JP2008505626A5 - - Google Patents
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- Publication number
- JP2008505626A5 JP2008505626A5 JP2007519805A JP2007519805A JP2008505626A5 JP 2008505626 A5 JP2008505626 A5 JP 2008505626A5 JP 2007519805 A JP2007519805 A JP 2007519805A JP 2007519805 A JP2007519805 A JP 2007519805A JP 2008505626 A5 JP2008505626 A5 JP 2008505626A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- nucleic acid
- repressor activity
- interest
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101710197208 Regulatory protein cro Proteins 0.000 claims 26
- 230000000694 effects Effects 0.000 claims 24
- 150000007523 nucleic acids Chemical class 0.000 claims 20
- 108090000623 proteins and genes Proteins 0.000 claims 17
- 239000012634 fragment Substances 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 239000003550 marker Substances 0.000 claims 5
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58700704P | 2004-07-08 | 2004-07-08 | |
| EPPCT/EP2004/051405 | 2004-07-08 | ||
| US60/587,007 | 2004-07-08 | ||
| EP2004051405 | 2004-07-08 | ||
| PCT/EP2005/053251 WO2006005718A2 (en) | 2004-07-08 | 2005-07-07 | Novel sequence for improving expression of nucleic acid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008505626A JP2008505626A (ja) | 2008-02-28 |
| JP2008505626A5 true JP2008505626A5 (enExample) | 2008-07-24 |
| JP4805262B2 JP4805262B2 (ja) | 2011-11-02 |
Family
ID=34971366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519805A Expired - Fee Related JP4805262B2 (ja) | 2004-07-08 | 2005-07-07 | 核酸の発現を改善するための新規配列 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7825232B2 (enExample) |
| JP (1) | JP4805262B2 (enExample) |
| KR (1) | KR101188013B1 (enExample) |
| CN (1) | CN1981057B (enExample) |
| AT (1) | ATE378426T1 (enExample) |
| AU (1) | AU2005261699B2 (enExample) |
| BR (1) | BRPI0512798A (enExample) |
| CA (1) | CA2573022C (enExample) |
| DE (1) | DE602005003369T2 (enExample) |
| DK (1) | DK1763586T3 (enExample) |
| EA (1) | EA011747B1 (enExample) |
| ES (1) | ES2296201T3 (enExample) |
| IL (1) | IL180531A (enExample) |
| MX (1) | MXPA06014553A (enExample) |
| NO (1) | NO341862B1 (enExample) |
| NZ (1) | NZ551510A (enExample) |
| PT (1) | PT1763586E (enExample) |
| WO (1) | WO2006005718A2 (enExample) |
| ZA (1) | ZA200610470B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1572994T3 (da) * | 2002-12-20 | 2007-05-29 | Chromagenics Bv | Midler og fremgangsmåder til fremstilling af en protein gennem chromatinåbnere, som kan göre chromatin mere tilgængeligt for transkriptionsfaktorer |
| BRPI0517380A (pt) * | 2004-11-08 | 2008-10-07 | Chromagenics Bv | molécula de dna, cassete de expressão, célula hospedeira, e, métodos para gerar uma célula hospedeira que expressa um polipeptìdeo de interesse e para produzir um polipeptìdeo de interesse |
| US8999667B2 (en) * | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| NZ553700A (en) | 2004-11-08 | 2010-09-30 | Chromagenics Bv | Selection of host cells expressing protein at high levels using a selectable marker with a non-optimal start codon |
| US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
| US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| CN102459607B (zh) * | 2009-06-15 | 2014-08-06 | 萨拉基尼克有限公司 | 新的严格的可选择的标志物 |
| BR112012031694A2 (pt) | 2010-06-15 | 2016-02-16 | Cellagenics B V | fragmento de ácido nucleíco, construto de ácido nucleíco, vetor de expressão, célula hospedeira, método de geração de uma célula hospedeira para a expressão de um produto gênico de interesse, e, método de expresão de um produto de gene de interesse |
| CN103180443B (zh) | 2010-09-01 | 2016-01-13 | 萨拉基尼克有限公司 | 用于增强基因表达的来自核糖体蛋白启动子的核酸片段 |
| CN110484563B (zh) * | 2019-07-25 | 2023-04-07 | 新乡医学院 | 哺乳动物细胞组合表达载体、表达系统、制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60237048D1 (de) * | 2001-07-04 | 2010-08-26 | Chromagenics Bv | DNS-Sequenzen mit Anti-Repressor-Aktivität |
| CA2489475C (en) | 2002-06-14 | 2011-03-29 | Chromagenics B.V. | A method for simultaneous production of multiple proteins; vectors and cells for use therein |
| DK1572994T3 (da) * | 2002-12-20 | 2007-05-29 | Chromagenics Bv | Midler og fremgangsmåder til fremstilling af en protein gennem chromatinåbnere, som kan göre chromatin mere tilgængeligt for transkriptionsfaktorer |
-
2005
- 2005-07-07 DE DE602005003369T patent/DE602005003369T2/de not_active Expired - Lifetime
- 2005-07-07 WO PCT/EP2005/053251 patent/WO2006005718A2/en not_active Ceased
- 2005-07-07 AU AU2005261699A patent/AU2005261699B2/en not_active Ceased
- 2005-07-07 PT PT05756870T patent/PT1763586E/pt unknown
- 2005-07-07 AT AT05756870T patent/ATE378426T1/de active
- 2005-07-07 EA EA200700233A patent/EA011747B1/ru not_active IP Right Cessation
- 2005-07-07 KR KR1020067027165A patent/KR101188013B1/ko not_active Expired - Fee Related
- 2005-07-07 DK DK05756870T patent/DK1763586T3/da active
- 2005-07-07 MX MXPA06014553A patent/MXPA06014553A/es active IP Right Grant
- 2005-07-07 CN CN2005800229700A patent/CN1981057B/zh not_active Expired - Fee Related
- 2005-07-07 NZ NZ551510A patent/NZ551510A/en not_active IP Right Cessation
- 2005-07-07 ES ES05756870T patent/ES2296201T3/es not_active Expired - Lifetime
- 2005-07-07 JP JP2007519805A patent/JP4805262B2/ja not_active Expired - Fee Related
- 2005-07-07 US US11/632,012 patent/US7825232B2/en not_active Expired - Fee Related
- 2005-07-07 BR BRPI0512798-0A patent/BRPI0512798A/pt not_active Application Discontinuation
- 2005-07-07 CA CA2573022A patent/CA2573022C/en not_active Expired - Fee Related
-
2006
- 2006-12-13 ZA ZA200610470A patent/ZA200610470B/xx unknown
-
2007
- 2007-01-03 IL IL180531A patent/IL180531A/en active IP Right Grant
- 2007-02-08 NO NO20070757A patent/NO341862B1/no not_active IP Right Cessation
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