JP2008507531A5 - - Google Patents
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- Publication number
- JP2008507531A5 JP2008507531A5 JP2007522672A JP2007522672A JP2008507531A5 JP 2008507531 A5 JP2008507531 A5 JP 2008507531A5 JP 2007522672 A JP2007522672 A JP 2007522672A JP 2007522672 A JP2007522672 A JP 2007522672A JP 2008507531 A5 JP2008507531 A5 JP 2008507531A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- angptl4
- hepatocytes
- subject
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58987504P | 2004-07-20 | 2004-07-20 | |
| US60/589,875 | 2004-07-20 | ||
| PCT/US2005/025650 WO2006014678A2 (en) | 2004-07-20 | 2005-07-19 | Compositions and methods of using angiopoietin-like 4 protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011184642A Division JP2011235179A (ja) | 2004-07-20 | 2011-08-26 | アンジオポエチン様4タンパク質を使用する組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008507531A JP2008507531A (ja) | 2008-03-13 |
| JP2008507531A5 true JP2008507531A5 (https=) | 2008-08-07 |
| JP5318412B2 JP5318412B2 (ja) | 2013-10-16 |
Family
ID=35787695
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007522672A Expired - Fee Related JP5318412B2 (ja) | 2004-07-20 | 2005-07-19 | アンジオポエチン様4タンパク質を使用する組成物および方法 |
| JP2011184642A Withdrawn JP2011235179A (ja) | 2004-07-20 | 2011-08-26 | アンジオポエチン様4タンパク質を使用する組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011184642A Withdrawn JP2011235179A (ja) | 2004-07-20 | 2011-08-26 | アンジオポエチン様4タンパク質を使用する組成物および方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US7371384B2 (https=) |
| EP (1) | EP1781698B1 (https=) |
| JP (2) | JP5318412B2 (https=) |
| KR (1) | KR20070061524A (https=) |
| CN (1) | CN101080419B (https=) |
| AU (1) | AU2005269758B2 (https=) |
| BR (1) | BRPI0513477A (https=) |
| CA (1) | CA2574791A1 (https=) |
| DK (1) | DK1781698T3 (https=) |
| HU (1) | HUE029170T2 (https=) |
| IL (4) | IL180752A0 (https=) |
| LT (1) | LT1781698T (https=) |
| MX (1) | MX2007000783A (https=) |
| NO (1) | NO342525B1 (https=) |
| NZ (2) | NZ552957A (https=) |
| RU (2) | RU2380411C2 (https=) |
| WO (1) | WO2006014678A2 (https=) |
| ZA (1) | ZA200701184B (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050123925A1 (en) | 2002-11-15 | 2005-06-09 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| SI1771474T1 (sl) * | 2004-07-20 | 2010-06-30 | Genentech Inc | Inhibitorji angiopoetinu podobnega proteina kombinacije in njihova uporaba |
| US8604185B2 (en) | 2004-07-20 | 2013-12-10 | Genentech, Inc. | Inhibitors of angiopoietin-like 4 protein, combinations, and their use |
| LT1781698T (lt) * | 2004-07-20 | 2016-09-26 | Genentech, Inc. | Į angiopoetiną panašaus baltymo 4 kompozicijos ir panaudojimo būdai |
| WO2006074228A1 (en) * | 2005-01-07 | 2006-07-13 | Lexicon Pharmaceuticals, Inc. | Monoclonal antibodies against angiopoietin-like protein 4 (angptl4 ) |
| WO2007024723A2 (en) * | 2005-08-19 | 2007-03-01 | Washington University In St. Louis | Methods and compositions for treating gastrointestinal radiosensitivity in a subject |
| EP2050335A1 (en) * | 2006-02-17 | 2009-04-22 | Genentech, Inc. | Gene disruptions, compositions and methods relating thereto |
| CN101970012A (zh) | 2007-09-14 | 2011-02-09 | 日东电工株式会社 | 药物载体 |
| EP2344890B1 (en) * | 2008-10-20 | 2021-08-11 | Liposcience, Inc. | Lipoprotein insulin resistance indexes and related methods |
| WO2011046515A1 (en) * | 2009-10-14 | 2011-04-21 | Nanyang Technological University | Antiproliferative agent |
| CN102753186B (zh) * | 2010-01-08 | 2016-09-14 | Isis制药公司 | 血管生成素样3表达的调节 |
| US20130023473A1 (en) * | 2010-01-20 | 2013-01-24 | Stephane Germain | Methods and pharmaceutical composition for the preservation of vascular endothelial cell barrier integrity |
| US9139629B2 (en) | 2010-06-05 | 2015-09-22 | The Uab Research Foundation | Methods for treatment of nephrotic syndrome and related conditions |
| EP3318269B1 (en) * | 2010-06-05 | 2024-03-13 | Chugh, Sumant S. | Use of an angiopoietin-like 4 (angptl4) polypeptide in the manufacture of a medicament for the treatment of proteinuria. |
| US9475850B2 (en) * | 2010-06-05 | 2016-10-25 | The Uab Research Foundation | Methods for treatment of nephrotic syndrome and related conditions |
| CA2824434A1 (en) * | 2011-01-08 | 2012-07-12 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN102692500B (zh) * | 2011-03-21 | 2015-06-10 | 上海市肿瘤研究所 | Angptl4作为血清学检测肝癌转移的标志物及其应用 |
| CN102692496B (zh) * | 2011-03-21 | 2015-10-28 | 上海市肿瘤研究所 | Angptl4作为缺氧检测的标志物及其应用 |
| CN102242198A (zh) * | 2011-05-25 | 2011-11-16 | 信阳师范学院 | 通过angptl4基因多态性进行牛育种方法 |
| EP2723758B1 (en) * | 2011-06-21 | 2018-06-20 | Alnylam Pharmaceuticals, Inc. | Angiopoietin-like 3 (angptl3) irna compostions and methods of use thereof |
| CN103635483B (zh) | 2011-07-01 | 2016-11-09 | 孟山都技术公司 | 用于选择性调控蛋白质表达的方法和组合物 |
| CN103782177B (zh) * | 2011-08-08 | 2017-10-03 | 南洋理工大学 | 血管生成素样4及其在调节细胞渗漏中的用途 |
| CA2857686C (en) * | 2011-12-09 | 2023-01-17 | Metabolic Pharmaceuticals Pty Ltd | Use of growth hormone fragments |
| TW201823460A (zh) | 2012-05-29 | 2018-07-01 | 美商再生元醫藥公司 | 生產細胞株增強子 |
| CN104822419B (zh) * | 2012-07-19 | 2020-08-18 | 南洋理工大学 | 血管生成素样4及其用于伤口愈合的方法 |
| CA2906982C (en) * | 2013-03-15 | 2022-05-31 | The Uab Research Foundation | Methods for treatment of nephrotic syndrome and related conditions |
| DK2992098T3 (da) | 2013-05-01 | 2019-06-17 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression |
| EP3021942A4 (en) * | 2013-07-19 | 2017-04-19 | The Regents of The University of California | Milk fat globule epidermal growth factor 8 regulates fatty acid uptake |
| PT3087183T (pt) | 2013-12-24 | 2020-10-08 | Ionis Pharmaceuticals Inc | Modulação da expressão da proteína relacionada com angiopoietina 3 |
| WO2015123576A2 (en) * | 2014-02-17 | 2015-08-20 | The Brigham And Women's Hospital, Inc. | Targeted nanoparticle compositions and methods of their use to treat obesity |
| US9382540B2 (en) | 2014-05-01 | 2016-07-05 | Isis Pharmaceuticals, Inc | Compositions and methods for modulating angiopoietin-like 3 expression |
| WO2016020882A2 (en) | 2014-08-07 | 2016-02-11 | Novartis Ag | Angiopoetin-like 4 (angptl4) antibodies and methods of use |
| WO2016020880A2 (en) | 2014-08-07 | 2016-02-11 | Novartis Ag | Angiopoietin-like 4 antibodies and methods of use |
| CN105021827B (zh) * | 2015-07-17 | 2016-09-28 | 北京大学第一医院 | 检测血清血管生成素样蛋白2含量的物质在制备检测肝脏炎症和纤维化程度产品中的应用 |
| AU2016296468B2 (en) | 2015-07-22 | 2020-08-27 | Monsanto Technology Llc | Methods and compositions for selective regulation of protein expression |
| KR20250078597A (ko) | 2015-11-06 | 2025-06-02 | 아이오니스 파마수티컬즈, 인코포레이티드 | 아포리포프로테인 (a) 발현 조정 |
| AU2017286835B2 (en) * | 2016-06-29 | 2023-12-14 | Crispr Therapeutics Ag | Compositions and methods for gene editing |
| EP3880819A2 (en) | 2018-11-13 | 2021-09-22 | Lipigon Pharmaceuticals AB | Angptl4 oligonucleotides influencing the regulation of the fatty acid metabolism |
| EP4037713A4 (en) * | 2019-11-06 | 2023-11-01 | Northwestern University | Inhibition of the ve-ptp phosphatase protects the kidney from ischemia-reperfusion injury |
| CA3164050A1 (en) * | 2019-12-09 | 2021-06-17 | Empirico Inc. | Oligonucleotides for treatment of angiopoietin like 4 (angptl4) related diseases |
| CN120254294B (zh) * | 2025-06-05 | 2025-09-09 | 南昌大学第一附属医院 | Angptl3在乙肝相关慢加急性肝衰竭预后中的应用 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5227158A (en) | 1991-06-10 | 1993-07-13 | Genentech, Inc. | Method of stimulating hepatocyte proliferation by administration of hepatocyte growth factor and gamma-interferon |
| US20020137890A1 (en) | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6348350B1 (en) | 1997-09-19 | 2002-02-19 | Genentech, Inc. | Ligand homologues |
| US20030207375A1 (en) | 1997-10-24 | 2003-11-06 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU1931599A (en) | 1997-12-19 | 1999-07-12 | Zymogenetics Inc. | Angiopoietin homolog, dna encoding it, and method of making it |
| IL138216A0 (en) | 1998-03-02 | 2001-10-31 | Millennium Pharm Inc | Novel fdrg protein and nucleic acid molecules and uses therefor |
| US20030099994A1 (en) | 1998-03-02 | 2003-05-29 | Millennium Pharamceuticals, Inc. | Novel FDRG protein and nucleic acid molecules and uses therefor |
| JP2000026767A (ja) | 1998-05-01 | 2000-01-25 | Daikin Ind Ltd | 熱硬化性粉体塗料組成物 |
| CA2331154A1 (en) | 1998-06-16 | 1999-12-23 | Human Genome Sciences, Inc. | Polypeptides having sequence identity with acid labile subunit of insulin-like growth factor |
| AU4643699A (en) | 1998-06-24 | 2000-01-10 | Compugen Ltd. | Angiopoietin-like growth factor sequences |
| WO2001054477A2 (en) | 2000-01-25 | 2001-08-02 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| WO2001053455A2 (en) | 1999-12-23 | 2001-07-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| JP2000308488A (ja) | 1999-02-23 | 2000-11-07 | Herikkusu Kenkyusho:Kk | 血管新生に関連するタンパク質および該タンパク質をコードする遺伝子 |
| AU3391200A (en) | 1999-03-04 | 2000-09-21 | Corixa Corporation | Compositions and methods for breast cancer therapy and diagnosis |
| PT1626058E (pt) | 1999-03-08 | 2008-02-15 | Genentech Inc | Composições e métodos para o diagnóstico de tumores |
| WO2003004623A2 (en) | 2001-03-27 | 2003-01-16 | Human Genome Sciences, Inc. | Human secreted proteins |
| AU4200900A (en) | 1999-04-09 | 2000-11-14 | Human Genome Sciences, Inc. | 49 human secreted proteins |
| ATE420177T1 (de) | 1999-04-16 | 2009-01-15 | Genentech Inc | Vaskuläre endothelzellen wachstumsfaktor (vegf) varianten und dessen verwendungen |
| AU5979300A (en) | 1999-07-02 | 2001-01-22 | Bayer Aktiengesellschaft | Angiopoietin-6 and uses thereof |
| EP1210363A2 (en) | 1999-07-16 | 2002-06-05 | Hyseq, Inc. | Novel angiopoietin materials and methods |
| EP1196576A2 (en) | 1999-07-20 | 2002-04-17 | Curagen Corporation | Secreted polypeptides and corresponding polynucleotides |
| US20030207348A1 (en) | 1999-07-20 | 2003-11-06 | Shimkets Richard A. | Polypeptides and polynucleotides encoding same |
| AU2001243142A1 (en) | 2000-02-03 | 2001-08-14 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| CN1315451A (zh) | 2000-03-29 | 2001-10-03 | 上海博德基因开发有限公司 | 一种新的多肽——人血管形成素类似因子45和编码这种多肽的多核苷酸 |
| AU2001249929A1 (en) | 2000-04-07 | 2001-10-23 | Dana-Farber Cancer Institute Inc. | Fdrg proteins and nucleic acid molecules and uses therefor |
| AU784231B2 (en) * | 2000-06-23 | 2006-02-23 | Schering Aktiengesellschaft | Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/tie receptor function and their use (II) |
| US6673545B2 (en) | 2000-07-28 | 2004-01-06 | Incyte Corporation | Prostate cancer markers |
| CN1170850C (zh) | 2000-09-19 | 2004-10-13 | 上海市肿瘤研究所 | 人血管生成素样蛋白和编码序列及其用途 |
| US20030120056A1 (en) | 2000-10-16 | 2003-06-26 | Audrey Goddard | TIE ligand homologues |
| IL159153A0 (en) | 2001-06-08 | 2004-06-01 | Sankyo Co | Methods for testing drugs for treating or preventing diseases such as hyperlipidemia |
| WO2003010205A1 (en) | 2001-07-26 | 2003-02-06 | Duke University Medical Center | Genes induced by hypoxia |
| AU2002330039A1 (en) | 2001-09-17 | 2003-04-01 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer |
| US20050123925A1 (en) | 2002-11-15 | 2005-06-09 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| WO2003040330A2 (en) | 2001-11-05 | 2003-05-15 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US20040038230A1 (en) | 2001-11-05 | 2004-02-26 | Alsobrook John P. | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| EP1451578B1 (en) | 2001-11-16 | 2013-08-21 | Genentech, Inc. | Use of angptl3 antagonists for the treatment of liver diseases |
| WO2003048185A2 (en) | 2001-11-30 | 2003-06-12 | Genvec, Inc. | Angiopioetin related factors |
| AU2002364586A1 (en) | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| IL165392A0 (en) | 2002-06-05 | 2006-01-15 | Genentech Inc | Compositions and methods for liver growth and liver protection |
| US20050239706A1 (en) | 2003-10-31 | 2005-10-27 | Washington University In St. Louis | Modulation of fiaf and the gastrointestinal microbiota as a means to control energy storage in a subject |
| CA2499791A1 (en) | 2004-03-30 | 2005-09-30 | F. Hoffmann-La Roche Ag | Angptl4/fiaf as marker for ppardelta modulation |
| LT1781698T (lt) * | 2004-07-20 | 2016-09-26 | Genentech, Inc. | Į angiopoetiną panašaus baltymo 4 kompozicijos ir panaudojimo būdai |
| SI1771474T1 (sl) * | 2004-07-20 | 2010-06-30 | Genentech Inc | Inhibitorji angiopoetinu podobnega proteina kombinacije in njihova uporaba |
| WO2006074228A1 (en) * | 2005-01-07 | 2006-07-13 | Lexicon Pharmaceuticals, Inc. | Monoclonal antibodies against angiopoietin-like protein 4 (angptl4 ) |
-
2005
- 2005-07-19 LT LTEP05790823.8T patent/LT1781698T/lt unknown
- 2005-07-19 KR KR1020077003874A patent/KR20070061524A/ko not_active Ceased
- 2005-07-19 CA CA002574791A patent/CA2574791A1/en not_active Abandoned
- 2005-07-19 ZA ZA200701184A patent/ZA200701184B/en unknown
- 2005-07-19 BR BRPI0513477-3A patent/BRPI0513477A/pt not_active Application Discontinuation
- 2005-07-19 US US11/185,204 patent/US7371384B2/en not_active Expired - Lifetime
- 2005-07-19 DK DK05790823.8T patent/DK1781698T3/en active
- 2005-07-19 WO PCT/US2005/025650 patent/WO2006014678A2/en not_active Ceased
- 2005-07-19 EP EP05790823.8A patent/EP1781698B1/en not_active Expired - Lifetime
- 2005-07-19 NZ NZ552957A patent/NZ552957A/en not_active IP Right Cessation
- 2005-07-19 RU RU2007106075/13A patent/RU2380411C2/ru active
- 2005-07-19 AU AU2005269758A patent/AU2005269758B2/en not_active Expired
- 2005-07-19 HU HUE05790823A patent/HUE029170T2/en unknown
- 2005-07-19 MX MX2007000783A patent/MX2007000783A/es active IP Right Grant
- 2005-07-19 JP JP2007522672A patent/JP5318412B2/ja not_active Expired - Fee Related
- 2005-07-19 CN CN200580031686.XA patent/CN101080419B/zh not_active Expired - Fee Related
-
2006
- 2006-09-28 US US11/540,430 patent/US20070054856A1/en not_active Abandoned
-
2007
- 2007-01-17 IL IL180752A patent/IL180752A0/en active IP Right Grant
- 2007-02-19 NO NO20070950A patent/NO342525B1/no not_active IP Right Cessation
-
2009
- 2009-10-05 US US12/573,832 patent/US8633155B2/en not_active Expired - Fee Related
- 2009-10-06 RU RU2009137017/10A patent/RU2009137017A/ru not_active Application Discontinuation
-
2010
- 2010-06-20 IL IL206483A patent/IL206483A/en active IP Right Grant
- 2010-12-07 IL IL209823A patent/IL209823A0/en unknown
-
2011
- 2011-05-20 NZ NZ592973A patent/NZ592973A/xx not_active IP Right Cessation
- 2011-08-26 JP JP2011184642A patent/JP2011235179A/ja not_active Withdrawn
-
2012
- 2012-02-28 IL IL218357A patent/IL218357A/en active IP Right Grant
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