IL180752A0 - Compositions and methods of using angiopoietin-like 4 protein - Google Patents

Compositions and methods of using angiopoietin-like 4 protein

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Publication number
IL180752A0
IL180752A0 IL180752A IL18075207A IL180752A0 IL 180752 A0 IL180752 A0 IL 180752A0 IL 180752 A IL180752 A IL 180752A IL 18075207 A IL18075207 A IL 18075207A IL 180752 A0 IL180752 A0 IL 180752A0
Authority
IL
Israel
Prior art keywords
angiopoietin
protein
compositions
methods
Prior art date
Application number
IL180752A
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English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL180752A0 publication Critical patent/IL180752A0/en

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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/515Angiogenesic factors; Angiogenin
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276Knock-out vertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1891Angiogenesic factors; Angiogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P37/02Immunomodulators
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    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
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    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K2267/03Animal model, e.g. for test or diseases
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
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    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Vascular Medicine (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cell Biology (AREA)
  • Animal Husbandry (AREA)
  • Pulmonology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Pain & Pain Management (AREA)
IL180752A 2004-07-20 2007-01-17 Compositions and methods of using angiopoietin-like 4 protein IL180752A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58987504P 2004-07-20 2004-07-20
PCT/US2005/025650 WO2006014678A2 (en) 2004-07-20 2005-07-19 Compositions and methods of using angiopoietin-like 4 protein

Publications (1)

Publication Number Publication Date
IL180752A0 true IL180752A0 (en) 2007-06-03

Family

ID=35787695

Family Applications (4)

Application Number Title Priority Date Filing Date
IL180752A IL180752A0 (en) 2004-07-20 2007-01-17 Compositions and methods of using angiopoietin-like 4 protein
IL206483A IL206483A (en) 2004-07-20 2010-06-20 Compounds and Methods for Use of Angiofitin-Like Protein 4
IL209823A IL209823A0 (en) 2004-07-20 2010-12-07 Compositions and methods of using angiopoietin-like 4 protein
IL218357A IL218357A (en) 2004-07-20 2012-02-28 Use of angiopoietin-like protein 4 or its agonist to suppress the immune system

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL206483A IL206483A (en) 2004-07-20 2010-06-20 Compounds and Methods for Use of Angiofitin-Like Protein 4
IL209823A IL209823A0 (en) 2004-07-20 2010-12-07 Compositions and methods of using angiopoietin-like 4 protein
IL218357A IL218357A (en) 2004-07-20 2012-02-28 Use of angiopoietin-like protein 4 or its agonist to suppress the immune system

Country Status (18)

Country Link
US (3) US7371384B2 (https=)
EP (1) EP1781698B1 (https=)
JP (2) JP5318412B2 (https=)
KR (1) KR20070061524A (https=)
CN (1) CN101080419B (https=)
AU (1) AU2005269758B2 (https=)
BR (1) BRPI0513477A (https=)
CA (1) CA2574791A1 (https=)
DK (1) DK1781698T3 (https=)
HU (1) HUE029170T2 (https=)
IL (4) IL180752A0 (https=)
LT (1) LT1781698T (https=)
MX (1) MX2007000783A (https=)
NO (1) NO342525B1 (https=)
NZ (2) NZ552957A (https=)
RU (2) RU2380411C2 (https=)
WO (1) WO2006014678A2 (https=)
ZA (1) ZA200701184B (https=)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
SI1771474T1 (sl) * 2004-07-20 2010-06-30 Genentech Inc Inhibitorji angiopoetinu podobnega proteina kombinacije in njihova uporaba
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
LT1781698T (lt) * 2004-07-20 2016-09-26 Genentech, Inc. Į angiopoetiną panašaus baltymo 4 kompozicijos ir panaudojimo būdai
WO2006074228A1 (en) * 2005-01-07 2006-07-13 Lexicon Pharmaceuticals, Inc. Monoclonal antibodies against angiopoietin-like protein 4 (angptl4 )
WO2007024723A2 (en) * 2005-08-19 2007-03-01 Washington University In St. Louis Methods and compositions for treating gastrointestinal radiosensitivity in a subject
EP2050335A1 (en) * 2006-02-17 2009-04-22 Genentech, Inc. Gene disruptions, compositions and methods relating thereto
CN101970012A (zh) 2007-09-14 2011-02-09 日东电工株式会社 药物载体
EP2344890B1 (en) * 2008-10-20 2021-08-11 Liposcience, Inc. Lipoprotein insulin resistance indexes and related methods
WO2011046515A1 (en) * 2009-10-14 2011-04-21 Nanyang Technological University Antiproliferative agent
CN102753186B (zh) * 2010-01-08 2016-09-14 Isis制药公司 血管生成素样3表达的调节
US20130023473A1 (en) * 2010-01-20 2013-01-24 Stephane Germain Methods and pharmaceutical composition for the preservation of vascular endothelial cell barrier integrity
US9139629B2 (en) 2010-06-05 2015-09-22 The Uab Research Foundation Methods for treatment of nephrotic syndrome and related conditions
EP3318269B1 (en) * 2010-06-05 2024-03-13 Chugh, Sumant S. Use of an angiopoietin-like 4 (angptl4) polypeptide in the manufacture of a medicament for the treatment of proteinuria.
US9475850B2 (en) * 2010-06-05 2016-10-25 The Uab Research Foundation Methods for treatment of nephrotic syndrome and related conditions
CA2824434A1 (en) * 2011-01-08 2012-07-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN102692500B (zh) * 2011-03-21 2015-06-10 上海市肿瘤研究所 Angptl4作为血清学检测肝癌转移的标志物及其应用
CN102692496B (zh) * 2011-03-21 2015-10-28 上海市肿瘤研究所 Angptl4作为缺氧检测的标志物及其应用
CN102242198A (zh) * 2011-05-25 2011-11-16 信阳师范学院 通过angptl4基因多态性进行牛育种方法
EP2723758B1 (en) * 2011-06-21 2018-06-20 Alnylam Pharmaceuticals, Inc. Angiopoietin-like 3 (angptl3) irna compostions and methods of use thereof
CN103635483B (zh) 2011-07-01 2016-11-09 孟山都技术公司 用于选择性调控蛋白质表达的方法和组合物
CN103782177B (zh) * 2011-08-08 2017-10-03 南洋理工大学 血管生成素样4及其在调节细胞渗漏中的用途
CA2857686C (en) * 2011-12-09 2023-01-17 Metabolic Pharmaceuticals Pty Ltd Use of growth hormone fragments
TW201823460A (zh) 2012-05-29 2018-07-01 美商再生元醫藥公司 生產細胞株增強子
CN104822419B (zh) * 2012-07-19 2020-08-18 南洋理工大学 血管生成素样4及其用于伤口愈合的方法
CA2906982C (en) * 2013-03-15 2022-05-31 The Uab Research Foundation Methods for treatment of nephrotic syndrome and related conditions
DK2992098T3 (da) 2013-05-01 2019-06-17 Ionis Pharmaceuticals Inc Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression
EP3021942A4 (en) * 2013-07-19 2017-04-19 The Regents of The University of California Milk fat globule epidermal growth factor 8 regulates fatty acid uptake
PT3087183T (pt) 2013-12-24 2020-10-08 Ionis Pharmaceuticals Inc Modulação da expressão da proteína relacionada com angiopoietina 3
WO2015123576A2 (en) * 2014-02-17 2015-08-20 The Brigham And Women's Hospital, Inc. Targeted nanoparticle compositions and methods of their use to treat obesity
US9382540B2 (en) 2014-05-01 2016-07-05 Isis Pharmaceuticals, Inc Compositions and methods for modulating angiopoietin-like 3 expression
WO2016020882A2 (en) 2014-08-07 2016-02-11 Novartis Ag Angiopoetin-like 4 (angptl4) antibodies and methods of use
WO2016020880A2 (en) 2014-08-07 2016-02-11 Novartis Ag Angiopoietin-like 4 antibodies and methods of use
CN105021827B (zh) * 2015-07-17 2016-09-28 北京大学第一医院 检测血清血管生成素样蛋白2含量的物质在制备检测肝脏炎症和纤维化程度产品中的应用
AU2016296468B2 (en) 2015-07-22 2020-08-27 Monsanto Technology Llc Methods and compositions for selective regulation of protein expression
KR20250078597A (ko) 2015-11-06 2025-06-02 아이오니스 파마수티컬즈, 인코포레이티드 아포리포프로테인 (a) 발현 조정
AU2017286835B2 (en) * 2016-06-29 2023-12-14 Crispr Therapeutics Ag Compositions and methods for gene editing
EP3880819A2 (en) 2018-11-13 2021-09-22 Lipigon Pharmaceuticals AB Angptl4 oligonucleotides influencing the regulation of the fatty acid metabolism
EP4037713A4 (en) * 2019-11-06 2023-11-01 Northwestern University Inhibition of the ve-ptp phosphatase protects the kidney from ischemia-reperfusion injury
CA3164050A1 (en) * 2019-12-09 2021-06-17 Empirico Inc. Oligonucleotides for treatment of angiopoietin like 4 (angptl4) related diseases
CN120254294B (zh) * 2025-06-05 2025-09-09 南昌大学第一附属医院 Angptl3在乙肝相关慢加急性肝衰竭预后中的应用

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227158A (en) 1991-06-10 1993-07-13 Genentech, Inc. Method of stimulating hepatocyte proliferation by administration of hepatocyte growth factor and gamma-interferon
US20020137890A1 (en) 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6348350B1 (en) 1997-09-19 2002-02-19 Genentech, Inc. Ligand homologues
US20030207375A1 (en) 1997-10-24 2003-11-06 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU1931599A (en) 1997-12-19 1999-07-12 Zymogenetics Inc. Angiopoietin homolog, dna encoding it, and method of making it
IL138216A0 (en) 1998-03-02 2001-10-31 Millennium Pharm Inc Novel fdrg protein and nucleic acid molecules and uses therefor
US20030099994A1 (en) 1998-03-02 2003-05-29 Millennium Pharamceuticals, Inc. Novel FDRG protein and nucleic acid molecules and uses therefor
JP2000026767A (ja) 1998-05-01 2000-01-25 Daikin Ind Ltd 熱硬化性粉体塗料組成物
CA2331154A1 (en) 1998-06-16 1999-12-23 Human Genome Sciences, Inc. Polypeptides having sequence identity with acid labile subunit of insulin-like growth factor
AU4643699A (en) 1998-06-24 2000-01-10 Compugen Ltd. Angiopoietin-like growth factor sequences
WO2001054477A2 (en) 2000-01-25 2001-08-02 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001053455A2 (en) 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
JP2000308488A (ja) 1999-02-23 2000-11-07 Herikkusu Kenkyusho:Kk 血管新生に関連するタンパク質および該タンパク質をコードする遺伝子
AU3391200A (en) 1999-03-04 2000-09-21 Corixa Corporation Compositions and methods for breast cancer therapy and diagnosis
PT1626058E (pt) 1999-03-08 2008-02-15 Genentech Inc Composições e métodos para o diagnóstico de tumores
WO2003004623A2 (en) 2001-03-27 2003-01-16 Human Genome Sciences, Inc. Human secreted proteins
AU4200900A (en) 1999-04-09 2000-11-14 Human Genome Sciences, Inc. 49 human secreted proteins
ATE420177T1 (de) 1999-04-16 2009-01-15 Genentech Inc Vaskuläre endothelzellen wachstumsfaktor (vegf) varianten und dessen verwendungen
AU5979300A (en) 1999-07-02 2001-01-22 Bayer Aktiengesellschaft Angiopoietin-6 and uses thereof
EP1210363A2 (en) 1999-07-16 2002-06-05 Hyseq, Inc. Novel angiopoietin materials and methods
EP1196576A2 (en) 1999-07-20 2002-04-17 Curagen Corporation Secreted polypeptides and corresponding polynucleotides
US20030207348A1 (en) 1999-07-20 2003-11-06 Shimkets Richard A. Polypeptides and polynucleotides encoding same
AU2001243142A1 (en) 2000-02-03 2001-08-14 Hyseq, Inc. Novel nucleic acids and polypeptides
CN1315451A (zh) 2000-03-29 2001-10-03 上海博德基因开发有限公司 一种新的多肽——人血管形成素类似因子45和编码这种多肽的多核苷酸
AU2001249929A1 (en) 2000-04-07 2001-10-23 Dana-Farber Cancer Institute Inc. Fdrg proteins and nucleic acid molecules and uses therefor
AU784231B2 (en) * 2000-06-23 2006-02-23 Schering Aktiengesellschaft Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/tie receptor function and their use (II)
US6673545B2 (en) 2000-07-28 2004-01-06 Incyte Corporation Prostate cancer markers
CN1170850C (zh) 2000-09-19 2004-10-13 上海市肿瘤研究所 人血管生成素样蛋白和编码序列及其用途
US20030120056A1 (en) 2000-10-16 2003-06-26 Audrey Goddard TIE ligand homologues
IL159153A0 (en) 2001-06-08 2004-06-01 Sankyo Co Methods for testing drugs for treating or preventing diseases such as hyperlipidemia
WO2003010205A1 (en) 2001-07-26 2003-02-06 Duke University Medical Center Genes induced by hypoxia
AU2002330039A1 (en) 2001-09-17 2003-04-01 Eos Biotechnology, Inc. Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
WO2003040330A2 (en) 2001-11-05 2003-05-15 Curagen Corporation Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20040038230A1 (en) 2001-11-05 2004-02-26 Alsobrook John P. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
EP1451578B1 (en) 2001-11-16 2013-08-21 Genentech, Inc. Use of angptl3 antagonists for the treatment of liver diseases
WO2003048185A2 (en) 2001-11-30 2003-06-12 Genvec, Inc. Angiopioetin related factors
AU2002364586A1 (en) 2001-12-21 2003-07-30 Delta Biotechnology Limited Albumin fusion proteins
IL165392A0 (en) 2002-06-05 2006-01-15 Genentech Inc Compositions and methods for liver growth and liver protection
US20050239706A1 (en) 2003-10-31 2005-10-27 Washington University In St. Louis Modulation of fiaf and the gastrointestinal microbiota as a means to control energy storage in a subject
CA2499791A1 (en) 2004-03-30 2005-09-30 F. Hoffmann-La Roche Ag Angptl4/fiaf as marker for ppardelta modulation
LT1781698T (lt) * 2004-07-20 2016-09-26 Genentech, Inc. Į angiopoetiną panašaus baltymo 4 kompozicijos ir panaudojimo būdai
SI1771474T1 (sl) * 2004-07-20 2010-06-30 Genentech Inc Inhibitorji angiopoetinu podobnega proteina kombinacije in njihova uporaba
WO2006074228A1 (en) * 2005-01-07 2006-07-13 Lexicon Pharmaceuticals, Inc. Monoclonal antibodies against angiopoietin-like protein 4 (angptl4 )

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JP2008507531A (ja) 2008-03-13
US20070054856A1 (en) 2007-03-08
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AU2005269758A1 (en) 2006-02-09
BRPI0513477A (pt) 2008-05-06
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US20060093606A1 (en) 2006-05-04
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NZ592973A (en) 2013-01-25
RU2009137017A (ru) 2011-04-20
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EP1781698B1 (en) 2016-07-06
IL209823A0 (en) 2011-02-28
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IL206483A (en) 2011-11-30
CN101080419A (zh) 2007-11-28
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IL218357A (en) 2015-01-29
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US8633155B2 (en) 2014-01-21
IL218357A0 (en) 2012-04-30
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US20100172915A1 (en) 2010-07-08
MX2007000783A (es) 2007-04-09
RU2380411C2 (ru) 2010-01-27
LT1781698T (lt) 2016-09-26
CN101080419B (zh) 2014-07-02
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KR20070061524A (ko) 2007-06-13
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