * | 2001-03-05 | 2006-01-11 | 特兰斯泰克制药公司 | 用作治疗剂的苯并咪唑衍生物 |
| JP3837494B2 (ja) * | 2001-03-19 | 2006-10-25 | 国立大学法人金沢大学 | 可溶型rageタンパク質 |
| US6861888B2 (en) * | 2002-01-16 | 2005-03-01 | Agilent Technologies, Inc. | High-sensitivity differential data latch system |
| DK1482931T3 (da) * | 2002-03-05 | 2011-12-19 | Transtech Pharma Inc | Mono- og bicycliske azolderivater der inhiberer interaktionen af ligander med RAGE |
| EP1575513A4 (en) * | 2002-08-16 | 2007-04-04 | Wyeth Corp | COMPOSITIONS AND METHODS FOR TREATING RAGE-ASSOCIATED DISEASES |
| US8067371B2 (en) * | 2003-05-09 | 2011-11-29 | The Trustees Of Columbia University In The City Of New York | RAGE G82S-related methods and compositions for treating inflammatory disorders |
| US20050008649A1 (en) * | 2003-06-02 | 2005-01-13 | University Of Miami | Chimeric molecules and methods of use |
| US6969545B2 (en) * | 2003-07-28 | 2005-11-29 | Deere & Company | Hydrogen storage container |
| ZA200601810B (en) * | 2003-09-05 | 2008-05-28 | Univ Columbia | Rage-related methods and compositions for treating glomerular injury |
| WO2005042782A1 (en) * | 2003-10-31 | 2005-05-12 | The Trustees Of Columbia University In The City Of New York | Methods for reducing seizure-induced neuronal damage |
| US20070167360A1 (en) * | 2003-10-31 | 2007-07-19 | Yan Shi D | Methods for treating multiple sclerosis |
| EP1771565B1 (en) * | 2004-07-20 | 2012-09-05 | The Feinstein Institute for Medical Research | Rage protein derivatives |
| GEP20105110B (en) * | 2004-08-03 | 2010-11-10 | Transtech Pharma Inc | Rage fusion proteins and their use |
| SG161242A1 (en) * | 2004-08-03 | 2010-05-27 | Transtech Pharma Inc | Rage fusion proteins and methods of use |
| WO2006036922A2 (en) * | 2004-09-27 | 2006-04-06 | Centocor, Inc. | Srage mimetibody, compositions, methods and uses |
| BRPI0608401A2 (pt) * | 2005-03-17 | 2010-11-16 | Columbia Univ New York | polipeptìdeo, composição farmacêutica, ácido nucleico, vetor de expressão, célula, métodos para inibir a ligação entre diáfano e o domìnio citoplasmático de rage, para identificar um agente que inibe a ligação entre o diáfano e o domìnio citoplasmático de rage, e, uso de um agente que inibe a ligação entre diáfano e o domìnio citoplasmático de rage |
| US20080207499A1 (en) * | 2005-06-29 | 2008-08-28 | Gaetano Barile | Rage-related methods for treating and preventing diabetic retinopathy |
| EP1989227A2 (en) * | 2006-02-09 | 2008-11-12 | Transtech Pharma, Inc. | Rage fusion proteins and methods of use |
| SG171670A1 (en) * | 2006-05-05 | 2011-06-29 | Transtech Pharma Inc | Rage fusion proteins, formulations, and methods of use thereof |
| WO2008100470A2 (en) * | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Rage - immunoglobulin fusion proteins |
| US20100254983A1 (en) * | 2007-06-07 | 2010-10-07 | Ann Marie Schmidt | Uses of rage antagonists for treating obesity and related diseases |
| US9491184B2 (en) * | 2008-04-04 | 2016-11-08 | Samsung Electronics Co., Ltd. | Method and apparatus for managing tokens for digital rights management |
-
2005
- 2005-08-03 SG SG201002393-5A patent/SG161242A1/en unknown
- 2005-08-03 JP JP2007524977A patent/JP2008508882A/ja not_active Withdrawn
- 2005-08-03 AU AU2005271449A patent/AU2005271449A1/en not_active Abandoned
- 2005-08-03 CA CA002575830A patent/CA2575830A1/en not_active Abandoned
- 2005-08-03 GE GEAP20059905A patent/GEP20105111B/en unknown
- 2005-08-03 US US11/630,916 patent/US20090060925A1/en not_active Abandoned
- 2005-08-03 KR KR1020077005162A patent/KR20070057818A/ko not_active Ceased
- 2005-08-03 NZ NZ552842A patent/NZ552842A/en not_active IP Right Cessation
- 2005-08-03 MX MX2007001556A patent/MX2007001556A/es active IP Right Grant
- 2005-08-03 CN CNA2005800261068A patent/CN101010430A/zh active Pending
- 2005-08-03 EA EA200700402A patent/EA012586B1/ru not_active IP Right Cessation
- 2005-08-03 EP EP05779648A patent/EP1776459A1/en not_active Withdrawn
- 2005-08-03 WO PCT/US2005/027694 patent/WO2006017643A1/en not_active Ceased
- 2005-08-03 US US11/197,644 patent/US20060078562A1/en not_active Abandoned
- 2005-08-03 AP AP2007003893A patent/AP2007003893A0/xx unknown
- 2005-08-03 UA UAA200702216A patent/UA92154C2/ru unknown
- 2005-08-03 BR BRPI0514013-7A patent/BRPI0514013A/pt not_active IP Right Cessation
-
2007
- 2007-01-04 NO NO20070062A patent/NO20070062L/no not_active Application Discontinuation
- 2007-01-04 IL IL180555A patent/IL180555A0/en unknown
- 2007-01-23 ZA ZA200700641A patent/ZA200700641B/xx unknown
- 2007-02-02 MA MA29649A patent/MA28781B1/fr unknown
- 2007-02-02 CR CR8897A patent/CR8897A/es unknown
- 2007-02-02 TN TNP2007000040A patent/TNSN07040A1/fr unknown
- 2007-03-02 EC EC2007007297A patent/ECSP077297A/es unknown
-
2010
- 2010-04-16 AU AU2010201531A patent/AU2010201531A1/en not_active Abandoned
-
2011
- 2011-10-20 CR CR20110557A patent/CR20110557A/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008508882A5 (https=) | ||
| CN110144009B (zh) | Cd47单域抗体及其用途 | |
| CN109096395B (zh) | 阻断型cd47纳米抗体及其用途 | |
| JP2008512988A5 (https=) | ||
| JP2022046510A (ja) | 血清アルブミン結合フィブロネクチンiii型ドメイン | |
| PT1888641E (pt) | Proteínas de ligação a albumina de soro | |
| CN109069591B (zh) | 治疗和诊断纤维化或纤维化相关疾病的手段和方法 | |
| US20130129727A1 (en) | Methods and systems for increasing protein stability | |
| CN102686611A (zh) | 与“渐进性糖化终产物受体”结合的多肽以及包括所述多肽的组合物和方法 | |
| CA2663042A1 (en) | Serum albumin binding proteins with long half-lives | |
| PH12014501604B1 (en) | Polypeptides binding to human complement c5 | |
| CN109796534B (zh) | 抗il-17抗体/tnfr ecd融合蛋白及其用途 | |
| CN117304315B (zh) | 抗il-6的纳米抗体及其在il-6相关疾病中的应用 | |
| CN116199795B (zh) | 融合蛋白及其用途 | |
| JP2008521426A5 (https=) | ||
| WO2021197359A1 (zh) | 一种构建多特异性抗体的平台 | |
| CN116284405B (zh) | 靶向cd150蛋白的纳米抗体及其应用 | |
| JP2020535151A5 (https=) | ||
| JP2010521139A5 (https=) | ||
| JP2019511457A5 (https=) | ||
| US20170114099A1 (en) | New polypeptide | |
| CN108431039A (zh) | 改进的p2x7受体结合剂和包含其的多肽 | |
| CN118043358A (zh) | Ctla-4结合分子及其应用 | |
| RU2004114878A (ru) | Агенты, увеличивающие аффинность | |
| CN120152992A (zh) | 双特异性抗体化合物 |