ZA200701184B - Compositions and methods of using angiopoietin-like 4 protein - Google Patents
Compositions and methods of using angiopoietin-like 4 protein Download PDFInfo
- Publication number
- ZA200701184B ZA200701184B ZA200701184A ZA200701184A ZA200701184B ZA 200701184 B ZA200701184 B ZA 200701184B ZA 200701184 A ZA200701184 A ZA 200701184A ZA 200701184 A ZA200701184 A ZA 200701184A ZA 200701184 B ZA200701184 B ZA 200701184B
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- ZA
- South Africa
- Prior art keywords
- angptl4
- angptla
- antibody
- human
- composition
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1891—Angiogenesic factors; Angiogenin
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
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- A—HUMAN NECESSITIES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Vascular Medicine (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cell Biology (AREA)
- Animal Husbandry (AREA)
- Pulmonology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58987504P | 2004-07-20 | 2004-07-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200701184B true ZA200701184B (en) | 2008-07-30 |
Family
ID=35787695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200701184A ZA200701184B (en) | 2004-07-20 | 2005-07-19 | Compositions and methods of using angiopoietin-like 4 protein |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US7371384B2 (https=) |
| EP (1) | EP1781698B1 (https=) |
| JP (2) | JP5318412B2 (https=) |
| KR (1) | KR20070061524A (https=) |
| CN (1) | CN101080419B (https=) |
| AU (1) | AU2005269758B2 (https=) |
| BR (1) | BRPI0513477A (https=) |
| CA (1) | CA2574791A1 (https=) |
| DK (1) | DK1781698T3 (https=) |
| HU (1) | HUE029170T2 (https=) |
| IL (4) | IL180752A0 (https=) |
| LT (1) | LT1781698T (https=) |
| MX (1) | MX2007000783A (https=) |
| NO (1) | NO342525B1 (https=) |
| NZ (2) | NZ552957A (https=) |
| RU (2) | RU2380411C2 (https=) |
| WO (1) | WO2006014678A2 (https=) |
| ZA (1) | ZA200701184B (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050123925A1 (en) | 2002-11-15 | 2005-06-09 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| SI1771474T1 (sl) * | 2004-07-20 | 2010-06-30 | Genentech Inc | Inhibitorji angiopoetinu podobnega proteina kombinacije in njihova uporaba |
| US8604185B2 (en) | 2004-07-20 | 2013-12-10 | Genentech, Inc. | Inhibitors of angiopoietin-like 4 protein, combinations, and their use |
| LT1781698T (lt) * | 2004-07-20 | 2016-09-26 | Genentech, Inc. | Į angiopoetiną panašaus baltymo 4 kompozicijos ir panaudojimo būdai |
| WO2006074228A1 (en) * | 2005-01-07 | 2006-07-13 | Lexicon Pharmaceuticals, Inc. | Monoclonal antibodies against angiopoietin-like protein 4 (angptl4 ) |
| WO2007024723A2 (en) * | 2005-08-19 | 2007-03-01 | Washington University In St. Louis | Methods and compositions for treating gastrointestinal radiosensitivity in a subject |
| EP2050335A1 (en) * | 2006-02-17 | 2009-04-22 | Genentech, Inc. | Gene disruptions, compositions and methods relating thereto |
| CN101970012A (zh) | 2007-09-14 | 2011-02-09 | 日东电工株式会社 | 药物载体 |
| EP2344890B1 (en) * | 2008-10-20 | 2021-08-11 | Liposcience, Inc. | Lipoprotein insulin resistance indexes and related methods |
| WO2011046515A1 (en) * | 2009-10-14 | 2011-04-21 | Nanyang Technological University | Antiproliferative agent |
| CN102753186B (zh) * | 2010-01-08 | 2016-09-14 | Isis制药公司 | 血管生成素样3表达的调节 |
| US20130023473A1 (en) * | 2010-01-20 | 2013-01-24 | Stephane Germain | Methods and pharmaceutical composition for the preservation of vascular endothelial cell barrier integrity |
| US9139629B2 (en) | 2010-06-05 | 2015-09-22 | The Uab Research Foundation | Methods for treatment of nephrotic syndrome and related conditions |
| EP3318269B1 (en) * | 2010-06-05 | 2024-03-13 | Chugh, Sumant S. | Use of an angiopoietin-like 4 (angptl4) polypeptide in the manufacture of a medicament for the treatment of proteinuria. |
| US9475850B2 (en) * | 2010-06-05 | 2016-10-25 | The Uab Research Foundation | Methods for treatment of nephrotic syndrome and related conditions |
| CA2824434A1 (en) * | 2011-01-08 | 2012-07-12 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN102692500B (zh) * | 2011-03-21 | 2015-06-10 | 上海市肿瘤研究所 | Angptl4作为血清学检测肝癌转移的标志物及其应用 |
| CN102692496B (zh) * | 2011-03-21 | 2015-10-28 | 上海市肿瘤研究所 | Angptl4作为缺氧检测的标志物及其应用 |
| CN102242198A (zh) * | 2011-05-25 | 2011-11-16 | 信阳师范学院 | 通过angptl4基因多态性进行牛育种方法 |
| EP2723758B1 (en) * | 2011-06-21 | 2018-06-20 | Alnylam Pharmaceuticals, Inc. | Angiopoietin-like 3 (angptl3) irna compostions and methods of use thereof |
| CN103635483B (zh) | 2011-07-01 | 2016-11-09 | 孟山都技术公司 | 用于选择性调控蛋白质表达的方法和组合物 |
| CN103782177B (zh) * | 2011-08-08 | 2017-10-03 | 南洋理工大学 | 血管生成素样4及其在调节细胞渗漏中的用途 |
| CA2857686C (en) * | 2011-12-09 | 2023-01-17 | Metabolic Pharmaceuticals Pty Ltd | Use of growth hormone fragments |
| TW201823460A (zh) | 2012-05-29 | 2018-07-01 | 美商再生元醫藥公司 | 生產細胞株增強子 |
| CN104822419B (zh) * | 2012-07-19 | 2020-08-18 | 南洋理工大学 | 血管生成素样4及其用于伤口愈合的方法 |
| CA2906982C (en) * | 2013-03-15 | 2022-05-31 | The Uab Research Foundation | Methods for treatment of nephrotic syndrome and related conditions |
| DK2992098T3 (da) | 2013-05-01 | 2019-06-17 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression |
| EP3021942A4 (en) * | 2013-07-19 | 2017-04-19 | The Regents of The University of California | Milk fat globule epidermal growth factor 8 regulates fatty acid uptake |
| PT3087183T (pt) | 2013-12-24 | 2020-10-08 | Ionis Pharmaceuticals Inc | Modulação da expressão da proteína relacionada com angiopoietina 3 |
| WO2015123576A2 (en) * | 2014-02-17 | 2015-08-20 | The Brigham And Women's Hospital, Inc. | Targeted nanoparticle compositions and methods of their use to treat obesity |
| US9382540B2 (en) | 2014-05-01 | 2016-07-05 | Isis Pharmaceuticals, Inc | Compositions and methods for modulating angiopoietin-like 3 expression |
| WO2016020882A2 (en) | 2014-08-07 | 2016-02-11 | Novartis Ag | Angiopoetin-like 4 (angptl4) antibodies and methods of use |
| WO2016020880A2 (en) | 2014-08-07 | 2016-02-11 | Novartis Ag | Angiopoietin-like 4 antibodies and methods of use |
| CN105021827B (zh) * | 2015-07-17 | 2016-09-28 | 北京大学第一医院 | 检测血清血管生成素样蛋白2含量的物质在制备检测肝脏炎症和纤维化程度产品中的应用 |
| AU2016296468B2 (en) | 2015-07-22 | 2020-08-27 | Monsanto Technology Llc | Methods and compositions for selective regulation of protein expression |
| KR20250078597A (ko) | 2015-11-06 | 2025-06-02 | 아이오니스 파마수티컬즈, 인코포레이티드 | 아포리포프로테인 (a) 발현 조정 |
| AU2017286835B2 (en) * | 2016-06-29 | 2023-12-14 | Crispr Therapeutics Ag | Compositions and methods for gene editing |
| EP3880819A2 (en) | 2018-11-13 | 2021-09-22 | Lipigon Pharmaceuticals AB | Angptl4 oligonucleotides influencing the regulation of the fatty acid metabolism |
| EP4037713A4 (en) * | 2019-11-06 | 2023-11-01 | Northwestern University | Inhibition of the ve-ptp phosphatase protects the kidney from ischemia-reperfusion injury |
| CA3164050A1 (en) * | 2019-12-09 | 2021-06-17 | Empirico Inc. | Oligonucleotides for treatment of angiopoietin like 4 (angptl4) related diseases |
| CN120254294B (zh) * | 2025-06-05 | 2025-09-09 | 南昌大学第一附属医院 | Angptl3在乙肝相关慢加急性肝衰竭预后中的应用 |
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2005
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- 2005-07-19 KR KR1020077003874A patent/KR20070061524A/ko not_active Ceased
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- 2005-07-19 BR BRPI0513477-3A patent/BRPI0513477A/pt not_active Application Discontinuation
- 2005-07-19 US US11/185,204 patent/US7371384B2/en not_active Expired - Lifetime
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