JP2008504280A5 - - Google Patents
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- Publication number
- JP2008504280A5 JP2008504280A5 JP2007518304A JP2007518304A JP2008504280A5 JP 2008504280 A5 JP2008504280 A5 JP 2008504280A5 JP 2007518304 A JP2007518304 A JP 2007518304A JP 2007518304 A JP2007518304 A JP 2007518304A JP 2008504280 A5 JP2008504280 A5 JP 2008504280A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- aryl
- heterocycloalkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 196
- 125000000753 cycloalkyl group Chemical group 0.000 claims 190
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 185
- 125000003118 aryl group Chemical group 0.000 claims 167
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 145
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 145
- 125000001072 heteroaryl group Chemical group 0.000 claims 141
- 125000003545 alkoxy group Chemical group 0.000 claims 115
- 125000005843 halogen group Chemical group 0.000 claims 113
- 229910052799 carbon Inorganic materials 0.000 claims 91
- 229910052739 hydrogen Inorganic materials 0.000 claims 79
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 72
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 64
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 64
- 125000003282 alkyl amino group Chemical group 0.000 claims 60
- 125000004663 dialkyl amino group Chemical group 0.000 claims 56
- 125000005466 alkylenyl group Chemical group 0.000 claims 48
- 125000003710 aryl alkyl group Chemical group 0.000 claims 47
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 43
- 125000004429 atom Chemical group 0.000 claims 34
- 150000001875 compounds Chemical class 0.000 claims 33
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 31
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 24
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 24
- 229910052717 sulfur Inorganic materials 0.000 claims 24
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 23
- 229910052760 oxygen Inorganic materials 0.000 claims 22
- -1 1- [3- (2-methoxy Phenoxy) benzyl] -piperidin-4-yl Chemical group 0.000 claims 16
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 14
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 13
- 125000004438 haloalkoxy group Chemical group 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 10
- 239000000651 prodrug Substances 0.000 claims 8
- 229940002612 prodrug Drugs 0.000 claims 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 7
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 7
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 6
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 6
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 6
- 125000006282 2-chlorobenzyl group Chemical group [H]C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims 3
- GSANCHMVYHNYKP-UHFFFAOYSA-N 2-[(2-chlorophenyl)methylsulfanyl]-n-(3-hydroxy-2,2-dimethylpropyl)-2-methylpropanamide Chemical compound OCC(C)(C)CNC(=O)C(C)(C)SCC1=CC=CC=C1Cl GSANCHMVYHNYKP-UHFFFAOYSA-N 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 125000000980 1H-indol-3-ylmethyl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C(C([H])([H])[*])C2=C1[H] 0.000 claims 1
- 125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 claims 1
- ZYSXLIVVDSRNFY-UHFFFAOYSA-N 2-(4-chlorophenoxy)-n-cyclohexyl-2-methylpropanamide Chemical compound C1CCCCC1NC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 ZYSXLIVVDSRNFY-UHFFFAOYSA-N 0.000 claims 1
- LRGIENGJMHQHAK-UHFFFAOYSA-N 2-(4-chlorophenyl)-2-methyl-n-(2-methyl-1-phenylpropan-2-yl)propanamide Chemical compound C=1C=C(Cl)C=CC=1C(C)(C)C(=O)NC(C)(C)CC1=CC=CC=C1 LRGIENGJMHQHAK-UHFFFAOYSA-N 0.000 claims 1
- VIYVIAVUVSHNFM-UHFFFAOYSA-N 2-(4-chlorophenyl)-2-methyl-n-(2-phenylcyclopropyl)propanamide Chemical compound C=1C=C(Cl)C=CC=1C(C)(C)C(=O)NC1CC1C1=CC=CC=C1 VIYVIAVUVSHNFM-UHFFFAOYSA-N 0.000 claims 1
- SGSFTGHPRUPOCH-UHFFFAOYSA-N 2-(4-chlorophenyl)-2-methyl-n-(4-phenylbutan-2-yl)propanamide Chemical compound C=1C=C(Cl)C=CC=1C(C)(C)C(=O)NC(C)CCC1=CC=CC=C1 SGSFTGHPRUPOCH-UHFFFAOYSA-N 0.000 claims 1
- NQPCWFYPMCXHEH-GOSISDBHSA-N 2-(4-chlorophenyl)-2-methyl-n-[(1r)-1,2,3,4-tetrahydronaphthalen-1-yl]propanamide Chemical compound N([C@H]1C2=CC=CC=C2CCC1)C(=O)C(C)(C)C1=CC=C(Cl)C=C1 NQPCWFYPMCXHEH-GOSISDBHSA-N 0.000 claims 1
- LRSJPZNIODZGAY-NHCUHLMSSA-N 2-(4-chlorophenyl)-2-methyl-n-[(1r,2r)-2-phenylmethoxycyclohexyl]propanamide Chemical compound O([C@@H]1CCCC[C@H]1NC(=O)C(C)(C)C=1C=CC(Cl)=CC=1)CC1=CC=CC=C1 LRSJPZNIODZGAY-NHCUHLMSSA-N 0.000 claims 1
- NQPCWFYPMCXHEH-SFHVURJKSA-N 2-(4-chlorophenyl)-2-methyl-n-[(1s)-1,2,3,4-tetrahydronaphthalen-1-yl]propanamide Chemical compound N([C@@H]1C2=CC=CC=C2CCC1)C(=O)C(C)(C)C1=CC=C(Cl)C=C1 NQPCWFYPMCXHEH-SFHVURJKSA-N 0.000 claims 1
- BOACGMASSUCCAT-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-methylpropanamide Chemical compound C1OC2=CC=CC=C2OC1CNC(=O)C(C)(C)C1=CC=C(Cl)C=C1 BOACGMASSUCCAT-UHFFFAOYSA-N 0.000 claims 1
- YJHSBOOCOWMAMB-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-(3-hydroxy-2,2-dimethylpropyl)-2-methylpropanamide Chemical compound OCC(C)(C)CNC(=O)C(C)(C)C1=CC=C(Cl)C=C1 YJHSBOOCOWMAMB-UHFFFAOYSA-N 0.000 claims 1
- HRVLAABWWCMEBE-GUYCJALGSA-N 2-(4-chlorophenyl)-n-[(1r,2s)-1-hydroxy-1-phenylpropan-2-yl]-2-methylpropanamide Chemical compound N([C@@H](C)[C@H](O)C=1C=CC=CC=1)C(=O)C(C)(C)C1=CC=C(Cl)C=C1 HRVLAABWWCMEBE-GUYCJALGSA-N 0.000 claims 1
- FMYNXGJVVQJYEC-DLBZAZTESA-N 2-(4-chlorophenyl)-n-[(1r,2s)-2-hydroxy-2,3-dihydro-1h-inden-1-yl]-2-methylpropanamide Chemical compound N([C@@H]1C2=CC=CC=C2C[C@@H]1O)C(=O)C(C)(C)C1=CC=C(Cl)C=C1 FMYNXGJVVQJYEC-DLBZAZTESA-N 0.000 claims 1
- GDNDZJKBTNRMEG-ZDUSSCGKSA-N 2-(4-chlorophenyl)-n-[(1s)-1-cyclohexylethyl]-2-methylpropanamide Chemical compound N([C@@H](C)C1CCCCC1)C(=O)C(C)(C)C1=CC=C(Cl)C=C1 GDNDZJKBTNRMEG-ZDUSSCGKSA-N 0.000 claims 1
- CKTLIUQWYYSOGZ-QGZVFWFLSA-N 2-(4-chlorophenyl)-n-[(2r)-1-hydroxy-3-phenylpropan-2-yl]-2-methylpropanamide Chemical compound C([C@H](CO)NC(=O)C(C)(C)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 CKTLIUQWYYSOGZ-QGZVFWFLSA-N 0.000 claims 1
- XARCMGHUOZUUIW-KRWDZBQOSA-N 2-(4-chlorophenyl)-n-[(2s)-1-hydroxy-3-(1h-indol-3-yl)propan-2-yl]-2-methylpropanamide Chemical compound N([C@H](CO)CC=1C2=CC=CC=C2NC=1)C(=O)C(C)(C)C1=CC=C(Cl)C=C1 XARCMGHUOZUUIW-KRWDZBQOSA-N 0.000 claims 1
- VMJUTIGJBCIOQZ-SFHVURJKSA-N 2-(4-chlorophenyl)-n-[(2s)-1-methoxy-3-phenylpropan-2-yl]-2-methylpropanamide Chemical compound C([C@@H](COC)NC(=O)C(C)(C)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 VMJUTIGJBCIOQZ-SFHVURJKSA-N 0.000 claims 1
- SBKKZZBIUSVCQK-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-[1-(3-hydroxy-4-methylphenyl)butan-2-yl]-2-methylpropanamide Chemical compound C=1C=C(Cl)C=CC=1C(C)(C)C(=O)NC(CC)CC1=CC=C(C)C(O)=C1 SBKKZZBIUSVCQK-UHFFFAOYSA-N 0.000 claims 1
- JTZNKWSSMDHLLZ-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-[1-(hydroxymethyl)cyclopentyl]-2-methylpropanamide Chemical compound C=1C=C(Cl)C=CC=1C(C)(C)C(=O)NC1(CO)CCCC1 JTZNKWSSMDHLLZ-UHFFFAOYSA-N 0.000 claims 1
- GRLZQCQXEKBAGF-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-[2-(hydroxymethyl)-3-bicyclo[2.2.1]heptanyl]-2-methylpropanamide Chemical compound C1C2CCC1C(CO)C2NC(=O)C(C)(C)C1=CC=C(Cl)C=C1 GRLZQCQXEKBAGF-UHFFFAOYSA-N 0.000 claims 1
- YGHOZONJDUKKIT-SWLSCSKDSA-N 2-(4-chlorophenyl)-n-[[(1s,2r)-2-hydroxycyclohexyl]methyl]-2-methylpropanamide Chemical compound C=1C=C(Cl)C=CC=1C(C)(C)C(=O)NC[C@@H]1CCCC[C@H]1O YGHOZONJDUKKIT-SWLSCSKDSA-N 0.000 claims 1
- SUISOQCJBMMJQH-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-cyclohexyl-2-methylpropanamide Chemical compound C=1C=C(Cl)C=CC=1C(C)(C)C(=O)NC1CCCCC1 SUISOQCJBMMJQH-UHFFFAOYSA-N 0.000 claims 1
- TYVCUHHTCILZHI-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-cyclopentyl-n-cyclopropyl-2-methylpropanamide Chemical compound C=1C=C(Cl)C=CC=1C(C)(C)C(=O)N(C1CCCC1)C1CC1 TYVCUHHTCILZHI-UHFFFAOYSA-N 0.000 claims 1
- VSGKHRRUNQCERT-UHFFFAOYSA-N 2-[(2-chlorophenyl)methylsulfanyl]-2-methyl-n-(2-methyl-1-phenylpropan-2-yl)propanamide Chemical compound C=1C=CC=C(Cl)C=1CSC(C)(C)C(=O)NC(C)(C)CC1=CC=CC=C1 VSGKHRRUNQCERT-UHFFFAOYSA-N 0.000 claims 1
- YHXOTDGBOPAKKX-UHFFFAOYSA-N 2-[(2-chlorophenyl)methylsulfanyl]-2-methyl-n-(4-phenylbutan-2-yl)propanamide Chemical compound C=1C=CC=C(Cl)C=1CSC(C)(C)C(=O)NC(C)CCC1=CC=CC=C1 YHXOTDGBOPAKKX-UHFFFAOYSA-N 0.000 claims 1
- WRAFJTVSVNKAJJ-LJQANCHMSA-N 2-[(2-chlorophenyl)methylsulfanyl]-2-methyl-n-[(1r)-1,2,3,4-tetrahydronaphthalen-1-yl]propanamide Chemical compound N([C@H]1C2=CC=CC=C2CCC1)C(=O)C(C)(C)SCC1=CC=CC=C1Cl WRAFJTVSVNKAJJ-LJQANCHMSA-N 0.000 claims 1
- ICBBNMJCOQAPFV-FGZHOGPDSA-N 2-[(2-chlorophenyl)methylsulfanyl]-2-methyl-n-[(1r,2r)-2-phenylmethoxycyclohexyl]propanamide Chemical compound N([C@H]1[C@@H](CCCC1)OCC=1C=CC=CC=1)C(=O)C(C)(C)SCC1=CC=CC=C1Cl ICBBNMJCOQAPFV-FGZHOGPDSA-N 0.000 claims 1
- KWIWRRZTNJFXES-UHFFFAOYSA-N 2-[(2-chlorophenyl)methylsulfanyl]-n-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-methylpropanamide Chemical compound C1OC2=CC=CC=C2OC1CNC(=O)C(C)(C)SCC1=CC=CC=C1Cl KWIWRRZTNJFXES-UHFFFAOYSA-N 0.000 claims 1
- JNFXWWFHUQLPBS-KSSFIOAISA-N 2-[(2-chlorophenyl)methylsulfanyl]-n-[(1r,2s)-1-hydroxy-1-phenylpropan-2-yl]-2-methylpropanamide Chemical compound N([C@@H](C)[C@H](O)C=1C=CC=CC=1)C(=O)C(C)(C)SCC1=CC=CC=C1Cl JNFXWWFHUQLPBS-KSSFIOAISA-N 0.000 claims 1
- DFCUFMGVRLSBHZ-ZWKOTPCHSA-N 2-[(2-chlorophenyl)methylsulfanyl]-n-[(1r,2s)-2-hydroxy-2,3-dihydro-1h-inden-1-yl]-2-methylpropanamide Chemical compound N([C@@H]1C2=CC=CC=C2C[C@@H]1O)C(=O)C(C)(C)SCC1=CC=CC=C1Cl DFCUFMGVRLSBHZ-ZWKOTPCHSA-N 0.000 claims 1
- VCYPYNIEECBFHT-AWEZNQCLSA-N 2-[(2-chlorophenyl)methylsulfanyl]-n-[(1s)-1-cyclohexylethyl]-2-methylpropanamide Chemical compound N([C@@H](C)C1CCCCC1)C(=O)C(C)(C)SCC1=CC=CC=C1Cl VCYPYNIEECBFHT-AWEZNQCLSA-N 0.000 claims 1
- ZHMVSIIXOCEHGX-KRWDZBQOSA-N 2-[(2-chlorophenyl)methylsulfanyl]-n-[(2s)-1-hydroxy-3-(1h-indol-3-yl)propan-2-yl]-2-methylpropanamide Chemical compound N([C@H](CO)CC=1C2=CC=CC=C2NC=1)C(=O)C(C)(C)SCC1=CC=CC=C1Cl ZHMVSIIXOCEHGX-KRWDZBQOSA-N 0.000 claims 1
- ZVPMHIKBMXWWHY-SFHVURJKSA-N 2-[(2-chlorophenyl)methylsulfanyl]-n-[(2s)-1-methoxy-3-phenylpropan-2-yl]-2-methylpropanamide Chemical compound C([C@@H](COC)NC(=O)C(C)(C)SCC=1C(=CC=CC=1)Cl)C1=CC=CC=C1 ZVPMHIKBMXWWHY-SFHVURJKSA-N 0.000 claims 1
- OZCRAYFUWMEKST-UHFFFAOYSA-N 2-[(2-chlorophenyl)methylsulfanyl]-n-[1-(3-hydroxy-4-methylphenyl)butan-2-yl]-2-methylpropanamide Chemical compound C=1C=CC=C(Cl)C=1CSC(C)(C)C(=O)NC(CC)CC1=CC=C(C)C(O)=C1 OZCRAYFUWMEKST-UHFFFAOYSA-N 0.000 claims 1
- AMHRFYAWZSNWRN-UHFFFAOYSA-N 2-[(2-chlorophenyl)methylsulfanyl]-n-[1-(hydroxymethyl)cyclopentyl]-2-methylpropanamide Chemical compound C1CCCC1(CO)NC(=O)C(C)(C)SCC1=CC=CC=C1Cl AMHRFYAWZSNWRN-UHFFFAOYSA-N 0.000 claims 1
- KCBUIDVUHWBFCR-UHFFFAOYSA-N 2-[(2-chlorophenyl)methylsulfanyl]-n-[2-(hydroxymethyl)-3-bicyclo[2.2.1]heptanyl]-2-methylpropanamide Chemical compound C1C2CCC1C(CO)C2NC(=O)C(C)(C)SCC1=CC=CC=C1Cl KCBUIDVUHWBFCR-UHFFFAOYSA-N 0.000 claims 1
- SUFMHACSNWMNHT-XJKSGUPXSA-N 2-[(2-chlorophenyl)methylsulfanyl]-n-[[(1s,2r)-2-hydroxycyclohexyl]methyl]-2-methylpropanamide Chemical compound C([C@H]1[C@@H](CCCC1)O)NC(=O)C(C)(C)SCC1=CC=CC=C1Cl SUFMHACSNWMNHT-XJKSGUPXSA-N 0.000 claims 1
- NLTDOFWXOYOWPU-UHFFFAOYSA-N 2-[(2-chlorophenyl)methylsulfanyl]-n-cyclohexyl-2-methylpropanamide Chemical compound C1CCCCC1NC(=O)C(C)(C)SCC1=CC=CC=C1Cl NLTDOFWXOYOWPU-UHFFFAOYSA-N 0.000 claims 1
- KWFFYGDZNARZBW-UHFFFAOYSA-N 2-[4-(cyanomethoxy)phenyl]sulfanyl-n-cyclohexyl-2-methylpropanamide Chemical compound C1CCCCC1NC(=O)C(C)(C)SC1=CC=C(OCC#N)C=C1 KWFFYGDZNARZBW-UHFFFAOYSA-N 0.000 claims 1
- WMKSPABBYBFOLD-UHFFFAOYSA-N 2-[4-[1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl]sulfanylphenoxy]acetic acid Chemical compound C1CCCCC1NC(=O)C(C)(C)SC1=CC=C(OCC(O)=O)C=C1 WMKSPABBYBFOLD-UHFFFAOYSA-N 0.000 claims 1
- 125000001847 2-phenylcyclopropyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010070901 Diabetic dyslipidaemia Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 206010049287 Lipodystrophy acquired Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 229960002478 aldosterone Drugs 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- QIEOLQHCMBKNBL-UHFFFAOYSA-N ethyl 2-[4-[1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl]sulfanylphenoxy]acetate Chemical compound C1=CC(OCC(=O)OCC)=CC=C1SC(C)(C)C(=O)NC1CCCCC1 QIEOLQHCMBKNBL-UHFFFAOYSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 208000020346 hyperlipoproteinemia Diseases 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 208000006132 lipodystrophy Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- ULXFLSPUFFPEGH-DLBZAZTESA-N n-[(1r,2s)-2-hydroxy-2,3-dihydro-1h-inden-1-yl]-2-methyl-2-phenylsulfanylpropanamide Chemical compound N([C@@H]1C2=CC=CC=C2C[C@@H]1O)C(=O)C(C)(C)SC1=CC=CC=C1 ULXFLSPUFFPEGH-DLBZAZTESA-N 0.000 claims 1
- BJQWNJXKECVEDA-UHFFFAOYSA-N n-cyclohexyl-2-(4-ethoxyphenyl)sulfanyl-2-methylpropanamide Chemical compound C1=CC(OCC)=CC=C1SC(C)(C)C(=O)NC1CCCCC1 BJQWNJXKECVEDA-UHFFFAOYSA-N 0.000 claims 1
- USWQWMWOFBZTOS-UHFFFAOYSA-N n-cyclohexyl-2-(4-hydroxyphenyl)sulfanyl-2-methylpropanamide Chemical compound C1CCCCC1NC(=O)C(C)(C)SC1=CC=C(O)C=C1 USWQWMWOFBZTOS-UHFFFAOYSA-N 0.000 claims 1
- NXLOCUZPMLSCMG-UHFFFAOYSA-N n-cyclohexyl-2-[4-(3-hydroxypropoxy)phenyl]sulfanyl-2-methylpropanamide Chemical compound C1CCCCC1NC(=O)C(C)(C)SC1=CC=C(OCCCO)C=C1 NXLOCUZPMLSCMG-UHFFFAOYSA-N 0.000 claims 1
- RNKXGCQFZNXIQF-UHFFFAOYSA-N n-cyclohexyl-2-methyl-2-(4-phenylmethoxyphenyl)sulfanylpropanamide Chemical compound C1CCCCC1NC(=O)C(C)(C)SC(C=C1)=CC=C1OCC1=CC=CC=C1 RNKXGCQFZNXIQF-UHFFFAOYSA-N 0.000 claims 1
- QTGVJHSAYOFFTG-UHFFFAOYSA-N n-cyclohexyl-2-methyl-2-(4-prop-2-enoxyphenyl)sulfanylpropanamide Chemical compound C1CCCCC1NC(=O)C(C)(C)SC1=CC=C(OCC=C)C=C1 QTGVJHSAYOFFTG-UHFFFAOYSA-N 0.000 claims 1
- 230000008816 organ damage Effects 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 0 C*1Oc(cccc2)c2OC(C)(*)C1 Chemical compound C*1Oc(cccc2)c2OC(C)(*)C1 0.000 description 4
- FPQOQDFWCJXVKF-UHFFFAOYSA-N CC1CC(C)OCC1 Chemical compound CC1CC(C)OCC1 FPQOQDFWCJXVKF-UHFFFAOYSA-N 0.000 description 1
- MGMHILKONGEISP-UHFFFAOYSA-N CCC(C)(CC)C(F)(F)F Chemical compound CCC(C)(CC)C(F)(F)F MGMHILKONGEISP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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Publications (2)
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Family Applications (1)
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Country Status (5)
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Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7064211B2 (en) * | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
| US7880001B2 (en) | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| US8415354B2 (en) | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US20100222316A1 (en) | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| WO2006002350A1 (en) * | 2004-06-24 | 2006-01-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| US20050288317A1 (en) * | 2004-06-24 | 2005-12-29 | Wenqing Yao | Amido compounds and their use as pharmaceuticals |
| CA2584502A1 (en) | 2004-06-24 | 2006-01-05 | Incyte Corporation | 2-methylpropanamides and their use as pharmaceuticals |
| US8071624B2 (en) | 2004-06-24 | 2011-12-06 | Incyte Corporation | N-substituted piperidines and their use as pharmaceuticals |
| WO2006012227A2 (en) * | 2004-06-24 | 2006-02-02 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| CA2571258A1 (en) * | 2004-06-24 | 2006-01-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| AU2005273986A1 (en) * | 2004-08-10 | 2006-02-23 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| HUE033977T2 (en) | 2004-08-23 | 2018-02-28 | Sylentis Sau | Treatment of eye disorders with siRNAs characterized by increased intraocular pressure |
| CN101300005B (zh) * | 2004-08-30 | 2013-05-01 | 詹森药业有限公司 | 作为11-β羟类固醇脱氢酶抑制剂的N-2金刚烷基-2-苯氧基-乙酰胺衍生物 |
| ES2547724T3 (es) * | 2004-11-10 | 2015-10-08 | Incyte Corporation | Compuestos de lactama y su uso como productos farmacéuticos |
| US8110581B2 (en) * | 2004-11-10 | 2012-02-07 | Incyte Corporation | Lactam compounds and their use as pharmaceuticals |
| CN101103016A (zh) * | 2004-11-18 | 2008-01-09 | 因塞特公司 | 11-β羟基类固醇脱氢酶1型抑制剂及其使用方法 |
| MX2007008238A (es) | 2005-01-05 | 2007-08-17 | Abbott Lab | Derivados de adamantilo como inhibidores de la enzima 11-beta-hidroxiesteroide deshidrogenasa tipo 1. |
| US8198331B2 (en) | 2005-01-05 | 2012-06-12 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US20090192198A1 (en) | 2005-01-05 | 2009-07-30 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| CN101142172A (zh) | 2005-01-05 | 2008-03-12 | 艾博特公司 | 11-β-羟甾类脱氢酶1型酶的抑制剂 |
| EP1866298A2 (en) * | 2005-03-31 | 2007-12-19 | Takeda San Diego, Inc. | Hydroxysteroid dehydrogenase inhibitors |
| TW200716576A (en) | 2005-06-07 | 2007-05-01 | Shionogi & Co | Heterocyclic derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| CA2621255A1 (en) * | 2005-09-21 | 2007-04-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| GB0521351D0 (en) * | 2005-10-20 | 2005-11-30 | Genomica Sau | Modulation of TRPV expression levels |
| GB0521716D0 (en) * | 2005-10-25 | 2005-11-30 | Genomica Sau | Modulation of 11beta-hydroxysteriod dehydrogenase 1 expression for the treatment of ocular diseases |
| CA2630492C (en) * | 2005-12-05 | 2015-04-14 | Incyte Corporation | Spiro-lactam compounds |
| WO2007084314A2 (en) * | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| AU2007210018A1 (en) * | 2006-01-31 | 2007-08-09 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| WO2007092435A2 (en) | 2006-02-07 | 2007-08-16 | Wyeth | 11-beta hsd1 inhibitors |
| US20070213311A1 (en) * | 2006-03-02 | 2007-09-13 | Yun-Long Li | Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| WO2007103719A2 (en) * | 2006-03-03 | 2007-09-13 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| EP2006286A4 (en) | 2006-03-30 | 2010-04-07 | Shionogi & Co | ISOXAZOLE DERIVATIVE AND ISOTHIAZONE DERIVATIVITY WITH ANTICIPATING EFFECT ON 11 TYPE I BETA HYDROXYSTEROIDDEHYDROGENASE |
| WO2007120083A1 (en) * | 2006-04-13 | 2007-10-25 | Astrazeneca Ab | The use of carboxamide derivatives in the manufacture of a medicament for the treatment of inflammatory, allergic and dermatological conditions |
| JP2009535420A (ja) * | 2006-05-01 | 2009-10-01 | インサイト・コーポレイション | １１−βヒドロキシルステロイドデヒドロゲナーゼタイプ１のモジュレーターとしてのテトラ置換ウレア |
| EP2018378A2 (en) * | 2006-05-17 | 2009-01-28 | Incyte Corporation | Heterocyclic inhibitors of 11-b hydroxyl steroid dehydrogenase type i and methods of using the same |
| ES2745411T3 (es) * | 2006-07-27 | 2020-03-02 | Wang Nai Fang | Compuestos y composiciones de arilsulfanilo para administración de agentes activos |
| KR20200123866A (ko) | 2007-02-09 | 2020-10-30 | 메타베이시스 테라퓨틱스, 인크. | 글루카곤 수용체의 길항제 |
| US8466296B2 (en) * | 2007-03-26 | 2013-06-18 | Ligand Pharmaceuticals | Compounds and processes for preparing substituted aminomethyl-2,3,8,9-tetrahydro-7H-1,4-dioxino[2,3-e]indol-8-ones |
| CL2008001839A1 (es) * | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
| JP5736098B2 (ja) | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | 中枢神経系障害を治療するための医薬組成物 |
| PT2799428T (pt) | 2008-08-13 | 2017-02-17 | Metabasis Therapeutics Inc | Antagonistas de glicagina |
| ES2350077B1 (es) | 2009-06-04 | 2011-11-04 | Laboratorios Salvat, S.A. | Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1. |
| GB201215857D0 (en) | 2012-09-05 | 2012-10-24 | Sylentis Sau | siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions |
| AU2012389270B2 (en) | 2012-09-05 | 2018-11-08 | Sylentis S.A.U. | siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions |
| US10011837B2 (en) | 2014-03-04 | 2018-07-03 | Sylentis Sau | SiRNAs and their use in methods and compositions for the treatment and/or prevention of eye conditions |
| WO2015191900A1 (en) | 2014-06-12 | 2015-12-17 | Ligand Pharmaceuticals, Inc. | Glucagon antagonists |
| CN105085345B (zh) * | 2015-08-14 | 2016-09-14 | 天津小新医药科技有限公司 | 含硝基的l-薄荷醇类p2y12受体拮抗剂及其用途 |
| CN105085346B (zh) * | 2015-08-14 | 2017-03-29 | 天津小新医药科技有限公司 | 含胺基的l-薄荷醇类p2y12受体拮抗剂及其用途 |
| EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
| WO2019160940A1 (en) | 2018-02-13 | 2019-08-22 | Ligand Pharmaceuticals Incorporated | Glucagon receptor antagonists |
| MA55556A (fr) | 2019-04-02 | 2022-02-09 | Aligos Therapeutics Inc | Composés ciblant prmt5 |
| TR202002326A2 (tr) * | 2020-02-17 | 2021-08-23 | Bahcesehir Ueniversitesi | Yeni̇ mouse double minute 2 (mdm2) i̇nhi̇bi̇törü olarak kullanmak i̇çi̇n drg-mdm2-5 |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE136963C (https=) | ||||
| NL130088C (https=) * | 1960-03-14 | |||
| US3201466A (en) * | 1963-03-08 | 1965-08-17 | Gulf Oil Corp | Substituted cyclopropanecarboxanilide herbicides |
| US3666860A (en) * | 1966-12-23 | 1972-05-30 | Gerald Berkelhammer | Substituted nitroimidazolylthiadiazoles and oxadiazoles as antiprotozoal agents |
| US3849403A (en) * | 1968-04-29 | 1974-11-19 | American Home Prod | 2,3,4,5-tetrahydro-1,1,5,5-tetrasubstituted-1h-3-benzazepines |
| FR1600908A (en) | 1968-11-14 | 1970-08-03 | Hypocholesterolaemic and anorexigenic - phenoxy alkanoylaralkylamines | |
| DE2114420A1 (de) * | 1971-03-25 | 1972-10-05 | Merck Patent Gmbh, 6100 Darmstadt | Substituierte Phenylalkanol-Derivate und Verfahren zu ihrer Herstellung |
| ES427013A1 (es) | 1974-06-05 | 1976-07-16 | Alter Sa | Un procedimiento de preparacion de ciertas amidas del aci- do 2 - (p - clorofenoxi) - 2 - metilpropionico. |
| GB1460389A (en) * | 1974-07-25 | 1977-01-06 | Pfizer Ltd | 4-substituted quinazoline cardiac stimulants |
| US3933829A (en) * | 1974-08-22 | 1976-01-20 | John Wyeth & Brother Limited | 4-Aminoquinoline derivatives |
| TR18917A (tr) | 1974-10-31 | 1977-12-09 | Ciba Geigy Ag | 1-(bis-triflormetilfenil)-2-oksopirolidin-4-karbonik asitleri ve bunlarin tuerevleri |
| FR2312247A1 (fr) | 1975-05-30 | 1976-12-24 | Parcor | Derives de la thieno-pyridine, leur procede de preparation et leurs applications |
| US4145435A (en) * | 1976-11-12 | 1979-03-20 | The Upjohn Company | 2-aminocycloaliphatic amide compounds |
| US4439606A (en) | 1982-05-06 | 1984-03-27 | American Cyanamid Company | Antiatherosclerotic 1-piperazinecarbonyl compounds |
| CA1325217C (en) | 1983-11-07 | 1993-12-14 | John T. Lai | 3,5-dialkyl-4-hydroxyphenyl-substituted derivatives |
| JPS60149562A (ja) | 1984-01-13 | 1985-08-07 | Kyorin Pharmaceut Co Ltd | 新規なピペリジン誘導体およびその製法 |
| EP0273659A1 (en) | 1986-12-27 | 1988-07-06 | Takeda Chemical Industries, Ltd. | Azaspiro compounds, their production and use |
| DE3920616A1 (de) | 1989-06-23 | 1991-01-03 | Boehringer Mannheim Gmbh | Arzneimittel, enthaltend di-tert.-butylhydroxyphenyl-derivate sowie neue derivate |
| JP2801269B2 (ja) * | 1989-07-10 | 1998-09-21 | キヤノン株式会社 | 化合物およびこれを含む液晶組成物およびこれを使用した液晶素子 |
| US5206240A (en) * | 1989-12-08 | 1993-04-27 | Merck & Co., Inc. | Nitrogen-containing spirocycles |
| US5852029A (en) * | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
| FR2672213B1 (fr) * | 1991-02-05 | 1995-03-10 | Sanofi Sa | Utilisation de derives 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridiniques comme capteurs de radicaux libres. |
| JPH04334357A (ja) | 1991-05-02 | 1992-11-20 | Fujirebio Inc | 酵素阻害作用を有するアシル誘導体 |
| FR2678272B1 (fr) * | 1991-06-27 | 1994-01-14 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
| DE4234295A1 (de) | 1992-10-12 | 1994-04-14 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| FR2705343B1 (fr) | 1993-05-17 | 1995-07-21 | Fournier Ind & Sante | Dérivés de beta,beta-diméthyl-4-pipéridineéthanamine, leur procédé de préparation et leur utilisation en thérapeutique. |
| FR2724656B1 (fr) | 1994-09-15 | 1996-12-13 | Adir | Nouveaux derives du benzopyranne, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2734265B1 (fr) | 1995-05-17 | 1997-06-13 | Adir | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
| US5693567A (en) * | 1995-06-07 | 1997-12-02 | Xerox Corporation | Separately etching insulating layer for contacts within array and for peripheral pads |
| FR2736053B1 (fr) | 1995-06-28 | 1997-09-19 | Sanofi Sa | Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines |
| GB9517622D0 (en) * | 1995-08-29 | 1995-11-01 | Univ Edinburgh | Regulation of intracellular glucocorticoid concentrations |
| WO1997011940A1 (en) | 1995-09-29 | 1997-04-03 | Eli Lilly And Company | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation |
| GB9604311D0 (en) * | 1996-02-29 | 1996-05-01 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase |
| ES2243996T3 (es) | 1996-05-01 | 2005-12-01 | Ortho-Mcneil Pharmaceutical, Inc. | Derivados carboxamida de pirrolidina, piperidina y hexahidroazepina utilizados en el tratamiento de trastornos de trombosis. |
| US6770748B2 (en) * | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| SI0921125T1 (en) | 1997-12-05 | 2002-04-30 | F. Hoffmann-La Roche Ag | 1,3,8-Triazaspiro(4,5)decan-4-on derivatives |
| US6087368A (en) | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
| JP2002519428A (ja) | 1998-07-02 | 2002-07-02 | メルク エンド カムパニー インコーポレーテッド | プレニル−タンパク質トランスフェラーゼの阻害剤 |
| CA2315050C (en) * | 1998-10-16 | 2009-02-03 | Suntory Limited | Aminophenoxyacetic acid derivatives and pharmaceutical composition containing thereof |
| EP1165500A1 (en) | 1999-04-02 | 2002-01-02 | Du Pont Pharmaceuticals Company | Amide derivatives as inhibitors of matrix metalloproteinases,tnf-alpha,and aggrecanase |
| HUP0203548A3 (en) | 1999-07-21 | 2003-04-28 | Astrazeneca Ab | New spirooxindole derivatives, process for their preparation, pharmaceutical compositions containing them and their use |
| ATE250604T1 (de) | 1999-10-27 | 2003-10-15 | Millennium Pharm Inc | Pyridyl enthaltende spirocyclische verbindungen als inhibitoren der fibrinogen-abhängigen blutplättchen aggregation |
| EP1236726B1 (en) * | 1999-12-03 | 2004-12-01 | Ono Pharmaceutical Co., Ltd. | Triazaspiro 5.5]undecane derivatives and drugs containing the same as the active ingredient |
| RU2265021C2 (ru) | 1999-12-03 | 2005-11-27 | Оно Фармасьютикал Ко., Лтд. | Производные триазаспиро[5,5]ундекана (варианты), фармацевтическая композиция и способ регулирования хемокина/рецептора хемокина |
| IL151552A0 (en) | 2000-03-17 | 2003-04-10 | Bristol Myers Squibb Pharma Co | Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha |
| MXPA02009659A (es) * | 2000-04-26 | 2003-03-10 | Warner Lambert Co | Derivado de ciclohexilamina como subtipo de los antagonistas del receptor selectivo nmda. |
| CA2415174A1 (en) | 2000-07-06 | 2002-01-17 | Thomas W. Bell | Methods and kits for the detection of arginine compounds |
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| US6496627B1 (en) | 2000-07-14 | 2002-12-17 | Tyco Telecommunications (Us) Inc. | Device and method for improved long term signal attenuation performance of fiber optic cable and apparatus interfaces |
| US7294637B2 (en) | 2000-09-11 | 2007-11-13 | Sepracor, Inc. | Method of treating addiction or dependence using a ligand for a monamine receptor or transporter |
| EP1318988A2 (en) | 2000-09-11 | 2003-06-18 | Sepracor, Inc. | Ligands for monoamine receptors and transporters, and methods of use thereof (neurotransmission) |
| WO2002046156A2 (en) | 2000-12-06 | 2002-06-13 | Sepracor, Inc. | 4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands |
| US7102009B2 (en) * | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| ES2284817T3 (es) | 2001-01-26 | 2007-11-16 | Chugai Seiyaku Kabushiki Kaisha | Procedimientos para el tratamiento de enfermedades con inhibidores de la malonil coa descarboxilasa. |
| WO2002069973A1 (en) | 2001-03-02 | 2002-09-12 | Sepracor, Inc. | Piperidine-piperazine ligand for neurotransmitter receptors |
| JP2004529134A (ja) | 2001-03-29 | 2004-09-24 | スミスクライン・ビーチャム・コーポレイション | ピロリジンスルホンアミド |
| EP1406884A1 (en) | 2001-05-11 | 2004-04-14 | Biovitrum Ab | Arylsusfonamide compounds for the treatment of obesity, type ii diabetes and cns-disorders |
| WO2003000657A1 (en) * | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
| US6547958B1 (en) | 2001-07-13 | 2003-04-15 | Chevron U.S.A. Inc. | Hydrocarbon conversion using zeolite SSZ-59 |
| GB0118238D0 (en) | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
| MY138086A (en) | 2001-09-13 | 2009-04-30 | Smithkline Beecham Plc | Novel urea derivative as vanilloid receptor-1 antagonist |
| WO2003037271A2 (en) | 2001-10-30 | 2003-05-08 | Millennium Pharmaceuticals,Inc. | Compounds, pharmaceutical compositions and methods of use therefor |
| GB0126292D0 (en) * | 2001-11-01 | 2002-01-02 | Smithkline Beecham Plc | Compounds |
| WO2003041641A2 (en) | 2001-11-09 | 2003-05-22 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity |
| RS44204A (sr) * | 2001-11-22 | 2007-06-04 | Biovitrum Ab., | Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1 |
| US7030141B2 (en) | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
| US7644394B2 (en) * | 2001-11-30 | 2010-01-05 | International Business Machines Corporation | Object-oriented creation breakpoints |
| AU2002360561A1 (en) | 2001-12-11 | 2003-06-23 | Sepracor, Inc. | 4-substituted piperidines, and methods of use thereof |
| US6818772B2 (en) | 2002-02-22 | 2004-11-16 | Abbott Laboratories | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor |
| JP3813152B2 (ja) * | 2002-03-12 | 2006-08-23 | メルク エンド カムパニー インコーポレーテッド | 置換アミド類 |
| AU2003221715A1 (en) * | 2002-06-14 | 2003-12-31 | Alcon, Inc. | Use of hydroxyeicosatetraenoic acid compounds to treat vaginal dryness |
| GB0213715D0 (en) * | 2002-06-14 | 2002-07-24 | Syngenta Ltd | Chemical compounds |
| JP2005529975A (ja) * | 2002-06-19 | 2005-10-06 | イーライ・リリー・アンド・カンパニー | アミドリンカーペルオキシソーム増殖因子活性化受容体調節因子 |
| US20040072802A1 (en) * | 2002-10-09 | 2004-04-15 | Jingwu Duan | Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha |
| EP1553098A1 (en) * | 2002-10-18 | 2005-07-13 | Ono Pharmaceutical Co., Ltd. | Spiroheterocyclic derivative compounds and drugs comprising the compounds as the active ingredient |
| WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| US20040188324A1 (en) * | 2003-03-26 | 2004-09-30 | Saleh Elomari | Hydrocarbon conversion using molecular sieve SSZ-65 |
| JPWO2005047286A1 (ja) * | 2003-11-13 | 2007-05-31 | 小野薬品工業株式会社 | スピロ複素環化合物 |
| TWI350168B (en) * | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| WO2006002350A1 (en) * | 2004-06-24 | 2006-01-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| CA2584502A1 (en) | 2004-06-24 | 2006-01-05 | Incyte Corporation | 2-methylpropanamides and their use as pharmaceuticals |
| WO2006012227A2 (en) * | 2004-06-24 | 2006-02-02 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| US20050288317A1 (en) * | 2004-06-24 | 2005-12-29 | Wenqing Yao | Amido compounds and their use as pharmaceuticals |
| CA2571258A1 (en) * | 2004-06-24 | 2006-01-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| US8071624B2 (en) * | 2004-06-24 | 2011-12-06 | Incyte Corporation | N-substituted piperidines and their use as pharmaceuticals |
| AU2005273986A1 (en) * | 2004-08-10 | 2006-02-23 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| ES2547724T3 (es) * | 2004-11-10 | 2015-10-08 | Incyte Corporation | Compuestos de lactama y su uso como productos farmacéuticos |
| ES2377758T3 (es) * | 2004-11-12 | 2012-03-30 | Bristol-Myers Squibb Company | Compuestos tricíclicos basados en tiazolo[4,5-b]piridina imidazo-fusionada y composiciones farmacéuticas que los comprenden |
| CN101103016A (zh) * | 2004-11-18 | 2008-01-09 | 因塞特公司 | 11-β羟基类固醇脱氢酶1型抑制剂及其使用方法 |
| CN101142172A (zh) | 2005-01-05 | 2008-03-12 | 艾博特公司 | 11-β-羟甾类脱氢酶1型酶的抑制剂 |
| EP1866285A1 (en) | 2005-03-03 | 2007-12-19 | F. Hoffmann-Roche AG | 1-sulfonyl-piperdine-3-carboxylic acid amide derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase for the treatment of type ii diabetes mellitus |
| TW200715993A (en) * | 2005-06-15 | 2007-05-01 | Senomyx Inc | Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers |
| CA2621255A1 (en) * | 2005-09-21 | 2007-04-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| CA2630492C (en) * | 2005-12-05 | 2015-04-14 | Incyte Corporation | Spiro-lactam compounds |
| WO2007084314A2 (en) * | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| AU2007210018A1 (en) * | 2006-01-31 | 2007-08-09 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| US20070213311A1 (en) * | 2006-03-02 | 2007-09-13 | Yun-Long Li | Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| WO2007103719A2 (en) * | 2006-03-03 | 2007-09-13 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| JP2009535420A (ja) * | 2006-05-01 | 2009-10-01 | インサイト・コーポレイション | １１−βヒドロキシルステロイドデヒドロゲナーゼタイプ１のモジュレーターとしてのテトラ置換ウレア |
| EP2018378A2 (en) * | 2006-05-17 | 2009-01-28 | Incyte Corporation | Heterocyclic inhibitors of 11-b hydroxyl steroid dehydrogenase type i and methods of using the same |
| US8799050B2 (en) * | 2007-05-18 | 2014-08-05 | Bank Of America Corporation | Resource demand capacity mechanism |
| CL2008001839A1 (es) * | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
-
2005
- 2005-06-23 CA CA002584502A patent/CA2584502A1/en not_active Abandoned
- 2005-06-23 JP JP2007518304A patent/JP2008504280A/ja not_active Withdrawn
- 2005-06-23 WO PCT/US2005/022434 patent/WO2006002361A2/en not_active Ceased
- 2005-06-23 EP EP05763245A patent/EP1768954A4/en not_active Withdrawn
- 2005-06-23 US US11/159,865 patent/US7687665B2/en not_active Expired - Fee Related
-
2010
- 2010-02-02 US US12/698,261 patent/US20100137401A1/en not_active Abandoned
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