JP2008508360A5 - - Google Patents
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- Publication number
- JP2008508360A5 JP2008508360A5 JP2007524924A JP2007524924A JP2008508360A5 JP 2008508360 A5 JP2008508360 A5 JP 2008508360A5 JP 2007524924 A JP2007524924 A JP 2007524924A JP 2007524924 A JP2007524924 A JP 2007524924A JP 2008508360 A5 JP2008508360 A5 JP 2008508360A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- compound
- carboxylic acid
- aryl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000002947 alkylene group Chemical group 0.000 claims description 62
- 125000003118 aryl group Chemical group 0.000 claims description 56
- 125000001072 heteroaryl group Chemical group 0.000 claims description 51
- 125000000623 heterocyclic group Chemical group 0.000 claims description 37
- 229910052739 hydrogen Inorganic materials 0.000 claims description 34
- 239000001257 hydrogen Substances 0.000 claims description 34
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 30
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 15
- 125000005843 halogen group Chemical group 0.000 claims description 15
- 125000004429 atom Chemical group 0.000 claims description 13
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 13
- -1 pyrrolidino, piperidino, morpholino Chemical group 0.000 claims description 11
- 125000003545 alkoxy group Chemical group 0.000 claims description 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 10
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 10
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 10
- 150000001602 bicycloalkyls Chemical group 0.000 claims description 9
- 125000003342 alkenyl group Chemical group 0.000 claims description 7
- 125000004414 alkyl thio group Chemical group 0.000 claims description 7
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 150000001412 amines Chemical group 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 6
- 125000005842 heteroatom Chemical group 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 6
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims description 6
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 6
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 6
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 5
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
- 125000005505 thiomorpholino group Chemical group 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 3
- 125000004104 aryloxy group Chemical group 0.000 claims description 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims description 3
- 125000006413 ring segment Chemical group 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 125000001424 substituent group Chemical group 0.000 claims description 3
- 125000006702 (C1-C18) alkyl group Chemical group 0.000 claims description 2
- 125000002837 carbocyclic group Chemical group 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 35
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 241000124008 Mammalia Species 0.000 claims 5
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 4
- IIEWJVIFRVWJOD-UHFFFAOYSA-N ethyl cyclohexane Natural products CCC1CCCCC1 IIEWJVIFRVWJOD-UHFFFAOYSA-N 0.000 claims 4
- QEGNUYASOUJEHD-UHFFFAOYSA-N gem-dimethylcyclohexane Natural products CC1(C)CCCCC1 QEGNUYASOUJEHD-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- UAEPNZWRGJTJPN-UHFFFAOYSA-N methylcyclohexane Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 3
- 229960005141 piperazine Drugs 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 claims 2
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 claims 2
- LJOODBDWMQKMFB-UHFFFAOYSA-N cyclohexyl-acetic acid Natural products OC(=O)CC1CCCCC1 LJOODBDWMQKMFB-UHFFFAOYSA-N 0.000 claims 2
- IGARGHRYKHJQSM-UHFFFAOYSA-N cyclohexylbenzene Chemical compound C1CCCCC1C1=CC=CC=C1 IGARGHRYKHJQSM-UHFFFAOYSA-N 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 230000002107 myocardial effect Effects 0.000 claims 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 230000010412 perfusion Effects 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 229940121896 radiopharmaceutical Drugs 0.000 claims 2
- 239000012217 radiopharmaceutical Substances 0.000 claims 2
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 2
- HJORMJIFDVBMOB-UHFFFAOYSA-N rolipram Chemical group COC1=CC=C(C2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-UHFFFAOYSA-N 0.000 claims 2
- 229950005741 rolipram Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- XTVMZZBLCLWBPM-UHFFFAOYSA-N tert-butylcyclohexane Chemical compound CC(C)(C)C1CCCCC1 XTVMZZBLCLWBPM-UHFFFAOYSA-N 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- AULUDJRRNHDTJI-UHFFFAOYSA-N 1,1,3,3-tetramethylcyclohexane Chemical compound CC1(C)CCCC(C)(C)C1 AULUDJRRNHDTJI-UHFFFAOYSA-N 0.000 claims 1
- GCYUJISWSVALJD-UHFFFAOYSA-N 1,1-diethylcyclohexane Chemical compound CCC1(CC)CCCCC1 GCYUJISWSVALJD-UHFFFAOYSA-N 0.000 claims 1
- XAZKFISIRYLAEE-UHFFFAOYSA-N 1,3-dimethylcyclopentane Chemical compound CC1CCC(C)C1 XAZKFISIRYLAEE-UHFFFAOYSA-N 0.000 claims 1
- FUFZNHHSSMCXCZ-UHFFFAOYSA-N 5-piperidin-4-yl-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole Chemical compound FC(F)(F)C1=CC=CC(C=2N=C(ON=2)C2CCNCC2)=C1 FUFZNHHSSMCXCZ-UHFFFAOYSA-N 0.000 claims 1
- 102000009346 Adenosine receptors Human genes 0.000 claims 1
- 108050000203 Adenosine receptors Proteins 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 201000000057 Coronary Stenosis Diseases 0.000 claims 1
- 206010011089 Coronary artery stenosis Diseases 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 230000008484 agonism Effects 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000001775 anti-pathogenic effect Effects 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- CFBUZOUXXHZCFB-OYOVHJISSA-N chembl511115 Chemical compound COC1=CC=C([C@@]2(CC[C@H](CC2)C(O)=O)C#N)C=C1OC1CCCC1 CFBUZOUXXHZCFB-OYOVHJISSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229950001653 cilomilast Drugs 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- HJZLEGIHUQOJBA-UHFFFAOYSA-N cyclohexane propionic acid Chemical compound OC(=O)CCC1CCCCC1 HJZLEGIHUQOJBA-UHFFFAOYSA-N 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000002651 drug therapy Methods 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000028709 inflammatory response Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 claims 1
- 229960002586 roflumilast Drugs 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 229940056501 technetium 99m Drugs 0.000 claims 1
- BKVIYDNLLOSFOA-OIOBTWANSA-N thallium-201 Chemical compound [201Tl] BKVIYDNLLOSFOA-OIOBTWANSA-N 0.000 claims 1
- 0 *C(C(C1O)O)OC1[n]1c2nc(C#C*)nc(*)c2nc1 Chemical compound *C(C(C1O)O)OC1[n]1c2nc(C#C*)nc(*)c2nc1 0.000 description 15
- 150000002431 hydrogen Chemical class 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 125000006553 (C3-C8) cycloalkenyl group Chemical group 0.000 description 2
- 125000001589 carboacyl group Chemical group 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- CTMHWPIWNRWQEG-UHFFFAOYSA-N CC1=CCCCC1 Chemical compound CC1=CCCCC1 CTMHWPIWNRWQEG-UHFFFAOYSA-N 0.000 description 1
- UYIFQFISDISICS-UHFFFAOYSA-N CC1=CCCN(C)CC1 Chemical compound CC1=CCCN(C)CC1 UYIFQFISDISICS-UHFFFAOYSA-N 0.000 description 1
- PAMIQIKDUOTOBW-UHFFFAOYSA-N CN1CCCCC1 Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 description 1
- HLPFCDWYPKEQQW-ZDJIGWQMSA-N COC(C1CCC(CC#Cc2nc(N)c3nc[n]([C@@H](C(C4)O)O[C@@H]4C(NC4CC4)=O)c3n2)CC1)=O Chemical compound COC(C1CCC(CC#Cc2nc(N)c3nc[n]([C@@H](C(C4)O)O[C@@H]4C(NC4CC4)=O)c3n2)CC1)=O HLPFCDWYPKEQQW-ZDJIGWQMSA-N 0.000 description 1
- ZJERYPUNSMPAKN-MWVIVRMESA-N COC(N1CCC(CC#Cc2nc(N)c3nc[n]([C@@H](C(C4)O)O[C@@H]4C(NC4CC4)=O)c3n2)CC1)=O Chemical compound COC(N1CCC(CC#Cc2nc(N)c3nc[n]([C@@H](C(C4)O)O[C@@H]4C(NC4CC4)=O)c3n2)CC1)=O ZJERYPUNSMPAKN-MWVIVRMESA-N 0.000 description 1
- SQJXTUJMBYVDBB-PNXXNBOHSA-N COC(N1CCC(CC#Cc2nc(N)c3nc[n]([C@@H](C(C4O)O)O[C@@H]4C(NC4CC4)=O)c3n2)CC1)=O Chemical compound COC(N1CCC(CC#Cc2nc(N)c3nc[n]([C@@H](C(C4O)O)O[C@@H]4C(NC4CC4)=O)c3n2)CC1)=O SQJXTUJMBYVDBB-PNXXNBOHSA-N 0.000 description 1
- FCDBTWBTNXSZLF-VSUKOPEASA-N C[C@H](CCC1)C[C@@]1(C#Cc1nc(N)c2nc[n]([C@@H](C(C3O)O)O[C@@H]3C(NC3CC3)=O)c2n1)O Chemical compound C[C@H](CCC1)C[C@@]1(C#Cc1nc(N)c2nc[n]([C@@H](C(C3O)O)O[C@@H]3C(NC3CC3)=O)c2n1)O FCDBTWBTNXSZLF-VSUKOPEASA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59801804P | 2004-08-02 | 2004-08-02 | |
| US60/598,018 | 2004-08-02 | ||
| PCT/US2005/027479 WO2006015357A2 (en) | 2004-08-02 | 2005-08-02 | 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008508360A JP2008508360A (ja) | 2008-03-21 |
| JP2008508360A5 true JP2008508360A5 (enExample) | 2012-02-09 |
| JP5046930B2 JP5046930B2 (ja) | 2012-10-10 |
Family
ID=35787921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007524924A Expired - Fee Related JP5046930B2 (ja) | 2004-08-02 | 2005-08-02 | Ａ２ａアゴニスト活性を有する修飾５’−リボース基を備えた２−プロピニルアデノシン類似体 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7605143B2 (enExample) |
| EP (2) | EP2266994B1 (enExample) |
| JP (1) | JP5046930B2 (enExample) |
| CN (1) | CN101068825B (enExample) |
| AU (1) | AU2005267706B2 (enExample) |
| CA (1) | CA2576826C (enExample) |
| NZ (2) | NZ553288A (enExample) |
| SG (1) | SG155182A1 (enExample) |
| WO (1) | WO2006015357A2 (enExample) |
| ZA (1) | ZA200701021B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6232297B1 (en) * | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
| US7214665B2 (en) | 2001-10-01 | 2007-05-08 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof |
| US7732484B2 (en) * | 2000-08-01 | 2010-06-08 | University Of Virginia Patent Foundation | Use of selective adenosine A1 receptor allosteric enhancers to manipulate angiogenesis |
| WO2003086408A1 (en) * | 2002-04-10 | 2003-10-23 | University Of Virginia Patent Foundation | Use of a2a adenosine receptor agonists for the treatment of inflammatory diseases |
| WO2006028618A1 (en) * | 2004-08-02 | 2006-03-16 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
| NZ553288A (en) | 2004-08-02 | 2010-12-24 | Univ Virginia | 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity |
| US7442687B2 (en) * | 2004-08-02 | 2008-10-28 | The University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
| WO2007092936A2 (en) * | 2006-02-08 | 2007-08-16 | University Of Virginia Patent Foundation | Method to treat gastric lesions |
| US8178509B2 (en) * | 2006-02-10 | 2012-05-15 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
| US7589076B2 (en) * | 2006-05-18 | 2009-09-15 | Pgx Health, Llc | Substituted aryl piperidinylalkynyladenosines as A2AR agonists |
| US8188063B2 (en) * | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
| GB0622826D0 (en) * | 2006-11-15 | 2006-12-27 | Acurepharma Ab | Novel amides acting on the adenosine receptors |
| JP2008266143A (ja) * | 2007-04-16 | 2008-11-06 | Santen Pharmaceut Co Ltd | アデノシン誘導体を有効成分として含有する緑内障治療剤 |
| US8293720B2 (en) * | 2007-12-20 | 2012-10-23 | Dogwood Pharmaceuticals, Inc. | Substituted 4-{3-[6-amino-9-(3, 4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
| US8058259B2 (en) * | 2007-12-20 | 2011-11-15 | University Of Virginia Patent Foundation | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
| EP2240020A4 (en) * | 2008-01-09 | 2011-05-11 | Trovis Pharmaceuticals Llc | INTRATHEAL TREATMENT OF NEUROPATHIC PAIN WITH A2AR AGONISTS |
| EP2274007B1 (en) | 2008-03-10 | 2016-12-14 | Cornell University | Modulation of blood brain barrier permeability |
| AU2009230679B2 (en) | 2008-03-26 | 2013-07-18 | Advinus Therapeutics Pvt. Ltd. | Heterocyclic compounds as adenosine receptor antagonist |
| DK2306971T3 (en) | 2008-07-03 | 2015-05-11 | Univ Virginia Patent Found | The unit dosage of apadenoson |
| JP5765239B2 (ja) | 2009-03-13 | 2015-08-19 | アドヴィナス・セラピューティックス・リミテッド | 置換縮合ピリミジン化合物 |
| US8263762B2 (en) * | 2009-06-30 | 2012-09-11 | Dogwood Pharmaceuticals, Inc. | Alkoxy-carbonyl-amino-alkynyl-adenosine compounds and derivatives thereof as A2AR agonists |
| WO2011055391A1 (en) | 2009-11-09 | 2011-05-12 | Advinus Therapeutics Private Limited | Substituted fused pyrimidine compounds, its preparation and uses thereof |
| WO2011143442A1 (en) * | 2010-05-12 | 2011-11-17 | Trovis Pharmaceuticals, Llc. | A method of treating multiple sclerosis with adenosine receptor agonists |
| AU2011303420B2 (en) | 2010-09-13 | 2014-03-20 | Impetis Biosciences Ltd. | Purine compounds as prodrugs of A2B adenosine receptor antagonists, their process and medicinal applications |
| BR112013013659B8 (pt) | 2010-12-03 | 2024-02-27 | Epizyme Inc | Compostos moduladores de enzimas epigenéticas, composição farmacêutica compreendendo ditos compostos e usos da dita composição farmacêutica para tratar câncer, câncer hematológico ou leucemia |
| BR112013013668A2 (pt) | 2010-12-03 | 2016-09-06 | Epizyme Inc | moduladores 7-deazapurina de histona metiltransferase, e métodos de uso dos mesmos |
| IN2015DN00538A (enExample) | 2012-08-01 | 2015-06-26 | Lewis And Clark Pharmaceuticals Inc | |
| US9822141B2 (en) | 2012-08-01 | 2017-11-21 | Lewis And Clark Pharmaceuticals, Inc. | N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists |
| WO2014026198A1 (en) | 2012-08-10 | 2014-02-13 | Epizyme, Inc. | Inhibitors of protein methyltransferase dot1l and methods of use thereof |
| EP2892536B1 (en) | 2012-09-06 | 2019-12-18 | Epizyme, Inc. | Method of treating leukemia |
| EP2968387A4 (en) | 2013-03-15 | 2017-04-05 | Epizyme, Inc. | Methods of synthesizing substituted purine compounds |
| KR102201319B1 (ko) | 2014-01-14 | 2021-01-11 | 삼성전자주식회사 | 축합환 화합물 및 이를 포함한 유기 발광 소자 |
| EP2907815B1 (en) | 2014-02-12 | 2023-12-06 | Samsung Electronics Co., Ltd. | Condensed cyclic compound and organic light-emitting device including the same |
| US11672167B2 (en) | 2015-03-13 | 2023-06-06 | Samsung Electronics Co., Ltd. | Organometallic compound and organic light-emitting device including the same |
| KR102429871B1 (ko) | 2015-03-13 | 2022-08-05 | 삼성전자주식회사 | 유기금속 화합물 및 이를 포함한 유기 발광 소자 |
| US20170047532A1 (en) | 2015-08-13 | 2017-02-16 | Samsung Electronics Co., Ltd. | Organometallic compound, organic light-emitting device including the organometallic compound, and diagnosis composition including the organometallic compound |
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| CN114025763B (zh) * | 2019-06-21 | 2023-09-12 | 中国人民解放军军事科学院军事医学研究院 | 腺苷类化合物、其可药用盐或其立体异构体及用途 |
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-
2005
- 2005-08-02 NZ NZ553288A patent/NZ553288A/en not_active IP Right Cessation
- 2005-08-02 NZ NZ585697A patent/NZ585697A/en not_active IP Right Cessation
- 2005-08-02 SG SG200905180-6A patent/SG155182A1/en unknown
- 2005-08-02 EP EP10181920A patent/EP2266994B1/en not_active Expired - Lifetime
- 2005-08-02 EP EP05803845A patent/EP1778712B1/en not_active Expired - Lifetime
- 2005-08-02 US US11/196,529 patent/US7605143B2/en active Active
- 2005-08-02 CN CN2005800332152A patent/CN101068825B/zh not_active Expired - Fee Related
- 2005-08-02 JP JP2007524924A patent/JP5046930B2/ja not_active Expired - Fee Related
- 2005-08-02 AU AU2005267706A patent/AU2005267706B2/en not_active Ceased
- 2005-08-02 WO PCT/US2005/027479 patent/WO2006015357A2/en not_active Ceased
- 2005-08-02 CA CA2576826A patent/CA2576826C/en not_active Expired - Lifetime
-
2007
- 2007-02-01 ZA ZA200701021A patent/ZA200701021B/en unknown
-
2009
- 2009-06-18 US US12/487,235 patent/US7989431B2/en not_active Expired - Lifetime
-
2011
- 2011-02-15 US US13/027,901 patent/US20110136755A1/en not_active Abandoned
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